DNA methylation and differentiation.

abstract：:Human exposure to carcinogenic Cr(VI) compounds is found among workers in a large number of professional groups, and it can also occur through environmental pollution. A significant number of toxic waste sites contain Cr as a major contaminant. In this paper we summarize our efforts to apply measurements of DNA-protei...

journal_title：Environmental health perspectives

authors： Zhitkovich A,Voitkun V,Kluz T,Costa M

更新日期：1998-08-01 00:00:00

abstract：:The role of the knowledge of high risk groups in the standard-setting process is examined. The overall conclusion is that many potential high risk segments of the population have not been studied adequately and that this deficiency in our knowledge markedly reduces the ability of decision makers to derive appropriate ...

journal_title：Environmental health perspectives

authors： Calabrese EJ

更新日期：1983-10-01 00:00:00

abstract：:Prostaglandin-H synthase is unique among enzymes of the plant and animal kingdom in its ability to biosynthesize and metabolize hydroperoxides. Its cyclooxygenase activity oxygenates polyunsaturated fatty acids to hydroperoxy endoperoxides, and its peroxidase activity reduces the hydroperoxy group to hydroxy groups. H...

journal_title：Environmental health perspectives

authors： Marnett LJ

更新日期：1990-08-01 00:00:00

abstract：:Children are uniquely vulnerable to toxic chemicals in the environment. Among the environmental toxicants to which children are at risk of exposure are endocrine disruptors (EDs)--chemicals that have the capacity to interfere with hormonal signaling systems. EDs may alter feedback loops in the brain, pituitary, gonads...

journal_title：Environmental health perspectives

authors： Landrigan P,Garg A,Droller DB

更新日期：2003-10-01 00:00:00

abstract：:Counties in the United States have been identified with chemical establishments whose primary manufacturing processes use vinyl chloride. Site-specific cancer mortality comparisons have revealed an excess of multiple myeloma in males associated with two of the manufacturing categories, synthetic rubber and synthetic f...

journal_title：Environmental health perspectives

authors： Mason TJ

更新日期：1975-06-01 00:00:00

abstract：BACKGROUND:There is general concern that persistent organic pollutants (POPs) found in the environment, wildlife, food, water, house dust, human tissues, and fluids may alter normal human physiologic activities (e.g., fetal development, immune and endocrine systems). Although the levels of some POPs [polychlorinated bi...

journal_title：Environmental health perspectives

authors： Doucet J,Tague B,Arnold DL,Cooke GM,Hayward S,Goodyer CG

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Cadmium is a commonly occurring toxic food contaminant, but health consequences of early-life exposure are poorly understood. OBJECTIVES:We evaluated the associations between cadmium exposure and neurobehavioral development in preschool children. METHODS:In our population-based mother-child cohort study in...

journal_title：Environmental health perspectives

authors： Kippler M,Tofail F,Hamadani JD,Gardner RM,Grantham-McGregor SM,Bottai M,Vahter M

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Bisphenol A (BPA), a ubiquitous environmental endocrine disruptor targeting estrogen receptors (ERs), has been implicated in the promotion of breast cancer. Perinatal exposure of BPA could induce longitudinal alteration of DNA hydroxymethylation in imprinted loci of mouse blood cells. To date, no data has be...

journal_title：Environmental health perspectives

authors： Li Z,Lyu C,Ren Y,Wang H

更新日期：2020-02-01 00:00:00

abstract：:The consideration of ethical issues relating to pediatric environmental health is a recent phenomenon. Discussions of biomedical ethics, research on children, and environmental health research have a longer history. In the late 1990s, researchers at the Kennedy Krieger Institute in Baltimore, Maryland, undertook a stu...

journal_title：Environmental health perspectives

authors： Paulson JA

更新日期：2006-10-01 00:00:00

abstract：:One of the most serious consequences of cancer therapy is the development of a second cancer, especially leukemia. Several distinct subsets of therapy-related leukemia can now be distinguished. Classic therapy-related myeloid leukemia typically occurs 5 to 7 years after exposure to alkylating agents and/or irradiation...

journal_title：Environmental health perspectives

authors： Larson RA,LeBeau MM,Vardiman JW,Rowley JD

更新日期：1996-12-01 00:00:00

abstract：:As part of a large pilot investigation of multimedia exposure to several classes of environmental contaminants, the National Human Exposure Assessment Survey (NHEXAS)-Maryland study, we collected 388 semiquantitative food checklists and duplicate diet solid food samples, analyzed for arsenic, cadmium, chromium, and le...

