Bioaerosol lung damage in a worker with repeated exposure to fungi in a water-damaged building.

abstract：:Metallothioneins (MTs) are encoded by a multigene family in man. We have isolated those genes and analyzed the structure of some of them. The MT-II variant is encoded by a single functional gene: MT-IIA. The MT-IIB gene is a processed pseudogene derived from a reverse transcript of MT-II mRNA. On the other hand, the M...

journal_title：Environmental health perspectives

authors： Karin M,Richards RI

更新日期：1984-03-01 00:00:00

abstract：:Metals continually rank at the top of the U.S. Environmental Protection Agency's annual list of agents that pose the greatest hazard to the people of the United States. Metals aren't going away, either. They do not biodegrade, and they often concentrate in human and animal cells and tissue. Many metals are known human...

journal_title：Environmental health perspectives

authors： Fisher BE

更新日期：1999-05-01 00:00:00

abstract：:There is a need to identify specific biological indicator(s) of cadmium exposure so that the renal damage can be prevented. Towards this end, we have examined the usefulness of urinary metallothionein as an indicator of cadmium body burden. It is found that, in both animals and humans, urinary metallothionein level is...

journal_title：Environmental health perspectives

authors： Shaikh ZA,Tohyama C

更新日期：1984-03-01 00:00:00

abstract：:In this study we investigated the potential impact of climate change in Portugal on heat-related mortality, air pollution-related health effects, and selected vectorborne diseases. The assessment used climate scenarios from two regional climate models for a range of future time periods. The annual heat-related death r...

journal_title：Environmental health perspectives

authors： Casimiro E,Calheiros J,Santos FD,Kovats S

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental pollutants, known human lung carcinogens, and potent mammary carcinogens in laboratory animals. However, the association between PAHs and breast cancer in women is unclear. Vehicular traffic is a major ambient source of PAH exposure. OBJEC...

journal_title：Environmental health perspectives

authors： Mordukhovich I,Beyea J,Herring AH,Hatch M,Stellman SD,Teitelbaum SL,Richardson DB,Millikan RC,Engel LS,Shantakumar S,Steck SE,Neugut AI,Rossner P Jr,Santella RM,Gammon MD

更新日期：2016-01-01 00:00:00

abstract：:Food allergy affects between 5% and 7.5% of children and between 1% and 2% of adults. The greater prevalence of food allergy in children reflects both the increased predisposition of children to develop food allergies and the development of immunologic tolerance to certain foods over time. Immunoglobulin (Ig) E-mediat...

journal_title：Environmental health perspectives

authors： Kagan RS

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Animal studies suggest that early-life lead exposure influences gene expression and production of proteins associated with Alzheimer's disease (AD). OBJECTIVES:We attempted to assess the relationship between early-life lead exposure and potential biomarkers for AD among young men and women. We also attempte...

journal_title：Environmental health perspectives

authors： Mazumdar M,Xia W,Hofmann O,Gregas M,Ho Sui S,Hide W,Yang T,Needleman HL,Bellinger DC

更新日期：2012-05-01 00:00:00

abstract：:Children may be more susceptible to exposures to environmental toxins than adults and may be more vulnerable to their effects. Because of this, the health care community and those responsible for children need to be alert to possible environmental factors in identifying and responding to the health problems of childre...

journal_title：Environmental health perspectives

authors： Goldman LR

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:Fine particulate matter (FPM) in ambient air causes premature mortality due to cardiac disease in susceptible populations. OBJECTIVE:Our objective in this study was to determine the most influential FPM components. METHODS:A mouse model of atherosclerosis (ApoE-/-) was exposed to either filtered air or con...

journal_title：Environmental health perspectives

authors： Lippmann M,Ito K,Hwang JS,Maciejczyk P,Chen LC

更新日期：2006-11-01 00:00:00

abstract：:Groups of female SENCAR or BALB/c mice were initiated once intraperitoneally with 300 micrograms/mouse of 7,12-dimethylbenz(a)anthracene (DMBA) or 20 mg/mouse of urethane at 7 weeks of age. Beginning one week later, mice received topically applied acetone or 12-O-tetradecanoylphorbol-13-acetate (TPA), once weekly, at ...

