Carcinogenicity of chlorinated methane and ethane compounds administered in drinking water to mice.

abstract：:Although press reports indicate that the leakage of methyl isocyanate (MIC) on December 3, 1984, in Bhopal has led to an increase in spontaneous abortions, stillbirths, infant mortality, and fetal abnormalities, no clinical or experimental studies on the reproductive toxicity of MIC were reported in scientific journal...

journal_title：Environmental health perspectives

authors： Varma DR

更新日期：1987-06-01 00:00:00

abstract：BACKGROUND:Cadmium exposure may increase the risk of cardiovascular disease. The only published longitudinal study on cadmium and incident cardiovascular disease was performed in American Indians with relatively high cadmium exposure. OBJECTIVES:Our aim was to examine the association between blood cadmium at baseline ...

journal_title：Environmental health perspectives

authors： Barregard L,Sallsten G,Fagerberg B,Borné Y,Persson M,Hedblad B,Engström G

更新日期：2016-05-01 00:00:00

abstract：:A patient with massive exposure to tetrachloroethylene fumes presented with coma and severe pulmonary edema. Sequential blood gases, chest x-rays, and clinical findings showed dramatic improvement with conventional but aggressive management and the patient recovered completely. There was no evidence of permanent renal...

journal_title：Environmental health perspectives

authors： Patel R,Janakiraman N,Towne WD

更新日期：1977-12-01 00:00:00

abstract：BACKGROUND:Traffic noise has been associated with cardiovascular and metabolic disorders. Potential modes of action are through stress and sleep disturbance, which may lead to endocrine dysregulation and overweight. OBJECTIVES:We aimed to investigate the relationship between residential traffic and railway noise and a...

journal_title：Environmental health perspectives

authors： Christensen JS,Raaschou-Nielsen O,Tjønneland A,Overvad K,Nordsborg RB,Ketzel M,Sørensen TIa,Sørensen M

更新日期：2016-03-01 00:00:00

abstract：:Many naturally occurring and man-made chemicals present in the environment possess estrogenic activity. Examples include plant and fungal products, pesticides, plasticizers, and other agricultural and industrial chemicals. These environmental estrogens as well as endogenous ovarian estrogens are thought to initiate th...

journal_title：Environmental health perspectives

authors： Stancel GM,Boettger-Tong HL,Chiappetta C,Hyder SM,Kirkland JL,Murthy L,Loose-Mitchell DS

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:Exposure to arsenic via drinking water is a global environmental health problem. In utero exposure to arsenic via drinking water increases the risk of lower respiratory tract infections during infancy and mortality from bronchiectasis in early adulthood. OBJECTIVES:We aimed to investigate how arsenic exposu...

journal_title：Environmental health perspectives

authors： Ramsey KA,Bosco A,McKenna KL,Carter KW,Elliot JG,Berry LJ,Sly PD,Larcombe AN,Zosky GR

更新日期：2013-02-01 00:00:00

abstract：:Man-made endocrine-disrupting chemicals (EDCs) present a threat to biodiversity, even in remote areas. To date, numerous wildlife species have been affected by EDCs in the environment, but it is likely that many more species are suffering effects that have not yet been reported. Impaired reproduction, damaged brain fu...

journal_title：Environmental health perspectives

authors： Lyons G

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:Glycol ethers (GE) are widely used organic solvents. Despite the potential neurotoxicity of several families of organic solvents, little is known about the impact of GE on the neurodevelopment of infants and children. OBJECTIVES:We investigated the relation between urinary concentrations of GE metabolites i...

journal_title：Environmental health perspectives

authors： Béranger R,Garlantézec R,Le Maner-Idrissi G,Lacroix A,Rouget F,Trowbridge J,Warembourg C,Monfort C,Le Gléau F,Jourdin M,Multigner L,Cordier S,Chevrier C

更新日期：2017-04-01 00:00:00

abstract：:The purpose of this investigation was to determine whether there has been a change in the human blood concentration of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and five other fluorochemicals since 1974. Blood samples were collected in 1974 (serum) and 1989 (plasma) from volunteer participants of a l...

journal_title：Environmental health perspectives

authors： Olsen GW,Huang HY,Helzlsouer KJ,Hansen KJ,Butenhoff JL,Mandel JH

更新日期：2005-05-01 00:00:00

abstract：:The role of cell-specific metabolism in benzene toxicity was examined in both murine and human bone marrow. Hemopoietic progenitor cells and stromal cells are important control points for regulation of hemopoiesis. We show that the selective toxicity of hydroquinone at the level of the macrophage in murine bone marrow...

