Effects of decabrominated diphenyl ether (PBDE-209) in regulation of growth and apoptosis of breast, ovarian, and cervical cancer cells.

abstract：:The effects of global change on biodiversity and ecosystem functioning encompass multiple complex dynamic processes. Climate change and exposure to endocrine-disrupting chemicals (EDCs) are currently regarded as two of the most serious anthropogenic threats to biodiversity and ecosystems. We should, therefore, be espe...

journal_title：Environmental health perspectives

authors： Jenssen BM

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:Most studies on endocrine-disrupting chemicals and breast cancer have focused on single compounds and have produced inconclusive findings. OBJECTIVES:We assessed the combined estrogenic effects of mixtures of xenoestrogens in serum and their relationship to breast cancer risk. METHODS:A total of 186 incide...

journal_title：Environmental health perspectives

authors： Pastor-Barriuso R,Fernández MF,Castaño-Vinyals G,Whelan D,Pérez-Gómez B,Llorca J,Villanueva CM,Guevara M,Molina-Molina JM,Artacho-Cordón F,Barriuso-Lapresa L,Tusquets I,Dierssen-Sotos T,Aragonés N,Olea N,Kogevinas M,Pollá

更新日期：2016-10-01 00:00:00

abstract：:Most published environmental remediation interventions have been directed at single allergens and have employed demanding strategies; few have been performed in the homes of inner-city children disproportionately burdened by asthma. Our objective was a) to describe the allergen sensitivities, environmental tobacco smo...

journal_title：Environmental health perspectives

authors： Crain EF,Walter M,O'Connor GT,Mitchell H,Gruchalla RS,Kattan M,Malindzak GS,Enright P,Evans R 3rd,Morgan W,Stout JW

更新日期：2002-09-01 00:00:00

abstract：:The possible risk for human health arising from consumption of lead-polluted shellfish was suggested by experiments on the bioavailability for mice of a "biologically detoxified" form of the metal. In this work, young mice were fed with a mixed diet including mussels collected in a Pb-polluted area. Metal concentratio...

journal_title：Environmental health perspectives

authors： Regoli F,Orlando E

更新日期：1994-09-01 00:00:00

abstract：:A series of experiments is described in which operant methodology is used to study the effects of drugs on "learning." Emphasis is placed on the technique of repeated acquisition as a behavioral baseline for studying this type of transition state. In this technique, each subject is required to learn a new discriminati...

journal_title：Environmental health perspectives

authors： Thompson DM,Moerschbaecher JM

更新日期：1978-10-01 00:00:00

abstract：BACKGROUND:Although numerous epidemiologic studies now use models of intraurban exposure, there has been little systematic evaluation of the performance of different models. OBJECTIVES:In this present article we proposed a modeling framework for assessing exposure model performance and the role of spatial autocorrelat...

journal_title：Environmental health perspectives

authors： Molitor J,Jerrett M,Chang CC,Molitor NT,Gauderman J,Berhane K,McConnell R,Lurmann F,Wu J,Winer A,Thomas D

更新日期：2007-08-01 00:00:00

abstract：:In this study we investigated the potential impact of climate change in Portugal on heat-related mortality, air pollution-related health effects, and selected vectorborne diseases. The assessment used climate scenarios from two regional climate models for a range of future time periods. The annual heat-related death r...

journal_title：Environmental health perspectives

authors： Casimiro E,Calheiros J,Santos FD,Kovats S

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:The damaging effects of exposure to environmental toxicants differentially affect genetically distinct individuals, but the mechanisms contributing to these differences are poorly understood. Genetic variation affects the establishment of the gene regulatory landscape and thus gene expression, and we hypothe...

journal_title：Environmental health perspectives

authors： Chappell GA,Israel JW,Simon JM,Pott S,Safi A,Eklund K,Sexton KG,Bodnar W,Lieb JD,Crawford GE,Rusyn I,Furey TS

更新日期：2017-10-16 00:00:00

abstract：:The association of blood lead (B-Pb) concentration to blood pressure was investigated in men aged 55 to 75 years living in the Rome area, who had no history of exposure to lead in the workplace and who participated between 1989 and 1990 in an epidemiologic survey for coronary heart disease (New Risk Factor Project). O...

journal_title：Environmental health perspectives

authors： Menditto A,Morisi G,Spagnolo A,Menotti A

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:There is a need to identify and evaluate an effective mitigation program for arsenic exposure from drinking water in Bangladesh. OBJECTIVE:We evaluated the effectiveness of a multifaceted mitigation program to reduce As exposure among 11,746 individuals in a prospective cohort study initiated in 2000 in Ara...

journal_title：Environmental health perspectives

authors： Chen Y,van Geen A,Graziano JH,Pfaff A,Madajewicz M,Parvez F,Hussain AZ,Slavkovich V,Islam T,Ahsan H