journal_title：Environmental health perspectives

authors： Ward JM,Rehm S,Devor D,Hennings H,Wenk ML

更新日期：1986-09-01 00:00:00

abstract：:Although broad links between climatic factors and coccidioidomycosis have been established, the identification of simple and robust relationships linking climatic controls to seasonal timing and outbreaks of the disease has remained elusive. Using an adaptive data-oriented method for estimating date of exposure, in th...

journal_title：Environmental health perspectives

authors： Comrie AC

更新日期：2005-06-01 00:00:00

abstract：:Human DNA adduct formation (covalent modification of DNA with chemical carcinogens) is a promising biomarker for elucidating the molecular epidemiology of cancer. Classes of compounds for which human DNA adducts have been observed include polycyclic aromatic hydrocarbons (PAHs), nitrosamines, mycotoxins, aromatic amin...

journal_title：Environmental health perspectives

authors： Poirier MC,Weston A

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:Organophosphate flame retardants (PFRs) are becoming popular replacements for the phased-out polybrominated diphenyl ether (PBDE) mixtures, and they are now commonly detected in indoor environments. However, little is known about human exposure to PFRs because they cannot be easily measured in blood or serum...

journal_title：Environmental health perspectives

authors： Hoffman K,Garantziotis S,Birnbaum LS,Stapleton HM

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:THE APHENA (AIR POLLUTION AND HEALTH: A Combined European and North American Approach) study is a collaborative analysis of multicity time-series data on the effect of air pollution on population health, bringing together data from the European APHEA (Air Pollution and Health: A European Approach) and U.S. N...

journal_title：Environmental health perspectives

authors： Samoli E,Peng R,Ramsay T,Pipikou M,Touloumi G,Dominici F,Burnett R,Cohen A,Krewski D,Samet J,Katsouyanni K

更新日期：2008-11-01 00:00:00

abstract：:The integrated exposure uptake biokinetic model for lead in children was developed to provide plausible blood lead distributions corresponding to particular combinations of multimedia lead exposure. The model is based on a set of equations that convert lead exposure (expressed as micrograms per day) to blood lead conc...

journal_title：Environmental health perspectives

authors： White PD,Van Leeuwen P,Davis BD,Maddaloni M,Hogan KA,Marcus AH,Elias RW

更新日期：1998-12-01 00:00:00

abstract：OBJECTIVE:Animal feeding practices in the United States have changed considerably over the past century. As large-scale, concentrated production methods have become the predominant model for animal husbandry, animal feeds have been modified to include ingredients ranging from rendered animals and animal waste to antibi...

journal_title：Environmental health perspectives

authors： Sapkota AR,Lefferts LY,McKenzie S,Walker P

更新日期：2007-05-01 00:00:00

abstract：:Studies conducted by the National Toxicology Program on the chronic toxicity of benzene indicated that B6C3F1 mice were more sensitive to the carcinogenic effects of benzene than were F344 rats. A physiological model was developed to describe the uptake and metabolism of benzene in rats and mice. Our objective was to ...

journal_title：Environmental health perspectives

authors： Medinsky MA,Sabourin PJ,Henderson RF,Lucier G,Birnbaum LS

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND:Bisphenol A (BPA) is widely used in the manufacture of polycarbonate plastic bottles, food and beverage can linings, thermal receipts, and dental sealants. Animal and human studies suggest that BPA may disrupt thyroid function. Although thyroid hormones play a determinant role in human growth and brain devel...

journal_title：Environmental health perspectives

authors： Chevrier J,Gunier RB,Bradman A,Holland NT,Calafat AM,Eskenazi B,Harley KG

更新日期：2013-01-01 00:00:00

abstract：:The chlorinated hydrocarbons chloroform (CHCl3), 1,1-dichlorethane (1,1-DCE) and 1,2-dichloroethane (1,2-DCE) have been detected in finished drinking water. When administered to B6C3F1 mice by gavage in corn oil, these compounds have been shown to induce hepatic tumors. The present study examines the effect on liver t...

journal_title：Environmental health perspectives

authors： Klaunig JE,Ruch RJ,Pereira MA

更新日期：1986-11-01 00:00:00

abstract：:Metals have been mined and used since ancient times. The industrial era has seen a sharp increase in both the amounts and variety of metals that find applications in industry. The inadvertent release of metals, such as from fossil fuel consumption, also adds to the global burden. A number of catastrophic outbreaks hav...

