A cross-sectional investigation of chronic exposure to microcystin in relationship to childhood liver damage in the Three Gorges Reservoir Region, China.

Abstract:

BACKGROUND:Microcystin-producing Microcystis bloom is a severe water problem in the world. Some reports indicate that chronic exposure to microcystin may result in liver damage in adults, but information on effects in children is limited. OBJECTIVE:We investigated the relationship between microcystin exposure and liver damage in children. METHODS:We measured microcystin concentrations in drinking water and aquatic food (carp and duck) from two lakes and four wells. Participants were 1,322 children 7-15 years of age who obtained drinking water from one of the tested sources, completed questionnaires, and provided blood samples for serum liver enzymes [alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and γ-glutamyltransferase (GGT)] and serum microcystin analysis. Multivariable logistic regression was used to identify risk factors associated with liver damage (two or more abnormal serum enzyme levels in ALT, AST, ALP, or GGT). RESULTS:Microcystin was detected in most samples of water and aquatic food from two lakes. Children who drank water from the lake with the highest microcystin concentrations had a total estimated daily microcystin intake of 2.03 μg, a value much higher than the tolerable daily intake (0.40 μg) proposed by the World Health Organization for children. Hepatitis B virus (HBV) infection, use of hepatotoxic medicines, and microcystin exposure were associated with liver damage. AST and ALP levels were significantly higher in high-microcystin-exposed children than in low-exposed children and unexposed children when participants who were HBV-positive or hepatotoxic medicine users were excluded from the analysis. CONCLUSION:These results suggest that chronic exposure to microcystin may be associated with liver damage in children in the Three Gorges Reservoir Region.

authors

Li Y,Chen JA,Zhao Q,Pu C,Qiu Z,Zhang R,Shu W

doi

10.1289/ehp.1002412

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

1483-8

issue

10

eissn

0091-6765

issn

1552-9924

journal_volume

119

pub_type

杂志文章
  • Topophilia and the quality of life.

    abstract::With this research I tested the hypothesis that individual preferences for specific ecosystem components and restorative environments are significantly associated with quality of life (QOL). A total of 379 human subjects responded to a structured 18-item questionnaire on topophilia and to the 26-item World Health Orga...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.7467

    authors: Ogunseitan OA

    更新日期:2005-02-01 00:00:00

  • Mercury in Alaskan Eskimo mothers and infants.

    abstract::The potential danger of natural mercury accumulation in the diet of the Eskimo is evaluated through mercury levels determined in cord blood, placenta, maternal blood, hair, and milk of 38 maternal-infant pairs from Anchorage and the Yukon-Kuskokwim Delta. Although mercury levels are not discernably dangerous, trends t...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.7615135

    authors: Galster WA

    更新日期:1976-06-01 00:00:00

  • Alveolar macrophage kinetics after inhalation of 239PuO2 by CBA/Ca mice: changes in synthesis of DNA.

    abstract::For workers in the nuclear industry, the primary route for the entry of radioactive materials into the body is by inhalation, and the rate of clearance of particles from the pulmonary region of the lung is an important factor in determining radiation dose. It is the function of alveolar macrophages (AM) to maintain th...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.929769

    authors: Kellington JP,Gibson K,Buckle TM,Talbot RJ,Hornby SB

    更新日期:1992-07-01 00:00:00

  • Outdoor formaldehyde and NO2 exposures and markers of genotoxicity in children living near chipboard industries.

    abstract:BACKGROUND:Industrial air pollution is a public health hazard. Previous evidence documented increased respiratory symptoms and hospitalizations in children who live near the factories in the largest chipboard manufacturing district in Italy (Viadana). OBJECTIVES:We evaluated the association of outdoor exposure to form...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1307259

    authors: Marcon A,Fracasso ME,Marchetti P,Doria D,Girardi P,Guarda L,Pesce G,Pironi V,Ricci P,de Marco R

    更新日期:2014-06-01 00:00:00

  • Assessing the effects of endocrine disruptors in the National Children's Study.

    abstract::Children are uniquely vulnerable to toxic chemicals in the environment. Among the environmental toxicants to which children are at risk of exposure are endocrine disruptors (EDs)--chemicals that have the capacity to interfere with hormonal signaling systems. EDs may alter feedback loops in the brain, pituitary, gonads...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.5799

    authors: Landrigan P,Garg A,Droller DB

    更新日期:2003-10-01 00:00:00

  • Biological monitoring of genotoxic hazard in workers of the rubber industry.