journal_title：Environmental health perspectives

authors： Ross D,Siegel D,Schattenberg DG,Sun XM,Moran JL

更新日期：1996-12-01 00:00:00

abstract：:A review of the literature is provided for the topic of health-related research and power frequency electromagnetic fields. Minimal evidence for concern is present on the basis of animal and plant research. General observation would accord with the implication that there is no single and manifest health effect as the ...

journal_title：Environmental health perspectives

authors： Aldrich TE,Easterly CE

更新日期：1987-11-01 00:00:00

abstract：:During 1992 and 1993 the Wisconsin Division of Health investigated five cases in which copper-contaminated drinking water was suspected of causing gastrointestinal upsets. Each of these case studies was conducted after our office was notified of high copper levels in drinking water or notified of unexplained illnesses...

journal_title：Environmental health perspectives

authors： Knobeloch L,Ziarnik M,Howard J,Theis B,Farmer D,Anderson H,Proctor M

更新日期：1994-11-01 00:00:00

abstract：:The Environmental Public Health Tracking Network (EPHTN) proposes to link environmental hazards and exposures to health outcomes. Statistical methods used in case-control and cohort studies to link health outcomes to individual exposure estimates are well developed. However, reliable exposure estimates for many contam...

journal_title：Environmental health perspectives

authors： Mather FJ,White LE,Langlois EC,Shorter CF,Swalm CM,Shaffer JG,Hartley WR

更新日期：2004-10-01 00:00:00

abstract：:The combination of cigarette smoke and high-level occupational asbestos exposure produces a synergistic increase in the incidence of lung cancer; however, smoking does not affect the incidence of mesothelioma. Here we present the results of tests of two theories that have been proposed to explain this phenomenon; name...

journal_title：Environmental health perspectives

authors： Sekhon HS,Keeling B,Churg A

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:Lead (Pb) exposure has been associated with a host of pathological conditions in humans. In rodents Pb exposure has been shown to alter the hypothalamic-pituitary-adrenal (HPA) axis function. OBJECTIVE:We investigated the effects of lead on responses of the HPA axis to a psychosocial laboratory stressor adm...

journal_title：Environmental health perspectives

authors： Fortin MC,Cory-Slechta DA,Ohman-Strickland P,Nwankwo C,Yanger TS,Todd AC,Moynihan J,Walton J,Brooks A,Fiedler N

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Incorporating the influence of genetic variation in the risk assessment process is often considered, but no generalized approach exists. Many common human diseases such as asthma, cancer, and cardiovascular disease are complex in nature, as they are influenced variably by environmental, physiologic, and gene...

journal_title：Environmental health perspectives

authors： Demchuk E,Yucesoy B,Johnson VJ,Andrew M,Weston A,Germolec DR,De Rosa CT,Luster MI

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Methylmercury (MeHg), a worldwide contaminant found in fish and seafood, has been linked to an increased risk of cardiovascular mortality. OBJECTIVE:We examined 42 Faroese whaling men (30-70 years of age) to assess possible adverse effects within a wide range of MeHg exposures from consumption of pilot whal...

journal_title：Environmental health perspectives

authors： Choi AL,Weihe P,Budtz-Jørgensen E,Jørgensen PJ,Salonen JT,Tuomainen TP,Murata K,Nielsen HP,Petersen MS,Askham J,Grandjean P

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:Globally, 2.8 billion people rely on household solid fuels. Reducing the resulting adverse health, environmental, and development consequences will involve transitioning through a mix of clean fuels and improved solid fuel stoves (IS) of demonstrable effectiveness. To date, achieving uptake of IS has present...

journal_title：Environmental health perspectives

authors： Rehfuess EA,Puzzolo E,Stanistreet D,Pope D,Bruce NG

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Perchlorate, thiocyanate, and nitrate are sodium/iodide symporter (NIS) inhibitors that block iodide uptake into the thyroid, thus affecting thyroid function. Thyroid dysfunction can adversely affect somatic growth and development in children. To our knowledge, no studies have examined effects of NIS inhibit...

journal_title：Environmental health perspectives

authors： Mervish NA,Pajak A,Teitelbaum SL,Pinney SM,Windham GC,Kushi LH,Biro FM,Valentin-Blasini L,Blount BC,Wolff MS,Breast Cancer and Environment Research Project (BCERP).

