Abstract:
:Groups of female SENCAR or BALB/c mice were initiated once intraperitoneally with 300 micrograms/mouse of 7,12-dimethylbenz(a)anthracene (DMBA) or 20 mg/mouse of urethane at 7 weeks of age. Beginning one week later, mice received topically applied acetone or 12-O-tetradecanoylphorbol-13-acetate (TPA), once weekly, at 2.5 micrograms/mouse for weeks 1 through 6 and 1.25 micrograms/mouse for weeks 7 through 52. The skin lesions were evaluated clinically. A complete necropsy was performed on all mice at week 52. SENCAR mice exposed to DMBA/TPA and urethane/TPA had more skin tumors than SENCAR mice exposed to DMBA or urethane alone and more than BALB/c mice in any treatment group. Of all skin carcinomas diagnosed histologically in DMBA/TPA-exposed mice, less than one-third had been identified clinically while the mice were alive. Most of the carcinomas arose within papillomas. BALB/c mice developed more vascular and uterine tumors than did SENCAR mice injected with DMBA and more lung and vascular tumors than did SENCAR mice injected with urethane. TPA exposure after treatment with either initiator had no significant effect on internal tumor development in either SENCAR or BALB/c mice.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Ward JM,Rehm S,Devor D,Hennings H,Wenk MLdoi
10.1289/ehp.866861subject
Has Abstractpub_date
1986-09-01 00:00:00pages
61-8eissn
0091-6765issn
1552-9924journal_volume
68pub_type
杂志文章abstract:BACKGROUND:Biomass smoke is an important source of particulate matter (PM), and much remains to be discovered with respect to the human health effects associated with this specific PM source. Exposure to biomass smoke can occur in one of two main categories: short-term exposures consist of periodic, seasonal exposures ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.11378
更新日期:2009-01-01 00:00:00
abstract::The clinical use of polymeric materials in the body to repair and restore damaged or diseased tissues and organs is substantially increasing on an annual basis. Concomitant with this use is an increase in materials related research on medically used polymers. Information on the historical and current clinical use of p...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.751171
更新日期:1975-06-01 00:00:00
abstract:BACKGROUND:Controversy remains regarding the relationship between ambient ozone and mortality worldwide. In mainland China, the largest developing country, there has been no prior study investigating the acute effect of O3 on death risk. Given the changes in types of air pollution from conventional coal combustion to t...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9014
更新日期:2006-08-01 00:00:00
abstract:BACKGROUND:Arsenic, cadmium, mercury, and lead are associated with cardiovascular disease in epidemiologic research. These associations may be mediated by direct effects of the metals on blood pressure (BP) elevation. Manganese is associated with cardiovascular dysfunction and hypotension in occupational cohorts. OBJE...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1002805
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:The National Institutes of Health's Environmental influences on Child Health Outcomes (ECHO) initiative aims to understand the impact of environmental factors on childhood disease. Over 40,000 chemicals are approved for commercial use. The challenge is to prioritize chemicals for biomonitoring that may prese...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP5133
更新日期:2019-12-01 00:00:00
abstract::Rats continuously exposed to NO2 at 0.04, 0.4, and 4.0 ppm for as long as 27 months were submitted to morphological observation and electronmicroscopic morphometry of the lung. At 4 ppm exposure for 9 months, bronchial epithelium showed typical proliferation, which progressed further at 18 months. At this stage, proli...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8773157
更新日期:1987-08-01 00:00:00
abstract::We estimated the disease burden from water, sanitation, and hygiene at the global level taking into account various disease outcomes, principally diarrheal diseases. The disability-adjusted life year (DALY) combines the burden from death and disability in a single index and permits the comparison of the burden from wa...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.110-1240845
更新日期:2002-05-01 00:00:00
abstract::[35S]t-Butylbicyclophosphorothionate or [35S]TBPS is an improved radioligand for the picrotoxinin binding site in rat brain synaptic membranes. The toxic isomers of the hexachlorocyclohexanes, polychlorobornanes, and chlorinated cyclodienes displace [35S]TBPS with a stereospecificity and potency generally correlated w...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.8561123
更新日期:1985-09-01 00:00:00
abstract::A simplified mathematical model which made use of Fick's laws of diffusion written in spherical coordinates was developed to describe the rate of diffusion of residual monomers from polymer resins. The properties of the monomer-polymer system which influenced the amount of monomer remaining in the polymer as a functio...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7617227
更新日期:1976-10-01 00:00:00
abstract::Atmospheric pollution from vehicular traffic is a matter of growing interest, often leading to temporary restrictions in urban areas. Although guidelines indicate limits for several parameters, the real toxicologic impacts remain largely unexplored in field conditions. In this study our aim was to validate an ecotoxic...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8397
更新日期:2006-01-01 00:00:00
abstract::Interleukin-3 (IL-3) and granulocyte/macrophage-colony-stimulating factor (GM-CSF) are responsible for maintaining survival and stimulating growth of early dormant hematopoietic progenitor cells (HPC). These cytokines exhibit extensive overlap, with GM-CSF supporting growth and differentiation of myeloid HPC. A charac...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.961041247
更新日期:1996-12-01 00:00:00
abstract:BACKGROUND:The association of DDT (dichlorodiphenyltrichloroethane) with breast cancer is controversial, but animal studies directly linking DDT to risk are lacking. Concerns with DDT reside in its environmental persistence, bioaccumulation in breast adipose tissue, and endocrine-disrupting actions. Whereas most attent...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1104327
更新日期:2012-08-01 00:00:00
abstract::A review of the present understanding of asthma leads to the following conclusions: an elevated IgE is the principal risk factor in the development of childhood asthma; secondary exposure to a wide range of environmental agents (including indoor bioallergens) accounts for the variations in prevalence; prevalence (defi...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.95103s6243
更新日期:1995-09-01 00:00:00
abstract::Recent investigations have demonstrated the ability of leukocytes to metabolize promutagens or procarcinogens into their genotoxic forms. As a possible explanation for the association between inflammation and cancer, we and others have hypothesized that local accumulations of leukocytes could take up nearby promutagen...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.93101s327
更新日期:1993-10-01 00:00:00
abstract:OBJECTIVE:This study was designed to determine whether prenatal mercury exposure, including potential releases from the World Trade Center (WTC) disaster, adversely affects fetal growth and child development. METHODS:We determined maternal and umbilical cord blood total mercury of nonsmoking women who delivered at ter...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.10831
更新日期:2008-08-01 00:00:00
abstract::Proto-oncogenes are cellular genes that are expressed during normal growth and developmental processes. Altered versions of normal proto-oncogenes have been implicated in the development of human neoplasia. In this report, we show the detection of activated proto-oncogenes in various spontaneous and chemically induced...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.877581
更新日期:1987-11-01 00:00:00
abstract:BACKGROUND:A growing body of evidence indicates a relationship between household indoor air pollution from cooking fires and adverse neonatal outcomes, such as low birth weight (LBW), in resource-poor countries. OBJECTIVE:We examined the effect of reduced wood smoke exposure in pregnancy on LBW of Guatemalan infants i...
