Induction of inflammation in vascular endothelial cells by metal oxide nanoparticles: effect of particle composition.

abstract：:Articles in the literature on alpha-1 antitrypsin (AAT) deficiency have been interpreted as indicating that AAT deficiency is a rare disease that affects mainly Caucasians (whites) from northern Europe. In a recent publication on the worldwide racial and ethnic distribution of AAT deficiency, new data were presented d...

journal_title：Environmental health perspectives

authors： de Serres FJ

更新日期：2003-12-01 00:00:00

abstract：:We have previously reported that rats are resilient to the hepatotoxic and lethal combination of chlordecone (CD) and carbon tetrachloride (CCl4) during early postnatal development. The overall findings pointed to stimulated cell division and tissue repair mechanisms as the underlying cause of resistance. The objectiv...

journal_title：Environmental health perspectives

authors： Dalu A,Rao PS,Mehendale HM

更新日期：1998-09-01 00:00:00

abstract：:Direct studies of the function of a given cell type often require that the cell type be obtained in pure culture. A number of different specific metabolic activities have been attributed to pulmonary endothelial cells, yet with few exceptions the conclusions were based on indirect evidence. Thus, to improve our abilit...

journal_title：Environmental health perspectives

authors： Ryan US,Ryan JW

更新日期：1980-04-01 00:00:00

abstract：:The problem of byssinosis has plagued cotton textile mills for hundreds of years, and it is still a problem today. With the regulations on airborne raw cotton dust set by OSHA and the ACGIH, research regarding the measurement of cotton dust in lint fiber is a necessity. A procedure known as the mass concentration part...

journal_title：Environmental health perspectives

authors： Parnell CB Jr,Niles GA,Rutherford RD

更新日期：1986-04-01 00:00:00

abstract：BACKGROUND:World Trade Center (WTC) rescue and recovery workers were exposed to a complex mix of pollutants and carcinogens. OBJECTIVE:The purpose of this investigation was to evaluate cancer incidence in responders during the first 7 years after 11 September 2001. METHODS:Cancers among 20,984 consented participants ...

journal_title：Environmental health perspectives

authors： Solan S,Wallenstein S,Shapiro M,Teitelbaum SL,Stevenson L,Kochman A,Kaplan J,Dellenbaugh C,Kahn A,Biro FN,Crane M,Crowley L,Gabrilove J,Gonsalves L,Harrison D,Herbert R,Luft B,Markowitz SB,Moline J,Niu X,Sacks H,

更新日期：2013-06-01 00:00:00

abstract：:Biological markers of intermediate health outcomes sometimes provide a superior alternative to traditional measures of pollutant-related disease. Some opportunities and methodologic issues associated with using markers are discussed in the context of exposures to four complex mixtures: environmental tobacco smoke and ...

journal_title：Environmental health perspectives

authors： Wilcosky TC

更新日期：1993-12-01 00:00:00

abstract：:Antisera elicited in rabbits were used in radioimmunoassay (RIA) and enzyme-linked immunosorbent assay (ELISA) to determine femtomole quantities of deoxyguanosin-(8-yl)-acetylaminofluorene (dg-8-AAF) and deoxyguanosin-(8-yl)-aminofluorene (dg-8-AF). These adducts have been monitored in liver and kidney DNA of male Wis...

journal_title：Environmental health perspectives

authors： Poirier MC,True B,Laishes BA

更新日期：1983-03-01 00:00:00

abstract：BACKGROUND:Previous studies have examined fine particulate matter (≤ 2.5 μm; PM2.5) and preterm birth, but there is a dearth of longitudinal studies on this topic and a paucity of studies that have investigated specific sources of this exposure. OBJECTIVES:Our aim was to assess whether anthropogenic sources are associ...

journal_title：Environmental health perspectives

authors： Pereira G,Bell ML,Lee HJ,Koutrakis P,Belanger K

更新日期：2014-10-01 00:00:00

abstract：:We studied peripheral lymphocyte HPRT variant frequency and endogenous nitrosation in human populations exposed to various nitrate levels in their drinking water. Four test populations of women volunteers were compared. Low and medium tap water nitrate exposure groups (14 and 21 subjects) were using public water suppl...

journal_title：Environmental health perspectives

authors： van Maanen JM,Welle IJ,Hageman G,Dallinga JW,Mertens PL,Kleinjans JC

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND:Arsenic, cadmium, mercury, and lead are associated with cardiovascular disease in epidemiologic research. These associations may be mediated by direct effects of the metals on blood pressure (BP) elevation. Manganese is associated with cardiovascular dysfunction and hypotension in occupational cohorts. OBJE...