journal_title：Environmental health perspectives

authors： Ryan PB,Scanlon KA,MacIntosh DL

更新日期：2001-02-01 00:00:00

abstract：:Carbon tetrachloride produces liver cell injury in a variety of animal species. The first structurally recognizable changes occur in the endoplasmic reticulum, with alteration in ribosome-membrane interactions. Later there is an increase in intracellular fat, and the formation of tangled nets of the ergastoplasm. At n...

journal_title：Environmental health perspectives

authors： Smuckler EA

更新日期：1976-06-01 00:00:00

abstract：:We have witnessed a tremendous increase in our knowledge of the molecular and biochemical mechanisms which underly the activities of the nervous system. Such knowledge is essential in order to determine the basic mechanisms involved in neurotoxic events. An overview of how neurotoxins could conceivably interfere with ...

journal_title：Environmental health perspectives

authors： Damstra T

更新日期：1978-10-01 00:00:00

abstract：:Serious problems emerge when evaluating evidence on lead neurotoxicity in children. The extent of these problems and ways to control them were explored in a study of 1291 children from the first class in the schools of Aarhus municipality, Denmark. The lead retention in circumpulpal dentin in shed deciduous teeth was ...

journal_title：Environmental health perspectives

authors： Grandjean P,Lyngbye T,Hansen ON

更新日期：1991-08-01 00:00:00

abstract：:Chemicals may induce cell proliferation directly as mitogens or indirectly via cell death with subsequent proliferation to replace lost cells. Chemically induced proliferation has been demonstrated to play a role in the carcinogenic process. A wide range of procedures and techniques are currently being used to define ...

journal_title：Environmental health perspectives

authors： Goldsworthy TL,Butterworth BE,Maronpot RR

更新日期：1993-12-01 00:00:00

abstract：:This article briefly summarizes the epidemiology of the health effects of fine particulate air pollution, provides an early, somewhat speculative, discussion of the contribution of epidemiology to evaluating biologic mechanisms, and evaluates who's at risk or is susceptible to adverse health effects. Based on prelimin...

journal_title：Environmental health perspectives

authors： Pope CA 3rd

更新日期：2000-08-01 00:00:00

abstract：:The presence of blue-green algae (BGA) toxins in surface waters used for drinking water sources and recreation is receiving increasing attention around the world as a public health concern. However, potential risks from exposure to these toxins in contaminated health food products that contain BGA have been largely ig...

journal_title：Environmental health perspectives

authors： Gilroy DJ,Kauffman KW,Hall RA,Huang X,Chu FS

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Exposure of the U.S. population to polybrominated diphenyl ethers (PBDEs) is thought to be via exposure to dust and diet. However, little work has been done to empirically link body burdens of these compounds to either route of exposure. OBJECTIVES:The primary goal of this research was to evaluate the dieta...

journal_title：Environmental health perspectives

authors： Fraser AJ,Webster TF,McClean MD

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Animal and epidemiologic studies suggest that exposure to light at night (LAN) may disrupt circadian patterns and decrease nocturnal secretion of melatonin, which may disturb estrogen regulation, leading to increased breast cancer risk. OBJECTIVES:We examined the association between residential outdoor LAN ...

journal_title：Environmental health perspectives

authors： James P,Bertrand KA,Hart JE,Schernhammer ES,Tamimi RM,Laden F

更新日期：2017-08-17 00:00:00

abstract：:The instrumentation and practical circuitry required for the detection of negative ions exiting the mass analysis section of a mass spectrometer is examined. The potentials needed to bias the electron multiplier when detecting negative ions from a low ion-energy mass spectrometer, e.g., a quadrupole, are contrasted wi...

journal_title：Environmental health perspectives

authors： McKeown M

更新日期：1980-06-01 00:00:00

abstract：:Short articles on the following topics: *NIEHS Strategic Plan: New Frontiers in Environmental Sciences and Human Health; Beyond the Bench: Environmental Health Nursing: Putting Knowledge into Practice; Headliners: Inhibition of RLIP76 Causes Complete Regression of Melanoma in Mice. ...