journal_title:Environmental health perspectives
pub_type: 杂志文章,随机对照试验
doi:10.1289/ehp.1002928
更新日期:2011-10-01 00:00:00
abstract::In this study, we aimed to estimate the contribution of environmental pollutants to the incidence, prevalence, mortality, and costs of pediatric disease in American children. We examined four categories of illness: lead poisoning, asthma, cancer, and neurobehavioral disorders. To estimate the proportion of each attrib...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.02110721
更新日期:2002-07-01 00:00:00
abstract::An impressive array of evidence has been obtained during the past decade establishing correlations between specific DNA adducts and carcinogenesis. Many of the studies utilized organ specific differences in carcinogenesis to establish the correlations. More recently, we have investigated similar relationships between ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8562177
更新日期:1985-10-01 00:00:00
abstract::Metallothioneins (MTs) are encoded by a multigene family in man. We have isolated those genes and analyzed the structure of some of them. The MT-II variant is encoded by a single functional gene: MT-IIA. The MT-IIB gene is a processed pseudogene derived from a reverse transcript of MT-II mRNA. On the other hand, the M...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8454111
更新日期:1984-03-01 00:00:00
abstract:BACKGROUND:Cumulative lead exposure is associated with a widened pulse pressure (PP; the -difference between systolic and diastolic blood pressure), a marker of arterial stiffness and a predictor of cardiovascular disease. Polymorphisms in the hemochromatosis gene (HFE) have been shown to modify the impact of cumulativ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1002251
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:Although many studies have examined the effects of air pollution on mortality, data limitations have resulted in fewer studies of both particulate matter with an aerodynamic diameter of
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.0800108
更新日期:2009-06-01 00:00:00
abstract::Methyl parathion (MP), an organophosphate pesticide licensed only for agricultural uses, was sprayed illegally for pest control in Mississippi and Ohio residences. To evaluate the association between MP exposure and neurobehavioral development, we assessed children 6 years or younger at the time of the spraying and lo...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.6430
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Few human studies have examined bisphenol A (BPA) exposure in relation to semen quality and reproductive hormones in men, and results are divergent. OBJECTIVES:We examined associations between urinary BPA concentration and reproductive hormones, as well as semen quality, in young men from the general popula...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1307309
更新日期:2014-05-01 00:00:00
abstract::At picomolar concentrations, lead activates protein kinase C (PKC). This activation has been implicated in the neurotoxicity of lead. No prior study has evaluated the association of PKC activity with neurobehavioral function in humans. The purpose of this study was to determine whether PKC activity is associated with ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.02110133
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND:Millions of individuals worldwide, particularly those living in rural and developing areas, are exposed to harmful levels of inorganic arsenic (iAs) in their drinking water. Inorganic As exposure during key developmental periods is associated with a variety of adverse health effects, including those that are...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1409360
更新日期:2016-02-01 00:00:00
abstract::The lymphocyte micronucleus assay was used to measure the average frequency of micronuclei in a population and thus assess genotoxic effects. Data from 174 persons give an average value of 16.4 +/- 7.3, and a slight age-dependence was observed. To detect combined environmental mutagen injuries the micronucleus assay w...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.101-1521140
更新日期:1993-10-01 00:00:00
abstract::Tobacco smoke contains a number of genotoxic compounds that are metabolized to their biologically active forms that subsequently react with cellular DNA to form covalently bound carcinogen-DNA adducts. Several analytical procedures have been developed to detect these adducts in human tissues. Using the nuclease P1-enh...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9399229
更新日期:1993-03-01 00:00:00
abstract::A human lymphoblastoid cell line has been used to test for mutations caused by combustion-generated soot particles and their constituent components, which are substrate carbon-black and adsorbed condensate, principally in the form of polycyclic aromatic hydrocarbons (PAH). It was found that the mutagenicity of the PAH...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9196239
更新日期:1991-12-01 00:00:00
abstract::The association of malignant mesothelioma (MM) and nonoccupational asbestos exposure is currently debated. Our study investigates environmental and domestic asbestos exposure in the city where the largest Italian asbestos cement (AC) factory was located. This population-based case-control study included pleural MM (hi...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.01109915
更新日期:2001-09-01 00:00:00