    abstract::Biological monitoring of genotoxic hazard in the rubber industry was performed in 19 male workers and 20 age-matched controls in a local health unit in northern Italy. Peripheral blood lymphocytes were analyzed for the presence of DNA damage (single-cell microgel-electrophoresis, or comet assay) and for cytogenetic pa...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.96104s3543

    authors: Moretti M,Villarini M,Scassellati-Sforzolini G,Monarca S,Libraro M,Fatigoni C,Donato F,Leonardis C,Perego L

    更新日期:1996-05-01 00:00:00

  • The three modern faces of mercury.

    abstract::The three modern "faces" of mercury are our perceptions of risk from the exposure of billions of people to methyl mercury in fish, mercury vapor from amalgam tooth fillings, and ethyl mercury in the form of thimerosal added as an antiseptic to widely used vaccines. In this article I review human exposure to and the to...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.02110s111

    authors: Clarkson TW

    更新日期:2002-02-01 00:00:00

  • Potential molecular mechanisms of oxidant-induced carcinogenesis.

    abstract::Chronic exposure to oxidants is associated with an increased incidence of malignancy; however, the mechanism(s) by which oxidants contribute to carcinogenesis is unknown. Since oncogene activation plays an important role in carcinogenesis, we hypothesized that hydroxyl radical-induced DNA damage might contribute to ca...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.94102s10155

    authors: Jackson JH

    更新日期:1994-12-01 00:00:00

  • Dioxins and endometriosis: a plausible hypothesis.

    abstract::A potential connection exists between exposure to organochlorine chemicals and the increasing prevalence of endometriosis. Evidence shows that dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin) can increase the incidence and severity of the disease in monkeys and can promote the growth or survival of endometrial tissue impl...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.0211015

    authors: Birnbaum LS,Cummings AM

    更新日期:2002-01-01 00:00:00

  • Unventilated indoor coal-fired stoves in Guizhou province, China: reduction of arsenic exposure through behavior changes resulting from mitigation and health education in populations with arsenicosis.

    abstract::We report the results of a coordinated mitigation effort aimed at reducing arsenic (As) exposure in three counties of Guizhou province, China. Mitigation occurred in 2005 and encompassed 21 villages with 47,000 inhabitants, who were exposed to high levels of As in their diet through consumption of As-contaminated chil...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.9273

    authors: An D,Li D,Liang Y,Jing Z

    更新日期:2007-04-01 00:00:00

  • Molecular conformation, receptor binding, and hormone action of natural and synthetic estrogens and antiestrogens.

    abstract::The X-ray crystallographic structural determinations of synthetic estrogens and antiestrogens provide reliable information on the global minimum energy conformation of these molecules or a local minimum energy conformation that is within 1 or 2 kcal/mole of the global minimum. In favorable cases, state-of-the-art mole...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.8561111

    authors: Duax WL,Griffin JF,Weeks CM,Korach KS

    更新日期:1985-09-01 00:00:00

  • Human cell exposure assays of Bacillus thuringiensis commercial insecticides: production of Bacillus cereus-like cytolytic effects from outgrowth of spores.

    abstract::Most contemporary bioinsecticides are derived from scaled-up cultures of Bacillus thuringiensis subspecies israelensis (Bti) and kurstaki (Btk), whose particulate fractions contain mostly B. thuringiensis spores (> 10(12)/L) and proteinaceous aggregates, including crystal-like parasporal inclusion bodies (PIB). Based ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.00108919

    authors: Tayabali AF,Seligy VL

    更新日期:2000-10-01 00:00:00

  • Alteration of pulmonary immunity to Listeria monocytogenes by diesel exhaust particles (DEPs). II. Effects of DEPs on T-cell-mediated immune responses in rats.

    abstract::Previously, we showed that diesel exhaust particles (DEPs) suppressed pulmonary clearance of Listeria monocytogenes (Listeria) and inhibited the phagocytosis of alveolar macrophages and their response to Listeria in the secretion of interleukin (IL)-1 beta, tumor necrosis factor alpha, and IL-12. In this report we exa...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.5709

    authors: Yin XJ,Schafer R,Ma JY,Antonini JM,Roberts JR,Weissman DN,Siegel PD,Ma JK

    更新日期:2003-04-01 00:00:00

  • Cumulative dietary energy intake determines the onset of puberty in female rats.

