PCBs as environmental estrogens: turtle sex determination as a biomarker of environmental contamination.


:Polychlorinated biphenyls (PCBs) are widespread, low-level environmental pollutants associated with adverse health effects such as immune suppression and teratogenicity. There is increasing evidence that some PCB compounds are capable of disrupting reproductive and endocrine function in fish, birds, and mammals, including humans, particularly during development. Research on the mechanism through which these compounds act to alter reproductive function indicates estrogenic activity, whereby the compounds may be altering sexual differentiation. Here we demonstrate the estrogenic effect of some PCBs by reversing gonadal sex in a reptile species that exhibits temperature-dependent sex determination.


Bergeron JM,Crews D,McLachlan JA




Has Abstract


1994-09-01 00:00:00












  • Putative inhibitory effects of chrysotile, crocidolite, and amosite mineral fibers on the more complex surface membrane glycolipids and glycoproteins.

    abstract::Syrian hamster embryo cells were treated with galactose oxidase, followed by reduction with tritiated sodium borohydride at pH 7.4. The labeling patterns of galactosyl and N-acetyl galactosaminyl residues on the cell surface were altered in comparing scraped vs. unscraped and buffer vs. media-soaked cells treated with...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Newman HA,Saat YA,Hart RW

    更新日期:1980-02-01 00:00:00

  • Three decades of silicosis: disease trends at autopsy in South African gold miners.

    abstract:BACKGROUND:Eliminating silicosis is a priority of the International Labour Organization and the World Health Organization. Prevalence is particularly high in developing countries. OBJECTIVES:We describe trends in silicosis among South African gold miners who had had an autopsy between 1975 and 2007 and quantify the co...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Nelson G,Girdler-Brown B,Ndlovu N,Murray J

    更新日期:2010-03-01 00:00:00

  • Structural and functional changes in acute liver injury.

    abstract::Carbon tetrachloride produces liver cell injury in a variety of animal species. The first structurally recognizable changes occur in the endoplasmic reticulum, with alteration in ribosome-membrane interactions. Later there is an increase in intracellular fat, and the formation of tangled nets of the ergastoplasm. At n...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Smuckler EA

    更新日期:1976-06-01 00:00:00

  • Physiological attributes of microbial BTEX degradation in oxygen-limited environments.

    abstract::Our work has focused on the determination of physiological traits that may facilitate in situ degradation of xenobiotic compounds by indigenous microorganisms. For this our interests center on the following questions: What are the ambient conditions in a benzene, toluene, ethylbenzene, and xylene (BTEX)-contaminated a...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审


    authors: Olsen RH,Mikesell MD,Kukor JJ,Byrne AM

    更新日期:1995-06-01 00:00:00

  • Implications of aquatic animal health for human health.

    abstract::Human health and aquatic animal health are organically related at three distinct interfaces. Aquatic animals serve as important contributors to the nutritional protein, lipid, and vitamin requirements of humans; as carriers and transmitters of many infectious and parasitic diseases to which humans are susceptible; and...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审


    authors: Dawe CJ

    更新日期:1990-06-01 00:00:00

  • Concentration of organochlorines in human brain, liver, and adipose tissue autopsy samples from Greenland.

    abstract::Organochlorines are persistent lipophilic compounds that accumulate in Inuit people living in circumpolar countries. Organochlorines accumulate as a result of the Inuits' large consumption of sea mammal fat; however, available data are limited to blood lipids, milk fat, and adipose tissue. We report results of organoc...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Dewailly E,Mulvad G,Pedersen HS,Ayotte P,Demers A,Weber JP,Hansen JC

    更新日期:1999-10-01 00:00:00

  • Real-time and integrated measurement of potential human exposure to particle-bound polycyclic aromatic hydrocarbons (PAHs) from aircraft exhaust.

    abstract::We used real-time monitors and low-volume air samplers to measure the potential human exposure to airborne polycyclic aromatic hydrocarbon (PAH) concentrations during various flight-related and ground-support activities of C-130H aircraft at an Air National Guard base. We used three types of photoelectric aerosol sens...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Childers JW,Witherspoon CL,Smith LB,Pleil JD