更新日期：2016-04-01 00:00:00

abstract：:A co-culture clonal survival assay was developed to measure the cytotoxicity of test chemical treatments to BALB/c-3T3 cells because the standard clonal survival assay using 200 wild type (WT) cells frequently overestimates chemical cytotoxicity when compared with identical treatment doses in high-density cultures. Th...

journal_title：Environmental health perspectives

authors： Matthews EJ

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:The incidence of asbestos-induced human cancers is increasing worldwide, and considerable evidence suggests that reactive oxygen species (ROS) are important mediators of these diseases. Our previous studies suggested that mitochondria might be involved in the initiation of oxidative stress in asbestos-expose...

journal_title：Environmental health perspectives

authors： Huang SX,Partridge MA,Ghandhi SA,Davidson MM,Amundson SA,Hei TK

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:One of the most widely used classes of insecticides is the synthetic pyrethroids. Although pyrethroids are less acutely toxic to humans than to insects, in vitro studies have suggested that pyrethroids may be estrogenic. OBJECTIVES:We assessed pubertal effects by orally administering 0.5, 1.0, and 5.0 mg/kg...

journal_title：Environmental health perspectives

authors： Pine MD,Hiney JK,Lee B,Dees WL

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Previous research suggests perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) may be associated with adverse pregnancy outcomes. OBJECTIVE:We conducted a population-based study of PFOA and PFOS and birth outcomes from 2005 through 2010 in a Mid-Ohio Valley community exposed to high levels of...

journal_title：Environmental health perspectives

authors： Darrow LA,Stein CR,Steenland K

更新日期：2013-10-01 00:00:00

abstract：:Calcium has been implicated as a regulatory factor in many physiological and pathophysiological processes in the renal cell. Under physiological conditions, the cytosolic free calcium concentration is maintained at approximately 100 nM. Most of the releasable cell Ca2+ resides in the nonmitochondrial compartments. In ...

journal_title：Environmental health perspectives

authors： Bonventre JV

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND:Phthalates are metabolized and eliminated in urine within hours after exposure. Several reports suggest that concentrations of phthalate metabolites in a spot urine sample can provide a reliable estimation of exposure to phthalates for up to several months. OBJECTIVES:We examined inter- and intraperson and ...

journal_title：Environmental health perspectives

authors： Preau JL Jr,Wong LY,Silva MJ,Needham LL,Calafat AM

更新日期：2010-12-01 00:00:00

abstract：:In this study, we evaluated the impact of long-term occupational exposure to elemental mercury vapor (Hg0) on the personality traits of ex-mercury miners. Study groups included 53 ex-miners previously exposed to Hg0 and 53 age-matched controls. Miners and controls completed the self-reporting Eysenck Personality Quest...

journal_title：Environmental health perspectives

authors： Kobal Grum D,Kobal AB,Arneric N,Horvat M,Zenko B,Dzeroski S,Osredkar J

更新日期：2006-02-01 00:00:00

abstract：:Millions of people worldwide are exposed to arsenic-contaminated drinking water, and ingestion of inorganic arsenic (InAs) has been associated with increased risks of cancer. The primary metabolic pathway of ingested InAs is methylation to monomethyl arsenic (MMA) and dimethyl arsenic (DMA). However, people vary great...

journal_title：Environmental health perspectives

authors： Steinmaus C,Carrigan K,Kalman D,Atallah R,Yuan Y,Smith AH

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:The World Health Organization (WHO) released the fourth edition of Guidelines for Drinking-Water Quality in July 2011. In this edition, the 400-µg/L drinking-water guideline for manganese (Mn) was discontinued with the assertion that because "this health-based value is well above concentrations of manganese ...

journal_title：Environmental health perspectives

authors： Frisbie SH,Mitchell EJ,Dustin H,Maynard DM,Sarkar B

更新日期：2012-06-01 00:00:00

abstract：:We measured tumor-associated proteins (TAPs) and pollutants in blood, serum, and urine of 200 nonsmoking women 50-65 years of age, residing in the rural municipality of Peer or in Hoboken or Wilrijk, industrial suburbs of Antwerp, Belgium. Persons with occupational exposures or commuting to other towns were excluded. ...

journal_title：Environmental health perspectives

authors： van Larebeke NA,Bracke ME,Nelen V,Koppen G,Schoeters G,Van Loon H,Vlietinck R

更新日期：2006-06-01 00:00:00

abstract：:The lysosomes of several varieties of cells such as the tubular proximal cell of the kidney and the alveolar macrophage have the ability to concentrate and precipitate several elements inhaled in water-soluble form, usually as phosphate. The mechanism involved is attributed to the high acid phosphatase activity of lys...

journal_title：Environmental health perspectives

authors： Galle P,Berry JP,Galle C

更新日期：1992-07-01 00:00:00