The work environment and workers' health in four large office buildings.

Abstract:

:We conducted a 1-year epidemiologic study in Boston, Massachusetts, beginning May 1997, to examine the associations between environmental factors and office workers' health. We recruited 98 subjects (81 females and 17 males) in 21 offices in four office buildings. We conducted environmental sampling every 6 weeks and concurrently administered detailed questionnaires to collect information on work-related symptoms, psychosocial factors, and perceptions of the office environments. In multivariate analyses, eye irritation was positively correlated with floor dust [odds ratio (OR) = 1.46; 95% confidence intervals (CI), 1.14-1.86] and reported lack of office cleanliness (OR = 1.52; 95% CI, 1.11-2.08). Nonspecific symptoms were positively associated with unidentified chair fungi (OR = 1.87; 95% CI, 1.11-3.15) and several self-reported conditions, including a history of asthma (OR = 3.15; 95% CI, 1.26-7.87), more people in offices (OR = 1.71; 95% CI, 1.16-2.51), lack of office cleanliness (OR = 2.85; 95% CI, 1.72-4.73), and low job satisfaction (OR = 1.72; 95% CI, 1.06-2.81). Upper respiratory symptoms were positively associated with total fungal concentrations recovered from chair dust (OR = 1.35; 95% CI, 1.07-1.70) and the following self-reported conditions: more people in offices (OR = 1.45; 95% CI, 1.01-2.08), lack of office cleanliness (OR = 1.62; 95% CI, 1.15-2.30), and jobs frequently requiring hard work (OR = 1.43; 95% CI, 1.05-1.95). This study emphasizes the importance of maintaining a clean, uncrowded workspace and the importance of chair fungi as a correlate for health effects.

authors

Chao HJ,Schwartz J,Milton DK,Burge HA

doi

10.1289/ehp.5697

subject

Has Abstract

pub_date

2003-07-01 00:00:00

pages

1242-8

issue

9

eissn

0091-6765

issn

1552-9924

journal_volume

111

pub_type

杂志文章
  • Chemical characterization and bioactivity of polycyclic aromatic hydrocarbons from non-oxidative thermal treatment of pyrene-contaminated soil at 250-1,000 degrees C.

    abstract::In this paper we report yields, identities, and mutagenicities of products from heating a polycyclic aromatic hydrocarbon (PAH)-contaminated, Superfund-related synthetic soil matrix without exogenous oxygen. We heated batch samples of soil pretreated with 5.08 wt% (by weight) pyrene in a tubular furnace under a consta...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.00108709

    authors: Richter H,Risoul V,Lafleur AL,Plummer EF,Howard JB,Peters WA

    更新日期:2000-08-01 00:00:00

  • Applications of physiologic pharmacokinetic modeling in carcinogenic risk assessment.

    abstract::The use of physiologically based pharmacokinetic (PBPK) models has been proposed as a means of estimating the dose of the reactive metabolites of carcinogenic xenobiotics reaching target tissues, thereby affording an opportunity to base estimates of potential cancer risk on tissue dose rather than external levels of e...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.94102s1137

    authors: Krewski D,Withey JR,Ku LF,Andersen ME

    更新日期:1994-12-01 00:00:00

  • A framework for assessing risks to children from exposure to environmental agents.

    abstract::In recent years there has been an increasing focus in environmental risk assessment on children as a potentially susceptible population. There also has been growing recognition of the need for a systematic approach for organizing, evaluating, and incorporating the available data on children's susceptibilities in risk ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.6182

    authors: Daston G,Faustman E,Ginsberg G,Fenner-Crisp P,Olin S,Sonawane B,Bruckner J,Breslin W,McLaughlin TJ

    更新日期:2004-02-01 00:00:00

  • Chernobyl fallout and outcome of pregnancy in Finland.

    abstract::Possible effects of Chernobyl fallout on outcome of pregnancy in Finland were evaluated in a nationwide follow-up study. The outcomes were the rate of live births and stillbirths, pregnancy loss, and induced abortions by municipality. Exposure was assessed based on nationwide surveys of radiation dose rate from the Ch...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.01109179

    authors: Auvinen A,Vahteristo M,Arvela H,Suomela M,Rahola T,Hakama M,Rytömaa T

    更新日期:2001-02-01 00:00:00

  • Effects of Developmental Activation of the Aryl Hydrocarbon Receptor by 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Long-term Self-renewal of Murine Hematopoietic Stem Cells.

