Abstract:
:Unlike laboratory animals, people are rarely exposed to a single hazardous chemical. However, most of the information documenting adverse human health effects from environmental and occupational contaminants has come from studies focused on exposure to single chemicals, and there is little information available on how two or more contaminants affect humans. Most information on the effects of mixtures comes from animal systems and limited investigations of isolated human cells in culture, even though the study of mixtures in such systems has also been neglected. Two or more compounds may show additive, antagonistic, or synergistic interactions or may act on totally different systems and thus not interact. Furthermore, even a single chemical may have multiple effects and affect more than one organ system. Effects may vary with age, and metabolites may have totally different actions from the parent compound. This paper will review the variety of health effects in humans that may result from environmental contaminants and discuss how such contaminants may interact with each other. We will also present examples on how different contaminants interact from toxicologic studies of polychlorinated biphenyls performed as part of our Albany, New York, Superfund Basic Research Program project.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Carpenter DO,Arcaro KF,Bush B,Niemi WD,Pang S,Vakharia DDdoi
10.1289/ehp.98106s61263subject
Has Abstractpub_date
1998-12-01 00:00:00pages
1263-70eissn
0091-6765issn
1552-9924journal_volume
106 Suppl 6pub_type
杂志文章,评审abstract::In recent years, exposure of man to increasing amounts of metals has occurred rather generally from industrial contamination and variably from intake of dietary mineral supplements. Adverse effects of individual metals can be markedly altered by dietary levels of other essential and nonessential inorganic elements, es...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7825137
更新日期:1978-08-01 00:00:00
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journal_title:Environmental health perspectives
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doi:10.1289/ehp.8562423
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pub_type: 杂志文章
doi:10.1289/ehp.02110s5871
更新日期:2002-10-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.10918
更新日期:2008-04-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
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更新日期:2003-02-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.747187
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journal_title:Environmental health perspectives
pub_type: 杂志文章
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
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更新日期:2000-08-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.8775159
更新日期:1987-11-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.929777
更新日期:1992-07-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8620
更新日期:2006-07-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.8774153
更新日期:1987-10-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.10659
更新日期:2007-12-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7617227
更新日期:1976-10-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1002775
更新日期:2011-07-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1307277
更新日期:2014-06-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.6901
更新日期:2004-09-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.108-1637679
更新日期:2000-08-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.95103s449
更新日期:1995-06-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.107-1566267
更新日期:1999-05-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
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更新日期:1986-12-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9833
更新日期:2007-06-01 00:00:00
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journal_title:Environmental health perspectives
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更新日期:1996-05-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
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更新日期:1985-12-01 00:00:00
abstract:BACKGROUND:Bisphenol A (BPA), a ubiquitous environmental endocrine disruptor targeting estrogen receptors (ERs), has been implicated in the promotion of breast cancer. Perinatal exposure of BPA could induce longitudinal alteration of DNA hydroxymethylation in imprinted loci of mouse blood cells. To date, no data has be...
journal_title:Environmental health perspectives
pub_type: 杂志文章
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更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Evidence suggests that cardiovascular effects of air pollution are mediated by inflammation and that air pollution can induce genetic expression of the interleukin-6 gene (IL6). OBJECTIVES:We investigated whether IL6 and fibrinogen gene variants can affect plasma IL-6 responses to air pollution in patients ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.0800370
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:Cumulative lead exposure is associated with a widened pulse pressure (PP; the -difference between systolic and diastolic blood pressure), a marker of arterial stiffness and a predictor of cardiovascular disease. Polymorphisms in the hemochromatosis gene (HFE) have been shown to modify the impact of cumulativ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1002251
更新日期:2010-09-01 00:00:00
abstract::In an attempt to elucidate the relationship between DNA adduct formation and tumorigenesis, DNA adducts were measured in the livers and bladders of mice during chronic exposure to several different doses of 2-acetylaminofluorene (2-AAF) and 4-aminobiphenyl (4-ABP). Continuous oral administration of these compounds for...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
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更新日期:1994-10-01 00:00:00
abstract::This paper reports the results of a comprehensive survey of the effects of the accidental release of radiation caused by the accident at the Chernobyl nuclear power station in April 1986. The accident and the resulting release of radiation and radioactive products into the atmosphere produced the most serious environm...
journal_title:Environmental health perspectives
pub_type: 杂志文章
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更新日期:1993-07-01 00:00:00
abstract:BACKGROUND:Harmful algal blooms (HABs) produce potent neurotoxins that threaten human health, but current regulations may not be protective of sensitive populations. Early life exposure to low levels of the HAB toxin domoic acid (DomA) produces long-lasting behavioral deficits in rodent and primate models; however, the...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP6652
更新日期:2020-11-01 00:00:00