journal_title：Environmental health perspectives

authors： Clarkson T

更新日期：1995-02-01 00:00:00

abstract：:The potential danger of natural mercury accumulation in the diet of the Eskimo is evaluated through mercury levels determined in cord blood, placenta, maternal blood, hair, and milk of 38 maternal-infant pairs from Anchorage and the Yukon-Kuskokwim Delta. Although mercury levels are not discernably dangerous, trends t...

journal_title：Environmental health perspectives

authors： Galster WA

更新日期：1976-06-01 00:00:00

abstract：:Current research indicates a role for several oncogenes in radiation-induced carcinogenesis in vivo and cell transformation in vitro. Certain oncogenes are probably also involved in some cases of human cancer caused by exposure to nonionizing radiation and may play a mechanistic role in the phenomenon of radioresistan...

journal_title：Environmental health perspectives

authors： Garte SJ,Burns FJ

更新日期：1991-06-01 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) are widespread, low-level environmental pollutants associated with adverse health effects such as immune suppression and teratogenicity. There is increasing evidence that some PCB compounds are capable of disrupting reproductive and endocrine function in fish, birds, and mammals, inclu...

journal_title：Environmental health perspectives

authors： Bergeron JM,Crews D,McLachlan JA

更新日期：1994-09-01 00:00:00

abstract：:The industrial accident that occurred in the town of Seveso, Italy, in 1976 exposed a large population to substantial amounts of relatively pure 2,3,7,8-tetrachlorodibenzo-p-dioxin. Extensive monitoring of soil levels and measurements of a limited number of human blood samples allowed classification of the exposed pop...

journal_title：Environmental health perspectives

authors： Bertazzi PA,Bernucci I,Brambilla G,Consonni D,Pesatori AC

更新日期：1998-04-01 00:00:00

abstract：:Groundwater contamination is a serious problem that is growing in the United States, but its true extent is not known and it is difficult to determine because of the complexities of contaminants, their transformation, and fate in groundwater systems. It is also difficult to predict their movement in groundwater. Since...

journal_title：Environmental health perspectives

authors： Patrick R

更新日期：1990-06-01 00:00:00

abstract：:We review pharmacokinetic and pharmacodynamic factors that should be considered in the design and interpretation of developmental neurotoxicity studies. Toxicologic effects on the developing nervous system depend on the delivered dose, exposure duration, and developmental stage at which exposure occurred. Several phar...

journal_title：Environmental health perspectives

authors： Dorman DC,Allen SL,Byczkowski JZ,Claudio L,Fisher JE Jr,Fisher JW,Harry GJ,Li AA,Makris SL,Padilla S,Sultatos LG,Mileson BE

更新日期：2001-03-01 00:00:00

abstract：:Noise exposure causes changes at different levels in human organs, particularly the cardiovascular system, where it is responsible for increasing heart rate, peripheral vascular resistance, and blood pressure. In this study, we evaluated the effect of noise exposure on DNA integrity and ultrastructure of rat cardiomyo...

journal_title：Environmental health perspectives

authors： Lenzi P,Frenzilli G,Gesi M,Ferrucci M,Lazzeri G,Fornai F,Nigro M

更新日期：2003-04-01 00:00:00

abstract：SUMMARY:From climate change to hydraulic fracturing, and from drinking water safety to wildfires, environmental challenges are changing. The United States has made substantial environmental protection progress based on media-specific and single pollutant risk-based frameworks. However, today’s environmental problems ar...

journal_title：Environmental health perspectives

authors： Burke TA,Cascio WE,Costa DL,Deener K,Fontaine TD,Fulk FA,Jackson LE,Munns WR,Orme-Zavaleta J,Slimak MW,Zartarian VG

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Manganese is a common natural contaminant of groundwater in Bangladesh. In this cross-sectional study we assessed the association between water manganese and all-cause infant mortality in the offspring of female participants in the Health Effects of Arsenic Longitudinal Study Cohort. METHODS:In 2001, drinki...

journal_title：Environmental health perspectives

authors： Hafeman D,Factor-Litvak P,Cheng Z,van Geen A,Ahsan H

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Microcystin-producing Microcystis bloom is a severe water problem in the world. Some reports indicate that chronic exposure to microcystin may result in liver damage in adults, but information on effects in children is limited. OBJECTIVE:We investigated the relationship between microcystin exposure and live...

journal_title：Environmental health perspectives

authors： Li Y,Chen JA,Zhao Q,Pu C,Qiu Z,Zhang R,Shu W

更新日期：2011-10-01 00:00:00