Abstract:
:Tobacco smoke contains a number of genotoxic compounds that are metabolized to their biologically active forms that subsequently react with cellular DNA to form covalently bound carcinogen-DNA adducts. Several analytical procedures have been developed to detect these adducts in human tissues. Using the nuclease P1-enhanced 32P-postlabeling procedure for bulky adducts, we have detected at least 24 adducts in DNA isolated from placenta and umbilical cord DNA. Adducts were detected in both smokers and nonsmokers, but the relative adduct level (RAL) was significantly higher in smokers (42.8, 8 cases) than in nonsmokers (19.7, 11 cases). The origin of the adducts in nonsmokers remains unknown. The adduct levels in artery DNA were significantly lower than in the vein and the placenta, and a paired nonparametric analysis showed a significant association between the adduct levels in the three tissues. Our results show a maternal transfer of carcinogens present in cigarette smoke to fetal tissues and show that the tissues can metabolize the carcinogens to their DNA binding metabolites. The presence of adducts in fetal tissues may be indicative of genomic damage and may predispose the individual for the development of a serious disease later in life.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Hansen C,Asmussen I,Autrup Hdoi
10.1289/ehp.9399229subject
Has Abstractpub_date
1993-03-01 00:00:00pages
229-31eissn
0091-6765issn
1552-9924journal_volume
99pub_type
杂志文章abstract::Previous NIOSH studies demonstrated the embryo- and fetotoxicity and teratogenicity of ethylene glycol monoethyl ether (EGEE) applied to the shaved skin of pregnant rats. In the present study ethylene glycol monoethyl ether acetate (EGEEA), ethylene glycol monobutyl ether (EGBE), and diethylene glycol monoethyl ether ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.845769
更新日期:1984-08-01 00:00:00
abstract:BACKGROUND:Bacterial meningitis causes a high burden of disease in the African meningitis belt, with regular seasonal hyperendemicity and sporadic short, but intense, localized epidemics during the late dry season occurring at a small spatial scale [i.e., below the district level, in individual health centers (HCs)]. I...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP2752
更新日期:2018-09-01 00:00:00
abstract::We describe the successes and challenges faced by federal and local government agencies in the United States as they have attempted in recent years to connect public and environmental health, housing, community development, and building design with environmental, housing, and building laws, codes, and policies. These ...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.8990
更新日期:2007-06-01 00:00:00
abstract::This paper will briefly outline those elements which must be considered in assessing the effects of any given compound which might impinge on the actions of adrenocortical steroids. Considerations that ought to be taken into account include the following: the delivery to the affected cells of corticosteroids, the upta...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.813899
更新日期:1981-04-01 00:00:00
abstract:BACKGROUND:Industrial air pollution is a public health hazard. Previous evidence documented increased respiratory symptoms and hospitalizations in children who live near the factories in the largest chipboard manufacturing district in Italy (Viadana). OBJECTIVES:We evaluated the association of outdoor exposure to form...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1307259
更新日期:2014-06-01 00:00:00
abstract::Fanconi anemia (FA) is an autosomal recessive disorder characterized by diverse developmental abnormalities, progressive bone marrow failure, and a markedly increased incidence of malignancy. FA cells are hypersensitive to DNA cross-linking agents, suggesting a general defect in the repair of DNA cross-links. Some for...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.02110s5773
更新日期:2002-10-01 00:00:00
abstract::This study assessed whether exposure of male rats to two estrogenic, environmental chemicals, 4-octylphenol (OP) and butyl benzyl phthalate (BBP) during gestation or during the first 21 days of postnatal life, affected testicular size or spermatogenesis in adulthood (90-95 days of age). Chemicals were administered via...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.951031136
更新日期:1995-12-01 00:00:00
abstract:BACKGROUND:After Hurricane Katrina, many New Orleans homes remained flooded for weeks, promoting heavy microbial growth. OBJECTIVES:A small demonstration project was conducted November 2005-January 2006 aiming to recommend safe remediation techniques and safe levels of worker protection, and to characterize airborne m...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9258
更新日期:2006-12-01 00:00:00
abstract::In this study, we determined the biologic activity of dichloromethane-extracted particulate matter < 10 micro m in aerodynamic diameter (PM10) obtained from filters at three sites in the Paso del Norte airshed, which includes El Paso, Texas, USA; Juarez, Chihuahua, Mexico, and Sunland Park, New Mexico, USA. The extrac...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.6058
更新日期:2003-08-01 00:00:00
abstract:BACKGROUND:There is general concern that persistent organic pollutants (POPs) found in the environment, wildlife, food, water, house dust, human tissues, and fluids may alter normal human physiologic activities (e.g., fetal development, immune and endocrine systems). Although the levels of some POPs [polychlorinated bi...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.0800205
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Ocean pollution affects marine organisms and ecosystems as well as humans. The International Oceanographic Commission recommends ocean health monitoring programs to investigate the presence of marine contaminants and the health of threatened species and the use of multiple and early-warning biomarker approac...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.0901809
更新日期:2011-03-01 00:00:00
abstract::The identification of certain organic compounds in drinking water has led water treatment specialists to be increasingly concerned about the eventual risks of such pollutants to the health of consumers. Our experiments focused on the role of ozone and granular activated carbon in removing mutagenic compounds and precu...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8669159
更新日期:1986-11-01 00:00:00
abstract:BACKGROUND:Assessing cumulative effects of the multiple environmental factors influencing mortality remains a challenging task. OBJECTIVES:This study aimed to examine the associations between cumulative environmental quality and all-cause and leading cause-specific (heart disease, cancer, and stroke) mortality rates. ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP119
更新日期:2017-03-01 00:00:00
