Abstract:
:The effects of chrysotile on DNA synthesis in the gastrointestinal tract of the rat were studied by measuring the uptake of tritium-labeled thymidine; whole stomach, small intestine, colon liver were removed, cleaned, and homogenized and the DNA was isolated and assayed for tritium label.A dose-response study indicated that 2 weeks after a 5 mg/kg dose of chrysotile, DNA synthesis was increased in the small intestine and colon and reduced in the liver; synthesis was reduced in the small intestine 2 weeks after a 500 mg/kg dose. Following a 100 mg/kg dose of chrysotile, a transient increase in DNA synthesis was noted in the stomach and small intestine at 1 and 7 days, respectively, besides increased synthesis in the colon from 28 to 63 days. These data suggest that asbestos penetrates the gastrointestinal mucosa and influences regulation of DNA synthesis in the gastrointestinal tract.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Amacher DE,Alarif A,Epstein SSdoi
10.1289/ehp.749319subject
Has Abstractpub_date
1974-12-01 00:00:00pages
319-24eissn
0091-6765issn
1552-9924journal_volume
9pub_type
杂志文章abstract::We conducted a 1-year epidemiologic study in Boston, Massachusetts, beginning May 1997, to examine the associations between environmental factors and office workers' health. We recruited 98 subjects (81 females and 17 males) in 21 offices in four office buildings. We conducted environmental sampling every 6 weeks and ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.5697
更新日期:2003-07-01 00:00:00
abstract::We present a pilot study of individuals (liquidators) who were engaged in clean-up operations after the disaster at the nuclear power plant at Chernobyl in Ukraine. In the 10 years since the disaster, adverse health effects among exposed individuals have not been clearly defined. There is widespread fear of damage to ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.97105s61445
更新日期:1997-12-01 00:00:00
abstract::Microarrays provide an unprecedented opportunity for comprehensive concurrent analysis of thousands of genes. The global analysis of the response of genes to a toxic insult (toxicogenomics), as opposed to the historical method of examining a few select genes, provides a more complete picture of toxicologically signifi...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.6709
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:Although adverse effects of high temperature on mortality have been studied extensively in urban areas, little is known of the heat-mortality associations outside of cities. OBJECTIVE:We investigated whether heat-mortality associations differed between urban and nonurban areas and how urbanicity affected th...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP204
更新日期:2016-12-01 00:00:00
abstract:OBJECTIVE:We reviewed the scientific background for the current health-based World Health Organization (WHO) guideline value for manganese in drinking water. DATA SOURCES AND EXTRACTION:The initial starting point was the background document for the development of the WHO's guideline value for manganese in drinking wat...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.10316
更新日期:2007-11-01 00:00:00
abstract::The capacity of in vitro bioassays to detect the potential carcinogenicity of metal compounds is reviewed. The in vitro bioassays discussed include: bacterial reversion analysis to determine the capacity of metal salts to revert Salmonella typhimurium histidine auxotrophs or to revert Escherichia coli WP 2 tryp- to tr...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.8140163
更新日期:1981-08-01 00:00:00
abstract::Biomarkers are desirable for quantitating human exposure to environmental tobacco smoke (ETS) and for predicting potential health risks for exposed individuals. A number of biomarkers of ETS have been proposed. At present cotinine, measured in blood, saliva, or urine, appears to be the most specific and the most sensi...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.99107s2349
更新日期:1999-05-01 00:00:00
abstract::One of the many forms that biological warfare may take is the targeting of major food crops. In a poor country where millions of citizens depend on staple crops such as rice, an act of bioterrorism that destroys the crop would create a famine, resulting not only in malnutrition and starvation but also in reduced immun...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.108-a126
更新日期:2000-03-01 00:00:00
abstract::The review of over 800 references on aluminum (Al) published since the mid-fifties covers the occurrence of Al in soil, air, water, plants and food products, as well as air and water pollution problems. In addition, the existing quality criteria, the biology and toxicology of Al, and the therapeutic and medical uses a...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7483
更新日期:1974-08-01 00:00:00
abstract::This subject concerns the complex interrelationship of a genetically determined protein deficiency, enzymes which are inhibited by that protein, environmental challenges such as cigarette smoke and industrial pollutants, and the occurrence of obstructive lung disease (Fig. 1). Unequivocal establishment of an etiologic...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.792957
更新日期:1979-04-01 00:00:00
abstract:BACKGROUND:The metabolome is a collection of exogenous chemicals and metabolites from cellular processes that may reflect the body's response to environmental exposures. Studies of air pollution and metabolomics are limited. OBJECTIVES:To explore changes in the human metabolome before, during, and after the 2008 Beiji...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP3705
更新日期:2019-05-01 00:00:00
abstract::Organophosphate (OP) pesticides are commonly used in the United States, and farmworkers are at risk for chronic exposure. Using a sample of 218 farmworkers in 24 communities and labor camps in eastern Washington State, we examined the association between agricultural crop and OP pesticide metabolite concentrations in ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8620
更新日期:2006-07-01 00:00:00
abstract::Short articles on the following topics: *NIEHS Strategic Plan: New Frontiers in Environmental Sciences and Human Health; Beyond the Bench: Environmental Health Nursing: Putting Knowledge into Practice; Headliners: Inhibition of RLIP76 Causes Complete Regression of Melanoma in Mice. ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:
更新日期:2006-05-01 00:00:00
abstract::The lysosomes of several varieties of cells such as the tubular proximal cell of the kidney and the alveolar macrophage have the ability to concentrate and precipitate several elements inhaled in water-soluble form, usually as phosphate. The mechanism involved is attributed to the high acid phosphatase activity of lys...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9297145
