Abstract:
BACKGROUND:Although many studies have examined the effects of air pollution on mortality, data limitations have resulted in fewer studies of both particulate matter with an aerodynamic diameter of
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Zanobetti A,Schwartz Jdoi
10.1289/ehp.0800108subject
Has Abstractpub_date
2009-06-01 00:00:00pages
898-903issue
6eissn
0091-6765issn
1552-9924journal_volume
117pub_type
杂志文章abstract::Heightened concern over endocrine-disrupting chemicals is driven by the hypothesis that they could reduce reproductive success and affect wildlife populations, but there is little evidence for this expectation. The pharmaceutical ethynylestradiol (EE2) is a potent endocrine modulator and is present in the aquatic envi...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7209
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:Benchmark dose (BMD) modeling is an important step in human health risk assessment and is used as the default approach to identify the point of departure for risk assessment. A probabilistic framework for dose-response assessment has been proposed and advocated by various institutions and organizations; ther...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP1289
更新日期:2018-01-11 00:00:00
abstract::We extended our previous analyses of term low birth weight (LBW) and preterm birth to 1994-2000, a period of declining air pollution levels in the South Coast Air Basin. We speculated that the effects we observed previously for carbon monoxide, particulate matter < 10 microm in aerodynamic diameter (PM10), and traffic...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7751
更新日期:2005-09-01 00:00:00
abstract::Occupational cancer research methods was identified in 1996 as 1 of 21 priority research areas in the National Occupational Research Agenda (NORA). To implement NORA, teams of experts from various sectors were formed and given the charge to further define research needs and develop strategies to enhance or augment res...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.111-1241299
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Early-life exposure to lead is associated with deficits in neurodevelopment and with hematopoietic system toxicity. DNA methylation may be one of the underlying mechanisms for the adverse effects of prenatal lead on the offspring, but epigenome-wide methylation data for low levels of prenatal lead exposure a...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP1246
更新日期:2017-08-25 00:00:00
abstract::We found an epidemic of juvenile hypothyroidism among a population of self-defined "downwinders" living near the Hanford nuclear facility located in southeast Washington State. The episode followed massive releases of 131I. Self-reported data on 60 cases of juvenile hypothyroidism (<20 years of age) among a group of 8...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.99107303
更新日期:1999-04-01 00:00:00
abstract::Medically unexplained physical symptoms (MUPS) are persistent idiopathic symptoms that drive patients to seek medical care. MUPS syndromes include chronic fatigue syndrome, fibromyalgia syndrome, and multiple chemical sensitivities. When MUPS occur after an environmental exposure or injury, an adversarial social conte...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.02110s4641
更新日期:2002-08-01 00:00:00
abstract:BACKGROUND:Cancer may be a stem cell (SC)-based disease involving formation of cancer SCs (CSCs) potentially arising from transformation of normal SCs. Cadmium has been linked to human pancreatic cancer. OBJECTIVE:We studied cadmium exposure of human pancreatic ductal epithelial (HPDE) cells and whether SCs may be tar...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1205082
更新日期:2012-09-01 00:00:00
abstract::In rats, a single administration of acrylonitrile (vinyl cyanide) produces a rapidly occurring bilateral adrenal apoplexy. Structure-activity studies have shown that a close derivative, propionitrile (ethyl cyanide), causes duodenal ulcer without markedly affecting the adrenal glands. Prolonging the two-carbon chain o...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7511135
更新日期:1975-06-01 00:00:00
abstract::There is concern about the human health effects of inhalation of acid compounds found in urban air pollution. It was the purpose of this study to investigate three of these acid compounds, sulfur dioxide (SO2), sulfuric acid (H2SO4), and nitric acid (HNO3) in a group of allergic adolescent subjects. Subjects were expo...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8979173
更新日期:1989-02-01 00:00:00
abstract::A physiologically based pharmacokinetic model for trichloroethylene (TCE) in rodents and humans was calibrated with published toxicokinetic data sets. A Bayesian statistical framework was used to combine previous information about the model parameters with the data likelihood, to yield posterior parameter distribution...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.00108s2307
更新日期:2000-05-01 00:00:00
abstract::In estimating the cancer mortality risk for radiation workers it is conventional to use data obtained from the populations exposed to radiation as a result of the atomic bomb blast in Hiroshima and Nagasaki. This A-bomb experience resulted in relatively high doses of radiation and short periods of exposure. The availa...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.97105s61603
更新日期:1997-12-01 00:00:00
abstract::The major aspects that must be considered in studies of the health effects of environmental pollutants are: the direct damage due to the exposure, the role of pre-existing disease, and effects of the exposure on the response to secondary stresses. In experimental studies at concentrations of air pollutants found in ur...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.803589
更新日期:1980-04-01 00:00:00
abstract:BACKGROUND:Exposures to high-dose ionizing radiation and high-dose rate ionizing radiation are established risk factors for childhood acute leukemia (AL). The risk of AL following exposure to lower doses due to natural background radiation (NBR) has yet to be conclusively determined. METHODS:AL cases diagnosed over 19...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP296
更新日期:2017-04-01 00:00:00
abstract::Noise exposure causes changes at different levels in human organs, particularly the cardiovascular system, where it is responsible for increasing heart rate, peripheral vascular resistance, and blood pressure. In this study, we evaluated the effect of noise exposure on DNA integrity and ultrastructure of rat cardiomyo...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.5847