更新日期：2007-06-01 00:00:00

abstract：:Adults eating a Western diet digest and absorb ingested food containing approximately 100 g fat, 350 g carbohydrate, and 75 g protein daily. Normal fat absorption requires adequate gastric, pancreatic, liver-biliary, mucosal, and lymphatic function. Carbohydrate and protein absorption is much less dependent on liver-b...

journal_title：Environmental health perspectives

authors： Heizer WD

更新日期：1979-12-01 00:00:00

abstract：:Many substances are active in in vitro tests for estrogenic activity, but data from multigenerational and other toxicity studies are not available for many of those substances. Controversy has arisen, therefore, concerning the likelihood of adverse health effects. Based on a toxic equivalence factor risk assessment ap...

journal_title：Environmental health perspectives

authors： Rudel R

更新日期：1997-04-01 00:00:00

abstract：:A set of 53 individuals from a population highly exposed to airborne hexachlorobenzene (HCB) were selected to study the elimination kinetics of this chemical in humans. The volunteers provided blood, 24-hr urine, and feces samples for analysis of HCB and metabolites. The serum HCB concentrations ranged from 2.4 to 1,4...

journal_title：Environmental health perspectives

authors： To-Figueras J,Barrot C,Sala M,Otero R,Silva M,Ozalla MD,Herrero C,Corbella J,Grimalt J,Sunyer J

更新日期：2000-07-01 00:00:00

abstract：:32P-Postlabeling analysis and enzyme-linked immunosorbent assay (ELISA) have been used to detect DNA adducts in peripheral blood lymphocytes from primary aluminum production plant workers who were exposed occupationally to a mixture of polycyclic aromatic hydrocarbons (PAHs). Preliminary results reported here are from...

journal_title：Environmental health perspectives

authors： Schoket B,Phillips DH,Poirier MC,Vincze I

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:Evidence on the association between colorectal cancer and exposure to disinfection by-products in drinking water is inconsistent. OBJECTIVES:We assessed long-term exposure to trihalomethanes (THMs), the most prevalent group of chlorination by-products, to evaluate the association with colorectal cancer. ME...

journal_title：Environmental health perspectives

authors： Villanueva CM,Gracia-Lavedan E,Bosetti C,Righi E,Molina AJ,Martín V,Boldo E,Aragonés N,Perez-Gomez B,Pollan M,Acebo IG,Altzibar JM,Zabala AJ,Ardanaz E,Peiró R,Tardón A,Chirlaque MD,Tavani A,Polesel J,Serraino D,Pi

更新日期：2017-01-01 00:00:00

abstract：:We used real-time monitors and low-volume air samplers to measure the potential human exposure to airborne polycyclic aromatic hydrocarbon (PAH) concentrations during various flight-related and ground-support activities of C-130H aircraft at an Air National Guard base. We used three types of photoelectric aerosol sens...

journal_title：Environmental health perspectives

authors： Childers JW,Witherspoon CL,Smith LB,Pleil JD

更新日期：2000-09-01 00:00:00

abstract：:In 1998 we published the results of a study suggesting an association between breast cancer and perchloroethylene (PCE; also called tetrachloroethylene) exposure from public drinking water. The present case-control study was undertaken to evaluate this association further. The cases were composed of female residents o...

journal_title：Environmental health perspectives

authors： Aschengrau A,Rogers S,Ozonoff D

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Hexavalent chromium [Cr(VI)] is recognized as a human carcinogen via inhalation. However, the molecular mechanisms by which Cr(VI) causes cancers are not well understood. OBJECTIVES:We evaluated cyclooxygenase-2 (COX-2) expression and the signaling pathway leading to this induction due to Cr(VI) exposure in...

journal_title：Environmental health perspectives

authors： Zuo Z,Cai T,Li J,Zhang D,Yu Y,Huang C

更新日期：2012-04-01 00:00:00

abstract：:Naturally occurring radon is a relatively ubiquitous environmental carcinogen to which large numbers of people can be exposed over their lifetimes. The accumulation of radon in homes, therefore, has led to a large program to determine the effects of the densely ionizing alpha particles that are produced when radon dec...

journal_title：Environmental health perspectives

authors： Wolff S,Afzal V,Jostes RF,Wiencke JK

更新日期：1993-10-01 00:00:00

abstract：:The development of inhalation toxicology as a distinct discipline can be traced back well over one hundred years. The technology has advanced in terms of materials and designs used to construct inhalation chambers and the equipment used to generate controlled test atmospheres of a wide variety of gases, vapors, dusts,...

