Abstract：
:Many mammals methylate trivalent inorganic arsenic in liver to species that are released into the bloodstream and excreted in urine and feces. This study addresses how methylated arsenicals pass through cell membranes. We have previously shown that aquaglyceroporin channels, including Escherichia coli GlpF, Saccharomyces cerevisiae Fps1p, AQP7, and AQP9 from rat and human, conduct trivalent inorganic arsenic [As(III)] as arsenic trioxide, the protonated form of arsenite. One of the initial products of As(III) methylation is methylarsonous acid [MAs(III)], which is considerably more toxic than inorganic As(III). In this study, we investigated the ability of GlpF, Fps1p, and AQP9 to facilitate movement of MAs(III) and found that rat aquaglyceroporin conducted MAs(III) at a higher rate than the yeast homologue. In addition, rat AQP9 facilitates MAs(III) at a higher rate than As(III). These results demonstrate that aquaglyceroporins differ both in selectivity for and in transport rates of trivalent arsenicals. In this study, the requirement of AQP9 residues Phe-64 and Arg-219 for MAs(III) movement was examined. A hydrophobic residue at position 64 is not required for MAs(III) transport, whereas an arginine at residue 219 may be required. This is similar to that found for As(III), suggesting that As(III) and MAs(III) use the same translocation pathway in AQP9. Identification of MAs(III) as an AQP9 substrate is an important step in understanding physiologic responses to arsenic in mammals, including humans.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Liu Z,Styblo M,Rosen BPdoi
10.1289/ehp.8600subject
Has Abstractpub_date
2006-04-01 00:00:00pages
527-31issue
4eissn
0091-6765issn
1552-9924journal_volume
114pub_type
杂志文章abstract：:In this article we report a simple and efficient method for detecting nonsteroidal estrogens in a biologic sample. This method uses polyclonal antibodies to estradiol (E2) to immunoprecipitate these major biologically active steroidal estrogens, leaving behind the nonsteroidal estrogens, which are then detected in a c...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.02110791
更新日期：2002-08-01 00:00:00
abstract：BACKGROUND:Research often suffers from overspecialization, a practice nurtured in academia and reinforced by funders. Indeed, investigators in household air pollution (HAP) and water, sanitation and hygiene (WaSH), working in poor parts of the world, rarely interact despite having similar training and using similar met...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/EHP4752
更新日期：2019-02-01 00:00:00
abstract：:This work group report addresses the central question: What are the critical windows during development (preconception through puberty) when exposure to xenobiotics may have the greatest adverse impact on subsequent reproductive health? The reproductive system develops in stages, with sex-specific organogenesis occurr...
journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
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更新日期：2000-06-01 00:00:00
abstract：:Soil samples were collected from 28 fields which had received manure from Michigan's most highly contaminated dairy herds. The number of fields in each concentration range of PBB in soil were: 2, not detectable; 15, 0.0 to 8.0 ppb; 6, 14-102 ppb, and 5, 153 to 371 ppb. Plant tissue sampled from the 10 most highly cont...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.78231
更新日期：1978-04-01 00:00:00
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更新日期：1993-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：1974-12-01 00:00:00
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doi：10.1289/ehp.0901214
更新日期：2010-05-01 00:00:00
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更新日期：2006-09-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1289/ehp.5840
更新日期：2003-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1289/ehp.7970
更新日期：2005-10-01 00:00:00
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journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.1206245
更新日期：2013-07-01 00:00:00
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journal_title：Environmental health perspectives
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更新日期：1997-06-01 00:00:00
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journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.929769
更新日期：1992-07-01 00:00:00
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journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.5847
更新日期：2003-04-01 00:00:00
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journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.8560241
更新日期：1985-05-01 00:00:00
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journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.01109213
更新日期：2001-03-01 00:00:00
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doi：10.1289/ehp.1509735
更新日期：2016-05-01 00:00:00
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doi：10.1289/ehp.01109s2309
更新日期：2001-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1289/ehp.001081019
更新日期：2000-11-01 00:00:00
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journal_title：Environmental health perspectives
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更新日期：1979-04-01 00:00:00
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更新日期：2010-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1289/ehp.93101s471
更新日期：1993-12-01 00:00:00
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journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.93101s4193
更新日期：1993-12-01 00:00:00
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journal_title：Environmental health perspectives
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更新日期：1994-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1289/ehp.8245111
更新日期：1982-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1289/ehp.0800193
更新日期：2009-07-01 00:00:00
abstract：:During the last three decades, the use of modern organic synthetic pesticides has increased about 40-fold. Total U.S. production, for domestic and expert use, in 1976 was about 1.4 million pounds. Crops receiving the most intensive application of various pesticides were cotton for insecticides, corn for herbicides, an...
journal_title：Environmental health perspectives
pub_type： 杂志文章
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更新日期：1978-12-01 00:00:00
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更新日期：2000-12-01 00:00:00
abstract：BACKGROUND:Traffic noise has been associated with cardiovascular and metabolic disorders. Potential modes of action are through stress and sleep disturbance, which may lead to endocrine dysregulation and overweight. OBJECTIVES:We aimed to investigate the relationship between residential traffic and railway noise and a...
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更新日期：2016-03-01 00:00:00