更新日期:1992-07-01 00:00:00
abstract::Nitroaromatic compounds, ArNO2 have widespread actual or potential use in medicine and cancer therapy. There is direct proof that free-radical metabolites are involved in many applications, and an appreciation of the conceptual basis for their therapeutic differential; however, an understanding of the detailed mechani...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8564309
更新日期:1985-12-01 00:00:00
abstract::The purpose of the investigation is to study whether an increased mortality from certain causes exists in an area around the Rönnskärsverken smelter works in northern Sweden. Founded in 1928, this metallurgical plant processing mainly nonferrous metals has since its initial operations been using ore with a high arseni...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7719133
更新日期:1977-08-01 00:00:00
abstract::The significance of the environment for health is increasingly being recognized. There is a need for systematic approaches to assessment of environmental factors most relevant to health, health outcomes most influenced by the environment, and the relationships between them, as well as for approaches to representing th...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8321
更新日期:2006-03-01 00:00:00
abstract::The findings of studies investigating whether exposures to ionizing radiation before birth, either pre- or post-conception, increase the risk of childhood cancer have provoked much scientific controversy. An epidemiological association between the abdominal exposure of pregnant women to diagnostic X-rays and childhood...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.951031018
更新日期:1995-11-01 00:00:00
abstract::A system suitable for the detection of meiotic aneuploidy is described in which various different origins of the aneuploidy can be distinguished. Aneuploid meiotic products are detected as black disomic spores held in asci containing all the products of a single meiosis. Aneuploidy may result from nondisjunction or fr...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.793167
更新日期:1979-08-01 00:00:00
abstract::Man-made endocrine-disrupting chemicals (EDCs) present a threat to biodiversity, even in remote areas. To date, numerous wildlife species have been affected by EDCs in the environment, but it is likely that many more species are suffering effects that have not yet been reported. Impaired reproduction, damaged brain fu...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.8070
更新日期:2006-04-01 00:00:00
abstract:BACKGROUND:Thyroid hormones are important regulators of brain development. During critical periods of development, even transient disorders in thyroid hormone availability may lead to profound neurologic impairment. Animal experiments have shown that certain environmental pollutants, including heavy metals and organoch...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.10486
更新日期:2007-12-01 00:00:00
abstract::Chronic exposure to inorganic arsenic (iAs) has been associated with increased risk of various forms of cancer and of noncancerous diseases. Metabolic conversions of iAs that yield highly toxic and genotoxic methylarsonite (MAsIII) and dimethylarsinite (DMAsIII) may play a significant role in determining the extent an...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7519
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:Global climate change is anticipated to reduce future cereal yields and threaten food security, thus potentially increasing the risk of undernutrition. The causation of undernutrition is complex, and there is a need to develop models that better quantify the potential impacts of climate change on population ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1003311
更新日期:2011-12-01 00:00:00
abstract::The results of our previous and recent work on cadmium metabolism in relation to age and diet are presented. Experiments were performed on albino rats aged 1-26 weeks. In some experiments rats were given different foods (milk, meat, bread) instead of standard rat diet. Some animals received trisodium calcium salt of d...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.845451
更新日期:1984-03-01 00:00:00
abstract:BACKGROUND:Chlorpyrifos is one of the most widely used organophosphate insecticides in the United States. Although the toxicity of chlorpyrifos has been extensively studied in animals, the epidemiologic data are limited. OBJECTIVE:To evaluate whether agricultural chlorpyrifos exposure was associated with mortality, we...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9662
更新日期:2007-04-01 00:00:00
abstract::The methylation of specific cytosine residues in DNA has been implicated in regulating gene expression and facilitating functional specialization of cellular phenotypes. Generally, the demethylation of certain CpG sites correlates with transcriptional activation of genes. 5-Azacytidine is an inhibitor of DNA methylati...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8980189
更新日期:1989-03-01 00:00:00
abstract::Factors affecting the design of an epidemiologic study assessing possible health effects from chemical waste disposal sites are reviewed. Such epidemiologic studies will most likely be prompted either by a known release of chemicals into the environment around the site, or by an unusual disease cluster in a population...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.8562423
更新日期:1985-10-01 00:00:00
abstract::There is widespread concern regarding the safety of silver-mercury amalgam dental restorations, yet little evidence to support their harm or safety. We examined whether mercury dental amalgams are adversely associated with cognitive functioning in a cross-sectional sample of healthy working adults. We studied 550 adul...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.5879
更新日期:2003-05-01 00:00:00
abstract::This article reviews the epidemiologic studies of the association of ischemic heart disease risk and environmental tobacco smoke (ETS) exposure from a spouse who smokes. Seventeen studies (nine cohort, eight case-control) comprising more than 485,000 lifelong nonsmokers and 7,345 coronary heart disease (CHD) events we...
journal_title:Environmental health perspectives
pub_type: 杂志文章,meta分析
doi:10.1289/ehp.99107s6841
更新日期:1999-12-01 00:00:00
abstract::This study constitutes one part of a program for assessing the impact of coal-fired power plants on the surrounding communities. A questionnaire was mailed to a total of 12,000 subjects living in six areas with coal-fired plants and in matched reference areas. The participation rate was 77.3%. In one coal-fired plant/...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8670239
更新日期:1986-12-01 00:00:00