E2F1-mediated FOS induction in arsenic trioxide-induced cellular transformation: effects of global H3K9 hypoacetylation and promoter-specific hyperacetylation in vitro.

abstract：:Millions of people worldwide are exposed to arsenic-contaminated drinking water, and ingestion of inorganic arsenic (InAs) has been associated with increased risks of cancer. The primary metabolic pathway of ingested InAs is methylation to monomethyl arsenic (MMA) and dimethyl arsenic (DMA). However, people vary great...

journal_title：Environmental health perspectives

authors： Steinmaus C,Carrigan K,Kalman D,Atallah R,Yuan Y,Smith AH

更新日期：2005-09-01 00:00:00

abstract：:In estimating the cancer mortality risk for radiation workers it is conventional to use data obtained from the populations exposed to radiation as a result of the atomic bomb blast in Hiroshima and Nagasaki. This A-bomb experience resulted in relatively high doses of radiation and short periods of exposure. The availa...

journal_title：Environmental health perspectives

authors： Stewart A

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND:Fine particulate matter (FPM) in ambient air causes premature mortality due to cardiac disease in susceptible populations. OBJECTIVE:Our objective in this study was to determine the most influential FPM components. METHODS:A mouse model of atherosclerosis (ApoE-/-) was exposed to either filtered air or con...

journal_title：Environmental health perspectives

authors： Lippmann M,Ito K,Hwang JS,Maciejczyk P,Chen LC

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Adapting to extreme heat is becoming more critical as our climate changes. Previous research reveals that very few communities in the United States have programs to sufficiently prevent health problems during hot weather. OBJECTIVE:Our goal was to examine county-level local heat preparedness and response in...

journal_title：Environmental health perspectives

authors： White-Newsome JL,Ekwurzel B,Baer-Schultz M,Ebi KL,O'Neill MS,Anderson GB

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Polybrominated diphenyl ethers (PBDEs), commonly used in building materials, electronics, plastics, polyurethane foams, and textiles, are health hazards found in the environment. OBJECTIVE:In this study we investigated the effects of PBDE-209, a deca-PBDE, on the regulation of growth and apoptosis of breast...

journal_title：Environmental health perspectives

authors： Li ZH,Liu XY,Wang N,Chen JS,Chen YH,Huang JT,Su CH,Xie F,Yu B,Chen DJ

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Bacterial meningitis causes a high burden of disease in the African meningitis belt, with regular seasonal hyperendemicity and sporadic short, but intense, localized epidemics during the late dry season occurring at a small spatial scale [i.e., below the district level, in individual health centers (HCs)]. I...

journal_title：Environmental health perspectives

authors： Woringer M,Martiny N,Porgho S,Bicaba BW,Bar-Hen A,Mueller JE

更新日期：2018-09-01 00:00:00

abstract：:The objective of this study was to provide a basis for effectively protecting nonsmokers from acute sensory impacts and for preventing deterioration of indoor air quality caused by environmental tobacco smoke (ETS) emissions. With an olfactory experiment we determined odor detection thresholds (OT) of sidestream ETS (...

journal_title：Environmental health perspectives

authors： Junker MH,Danuser B,Monn C,Koller T

更新日期：2001-10-01 00:00:00

abstract：:The identification of certain organic compounds in drinking water has led water treatment specialists to be increasingly concerned about the eventual risks of such pollutants to the health of consumers. Our experiments focused on the role of ozone and granular activated carbon in removing mutagenic compounds and precu...

journal_title：Environmental health perspectives

authors： Bourbigot MM,Hascoet MC,Levi Y,Erb F,Pommery N

更新日期：1986-11-01 00:00:00

abstract：BACKGROUND:Few studies have been conducted to identify risk factors for balance and vestibular dysfunction in general populations, but previous studies have reported evidence of adverse effects of lead and cadmium on balance control in high-risk groups. OBJECTIVE:We evaluated the relationship between blood lead and ca...

journal_title：Environmental health perspectives

authors： Min KB,Lee KJ,Park JB,Min JY

更新日期：2012-03-01 00:00:00

abstract：:Spatial epidemiology is the description and analysis of geographic variations in disease with respect to demographic, environmental, behavioral, socioeconomic, genetic, and infectious risk factors. We focus on small-area analyses, encompassing disease mapping, geographic correlation studies, disease clusters, and clus...

journal_title：Environmental health perspectives

authors： Elliott P,Wartenberg D

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:The mechanisms governing the correlation between exposure to ultrafine particles and the increased incidence of cardiovascular disease remain unknown. Ultrafine particles appear to cross the pulmonary epithelial barrier into the bloodstream, raising the possibility of direct contact with the vascular endothe...

