Abstract:
:Di(2-ethylhexyl) phthalate (DEHP) is used to make polyvinyl chloride (PVC) plastic tubing soft and flexible. Animal data show that adverse effects of DEHP exposure may include reduced fertility, reduced sperm production in males, and ovarian dysfunction in females. Known treatments that involve high DEHP exposures are blood exchange transfusions, extracorporeal membrane oxygenation (ECMO), and cardiovascular surgery. Although potential exposure to DEHP in ECMO patients is significant, the exposure has not been associated with short-term toxicity. To evaluate long-term toxicity, we undertook a study of neonatal ECMO survivors to assess their onset of puberty and sexual maturity. We evaluated 13 male and 6 female subjects at 14-16 years of age who had undergone ECMO as neonates. All subjects had a complete physical examination including measurements for height, weight, head circumference, and pubertal assessment by Tanner staging. The testicular volume and the phallic length were measured in male participants. Laboratory tests included thyroid, liver, and renal function as well as measurements of luteinizing hormone, follicle-stimulating hormone, testosterone for males, and estradiol for females. Except for one patient with Marfan syndrome, the rest had normal growth percentile for age and sex. All had normal values for thyroid, liver, and renal functions. Sexual hormones were appropriate for the stage of pubertal maturity. Our results indicate that adolescents exposed to significant quantities of DEHP as neonates showed no significant adverse effects on their physical growth and pubertal maturity. Thyroid, liver, renal, and male and female gonadal functions tested were within normal range for age and sex distribution. Key Words: DEHP, ECMO, toxicity.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Rais-Bahrami K,Nunez S,Revenis ME,Luban NL,Short BLdoi
10.1289/ehp.6901subject
Has Abstractpub_date
2004-09-01 00:00:00pages
1339-40issue
13eissn
0091-6765issn
1552-9924journal_volume
112pub_type
杂志文章abstract::Metal ions form complexes with naturally occurring complexing agents or ligands released from industrial activity. The metal complexes are thereby mobilized and transported in environmental and biological systems. The impact of such metal complexes depends on the metal complex species that are kinetically and thermody...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.95103s113
更新日期:1995-02-01 00:00:00
abstract::The cytotoxic action of a series of mineral dusts has been studied using Chinese hamster V79-4 cells obtained from three separate laboratories in the UK. The dusts which have been studied include samples of asbestos from the Union Internationale Contre le Cancer reference series and an internationally available sample...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8351189
更新日期:1983-09-01 00:00:00
abstract::The fundamental problems in population monitoring for genetic effects are twofold: the binomialized nature of the data and the lower power due to small risk of finding positive results. The binomial character is artificial, even forced, and can with advantage be replaced by more refined analysis, and by a focus on all...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8142127
更新日期:1981-12-01 00:00:00
abstract::Multiple factors, known and unknown, contribute to human breast cancer. Hereditary, hormonal, and reproductive factors are associated with risk of breast cancer. Environmental agents, including chemical carcinogens, are modifiable risk factors to which over 70% of breast cancers have been attributed. Polymorphisms of ...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.02110s1119
更新日期:2002-02-01 00:00:00
abstract::We conducted a case-control study to determine the contribution of lead to blood from consumption of calcium supplements approximating the recommended daily intakes over a 6-month period. Subjects were males and females ages 21 to 47 years (geometric mean 32 years) with a geometric mean blood lead concentration of 2.5...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.01109283
更新日期:2001-03-01 00:00:00
abstract::The many anatomical, physiological, and biochemical differences among various mammalian species make it difficult to extrapolate carcinogenic potency data from animals to humans. The process is further complicated by the multistep origin of most malignant tumors in animals and humans due to the interaction of target c...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.887773
更新日期:1988-04-01 00:00:00
abstract::Most of the general population is exposed to carbaryl and other contemporary-use insecticides at low levels. Studies of laboratory animals, in addition to limited human data, show an association between carbaryl exposure and decreased semen quality. In the present study we explored whether environmental exposures to 1...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7234
更新日期:2004-12-01 00:00:00
abstract::Human biomonitoring investigations have provided data on a wide array of chemicals in blood and urine and in other tissues and fluids such as hair and human milk. These data have prompted questions such as a) What is the relationship between levels of environmental chemicals in humans and external exposures? b) What i...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8197
更新日期:2005-11-01 00:00:00
abstract::Many mammals methylate trivalent inorganic arsenic in liver to species that are released into the bloodstream and excreted in urine and feces. This study addresses how methylated arsenicals pass through cell membranes. We have previously shown that aquaglyceroporin channels, including Escherichia coli GlpF, Saccharomy...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8600
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVE:The World Health Organization is the agency responsible for reporting the Millennium Development Goal (MDG) indicator "percentage of population using solid fuels." In this article, we present the results of a comprehensive assessment of solid fuel use, conducted in 2005, and discuss the implications of our fi...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8603
更新日期:2006-03-01 00:00:00
abstract::The clinical use of polymeric materials in the body to repair and restore damaged or diseased tissues and organs is substantially increasing on an annual basis. Concomitant with this use is an increase in materials related research on medically used polymers. Information on the historical and current clinical use of p...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.751171
更新日期:1975-06-01 00:00:00
abstract::Differences in genetic susceptibility to hazardous chemicals affect individuals of both human and nonhuman populations. In both cases, differences in response to chemicals or general ill health result as a function of these differences in genetic susceptibility. However, ecological systems are a compilation of hundred...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.97105s4843
更新日期:1997-06-01 00:00:00
abstract::Although broad links between climatic factors and coccidioidomycosis have been established, the identification of simple and robust relationships linking climatic controls to seasonal timing and outbreaks of the disease has remained elusive. Using an adaptive data-oriented method for estimating date of exposure, in th...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7786