    更新日期:2000-09-01 00:00:00

  • Cell proliferation in the liver and thyroid of C57Bl/10J mice after dietary administration of chlordane.

    abstract::Chlordane is a polychlorinated hydrocarbon that causes liver enlargement and induces mixed-function oxidases similar to those induced by phenobarbitone in the mouse. We have assessed the hepatocarcinogenicity (after 2 years) and the time course (over 6 months) of liver and thyroid cell proliferation in C57Bl/10J mice ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Barrass N,Stewart M,Warburton S,Aitchison J,Jackson D,Wadsworth P,Marsden A,Orton T

    更新日期:1993-12-01 00:00:00

  • Chemical models important in understanding the ways in which chromate can damage DNA.

    abstract::Chromate is an established human carcinogen. There have been many studies of the reactivity of chromate aimed at improving understanding of chromate toxicity. In the present paper a number of conclusions of these studies are reviewed and considered in the light of new results obtained in our laboratories. A number of ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: O'Brien P,Kortenkamp A

    更新日期:1994-09-01 00:00:00

  • Sequence specificity of mutagenesis in the cI gene of bacteriophage lambda.

    abstract::Studies of DNA base sequence alterations have shown that for every agent the mutagenic process is specific with respect to the types of base changes induced and the location of the changes in the DNA. Analysis of the types of mutations produced by mutagenic agents can provide insight into the mechanism of mutation and...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Skopek TR,Wood RD,Hutchinson F

    更新日期:1985-10-01 00:00:00

  • Perchloroethylene-contaminated drinking water and the risk of breast cancer: additional results from Cape Cod, Massachusetts, USA.

    abstract::In 1998 we published the results of a study suggesting an association between breast cancer and perchloroethylene (PCE; also called tetrachloroethylene) exposure from public drinking water. The present case-control study was undertaken to evaluate this association further. The cases were composed of female residents o...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Aschengrau A,Rogers S,Ozonoff D

    更新日期:2003-02-01 00:00:00

  • Asbestos-induced peritoneal mesothelioma in a construction worker.

    abstract::Occupational and environmental asbestos exposure continues to represent a public health problem, despite increasingly restrictive laws adopted by most industrialized countries. Peritoneal mesothelioma is a rare and aggressive asbestos-related malignancy. We present the case of a 65-year-old man who developed recurrent...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Fonte R,Gambettino S,Melazzini M,Scelsi M,Zanon C,Candura SM

    更新日期:2004-04-01 00:00:00

  • A statistical model for assessing genetic susceptibility as a risk factor in multifactorial diseases: lessons from occupational asthma.

    abstract:BACKGROUND:Incorporating the influence of genetic variation in the risk assessment process is often considered, but no generalized approach exists. Many common human diseases such as asthma, cancer, and cardiovascular disease are complex in nature, as they are influenced variably by environmental, physiologic, and gene...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Demchuk E,Yucesoy B,Johnson VJ,Andrew M,Weston A,Germolec DR,De Rosa CT,Luster MI

    更新日期:2007-02-01 00:00:00

  • Evaluating potential response-modifying factors for associations between ozone and health outcomes: a weight-of-evidence approach.

    abstract:BACKGROUND:Epidemiologic and experimental studies have reported a variety of health effects in response to ozone (O3) exposure, and some have indicated that certain populations may be at increased or decreased risk of O3-related health effects. OBJECTIVES:We sought to identify potential response-modifying factors to d...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审


    authors: Vinikoor-Imler LC,Owens EO,Nichols JL,Ross M,Brown JS,Sacks JD

    更新日期:2014-11-01 00:00:00

  • Exposures to acidic aerosols.

