Apoptosis and Bax expression are increased by coal dust in the polycyclic aromatic hydrocarbon-exposed lung.

abstract：:Methylation is considered the detoxification pathway for inorganic arsenic (InAs), an established human carcinogen. Urinary speciation analysis is used to assess the distribution of metabolites [monomethylarsonate (MMA), dimethylarsinate (DMA), and unmethylated arsenic (InAs)], as indicators of methylation capacity. W...

journal_title：Environmental health perspectives

authors： Hopenhayn-Rich C,Biggs ML,Smith AH,Kalman DA,Moore LE

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND:Per- and polyfluoroalkyl substances (PFAS) are widespread persistent organic pollutants and endocrine disruptors. High doses of perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) exposure can cause pregnancy loss and infant deaths in animals, but the associations between PFAS exposures and...

journal_title：Environmental health perspectives

authors： Liew Z,Luo J,Nohr EA,Bech BH,Bossi R,Arah OA,Olsen J

更新日期：2020-04-01 00:00:00

abstract：:The effects of chrysotile on DNA synthesis in the gastrointestinal tract of the rat were studied by measuring the uptake of tritium-labeled thymidine; whole stomach, small intestine, colon liver were removed, cleaned, and homogenized and the DNA was isolated and assayed for tritium label.A dose-response study indicate...

journal_title：Environmental health perspectives

authors： Amacher DE,Alarif A,Epstein SS

更新日期：1974-12-01 00:00:00

abstract：BACKGROUND:A critical question regarding the association between short-term exposure to ozone and mortality is the extent to which this relationship is confounded by ambient exposure to particles. OBJECTIVES:We investigated whether particulate matter < 10 and < 2.5 microm in aerodynamic diameter (PM(10) and PM(2.5)) i...

journal_title：Environmental health perspectives

authors： Bell ML,Kim JY,Dominici F

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Tens of millions of Americans suffer from a range of adverse health outcomes due to noise exposure, including heart disease and hearing loss. Reducing environmental noise pollution is achievable and consistent with national prevention goals, yet there is no national plan to reduce environmental noise polluti...

journal_title：Environmental health perspectives

authors： Hammer MS,Swinburn TK,Neitzel RL

更新日期：2014-02-01 00:00:00

abstract：:An important public health challenge has been the need to protect children's health. To accomplish this goal, the scientific community needs scientifically based child-specific risk assessment methods. Critical to their development is the need to understand mechanisms underlying children's sensitivity to environmental...

journal_title：Environmental health perspectives

authors： Faustman EM,Silbernagel SM,Fenske RA,Burbacher TM,Ponce RA

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Chronic exposure to traffic-related air pollution (TRAP) may contribute to premature mortality, but few studies to date have addressed this topic. OBJECTIVES:In this study we assessed the association between TRAP and mortality in Toronto, Ontario, Canada. METHODS:We collected nitrogen dioxide samples over ...

journal_title：Environmental health perspectives

authors： Jerrett M,Finkelstein MM,Brook JR,Arain MA,Kanaroglou P,Stieb DM,Gilbert NL,Verma D,Finkelstein N,Chapman KR,Sears MR

更新日期：2009-05-01 00:00:00

abstract：:A human lymphoblastoid cell line has been used to test for mutations caused by combustion-generated soot particles and their constituent components, which are substrate carbon-black and adsorbed condensate, principally in the form of polycyclic aromatic hydrocarbons (PAH). It was found that the mutagenicity of the PAH...

journal_title：Environmental health perspectives

authors： Bolsaitis PP,Feitelberg AS,Dekermendjian V,Elliott JF,Sarofim AF,Thilly WG

更新日期：1991-12-01 00:00:00

abstract：:Examining global effects of toxic metals on gene expression can be useful for elucidating patterns of biological response, discovering underlying mechanisms of toxicity, and identifying candidate metal-specific genetic markers of exposure and response. Using a 1,200 gene nylon array, we examined changes in gene expres...

journal_title：Environmental health perspectives

authors： Andrew AS,Warren AJ,Barchowsky A,Temple KA,Klei L,Soucy NV,O'Hara KA,Hamilton JW

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Phthalates comprise a large class of chemicals used in a variety of consumer products. Several have anti-androgenic properties, and in rodents prenatal exposure has been associated with reduced anogenital distance (AGD)-the distance from the anus to the genitals in male offspring. Few human studies have been...