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:The widespread use of organophosphorus (OP) pesticides has led to frequent exposure in adults and children. Because such exposure may cause adverse health effects, particularly in children, the sources and patterns of exposure need to be studied further. OBJECTIVES:We assessed young urban/suburban children'...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.10912
更新日期:2008-04-01 00:00:00
abstract::Clinical and experimental studies on respiratory involvement and alterations in immune status were carried out. Respiratory distress occurring in these patients has improved gradually for 14 years but still remains. Copious expectoration at an early stage of the disease may be related to the fact that a number of disc...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.59-1568074
更新日期:1985-02-01 00:00:00
abstract:BACKGROUND:Differences in the neighborhood food environment may contribute to disparities in obesity. OBJECTIVES:The purpose of this study was to examine the association of neighborhood food environments with body mass index (BMI) and obesity after control for neighborhood walkability. METHODS:This study employed a c...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.11590
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:Air pollution exposure during pregnancy might affect placental growth and function, perhaps leading to pregnancy complications. OBJECTIVE:We prospectively evaluated the associations of maternal air pollution exposure with markers of placental growth and function among 7,801 pregnant women in the Netherlands...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1204918
更新日期:2012-12-01 00:00:00
abstract::The carcinogenic properties of selected metals and their compounds are reviewed to provide a useful reference for existing knowledge on relationships between physical and chemical forms, kinetics and carcinogenic potential and between epidemiology, bioassays, and short-term tests. Extensive consideration is given to a...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.9195157
更新日期:1991-11-01 00:00:00
abstract:BACKGROUND:Although animal experiments have shown that cadmium exposure results in severe dental caries, limited epidemiologic data are available on this issue. OBJECTIVES:We aimed to examine the relationship between environmental cadmium exposure and dental caries in children 6-12 years of age. METHODS:We analyzed c...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.10947
更新日期:2008-06-01 00:00:00
abstract::This work group report addresses the central question: What are the critical windows during development (preconception through puberty) when exposure to xenobiotics may have the greatest adverse impact on subsequent reproductive health? The reproductive system develops in stages, with sex-specific organogenesis occurr...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.00108s3505
更新日期:2000-06-01 00:00:00
abstract::We have demonstrated that the pyrolysis products of amino acids and proteins in model systems are mutagenic. The mutagenic principles in the pyrolyzates of amino acids have been isolated and identified by Sugimura et al. We have isolated and identified amino-alpha-carbolines from pyrolyzed soybean globulin as mutagens...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.866755
更新日期:1986-08-01 00:00:00
abstract::The importance of urban dust as a source of lead for young children is still disputed. Although blood-lead data from various population surveys usually show a peak concentration in early childhood, there is evidence that such a peak is small or absent altogether in children without much access to the general environme...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8350371
更新日期:1983-04-01 00:00:00
abstract:BACKGROUND:After Hurricane Katrina, many New Orleans homes remained flooded for weeks, promoting heavy microbial growth. OBJECTIVES:A small demonstration project was conducted November 2005-January 2006 aiming to recommend safe remediation techniques and safe levels of worker protection, and to characterize airborne m...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9258
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:Diethylstilbestrol (DES) is a synthetic estrogen associated with adverse effects on reproductive organs. DES-induced toxicity of the mouse seminal vesicle (SV) is mediated by estrogen receptor α (ERα), which alters expression of seminal vesicle secretory protein IV (Svs4) and lactoferrin (Ltf) genes. OBJECT...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1307351
更新日期:2014-03-01 00:00:00
abstract::Cytotoxic chemicals have in common the ability to act specifically on cells in cycle. Bacteria are more sensitive in the exponential growth phase than when growing slowly in media. Similar observations have been made on a variety of systems ranging from bacteria, yeast, higher plants and invertebrates to vertebrates i...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.782487
更新日期:1978-06-01 00:00:00
abstract::A system suitable for the detection of meiotic aneuploidy is described in which various different origins of the aneuploidy can be distinguished. Aneuploid meiotic products are detected as black disomic spores held in asci containing all the products of a single meiosis. Aneuploidy may result from nondisjunction or fr...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.793167
更新日期:1979-08-01 00:00:00
abstract::Once a sign of modernization and growth, dams are often seen today as symbols of environmental and social devastation. Over 800,000 dams have been built worldwide to provide drinking water, flood control, hydropower, irrigation, navigation, and water storage. Dams do indeed provide these things,but at the cost of seve...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.971051050
更新日期:1997-10-01 00:00:00
abstract::Acetylcholinesterase (AChE) is the enzyme that hydrolyzes the neurotransmitter acetylcholine at cholinergic synapses and neuromuscular junctions. However, results from our laboratory and others indicate that AChE has an extrasynaptic, noncholinergic role during neural development. This article is a review of our findi...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.99107s181
更新日期:1999-02-01 00:00:00
abstract:BACKGROUND:Exposure to organophosphate (OP) pesticides is an occupational hazard for farmworkers and affects their children through the take-home pathway. OBJECTIVES:We examined the effectiveness of a randomized community intervention to reduce pesticide exposure among farmworkers and their children. METHODS:We condu...
journal_title:Environmental health perspectives
pub_type: 杂志文章,随机对照试验
doi:10.1289/ehp.10882
更新日期:2008-05-01 00:00:00
abstract::Epidemiologic studies have shown that airborne particulate matter (PM) with a mass median aerodynamic diameter < 10 microm (PM10) is associated with an increase in respiratory-related disease. However, there is a growing consensus that particles < 2.5 microm (PM2.5), including many in the ultrafine (< 0.1 microm) size...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.5964
更新日期:2003-06-01 00:00:00