journal_title：Environmental health perspectives

authors： Gojova A,Guo B,Kota RS,Rutledge JC,Kennedy IM,Barakat AI

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Arsenic is metabolized through a series of oxidative methylation reactions by arsenic (3) methyltransferase (As3MT) to yield methylated intermediates. Although arsenic exposure is known to increase the risk of atherosclerosis, the contribution of arsenic methylation and As3MT remains undefined. OBJECTIVES:O...

journal_title：Environmental health perspectives

authors： Negro Silva LF,Lemaire M,Lemarié CA,Plourde D,Bolt AM,Chiavatti C,Bohle DS,Slavkovich V,Graziano JH,Lehoux S,Mann KK

更新日期：2017-07-05 00:00:00

abstract：:In this paper we report DNA binding of butadiene monoepoxide, a first metabolite of 1,3-butadiene catalyzed by monooxygenases. We prepared alkylated purines as marker compounds for 32-P-postlabeling and electrochemical analysis and developed methods to measure the corresponding products. The traditional postlabeling a...

journal_title：Environmental health perspectives

authors： Koivisto P,Adler ID,Sorsa M,Peltonen K

更新日期：1996-05-01 00:00:00

abstract：:Organophosphates in increasing amounts and wider varieties of molecular structure are being used to replace the organochlorine pesticides. It has been assumed that the organophosphates as a class would have a minimal chronic toxicity due to rapid hydrolysis and an unfavorable partitioning as regards to lipids. The phy...

journal_title：Environmental health perspectives

authors： Freed VH,Haque R,Schmedding D,Kohnert R

更新日期：1976-02-01 00:00:00

abstract：:A review of the experimental studies relating boron to biological effects on appendicular and axial bones in animal models suggests that numerous influences, known and unknown, affect the responsiveness of bone to dietary boron. Degrees of skeletal response to boron are modified by other nutritional variables that inc...

journal_title：Environmental health perspectives

authors： McCoy H,Kenney MA,Montgomery C,Irwin A,Williams L,Orrell R

更新日期：1994-11-01 00:00:00

abstract：:Numerous publications and reports have expressed health and safety concerns about the production and use of nanoparticles, especially in areas of exposure monitoring, personal use, and environmental fate and transport. We suggest that stable isotopic tracers, which have been used widely in the earth sciences and in me...

journal_title：Environmental health perspectives

authors： Gulson B,Wong H

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:Endocrine-disrupting chemicals have been shown to have broad effects on development, but their mutagenic actions that can lead to cancer have been less clearly demonstrated. Physiological levels of estrogen have been shown to stimulate DNA damage in breast epithelial cells through mechanisms mediated by estr...

journal_title：Environmental health perspectives

authors： Majhi PD,Sharma A,Roberts AL,Daniele E,Majewski AR,Chuong LM,Black AL,Vandenberg LN,Schneider SS,Dunphy KA,Jerry DJ

更新日期：2020-01-01 00:00:00

abstract：:Toxicity testing in AS52 cells (24-hr exposures) gave LC50 values of 2 to 130 micrograms Ni/ml for particulate nickel compounds and 45 to 60 micrograms Ni/ml for water-soluble salts (NiCl2, NiSO4, Ni(CH3COO)2). The Ni(OH)2, NiCO3, and sulfides (Ni3S2, Ni7S6, "amorphous NiS") exhibited similar toxicities (LC50's of 2 t...

journal_title：Environmental health perspectives

authors： Fletcher GG,Rossetto FE,Turnbull JD,Nieboer E

更新日期：1994-09-01 00:00:00

abstract：:Recent studies show that young children can be exposed to pesticides during normal oral exploration of their environment and their level of dermal contact with floors and other surfaces. Children living in agricultural areas may be exposed to higher pesticide levels than other children because of pesticides tracked in...

journal_title：Environmental health perspectives

authors： Eskenazi B,Bradman A,Castorina R

更新日期：1999-06-01 00:00:00

abstract：:We present evidence that the El Niño phenomenon intensifies the annual cycle of malaria cases for Plasmodium vivax and Plasmodium falciparum in endemic areas of Colombia as a consequence of concomitant anomalies in the normal annual cycle of temperature and precipitation. We used simultaneous analyses of both variable...

journal_title：Environmental health perspectives

authors： Poveda G,Rojas W,Quiñones ML,Vélez ID,Mantilla RI,Ruiz D,Zuluaga JS,Rua GL