    abstract::Laboratory animal diets for studies to determine the endocrine-disrupting potential of chemicals are under scrutiny because they can affect both assay control values and assay sensitivity. Although phytoestrogen content is important, we have previously shown that a phytoestrogen-rich diet and a phytoestrogen-free diet...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.7039

    authors: Odum J,Tinwell H,Tobin G,Ashby J

    更新日期:2004-11-01 00:00:00

  • Formation and persistence of 8-oxoguanine in rat lung cells as an important determinant for tumor formation following particle exposure.

    abstract::Exposure of rats to quartz (or various other particles) can lead to the development of lung tumors. At the moment, the mechanisms involved in particle-induced tumor formation are not clarified. However, it is suggested that inflammation, in conjunction with the production of reactive oxygen species (ROS) and an enhanc...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.97105s51291

    authors: Nehls P,Seiler F,Rehn B,Greferath R,Bruch J

    更新日期:1997-09-01 00:00:00

  • Role of alveolar macrophages in precipitation of mineral elements inhaled as soluble aerosols.

    abstract::The lysosomes of several varieties of cells such as the tubular proximal cell of the kidney and the alveolar macrophage have the ability to concentrate and precipitate several elements inhaled in water-soluble form, usually as phosphate. The mechanism involved is attributed to the high acid phosphatase activity of lys...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.9297145

    authors: Galle P,Berry JP,Galle C

    更新日期:1992-07-01 00:00:00

  • Chronic air pollution exposure during pregnancy and maternal and fetal C-reactive protein levels: the Generation R Study.

    abstract:BACKGROUND:Exposure to air pollution has been associated with higher C-reactive protein (CRP) levels, suggesting an inflammatory response. Not much is known about this association in pregnancy. OBJECTIVES:We investigated the associations of air pollution exposure during pregnancy with maternal and fetal CRP levels in ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1104345

    authors: van den Hooven EH,de Kluizenaar Y,Pierik FH,Hofman A,van Ratingen SW,Zandveld PY,Lindemans J,Russcher H,Steegers EA,Miedema HM,Jaddoe VW

    更新日期:2012-05-01 00:00:00

  • Pesticide-induced immunotoxicity: are Great Lakes residents at risk?

    abstract::Several organophosphate and organochlorine compounds, including pesticides commonly found in the Great Lakes basin, have the potential to induce immunotoxicity. Because of biomagnification and accumulation in the food chain, Great Lakes residents may inadvertently be exposed to these compounds and thus face increased ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.95103s955

    authors: Thomas PT

    更新日期:1995-12-01 00:00:00

  • The role of syntrophic associations in sustaining anaerobic mineralization of chlorinated organic compounds.

    abstract::Stable associations of syntrophic fermentative organisms and populations that consume fermentation products play key roles in the anaerobic biodegradation of chlorinated organic contaminants. The involvement of these syntrophic populations is essential for mineralization of chlorinated aromatic compounds under methano...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.6933

    authors: Becker JG,Berardesco G,Rittmann BE,Stahl DA

    更新日期:2005-03-01 00:00:00

  • Influence of exogenous estrogen receptor ligands on uterine leiomyoma: evidence from an in vitro/in vivo animal model for uterine fibroids.

    abstract::The remarkable frequency of uterine leiomyoma in the human population calls into question the potential for the participation of environmental factors in tumor etiology. Having been implicated in the dramatic rise in hormone-related cancers in recent years, endocrine disruptors are salient suspects in this pathogenesi...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.00108s5829

    authors: Hunter DS,Hodges LC,Eagon PK,Vonier PM,Fuchs-Young R,Bergerson JS,Walker CL

    更新日期:2000-10-01 00:00:00

  • Relationships among polycyclic aromatic hydrocarbon-DNA adducts, proximity to the World Trade Center, and effects on fetal growth.

    abstract::Polycyclic aromatic hydrocarbons (PAHs) are toxic pollutants released by the World Trade Center (WTC) fires and various urban combustion sources. Benzo[a]pyrene (BaP) is a representative member of the class of PAHs. PAH-DNA adducts, or BaP-DNA adducts as their proxy, provide a measure of chemical-specific genetic dama...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.7908

    authors: Perera FP,Tang D,Rauh V,Lester K,Tsai WY,Tu YH,Weiss L,Hoepner L,King J,Del Priore G,Lederman SA

    更新日期:2005-08-01 00:00:00

  • Occupational Pesticide Use and Risk of Renal Cell Carcinoma in the Agricultural Health Study.