journal_title：Environmental health perspectives

authors： Jensen TK,Frederiksen H,Kyhl HB,Lassen TH,Swan SH,Bornehag CG,Skakkebaek NE,Main KM,Lind DV,Husby S,Andersson AM

更新日期：2016-07-01 00:00:00

abstract：:Nitrate contamination of drinking water implies a genotoxic risk to man due to the endogenous formation of carcinogenic N-nitroso compounds from nitrate-derived nitrite. Thus far, epidemiological studies have presented conflicting results on the relation of drinking water nitrate levels with gastric cancer incidence. ...

journal_title：Environmental health perspectives

authors： Kleinjans JC,Albering HJ,Marx A,van Maanen JM,van Agen B,ten Hoor F,Swaen GM,Mertens PL

更新日期：1991-08-01 00:00:00

abstract：BACKGROUND:Studies suggest that phthalate exposures may adversely affect child respiratory health. OBJECTIVES:We evaluated associations between asthma diagnosed in children between 5 and 11 years of age and prenatal exposures to butylbenzyl phthalate (BBzP), di-n-butyl phthalate (DnBP), di(2-ethylhexyl) phthalate (DEH...

journal_title：Environmental health perspectives

authors： Whyatt RM,Perzanowski MS,Just AC,Rundle AG,Donohue KM,Calafat AM,Hoepner LA,Perera FP,Miller RL

更新日期：2014-10-01 00:00:00

abstract：:Chemicals, including commonly used drugs (e.g., penicillin, meprobamate, pyridium, and mercaptomerin) penetrate and persist for some time in the ovarian follicular fluid at concentrations approximately similar to that of the serum. Information as to the penetration of chemicals into the granulosa cells and into the oo...

journal_title：Environmental health perspectives

authors： Fabro S

更新日期：1978-06-01 00:00:00

abstract：:A system suitable for the detection of meiotic aneuploidy is described in which various different origins of the aneuploidy can be distinguished. Aneuploid meiotic products are detected as black disomic spores held in asci containing all the products of a single meiosis. Aneuploidy may result from nondisjunction or fr...

journal_title：Environmental health perspectives

authors： Bond DJ,McMillan L

更新日期：1979-08-01 00:00:00

abstract：BACKGROUND:Arsenicals (roxarsone and nitarsone) used in poultry production likely increase inorganic arsenic (iAs), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), and roxarsone or nitarsone concentrations in poultry meat. However, the association between poultry intake and exposure to these arsenic species, ...

journal_title：Environmental health perspectives

authors： Nigra AE,Nachman KE,Love DC,Grau-Perez M,Navas-Acien A

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Whether there is a causal relation between long-term exposure to traffic and asthma development is so far not clear. This may be explained by inaccurate exposure assessment. OBJECTIVE:We investigated the associations of long-term traffic-related exposures with asthma onset assessed retrospectively and respi...

journal_title：Environmental health perspectives

authors： Oftedal B,Nystad W,Brunekreef B,Nafstad P

更新日期：2009-05-01 00:00:00

abstract：:Repeated inhalation of silica dust can lead to inflammation and fibrosis in human lung and in experimental animal models. The alveolar macrophage is believed to play a pivotal role in this process. Numerous macrophage-derived growth factors, cytokines, and arachidonic acid metabolites have been shown to contribute to ...

journal_title：Environmental health perspectives

authors： Koren HS,Joyce M,Devlin RB,Becker S,Driscoll K,Madden MC

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:The presence of pharmaceuticals in aquatic environments and in drinking water has prompted significant public interest regarding potential adverse ecological effects and risks to human health. OBJECTIVES:The Environmental Health Summit held in North Carolina, 10-11 November 2008, explored the issues associa...

journal_title：Environmental health perspectives

authors： Rodriguez-Mozaz S,Weinberg HS

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:The relationship of fine particulate matter < 2.5 microm in diameter (PM(2.5)) air pollution with mortality and cardiovascular disease is well established, with more recent long-term studies reporting larger effect sizes than earlier long-term studies. Some studies have suggested the coarse fraction, particl...

journal_title：Environmental health perspectives

authors： Puett RC,Hart JE,Yanosky JD,Paciorek C,Schwartz J,Suh H,Speizer FE,Laden F

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:The upward trend in industrial nations in the incidence of male genitourinary (GU) conditions may be attributed to increased exposure to endocrine disruptors. Polybrominated biphenyl (PBB), a brominated flame retardant, is one such suspected endocrine disruptor. OBJECTIVE:We investigated the relationship be...