    abstract:BACKGROUND:Human epidemiological and animal studies suggest that developmental exposure to contaminants that activate the aryl hydrocarbon receptor (AHR) lead to suppression of immune system function throughout life. The persistence of immune deficiency throughout life suggests that the cellular target of AHR activatio...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1509820

    authors: Laiosa MD,Tate ER,Ahrenhoerster LS,Chen Y,Wang D

    更新日期:2016-07-01 00:00:00

  • Use of geographic information system technology to aid Health Department decision making about childhood lead poisoning prevention activities.

    abstract::The Centers for Disease Control and Prevention recommend that local public health agencies use local data to identify children at risk for lead exposure to ensure that they receive preventive services. The objective of this study was to demonstrate the usefulness of a geographic information system (GIS) in identifying...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.0110989

    authors: Reissman DB,Staley F,Curtis GB,Kaufmann RB

    更新日期:2001-01-01 00:00:00

  • Role of TET Dioxygenases and DNA Hydroxymethylation in Bisphenols-Stimulated Proliferation of Breast Cancer Cells.

    abstract:BACKGROUND:Bisphenol A (BPA), a ubiquitous environmental endocrine disruptor targeting estrogen receptors (ERs), has been implicated in the promotion of breast cancer. Perinatal exposure of BPA could induce longitudinal alteration of DNA hydroxymethylation in imprinted loci of mouse blood cells. To date, no data has be...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP5862

    authors: Li Z,Lyu C,Ren Y,Wang H

    更新日期:2020-02-01 00:00:00

  • Trends in health in the United States.

    abstract::The National Center for Health Statistics (NCHS) conducts a variety of surveys designed to provide cross-sectional estimates of the prevalence of various factors measuring the health of Americans. When these cross-sectional estimates are put together and plotted over time, they provide a picture of the trends in the h...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8562267

    authors: Feinleib M,Wilson RW

    更新日期:1985-10-01 00:00:00

  • The three modern faces of mercury.

    abstract::The three modern "faces" of mercury are our perceptions of risk from the exposure of billions of people to methyl mercury in fish, mercury vapor from amalgam tooth fillings, and ethyl mercury in the form of thimerosal added as an antiseptic to widely used vaccines. In this article I review human exposure to and the to...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.02110s111

    authors: Clarkson TW

    更新日期:2002-02-01 00:00:00

  • Genomic and proteomic profiling of responses to toxic metals in human lung cells.

    abstract::Examining global effects of toxic metals on gene expression can be useful for elucidating patterns of biological response, discovering underlying mechanisms of toxicity, and identifying candidate metal-specific genetic markers of exposure and response. Using a 1,200 gene nylon array, we examined changes in gene expres...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.111-1241504

    authors: Andrew AS,Warren AJ,Barchowsky A,Temple KA,Klei L,Soucy NV,O'Hara KA,Hamilton JW

    更新日期:2003-05-01 00:00:00

  • Pulmonary edema due to tetrachloroethylene.

    abstract::A patient with massive exposure to tetrachloroethylene fumes presented with coma and severe pulmonary edema. Sequential blood gases, chest x-rays, and clinical findings showed dramatic improvement with conventional but aggressive management and the patient recovered completely. There was no evidence of permanent renal...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.7721247

    authors: Patel R,Janakiraman N,Towne WD

    更新日期:1977-12-01 00:00:00

  • Biological monitoring of genotoxic hazard in workers of the rubber industry.

    abstract::Biological monitoring of genotoxic hazard in the rubber industry was performed in 19 male workers and 20 age-matched controls in a local health unit in northern Italy. Peripheral blood lymphocytes were analyzed for the presence of DNA damage (single-cell microgel-electrophoresis, or comet assay) and for cytogenetic pa...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.96104s3543

    authors: Moretti M,Villarini M,Scassellati-Sforzolini G,Monarca S,Libraro M,Fatigoni C,Donato F,Leonardis C,Perego L

    更新日期:1996-05-01 00:00:00

  • Maternal fish consumption, hair mercury, and infant cognition in a U.S. Cohort.

    abstract::Fish and other seafood may contain organic mercury but also beneficial nutrients such as n-3 polyunsaturated fatty acids. We endeavored to study whether maternal fish consumption during pregnancy harms or benefits fetal brain development. We examined associations of maternal fish intake during pregnancy and maternal h...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8041

    authors: Oken E,Wright RO,Kleinman KP,Bellinger D,Amarasiriwardena CJ,Hu H,Rich-Edwards JW,Gillman MW

    更新日期:2005-10-01 00:00:00

  • Mortality Risk and Fine Particulate Air Pollution in a Large, Representative Cohort of U.S. Adults.