    abstract:BACKGROUND:Agricultural work and occupational pesticide use have been associated with increased risk of renal cell carcinoma (RCC), the most common form of kidney cancer. However, few prospective studies have investigated links to specific pesticides. OBJECTIVE:We evaluated the lifetime use of individual pesticides an...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP6334

    authors: Andreotti G,Beane Freeman LE,Shearer JJ,Lerro CC,Koutros S,Parks CG,Blair A,Lynch CF,Lubin JH,Sandler DP,Hofmann JN

    更新日期:2020-06-01 00:00:00

  • Follow-up screening of lead-poisoned children near an auto battery recycling plant, Haina, Dominican Republic.

    abstract::In August 1997 we performed a follow-up survey of 146 lead-poisoned children from a community near a previously active auto battery recycling smelter in Haina near Santo Domingo, Dominican Republic. Our follow-up survey confirmed a severe incidence of elevated blood lead (BPb) and erythrocyte protoporphyrin/zinc proto...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.99107917

    authors: Kaul B,Sandhu RS,Depratt C,Reyes F

    更新日期:1999-11-01 00:00:00

  • Detection of carcinogen-DNA adducts in human fetal tissues by the 32P-postlabeling procedure.

    abstract::Tobacco smoke contains a number of genotoxic compounds that are metabolized to their biologically active forms that subsequently react with cellular DNA to form covalently bound carcinogen-DNA adducts. Several analytical procedures have been developed to detect these adducts in human tissues. Using the nuclease P1-enh...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.9399229

    authors: Hansen C,Asmussen I,Autrup H

    更新日期:1993-03-01 00:00:00

  • Indoor air pollution and childhood asthma: effective environmental interventions.

    abstract::Exposure to indoor air pollutants such as tobacco smoke and dust mites may exacerbate childhood asthma. Environmental interventions to reduce exposures to these pollutants can help prevent exacerbations of the disease. Among the most important interventions is the elimination of environmental tobacco smoke from the en...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.95103s655

    authors: Etzel RA

    更新日期:1995-09-01 00:00:00

  • Cardiovascular effects of nickel in ambient air.

    abstract:BACKGROUND:Fine particulate matter (FPM) in ambient air causes premature mortality due to cardiac disease in susceptible populations. OBJECTIVE:Our objective in this study was to determine the most influential FPM components. METHODS:A mouse model of atherosclerosis (ApoE-/-) was exposed to either filtered air or con...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.9150

    authors: Lippmann M,Ito K,Hwang JS,Maciejczyk P,Chen LC

    更新日期:2006-11-01 00:00:00

  • Epidemiological bases for the current ambient carbon monoxide standards.

    abstract::Carbon monoxide is widely distributed in the environment, and acute or chronic toxic effects may be of considerable public health significance. A review of the basis for current ambient standards is given. Mortality and morbidity studies have been negative or equivocal in relating carbon monoxide levels to health effe...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8352131

    authors: Kuller LH,Radford EP

    更新日期:1983-10-01 00:00:00

  • Persistent pesticides in human breast milk and cryptorchidism.

    abstract:INTRODUCTION:Prenatal exposure to some pesticides can adversely affect male reproductive health in animals. We investigated a possible human association between maternal exposure to 27 organochlorine compounds used as pesticides and cryptorchidism among male children. DESIGN:Within a prospective birth cohort, we perfo...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8741

    authors: Damgaard IN,Skakkebaek NE,Toppari J,Virtanen HE,Shen H,Schramm KW,Petersen JH,Jensen TK,Main KM,Nordic Cryptorchidism Study Group.

    更新日期:2006-07-01 00:00:00

  • Associations between Environmental Quality and Mortality in the Contiguous United States, 2000-2005.

    abstract:BACKGROUND:Assessing cumulative effects of the multiple environmental factors influencing mortality remains a challenging task. OBJECTIVES:This study aimed to examine the associations between cumulative environmental quality and all-cause and leading cause-specific (heart disease, cancer, and stroke) mortality rates. ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP119

    authors: Jian Y,Messer LC,Jagai JS,Rappazzo KM,Gray CL,Grabich SC,Lobdell DT

    更新日期:2017-03-01 00:00:00

  • Disrupted patterns of behavior in natural populations as an index of ecotoxicity.

    abstract::This paper examines behavioral changes in natural populations of wildlife associated with pollution. Although some changes such as lack of nest attentiveness and decreased nest defense have been noted, the results have not been consistent and have been difficult to relate to specific pollutants. Experimental studies i...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.96104s2331

    authors: Peakall DB

    更新日期:1996-04-01 00:00:00