journal_title：Environmental health perspectives

authors： Small CM,DeCaro JJ,Terrell ML,Dominguez C,Cameron LL,Wirth J,Marcus M

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Particulate matter (PM) in outdoor air pollution was recently designated a Group I carcinogen by the International Agency for Research on Cancer (IARC). This determination was based on the evidence regarding the relationship of PM2.5 and PM10 to lung cancer risk; however, the IARC evaluation did not include ...

journal_title：Environmental health perspectives

authors： Hamra GB,Guha N,Cohen A,Laden F,Raaschou-Nielsen O,Samet JM,Vineis P,Forastiere F,Saldiva P,Yorifuji T,Loomis D

更新日期：2014-09-01 00:00:00

abstract：:Many epidemiologic reports associate ambient levels of particulate matter (PM) with human mortality and morbidity, particularly in people with preexisting cardiopulmonary disease (e.g., chronic obstructive pulmonary disease, infection, asthma). Because much ambient PM is derived from combustion sources, we tested the ...

journal_title：Environmental health perspectives

authors： Costa DL,Dreher KL

更新日期：1997-09-01 00:00:00

abstract：:The historical exposures to aromatic amines of various occupational groups are briefly reviewed. Modern studies indicate that other occupational groups might have risks worth investigating; these include machinists and workers in the chemical industry. Details of a recent investigation into the exposure of dye workers...

journal_title：Environmental health perspectives

authors： Cartwright RA

更新日期：1983-03-01 00:00:00

abstract：:The many anatomical, physiological, and biochemical differences among various mammalian species make it difficult to extrapolate carcinogenic potency data from animals to humans. The process is further complicated by the multistep origin of most malignant tumors in animals and humans due to the interaction of target c...

journal_title：Environmental health perspectives

authors： Slaga TJ

更新日期：1988-04-01 00:00:00

abstract：:A subset of workers was followed after exposure to polychlorinated biphenyls (PCBs), dioxins, and furans in an occupational medicine clinic setting. Patterns of PCBs found in adipose tissue resembled the pattern seen when soot from the incident or Aroclor 1254 was examined by GC-MS. Adipose tissue also revealed levels...

journal_title：Environmental health perspectives

authors： Schecter A,Tiernan T,Schaffner F,Taylor M,Gitlitz G,VanNess GF,Garrett JH,Wagel DJ

更新日期：1985-05-01 00:00:00

abstract：:High cadmium exposure is known to cause bone damage, but the association between low-level cadmium exposure and osteoporosis remains to be clarified. Using a population-based women's health survey in southern Sweden [Women's Health in the Lund Area (WHILA) ] with no known historical cadmium contamination, we investiga...

journal_title：Environmental health perspectives

authors： Akesson A,Bjellerup P,Lundh T,Lidfeldt J,Nerbrand C,Samsioe G,Skerfving S,Vahter M

更新日期：2006-06-01 00:00:00

abstract：:Prostaglandin-H synthase is unique among enzymes of the plant and animal kingdom in its ability to biosynthesize and metabolize hydroperoxides. Its cyclooxygenase activity oxygenates polyunsaturated fatty acids to hydroperoxy endoperoxides, and its peroxidase activity reduces the hydroperoxy group to hydroxy groups. H...

journal_title：Environmental health perspectives

authors： Marnett LJ

更新日期：1990-08-01 00:00:00

abstract：BACKGROUND:Eliminating silicosis is a priority of the International Labour Organization and the World Health Organization. Prevalence is particularly high in developing countries. OBJECTIVES:We describe trends in silicosis among South African gold miners who had had an autopsy between 1975 and 2007 and quantify the co...

journal_title：Environmental health perspectives

authors： Nelson G,Girdler-Brown B,Ndlovu N,Murray J

更新日期：2010-03-01 00:00:00

abstract：:The formation of reactive oxygen species resulting from the interaction of silica dust particles with red blood cell membranes was investigated; particularly, the effect of surface hydroxyl (silanol) group concentration on the rate of formation of such reactive oxygen species was investigated. The rate of formation wa...

journal_title：Environmental health perspectives

authors： Razzaboni BL,Bolsaitis P

更新日期：1990-07-01 00:00:00

abstract：:The anatomy of the intestine is outlined. The kinetics of cell proliferation, differentiation, and migration in intestinal epithelium are described. The distribution of cell types between the proliferation and differentiation compartments of the epithelium is summarized. Seven preparations of intestine in current use ...

journal_title：Environmental health perspectives

authors： Porteous JW

更新日期：1979-12-01 00:00:00