    abstract:BACKGROUND:Evidence indicates that air pollution contributes to cardiopulmonary mortality. There is ongoing debate regarding the size and shape of the pollution–mortality exposure–response relationship. There are also growing appeals for estimates of pollution–mortality relationships that use public data and are based ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP4438

    authors: Pope CA 3rd,Lefler JS,Ezzati M,Higbee JD,Marshall JD,Kim SY,Bechle M,Gilliat KS,Vernon SE,Robinson AL,Burnett RT

    更新日期:2019-07-01 00:00:00

  • A Case-Control Study of Prenatal Thallium Exposure and Low Birth Weight in China.

    abstract:BACKGROUND:Thallium (Tl) is a highly toxic heavy metal widely present in the environment. Case reports have suggested that maternal exposure to high levels of Tl during pregnancy is associated with low birth weight (LBW), but epidemiological data are limited. OBJECTIVES:This study was designed to evaluate whether pren...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1409202

    authors: Xia W,Du X,Zheng T,Zhang B,Li Y,Bassig BA,Zhou A,Wang Y,Xiong C,Li Z,Yao Y,Hu J,Zhou Y,Liu J,Xue W,Ma Y,Pan X,Peng Y,Xu S

    更新日期:2016-01-01 00:00:00

  • The World Trade Center residents' respiratory health study: new-onset respiratory symptoms and pulmonary function.

    abstract::The destruction of the World Trade Center (WTC) on 11 September 2001 in New York City resulted in the massive release of pulverized dust and combustion products. The dust and smoke settled in the surrounding area, which encompassed a large residential community. We hypothesized that previously normal residents in the ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.7375

    authors: Reibman J,Lin S,Hwang SA,Gulati M,Bowers JA,Rogers L,Berger KI,Hoerning A,Gomez M,Fitzgerald EF

    更新日期:2005-04-01 00:00:00

  • In vitro comparisons of SENCAR and BALB/c primary epidermal cells.

    abstract::Grafting experiments show that the enhanced sensitivity of the SENCAR mouse to skin carcinogenesis by initiation and promotion is a property of the skin itself, suggesting the usefulness of in vitro studies to elucidate the mechanism. Such studies have indicated that cultured epidermal cells of SENCAR mice and the res...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.866839

    authors: Strickland JE,Allen PT,Sauder DN,Kawamura H,Fong MC,Yuspa SH

    更新日期:1986-09-01 00:00:00

  • The sources, fate, and toxicity of chemical warfare agent degradation products.

    abstract::We include in this review an assessment of the formation, environmental fate, and mammalian and ecotoxicity of CW agent degradation products relevant to environmental and occupational health. These parent CW agents include several vesicants: sulfur mustards [undistilled sulfur mustard (H), sulfur mustard (HD), and an ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.99107933

    authors: Munro NB,Talmage SS,Griffin GD,Waters LC,Watson AP,King JF,Hauschild V

    更新日期:1999-12-01 00:00:00

  • Isothiocyanates reduce mercury accumulation via an Nrf2-dependent mechanism during exposure of mice to methylmercury.

    abstract:BACKGROUND:Methylmercury (MeHg) exhibits neurotoxicity through accumulation in the brain. The transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) plays an important role in reducing the cellular accumulation of MeHg. OBJECTIVES:We investigated the protective effect of isothiocyanates, which are kno...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1003123

    authors: Toyama T,Shinkai Y,Yasutake A,Uchida K,Yamamoto M,Kumagai Y

    更新日期:2011-08-01 00:00:00

  • Concepts, labeling procedures, and design of cell proliferation studies relating to carcinogenesis.

    abstract::Chemicals may induce cell proliferation directly as mitogens or indirectly via cell death with subsequent proliferation to replace lost cells. Chemically induced proliferation has been demonstrated to play a role in the carcinogenic process. A wide range of procedures and techniques are currently being used to define ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.93101s559

    authors: Goldsworthy TL,Butterworth BE,Maronpot RR

    更新日期:1993-12-01 00:00:00

  • What do we feed to food-production animals? A review of animal feed ingredients and their potential impacts on human health.

    abstract:OBJECTIVE:Animal feeding practices in the United States have changed considerably over the past century. As large-scale, concentrated production methods have become the predominant model for animal husbandry, animal feeds have been modified to include ingredients ranging from rendered animals and animal waste to antibi...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.9760

    authors: Sapkota AR,Lefferts LY,McKenzie S,Walker P

    更新日期:2007-05-01 00:00:00

  • Transformation of BALB/c-3T3 cells: III. Development of a co-culture clonal survival assay for quantification of chemical cytotoxicity in high-density cell cultures.