更新日期:2003-04-01 00:00:00
abstract::In an attempt to elucidate the relationship between DNA adduct formation and tumorigenesis, DNA adducts were measured in the livers and bladders of mice during chronic exposure to several different doses of 2-acetylaminofluorene (2-AAF) and 4-aminobiphenyl (4-ABP). Continuous oral administration of these compounds for...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.94102s6161
更新日期:1994-10-01 00:00:00
abstract:BACKGROUND:Phthalates may pose a risk for perinatal developmental effects. An important question relates to the choice of suitable biological matrices for assessing exposure during this period. OBJECTIVES:This study was designed to measure the concentrations of phthalate diesters or their metabolites in breast milk, b...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.10788
更新日期:2008-03-01 00:00:00
abstract::A review of the experimental studies relating boron to biological effects on appendicular and axial bones in animal models suggests that numerous influences, known and unknown, affect the responsiveness of bone to dietary boron. Degrees of skeletal response to boron are modified by other nutritional variables that inc...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.94102s749
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND:Despite evidence of atrazine toxicity in developing organisms from experimental studies, few studies--and fewer epidemiologic investigations--have examined the potential effects of prenatal exposure. OBJECTIVES:We assessed the association between adverse birth outcomes and urinary biomarkers of prenatal atr...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1002775
更新日期:2011-07-01 00:00:00
abstract::All cells contain elaborate systems for the spatial and temporal regulation of the calcium ion, [Ca2+]i, and diverse Ca2+ receptor and biochemical response systems that are regulated by these changes in [Ca2+]i. Toxicants that perturb the mobilization or homeostasis of [Ca2+]i will place the regulation of these proces...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.90847
更新日期:1990-03-01 00:00:00
abstract:BACKGROUND:Polybrominated diphenyl ethers (PBDEs) are flame retardants found in North American household products during the past four decades. These chemicals leach out in dust as products age, exposing individuals daily through inhalation and ingestion. Animal studies suggest that PBDEs disrupt sex hormones and adver...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP522
更新日期:2017-05-26 00:00:00
abstract:BACKGROUND:Cumulative lead exposure is associated with a widened pulse pressure (PP; the -difference between systolic and diastolic blood pressure), a marker of arterial stiffness and a predictor of cardiovascular disease. Polymorphisms in the hemochromatosis gene (HFE) have been shown to modify the impact of cumulativ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1002251
更新日期:2010-09-01 00:00:00
abstract::Trichloroethylene is an organic chemical that has been used in dry cleaning, for metal degreasing, and as a solvent for oils and resins. It has been shown to cause liver and kidney cancer in experimental animals. This article reviews over 80 published papers and letters on the cancer epidemiology of people exposed to ...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.00108s2161
更新日期:2000-05-01 00:00:00
abstract::The possible risk for human health arising from consumption of lead-polluted shellfish was suggested by experiments on the bioavailability for mice of a "biologically detoxified" form of the metal. In this work, young mice were fed with a mixed diet including mussels collected in a Pb-polluted area. Metal concentratio...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102s3335
更新日期:1994-09-01 00:00:00
abstract::Uranium accumulates in bone, affects bone metabolism in laboratory animals, and when ingested in drinking water increases urinary excretion of calcium and phosphate, important components in the bone structure. However, little is known about bone effects of ingested natural uranium in humans. We studied 146 men and 142...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7475
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:We previously demonstrated that among 54 infants in neonatal intensive care units, exposure to polyvinyl chloride plastic medical devices containing the plasticizer di(2-ethylhexyl) phthalate (DEHP) is associated with urinary concentrations of mono(2-ethylhexyl) phthalate (MEHP) , a DEHP metabolite. In this f...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8926
更新日期:2006-09-01 00:00:00
abstract::In this study we examined the impact of weather variability and tides on the transmission of Barmah Forest virus (BFV) disease and developed a weather-based forecasting model for BFV disease in the Gladstone region, Australia. We used seasonal autoregressive integrated moving-average (SARIMA) models to determine the c...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8568
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:Previous studies have examined fine particulate matter (≤ 2.5 μm; PM2.5) and preterm birth, but there is a dearth of longitudinal studies on this topic and a paucity of studies that have investigated specific sources of this exposure. OBJECTIVES:Our aim was to assess whether anthropogenic sources are associ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1307741
更新日期:2014-10-01 00:00:00
abstract::The Lower North Shore region of the St. Lawrence River is home to a fish-eating population that displays an unusually high body burden of several organochlorines, including polychlorinated biphenyls (PCBs) and dioxin-like compounds (DLCs). We measured biomarkers indicative of liver enzyme induction and investigated th...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7970
更新日期:2005-10-01 00:00:00
abstract::Thirty compounds of various chemical classes were investigated for mutagenicity in a collaborative study (three laboratories) using Salmonella typhimurium TA102. With five compounds, hydrazine sulfate, phenylhydrazine, hydralazine, glutardialdehyde, and glyoxal, mutagenicity was detected by all laboratories. Formaldeh...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.101-1521147
更新日期:1993-10-01 00:00:00