abstract::Unlike laboratory animals, people are rarely exposed to a single hazardous chemical. However, most of the information documenting adverse human health effects from environmental and occupational contaminants has come from studies focused on exposure to single chemicals, and there is little information available on how...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.98106s61263
更新日期:1998-12-01 00:00:00
abstract::We used real-time monitors and low-volume air samplers to measure the potential human exposure to airborne polycyclic aromatic hydrocarbon (PAH) concentrations during various flight-related and ground-support activities of C-130H aircraft at an Air National Guard base. We used three types of photoelectric aerosol sens...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.00108853
更新日期:2000-09-01 00:00:00
abstract::It has been estimated that 4 of 1,000 live births and 35% of spontaneous abortions are aneuploid and that an important proportion of embryo and newborn aneuploidy is of paternal origin. Exposure to organophosphorous pesticides (OP) has been associated with sperm hyperploidy/polyploidy. Therefore, we aimed to assess th...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.011091237
更新日期:2001-12-01 00:00:00
abstract::A comparative analysis was performed of the phenotype and function of peripheral blood leukocytes of two age-matched cohorts of industrial workers in chemical plants, one of which was exposed occupationally to high concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Median actual TCDD burdens were 116 ng/kg ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.98106701
更新日期:1998-04-01 00:00:00
abstract:BACKGROUND:Modern toxicology is shifting from an observational to a mechanistic science. As part of this shift, high-throughput toxicity assays are being developed using alternative, nonmammalian species to prioritize chemicals and develop prediction models of human toxicity. METHODS:The nematode Caenorhabditis elegan...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1409645
更新日期:2016-05-01 00:00:00
abstract::A biodosimetric approach to determine alpha-particle dose to the respiratory tract epithelium from known exposures to radon has been developed in the rat. Cytotoxicity assays have been used to obtain dose-conversion factors for cumulative exposures typical of those encountered by underground uranium miners. However, t...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.97105s4913
更新日期:1997-06-01 00:00:00
abstract::An impressive array of evidence has been obtained during the past decade establishing correlations between specific DNA adducts and carcinogenesis. Many of the studies utilized organ specific differences in carcinogenesis to establish the correlations. More recently, we have investigated similar relationships between ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8562177
更新日期:1985-10-01 00:00:00
abstract:BACKGROUND:Endocrine disrupting chemicals (EDCs) are xenobiotics that mimic the interaction of natural hormones and alter synthesis, transport, or metabolic pathways. The prospect of EDCs causing adverse health effects in humans and wildlife has led to the development of scientific and regulatory approaches for evaluat...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP5580
更新日期:2020-02-01 00:00:00
abstract::Effects of respirable aerosols of sulfuric acid, ammonium sulfate, sodium sulfite, and ammonium persulfate on lungs of rats are reviewed. The literature regarding interactions between ozone or nitrogen dioxide and acidic aerosols (ammonium sulfate, sulfuric acid) is discussed. An unexpected interaction between nitroge...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8979115
更新日期:1989-02-01 00:00:00
abstract::Most of the general population is exposed to carbaryl and other contemporary-use insecticides at low levels. Studies of laboratory animals, in addition to limited human data, show an association between carbaryl exposure and decreased semen quality. In the present study we explored whether environmental exposures to 1...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7234
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:After several decades of commercial use, the flame-retardant chemicals polybrominated diphenyl ethers (PBDEs) and their metabolites are pervasive environmental contaminants and are detected in the human body. Decabrominated diphenyl ether (decaBDE) is currently the only PBDE in production in the United State...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.11814
更新日期:2009-12-01 00:00:00
abstract::The objective of this study was to provide a basis for effectively protecting nonsmokers from acute sensory impacts and for preventing deterioration of indoor air quality caused by environmental tobacco smoke (ETS) emissions. With an olfactory experiment we determined odor detection thresholds (OT) of sidestream ETS (...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.011091045
更新日期:2001-10-01 00:00:00
abstract:BACKGROUND:Rates of preterm birth have been rising over the past several decades. Factors contributing to this trend remain largely unclear, and exposure to environmental contaminants may play a role. OBJECTIVE:We investigated the relationship between phthalate exposure and preterm birth. METHODS:Within a large Mexic...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.0800522
更新日期:2009-10-01 00:00:00
abstract::We report the results of a coordinated mitigation effort aimed at reducing arsenic (As) exposure in three counties of Guizhou province, China. Mitigation occurred in 2005 and encompassed 21 villages with 47,000 inhabitants, who were exposed to high levels of As in their diet through consumption of As-contaminated chil...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9273
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:Global climate change is anticipated to reduce future cereal yields and threaten food security, thus potentially increasing the risk of undernutrition. The causation of undernutrition is complex, and there is a need to develop models that better quantify the potential impacts of climate change on population ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1003311
更新日期:2011-12-01 00:00:00
abstract::Asthma is the most common chronic illness of childhood and its prevalence is increasing, causing much concern for identification of risk factors such as air pollution. We previously conducted a study showing a relationship between asthma visits in all persons < 65 years of age to emergency departments (EDs) and air po...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.99107489
更新日期:1999-06-01 00:00:00
abstract::Isolated rat and human hepatocytes in primary culture were shown to metabolize AAF to reactive intermediates which damaged hepatocyte DNA. A significant increase in unscheduled DNA synthesis was detectable by autoradiography in rat and human hepatocytes exposed to concentrations of AAF as low as 1 microM. When rat hep...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8349165
更新日期:1983-03-01 00:00:00