    abstract::A co-culture clonal survival assay was developed to measure the cytotoxicity of test chemical treatments to BALB/c-3T3 cells because the standard clonal survival assay using 200 wild type (WT) cells frequently overestimates chemical cytotoxicity when compared with identical treatment doses in high-density cultures. Th...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.93101s2311

    authors: Matthews EJ

    更新日期:1993-07-01 00:00:00

  • Helicobacter pylori prevalences and risk factors among school beginners in a German urban center and its rural county.

    abstract::In 1998, the Helicobacter pylori [(13)C]urea breath test was offered to all school beginners (birth cohort 1991/1992) in the city of Leipzig and in Leipzig County, Germany, to determine the colonization prevalence and potential transmission pathways of the bacterium. A total of 3,347 school beginners participated in t...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.01109573

    authors: Herbarth O,Krumbiegel P,Fritz GJ,Richter M,Schlink U,Müller DM,Richter T

    更新日期:2001-06-01 00:00:00

  • Pavlovian conditioning and multiple chemical sensitivity.

    abstract::Pavlovian conditioning processes may contribute to some symptoms of multiple chemical sensitivity (MCS). This review summarizes the potential relevance of the literature on conditional taste and olfactory aversions, conditional sensitization, and conditional immunomodulation to understanding MCS. A conditioning-based ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.97105s2521

    authors: Siegel S,Kreutzer R

    更新日期:1997-03-01 00:00:00

  • Comparative results of 327 chemical carcinogenicity studies.

    abstract::The National Cancer Institute (NCI) and the National Toxicology Program (NTP) have carried out a number of laboratory animal carcinogenicity studies and presented the results of these experiments in a series of Technical Reports. This paper tabulates the results of the 327 NCI/NTP studies carried out to date on 308 di...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8774229

    authors: Haseman JK,Huff JE,Zeiger E,McConnell EE

    更新日期:1987-10-01 00:00:00

  • Public health decisions: the laboratory's role in the Lorain County, Ohio, investigation.

    abstract::In 1994 officials from the Ohio Department of Health reported that some residents of Lorain County, Ohio, possibly had been exposed to methyl parathion (MP), a highly toxic restricted-use pesticide. The U.S. Centers for Disease Control and Prevention (CDC) assisted in the investigation by providing epidemiologic and l...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.02110s61057

    authors: Hill RH Jr,Head S,Barr DB,Rubin C,Esteban E,Baker SE,Bailey S,Needham LL

    更新日期:2002-12-01 00:00:00

  • Body burdens of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls and their relations to estrogen metabolism in pregnant women.

    abstract::Polychlorinated dibenzo-p-dioxins (PCDDs, dioxins), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs) are environmental endocrine disruptors that have half-lives of 7-10 years in the human body and have toxicities that probably include carcinogenesis. A high ratio of 4-hydroxyl estradiol (4-O...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8809

    authors: Wang SL,Chang YC,Chao HR,Li CM,Li LA,Lin LY,Päpke O

    更新日期:2006-05-01 00:00:00

  • Evidence of an oxidative mechanism for the hemolytic activity of silica particles.

    abstract::The formation of reactive oxygen species resulting from the interaction of silica dust particles with red blood cell membranes was investigated; particularly, the effect of surface hydroxyl (silanol) group concentration on the rate of formation of such reactive oxygen species was investigated. The rate of formation wa...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.9087337

    authors: Razzaboni BL,Bolsaitis P

    更新日期:1990-07-01 00:00:00

  • Predictors and variability of repeat measurements of urinary phenols and parabens in a cohort of Shanghai women and men.

    abstract:BACKGROUND:Exposure to certain phenols is ubiquitous because of their use in many consumer and personal care products. However, predictors of exposure have not been well characterized in most populations. OBJECTIVES:We sought to identify predictors of exposure and to assess the reproducibility of phenol concentrations...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1306830

    authors: Engel LS,Buckley JP,Yang G,Liao LM,Satagopan J,Calafat AM,Matthews CE,Cai Q,Ji BT,Cai H,Engel SM,Wolff MS,Rothman N,Zheng W,Xiang YB,Shu XO,Gao YT,Chow WH

    更新日期:2014-07-01 00:00:00

  • Use of selected toxicology information resources in assessing relationships between chemical structure and biological activity.

    abstract::This paper addresses the subject of the use of selected toxicology information resources in assessing relationships between chemical structure and specific biological end points. To assist the researcher in how to access the primary literature of genetic toxicology, teratogenesis, and carcinogenesis, three specific sp...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8561287

    authors: Wassom JS

    更新日期:1985-09-01 00:00:00