journal_title：Environmental health perspectives

authors： Hood E,Tillett T,Phelps J

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Toxicology studies have shown adverse effects of developmental exposure to industrial phenols. Evaluation in humans is challenged by potentially marked within-subject variability of phenol biomarkers in pregnant women, which is poorly characterized. OBJECTIVES:We aimed to characterize within-day, between-da...

journal_title：Environmental health perspectives

authors： Vernet C,Philippat C,Calafat AM,Ye X,Lyon-Caen S,Siroux V,Schisterman EF,Slama R

更新日期：2018-03-16 00:00:00

abstract：:Techniques are available to minimize the concentration of asbestos fibers in drinking water. Filtration research conducted at locations on Lake Superior and in the Cascade Mountains in Washington has shown that amphibole and chrysotile fibers can be removed by granular media filtration. Removal percentages can exceed ...

journal_title：Environmental health perspectives

authors： Logsdon GS

更新日期：1983-11-01 00:00:00

abstract：:In an attempt to elucidate the relationship between DNA adduct formation and tumorigenesis, DNA adducts were measured in the livers and bladders of mice during chronic exposure to several different doses of 2-acetylaminofluorene (2-AAF) and 4-aminobiphenyl (4-ABP). Continuous oral administration of these compounds for...

journal_title：Environmental health perspectives

authors： Poirier MC,Beland FA

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:Genetics may partially explain observed heterogeneity in associations between traffic-related air pollution and incident asthma. OBJECTIVE:Our aim was to investigate the impact of gene variants associated with oxidative stress and inflammation on associations between air pollution and incident childhood ast...

journal_title：Environmental health perspectives

authors： MacIntyre EA,Brauer M,Melén E,Bauer CP,Bauer M,Berdel D,Bergström A,Brunekreef B,Chan-Yeung M,Klümper C,Fuertes E,Gehring U,Gref A,Heinrich J,Herbarth O,Kerkhof M,Koppelman GH,Kozyrskyj AL,Pershagen G,Postma DS,Th

更新日期：2014-04-01 00:00:00

abstract：:Much public health research has been directed to studies of cancer risks due to chemical agents. Recently, increasing attention has been given to adverse reproductive outcomes as another, shorter-term biologic indicator of public health impact. Further, several low-level ubiquitous physical agents have been implicated...

journal_title：Environmental health perspectives

authors： Meyer RE,Aldrich TE,Easterly CE

更新日期：1989-05-01 00:00:00

abstract：:The Sertoli cell is the primary target for FSH action in the mammalian testis. These cells contain the majority of testicular plasma membrane receptors for this hormone. Receptor occupancy is directly correlated with a stimulation of adenylyl cyclase and a decrease in the activity of a cytoplasmic Ca++-sensitive cAMP ...

journal_title：Environmental health perspectives

authors： Tindall DJ,Tash JS,Means AR

更新日期：1981-04-01 00:00:00

abstract：BACKGROUND:Microcystin-LR, a cyclic heptapeptide, possesses the ability to inhibit the serine/threonine protein phosphatases PP1 and PP2A and, consequently, exhibits acute hepatocytotoxicity. Moreover, microcystin-LR induces cellular proliferation, resulting in tumor-promoting activity in hepatocytes. However, mechanis...

journal_title：Environmental health perspectives

authors： Takumi S,Komatsu M,Furukawa T,Ikeda R,Sumizawa T,Akenaga H,Maeda Y,Aoyama K,Arizono K,Ando S,Takeuchi T

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Agricultural work and occupational pesticide use have been associated with increased risk of renal cell carcinoma (RCC), the most common form of kidney cancer. However, few prospective studies have investigated links to specific pesticides. OBJECTIVE:We evaluated the lifetime use of individual pesticides an...

journal_title：Environmental health perspectives

authors： Andreotti G,Beane Freeman LE,Shearer JJ,Lerro CC,Koutros S,Parks CG,Blair A,Lynch CF,Lubin JH,Sandler DP,Hofmann JN

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:High-level occupational exposures to some industrial chemicals have been associated with liver diseases, including nonalcoholic fatty liver disease (NAFLD). However, the potential role of low-level environmental pollution on liver disease in the general population has not been evaluated. OBJECTIVE:We determ...

journal_title：Environmental health perspectives

authors： Cave M,Appana S,Patel M,Falkner KC,McClain CJ,Brock G

更新日期：2010-12-01 00:00:00