Abstract:
:Carbon tetrachloride produces liver cell injury in a variety of animal species. The first structurally recognizable changes occur in the endoplasmic reticulum, with alteration in ribosome-membrane interactions. Later there is an increase in intracellular fat, and the formation of tangled nets of the ergastoplasm. At no time are there changes in mitochondria or single membrane limited bodies in cells with intact plasmalemma, although a relative increase in cell sap may appear. In dead cells (those with plasmalemma discontinuties) crystalline deposits of calcium phosphatase may be noted. Functional changes are related to the endoplasmic reticulum and the plasma membrane. An early decrease in protein synthesis takes place; an accumulation of neutral lipid is related to this change. Later alterations in the ergastoplasmic functions (e.g., mixed function oxidation) occurs. Carbon tetrachloride is not the active agent; rather, a product of its metabolism, probably the CC1, free radical, is. The mechanisms of injury include macromolecular adduction and peroxide propagation. A third possibility includes a cascade effect with the production of secondary and tertiary products, also toxic in nature, with the ability to produce more widespread damage to intracellular structures.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Smuckler EAdoi
10.1289/ehp.761513subject
Has Abstractpub_date
1976-06-01 00:00:00pages
13-25eissn
0091-6765issn
1552-9924journal_volume
15pub_type
杂志文章abstract::This paper will briefly outline those elements which must be considered in assessing the effects of any given compound which might impinge on the actions of adrenocortical steroids. Considerations that ought to be taken into account include the following: the delivery to the affected cells of corticosteroids, the upta...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.813899
更新日期:1981-04-01 00:00:00
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journal_title:Environmental health perspectives
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更新日期:2016-05-01 00:00:00
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doi:10.1289/ehp.94-1567968
更新日期:1991-08-01 00:00:00
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journal_title:Environmental health perspectives
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doi:10.1289/ehp.9087337
更新日期:1990-07-01 00:00:00
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更新日期:2010-06-01 00:00:00
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journal_title:Environmental health perspectives
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doi:10.1289/ehp.1003296
更新日期:2011-08-01 00:00:00
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更新日期:2015-11-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
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更新日期:1983-03-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.919145
更新日期:1991-02-01 00:00:00
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更新日期:2006-04-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.0900572
更新日期:2009-11-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.108-a126
更新日期:2000-03-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1289/ehp.8774153
更新日期:1987-10-01 00:00:00
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journal_title:Environmental health perspectives
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doi:10.1289/ehp.98106797
更新日期:1998-12-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP5580
更新日期:2020-02-01 00:00:00
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更新日期:2005-07-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.887823
更新日期:1988-06-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8926
更新日期:2006-09-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8562177
更新日期:1985-10-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.6251
更新日期:2003-11-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
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更新日期:2004-02-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.803491
更新日期:1980-02-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.95103s8237
更新日期:1995-11-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP2083
更新日期:2018-04-26 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.01109335
更新日期:2001-04-01 00:00:00
abstract::We tested the hypothesis that exposure of healthy volunteers to concentrated ambient air particles (CAPS) between 0.1 and 2.5 microm in diameter is associated with modulation of human alveolar macrophage (AM) function, cytokine production, and immune phenotype in both blood and lung. Thirty-eight volunteers were expos...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.01109s4599
更新日期:2001-08-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.111-1241299
更新日期:2003-01-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.749161
更新日期:1974-12-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.02110411
更新日期:2002-04-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.771943
更新日期:1977-08-01 00:00:00