journal_title：Environmental health perspectives

authors： Dorato MA

更新日期：1990-04-01 00:00:00

abstract：:Previous occupational cohort studies of benzene-exposed workers have for the most part used only death certificates to validate diagnoses of workers developing leukemia and other hematopoietic and lymphoproliferative malignancies and related disorders (HLD). In a follow-up study of 74,828 benzene-exposed workers and a...

journal_title：Environmental health perspectives

authors： Linet MS,Yin SN,Travis LB,Li CY,Zhang ZN,Li DG,Rothman N,Li GL,Chow WH,Donaldson J,Dosemeci M,Wacholder S,Blot WJ,Hayes RB

更新日期：1996-12-01 00:00:00

abstract：:Individual variability in human arsenic metabolism has been reported frequently in the literature. This variability could be an underlying determinant of individual susceptibility to arsenic-induced disease in humans. Recent analysis revealing familial aggregation of arsenic metabolic profiles suggests that genetic fa...

journal_title：Environmental health perspectives

authors： Yu L,Kalla K,Guthrie E,Vidrine A,Klimecki WT

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:Dozens of studies link acute exposure to particulate matter (PM) air pollution with premature mortality and morbidity, but questions remain about which species and sources in the vast PM mixture are responsible for the observed health effects. Although a few studies exist on the effects of species and source...

journal_title：Environmental health perspectives

authors： Ostro B,Tobias A,Querol X,Alastuey A,Amato F,Pey J,Pérez N,Sunyer J

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Air pollution exposure increases cardiovascular morbidity and mortality and is a major global public health concern. OBJECTIVES:We investigated the benefits of reducing personal exposure to urban air pollution in patients with coronary heart disease. METHODS:In an open randomized crossover trial, 98 patien...

journal_title：Environmental health perspectives

authors： Langrish JP,Li X,Wang S,Lee MM,Barnes GD,Miller MR,Cassee FR,Boon NA,Donaldson K,Li J,Li L,Mills NL,Newby DE,Jiang L

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Exposures to high-dose ionizing radiation and high-dose rate ionizing radiation are established risk factors for childhood acute leukemia (AL). The risk of AL following exposure to lower doses due to natural background radiation (NBR) has yet to be conclusively determined. METHODS:AL cases diagnosed over 19...

journal_title：Environmental health perspectives

authors： Demoury C,Marquant F,Ielsch G,Goujon S,Debayle C,Faure L,Coste A,Laurent O,Guillevic J,Laurier D,Hémon D,Clavel J

更新日期：2017-04-01 00:00:00

abstract：:Exposure of the scallop Placopecten magellanicus to 20 ppb Cd2+ in seawater for 7 weeks results in a 7-fold increase in the kidney cytosol content of Cd and 5-fold increase in Zn. Sephadex G-75 column chromatography of the kidney cytosol showed that most of the Cd and Zn were bound to a protein complex with an estimat...

journal_title：Environmental health perspectives

authors： Fowler BA,Megginson MM

更新日期：1986-03-01 00:00:00

abstract：:Chronic exposure to oxidants is associated with an increased incidence of malignancy; however, the mechanism(s) by which oxidants contribute to carcinogenesis is unknown. Since oncogene activation plays an important role in carcinogenesis, we hypothesized that hydroxyl radical-induced DNA damage might contribute to ca...

journal_title：Environmental health perspectives

authors： Jackson JH

更新日期：1994-12-01 00:00:00

abstract：:The many anatomical, physiological, and biochemical differences among various mammalian species make it difficult to extrapolate carcinogenic potency data from animals to humans. The process is further complicated by the multistep origin of most malignant tumors in animals and humans due to the interaction of target c...

journal_title：Environmental health perspectives

authors： Slaga TJ

更新日期：1988-04-01 00:00:00

abstract：OBJECTIVE:Daily adult human exposure to bisphenol A (BPA) has been estimated at <1 µg/kg, with virtually complete first-pass conjugation in the liver in primates but not in mice. We measured unconjugated and conjugated BPA levels in serum from adult female rhesus monkeys and adult female mice after oral administration ...

journal_title：Environmental health perspectives

authors： Taylor JA,Vom Saal FS,Welshons WV,Drury B,Rottinghaus G,Hunt PA,Toutain PL,Laffont CM,VandeVoort CA

更新日期：2011-04-01 00:00:00

abstract：:Hamsters were exposed to an aerosol of fused aluminosilicate particles (FAP) labeled with 57Co. Three groups of animals were given bronchopulmonary lavage, beginning at either 1 week, 1 month, or 6 months after exposure. Each treated group was lavaged eight times over a period of 25 days. Each lavage involved 10 salin...

journal_title：Environmental health perspectives

authors： Ellender M,Hodgson A,Wood KL,Moody JC

更新日期：1992-07-01 00:00:00