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Green spaces have been associated with both health benefits and risks in children; however, available evidence simultaneously investigating these conflicting influences, especially in association with different types of greenness, is scarce. OBJECTIVES:We aimed to simultaneously evaluate health benefits and...

journal_title：Environmental health perspectives

authors： Dadvand P,Villanueva CM,Font-Ribera L,Martinez D,Basagaña X,Belmonte J,Vrijheid M,Gražulevičienė R,Kogevinas M,Nieuwenhuijsen MJ

更新日期：2014-12-01 00:00:00

abstract：:Metallothionein from livers of mice was isolated by gel chromatography and isoelectric focusing. One of two forms thus obtained contained 32 percent cysteine. This form, labeled in vitro with 109Cd, was injected intravenously in mice, and the distribution of 109Cd was studied. Animals killed after 4 hrs had over 80 pe...

journal_title：Environmental health perspectives

authors： Nordberg M,Nordberg GF

更新日期：1975-12-01 00:00:00

abstract：:Male rats were treated with various model compounds or the appropriate vehicle controls. Most substances were either well-known hepatotoxicants or showed hepatotoxicity during preclinical testing. The aim of the present study was to determine if biological samples from rats treated with various compounds can be classi...

journal_title：Environmental health perspectives

authors： Steiner G,Suter L,Boess F,Gasser R,de Vera MC,Albertini S,Ruepp S

更新日期：2004-08-01 00:00:00

abstract：:This report reviews the recent literature on the adverse effects of occupational factors on fertility and related reproductive outcomes. Few studies fulfill the criteria of good study design because of small sample size, insensitive measures of effect, selection, recall, and observation bias, weak if any control of co...

journal_title：Environmental health perspectives

authors： Baranski B

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:Exposure to flame retardants has been associated with negative health outcomes including metabolic effects. As polybrominated diphenyl ether flame retardants were pulled from commerce, human exposure to new flame retardants such as Firemaster® 550 (FM550) has increased. Although previous studies in murine sy...

journal_title：Environmental health perspectives

authors： Tung EWY,Peshdary V,Gagné R,Rowan-Carroll A,Yauk CL,Boudreau A,Atlas E

更新日期：2017-09-14 00:00:00

abstract：:This paper addresses the subject of the use of selected toxicology information resources in assessing relationships between chemical structure and specific biological end points. To assist the researcher in how to access the primary literature of genetic toxicology, teratogenesis, and carcinogenesis, three specific sp...

journal_title：Environmental health perspectives

authors： Wassom JS

更新日期：1985-09-01 00:00:00

abstract：:In April 2004, one of the largest aflatoxicosis outbreaks occurred in rural Kenya, resulting in 317 cases and 125 deaths. Aflatoxin-contaminated homegrown maize was the source of the outbreak, but the extent of regional contamination and status of maize in commercial markets (market maize) were unknown. We conducted a...

journal_title：Environmental health perspectives

authors： Lewis L,Onsongo M,Njapau H,Schurz-Rogers H,Luber G,Kieszak S,Nyamongo J,Backer L,Dahiye AM,Misore A,DeCock K,Rubin C,Kenya Aflatoxicosis Investigation Group.

更新日期：2005-12-01 00:00:00

abstract：:We describe the successes and challenges faced by federal and local government agencies in the United States as they have attempted in recent years to connect public and environmental health, housing, community development, and building design with environmental, housing, and building laws, codes, and policies. These ...

journal_title：Environmental health perspectives

authors： Jacobs DE,Kelly T,Sobolewski J

更新日期：2007-06-01 00:00:00

abstract：:We evaluated the effect of chronic exposure to dioxin and dioxin-like compounds on the pancreas in female Harlan Sprague-Dawley rats. This investigation represents part of an ongoing National Toxicology Program initiative to determine the relative potency of chronic toxicity and carcinogenicity of polychlorinated diox...

journal_title：Environmental health perspectives

authors： Nyska A,Jokinen MP,Brix AE,Sells DM,Wyde ME,Orzech D,Haseman JK,Flake G,Walker NJ

更新日期：2004-06-01 00:00:00

abstract：:Epidemiological studies report a small but positive association between short-term increases in airborne particulate matter and small increases in morbidity and mortality from respiratory and cardiovascular disease in urban areas. However, the lack of a mechanistic explanation to link particle exposure and human healt...

journal_title：Environmental health perspectives

authors： Holian A,Hamilton RF Jr,Morandi MT,Brown SD,Li L

更新日期：1998-03-01 00:00:00