journal_title：Environmental health perspectives

authors： Mordukhovich I,Wright RO,Hu H,Amarasiriwardena C,Baccarelli A,Litonjua A,Sparrow D,Vokonas P,Schwartz J

更新日期：2012-01-01 00:00:00

abstract：:We report the results of a coordinated mitigation effort aimed at reducing arsenic (As) exposure in three counties of Guizhou province, China. Mitigation occurred in 2005 and encompassed 21 villages with 47,000 inhabitants, who were exposed to high levels of As in their diet through consumption of As-contaminated chil...

journal_title：Environmental health perspectives

authors： An D,Li D,Liang Y,Jing Z

更新日期：2007-04-01 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) are widespread, low-level environmental pollutants associated with adverse health effects such as immune suppression and teratogenicity. There is increasing evidence that some PCB compounds are capable of disrupting reproductive and endocrine function in fish, birds, and mammals, inclu...

journal_title：Environmental health perspectives

authors： Bergeron JM,Crews D,McLachlan JA

更新日期：1994-09-01 00:00:00

abstract：:The role of cell-specific metabolism in benzene toxicity was examined in both murine and human bone marrow. Hemopoietic progenitor cells and stromal cells are important control points for regulation of hemopoiesis. We show that the selective toxicity of hydroquinone at the level of the macrophage in murine bone marrow...

journal_title：Environmental health perspectives

authors： Ross D,Siegel D,Schattenberg DG,Sun XM,Moran JL

更新日期：1996-12-01 00:00:00

abstract：OBJECTIVES:The National Environmental Policy Act and related state laws require many public agencies to analyze and disclose potentially significant environmental effects of agency actions, including effects on human health. In this paper we review the purpose and procedures of environmental impact assessment (EIA), ex...

journal_title：Environmental health perspectives

authors： Bhatia R,Wernham A

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Particulate matter (PM) air pollution has been associated with cardiovascular morbidity and mortality, and elevated blood pressure (BP) is a known risk factor for cardiovascular disease. A small number of studies have investigated the relationship between PM and BP and found mixed results. Evidence suggests ...

journal_title：Environmental health perspectives

authors： Mordukhovich I,Wilker E,Suh H,Wright R,Sparrow D,Vokonas PS,Schwartz J

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:In the developing brain, serotonin (5HT) systems are among the most sensitive to disruption by organophosphates. OBJECTIVES:We exposed neonatal rats to daily doses of diazinon or parathion on postnatal days (PND)1-4 and evaluated 5HT receptors and the 5HT transporter in brainstem and forebrain on PND5, focu...

journal_title：Environmental health perspectives

authors： Slotkin TA,Tate CA,Ryde IT,Levin ED,Seidler FJ

更新日期：2006-10-01 00:00:00

abstract：:Isoflavonoids and related compounds such as coumestrol have classically been categorized as phytoestrogens because these environmentally derived substances bind to the estrogen receptor (ER) and increase uterine wet weight in immature rats and mice. Assessment of the binding affinities of isoflavonoids for ER and subs...

journal_title：Environmental health perspectives

authors： Markaverich BM,Webb B,Densmore CL,Gregory RR

更新日期：1995-06-01 00:00:00

abstract：:Environmental tobacco smoke (ETS) has been associated with cardiovascular mortality. Pathophysiologic pathways leading from ETS exposure to cardiopulmonary disease are still being explored. Reduced cardiac autonomic function, as measured by heart rate variability (HRV), has been associated with cardiac vulnerability a...

journal_title：Environmental health perspectives

authors： Pope CA 3rd,Eatough DJ,Gold DR,Pang Y,Nielsen KR,Nath P,Verrier RL,Kanner RE

更新日期：2001-07-01 00:00:00

abstract：:Ingestion is an important exposure route for polycyclic aromatic hydrocarbons (PAHs) to enter the human body. Although the formation of hazardous PAH metabolites by human biotransformation enzymes is well documented, nothing is known about the PAH transformation potency of human intestinal microbiota. Using a gastroin...

journal_title：Environmental health perspectives

authors： Van de Wiele T,Vanhaecke L,Boeckaert C,Peru K,Headley J,Verstraete W,Siciliano S

更新日期：2005-01-01 00:00:00

abstract：:We measured tumor-associated proteins (TAPs) and pollutants in blood, serum, and urine of 200 nonsmoking women 50-65 years of age, residing in the rural municipality of Peer or in Hoboken or Wilrijk, industrial suburbs of Antwerp, Belgium. Persons with occupational exposures or commuting to other towns were excluded. ...