    abstract::Ambient monitoring of acid aerosols in four U.S. cities and in a rural region of southern Ontario clearly show distinct periods of strong acidity. Measurements made in Kingston, TN, and Steubenville, OH, resulted in 24-hr H+ ion concentrations exceeding 100 nmole/m3 more than 10 times during summer months. Periods of ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Spengler JD,Keeler GJ,Koutrakis P,Ryan PB,Raizenne M,Franklin CA

    更新日期:1989-02-01 00:00:00

  • Carcinogenesis studies in rodents for evaluating risks associated with chemical carcinogens in aquatic food animals.

    abstract::Fish and shellfish caught in polluted waters contain potentially dangerous amounts of toxic and carcinogenic chemicals. Public concern was heightened when a large percentage of winter flounder taken from Boston Harbor was found to have visible cancer of the liver; winter flounder outside the estuary area had no liver ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审


    authors: Huff J,Bucher J,Yang R

    更新日期:1991-01-01 00:00:00

  • Toxicological interactions between nickel and radiation on chromosome damage and repair.

    abstract::Carcinogenic nickel compounds are usually found to be weak mutagens; therefore these compounds may not exert their carcinogenic activity through conventional genotoxic mechanisms. On the other hand, the activities of many nickel compounds have not been adequately investigated. We evaluated the genotoxic activities of ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Au WW,Heo MY,Chiewchanwit T

    更新日期:1994-11-01 00:00:00

  • Pharmaceuticals and personal care products in the environment: agents of subtle change?

    abstract::During the last three decades, the impact of chemical pollution has focused almost exclusively on the conventional "priority" pollutants, especially those acutely toxic/carcinogenic pesticides and industrial intermediates displaying persistence in the environment. This spectrum of chemicals, however, is only one piece...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审


    authors: Daughton CG,Ternes TA

    更新日期:1999-12-01 00:00:00

  • Phenotypic anchoring of gene expression changes during estrogen-induced uterine growth.

    abstract::A major challenge in the emerging field of toxicogenomics is to define the relationships between chemically induced changes in gene expression and alterations in conventional toxicologic parameters such as clinical chemistry and histopathology. We have explored these relationships in detail using the rodent uterotroph...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Moggs JG,Tinwell H,Spurway T,Chang HS,Pate I,Lim FL,Moore DJ,Soames A,Stuckey R,Currie R,Zhu T,Kimber I,Ashby J,Orphanides G

    更新日期:2004-11-01 00:00:00

  • World Health Organization discontinues its drinking-water guideline for manganese.

    abstract:BACKGROUND:The World Health Organization (WHO) released the fourth edition of Guidelines for Drinking-Water Quality in July 2011. In this edition, the 400-µg/L drinking-water guideline for manganese (Mn) was discontinued with the assertion that because "this health-based value is well above concentrations of manganese ...

    journal_title:Environmental health perspectives

    pub_type: 历史文章,杂志文章


    authors: Frisbie SH,Mitchell EJ,Dustin H,Maynard DM,Sarkar B

    更新日期:2012-06-01 00:00:00

  • The pulmonary extracellular lining.

    abstract::The extracellular lining of the lungs is reviewed. The pulmonary extracellular lining is a complex mixture of phospholipids, proteins and carbohydrates which is absolutely essential for the maintenance of normal pulmonary functions such as gas exchange. Without the lining the lungs would collapse. Alterations in the p...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审


    authors: George G,Hook GE

    更新日期:1984-04-01 00:00:00

  • Interaction of asbestos with metaplastic squamous epithelium developing in organ cultures of hamster trachea.

    abstract::The normal mucociliary epithelium of the respiratory tract in chronic cigarette smokers often is replaced focally by a metaplastic squamous epithelium. Because asbestos workers who smoke have a substantially greater risk of bronchogenic carcinoma than nonsmokers, we hypothesized that interaction of asbestos with squam...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Woodworth CD,Mossman BT,Craighead JE

    更新日期:1983-09-01 00:00:00

  • Enablers and barriers to large-scale uptake of improved solid fuel stoves: a systematic review.

