Abstract:
:Biological monitoring of genotoxic hazard in the rubber industry was performed in 19 male workers and 20 age-matched controls in a local health unit in northern Italy. Peripheral blood lymphocytes were analyzed for the presence of DNA damage (single-cell microgel-electrophoresis, or comet assay) and for cytogenetic parameters (sister chromatid exchanges and micronuclei frequency, and proliferative rate index). The following bioassays were performed in urine samples: a) mutagenicity test and concentration of thioethers as markers of exposure, and b) excretion of D-glucaric acid and 6-beta-hydroxycortisol (related to 17-hydroxycorticosteroid excretion) as indicators of the inductive status of the microsomal enzyme system (phase-I). The exposed subjects showed statistically higher mean values of 17-hydroxycorticosteroids and micronuclei and lower values of 6-beta-hydroxycortisol than controls, when taking cigarette smoking into account. The comet assay showed higher values for migration distance in exposed subjects than controls, although the differences were not significant at a p-value of 0.05. These findings suggest that industrial exposure in the rubber processing industry may cause genetic damage and may modify the activity level of some enzymes; these results should be considered with caution due to the small number of subjects enrolled.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Moretti M,Villarini M,Scassellati-Sforzolini G,Monarca S,Libraro M,Fatigoni C,Donato F,Leonardis C,Perego Ldoi
10.1289/ehp.96104s3543subject
Has Abstractpub_date
1996-05-01 00:00:00pages
543-5eissn
0091-6765issn
1552-9924journal_volume
104 Suppl 3pub_type
杂志文章abstract::The purpose of this investigation was to determine whether there has been a change in the human blood concentration of perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and five other fluorochemicals since 1974. Blood samples were collected in 1974 (serum) and 1989 (plasma) from volunteer participants of a l...
journal_title:Environmental health perspectives
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journal_title:Environmental health perspectives
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journal_title:Environmental health perspectives
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journal_title:Environmental health perspectives
pub_type: 杂志文章,已发布勘误
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doi:10.1289/ehp.866593
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pub_type: 杂志文章,评审
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更新日期:1998-12-01 00:00:00
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更新日期:2008-03-01 00:00:00
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doi:10.1289/ehp.8774229
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更新日期:2012-12-01 00:00:00
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更新日期:1993-12-01 00:00:00
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更新日期:1983-02-01 00:00:00