journal_title：Environmental health perspectives

authors： van Larebeke NA,Bracke ME,Nelen V,Koppen G,Schoeters G,Van Loon H,Vlietinck R

更新日期：2006-06-01 00:00:00

abstract：:Present available information regarding ovarian tumors in hens is incomplete in most aspects, and this lack of knowledge hampers use of hens as models for study of ovarian cancer. A study of 466 hens ranging from 2 to 7 years of age and covering a period of more than 3 years has provided much needed information relati...

journal_title：Environmental health perspectives

authors： Fredrickson TN

更新日期：1987-08-01 00:00:00

abstract：:The identification of certain organic compounds in drinking water has led water treatment specialists to be increasingly concerned about the eventual risks of such pollutants to the health of consumers. Our experiments focused on the role of ozone and granular activated carbon in removing mutagenic compounds and precu...

journal_title：Environmental health perspectives

authors： Bourbigot MM,Hascoet MC,Levi Y,Erb F,Pommery N

更新日期：1986-11-01 00:00:00

abstract：BACKGROUND:In male rodents, anogenital distance (AGD) provides a sensitive and continuous correlate of androgen exposure in the intrauterine environment and predicts later reproductive success. Some endocrine-disrupting chemicals can alter male reproductive tract development, including shortening AGD, in both rodents a...

journal_title：Environmental health perspectives

authors： Mendiola J,Stahlhut RW,Jørgensen N,Liu F,Swan SH

更新日期：2011-07-01 00:00:00

abstract：:Recent increases have been reported in industrial countries for several sites of cancer. The causes of these increases remain unknown. Efforts should proceed to identify those occupational groups with increases in the same sites, as these may indicate relevant exposures. Two analyses were undertaken: trends in cancer ...

journal_title：Environmental health perspectives

authors： Davis DL,Blair A,Hoel DG

更新日期：1993-04-01 00:00:00

abstract：:To assess quantitatively the association between benzene and leukemia, we evaluated the rate of mortality experienced by a cohort occupationally exposed to benzene. Using data from historical air sampling surveys, we estimated the daily benzene exposure for each member of the cohort. The expected number of leukemia de...

journal_title：Environmental health perspectives

authors： Rinsky RA

更新日期：1989-07-01 00:00:00

abstract：:A human lymphoblastoid cell line has been used to test for mutations caused by combustion-generated soot particles and their constituent components, which are substrate carbon-black and adsorbed condensate, principally in the form of polycyclic aromatic hydrocarbons (PAH). It was found that the mutagenicity of the PAH...

journal_title：Environmental health perspectives

authors： Bolsaitis PP,Feitelberg AS,Dekermendjian V,Elliott JF,Sarofim AF,Thilly WG

更新日期：1991-12-01 00:00:00

abstract：:We evaluated predictors of plasma concentrations of dichlorodiphenyldichloroethylene (DDE), a metabolite of dichlorodiphenyltrichloroethane (DDT), and polychlorinated biphenyls (PCBs) in a group of 240 women, controls from a breast cancer case-control study nested in the Nurses' Health Study. We considered personal at...

journal_title：Environmental health perspectives

authors： Laden F,Neas LM,Spiegelman D,Hankinson SE,Willett WC,Ireland K,Wolff MS,Hunter DJ

更新日期：1999-01-01 00:00:00

abstract：:This paper will briefly outline those elements which must be considered in assessing the effects of any given compound which might impinge on the actions of adrenocortical steroids. Considerations that ought to be taken into account include the following: the delivery to the affected cells of corticosteroids, the upta...

journal_title：Environmental health perspectives

authors： Thompson EB

更新日期：1981-04-01 00:00:00

abstract：:[35S]t-Butylbicyclophosphorothionate or [35S]TBPS is an improved radioligand for the picrotoxinin binding site in rat brain synaptic membranes. The toxic isomers of the hexachlorocyclohexanes, polychlorobornanes, and chlorinated cyclodienes displace [35S]TBPS with a stereospecificity and potency generally correlated w...

journal_title：Environmental health perspectives

authors： Casida JE,Lawrence LJ

更新日期：1985-09-01 00:00:00

abstract：BACKGROUND:We characterized an endocrine disruptor from ground corncob bedding material that interferes with male and female sexual behavior and ovarian cyclicity in rats and stimulates estrogen receptor (ER)-positive and ER-negative breast cancer cell proliferation. The agents were identified as an isomeric mixture of...

journal_title：Environmental health perspectives

authors： Markaverich BM,Crowley J,Rodriquez M,Shoulars K,Thompson T

更新日期：2007-12-01 00:00:00