    abstract:BACKGROUND:Globally, 2.8 billion people rely on household solid fuels. Reducing the resulting adverse health, environmental, and development consequences will involve transitioning through a mix of clean fuels and improved solid fuel stoves (IS) of demonstrable effectiveness. To date, achieving uptake of IS has present...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审


    authors: Rehfuess EA,Puzzolo E,Stanistreet D,Pope D,Bruce NG

    更新日期:2014-02-01 00:00:00

  • Interactive effects between trichloroethylene and pesticides at metabolic and genetic level in mice.

    abstract::A combined cytogeneticurine metabolite analysis approach was used to assess potential interactive effects between Fenarimol (FN), a fungicide, and trichloroethylene (TRI), a halogenated solvent. FN was demonstrated to selectively induce P450-2B1 isoforms in different organs of treated mice. Since the rate of metabolis...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Hrelia P,Maffei F,Vigagni F,Fimognari C,Flori P,Stanzani R,Cantelli Forti G

    更新日期:1994-11-01 00:00:00

  • Occupational cancer in Spain.

    abstract::The knowledge of specific problems of occupational cancer in Spain is scarce. The environment of the workplace has improved over the last few years after a long period distinguished by bad working conditions, incomplete legislation, and insufficient safety measures and control. It has been estimated that 3,083,479 wor...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审


    authors: González CA,Agudo A

    更新日期:1999-05-01 00:00:00

  • Exposure to fumonisins and the occurrence of neural tube defects along the Texas-Mexico border.

    abstract::Along the Texas-Mexico border, the prevalence of neural tube defects (NTDs) among Mexican-American women doubled during 1990-1991. The human outbreak began during the same crop year as epizootics attributed to exposure to fumonisin, a mycotoxin that often contaminates corn. Because Mexican Americans in Texas consume l...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Missmer SA,Suarez L,Felkner M,Wang E,Merrill AH Jr,Rothman KJ,Hendricks KA

    更新日期:2006-02-01 00:00:00

  • Increased lead biomarker levels are associated with changes in hormonal response to stress in occupationally exposed male participants.

    abstract:BACKGROUND:Lead (Pb) exposure has been associated with a host of pathological conditions in humans. In rodents Pb exposure has been shown to alter the hypothalamic-pituitary-adrenal (HPA) axis function. OBJECTIVE:We investigated the effects of lead on responses of the HPA axis to a psychosocial laboratory stressor adm...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Fortin MC,Cory-Slechta DA,Ohman-Strickland P,Nwankwo C,Yanger TS,Todd AC,Moynihan J,Walton J,Brooks A,Fiedler N

    更新日期:2012-02-01 00:00:00

  • Environmental determinants of infectious disease: a framework for tracking causal links and guiding public health research.

    abstract:BACKGROUND:Discoveries that emerging and re-emerging pathogens have their origin in environmental change has created an urgent need to understand how these environmental changes impact disease burden. In this article we present a framework that provides a context from which to examine the relationship between environme...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Eisenberg JN,Desai MA,Levy K,Bates SJ,Liang S,Naumoff K,Scott JC

    更新日期:2007-08-01 00:00:00

  • Experimental lead nitrate poisoning: microscopic and ultrastructural study of the gills of tench (Tinca tinca, L.).

    abstract::A microscopic, ultrastructural, and morphometric study was made of the gills of tench (Tinca tinca, L.) subjected to acute experimental lead nitrate poisoning. Twenty-one adult tench were subjected to poisoning and a further 22 were used as controls. Lesions were characterized by the appearance of edema and epithelial...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Roncero V,Vincente JA,Redondo E,Gãzquez A,Duran E

    更新日期:1990-11-01 00:00:00

  • Molecular analysis of heritable mouse mutations.

    abstract::Germ-line mutations of the mouse have for years comprised one class of biological markers for mammalian reproductive and developmental toxicology. Understanding the molecular nature of mutations and the mechanisms by which mutations are translated into specific (and often complex) phenotypes, however, still looms as a...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审


    authors: Rinchik EM

    更新日期:1987-10-01 00:00:00