Abstract:
:Environmental tobacco smoke (ETS) has been associated with cardiovascular mortality. Pathophysiologic pathways leading from ETS exposure to cardiopulmonary disease are still being explored. Reduced cardiac autonomic function, as measured by heart rate variability (HRV), has been associated with cardiac vulnerability and may represent an important pathophysiologic mechanism linking ETS and risk of cardiac mortality. In this study we evaluated acute ETS exposure in a commercial airport with changes in HRV in 16 adult nonsmokers. We conducted ambulatory electrocardiographic (ECG) monitoring for 8-hr periods while participants alternated 2 hr in nonsmoking and smoking areas. Nicotine and respirable suspended particle concentrations and participants' blood oxygen saturation were also monitored. We calculated time and frequency domain measures of HRV for periods in and out of the smoking area, and we evaluated associations with ETS using comparative statistics and regression modeling. ETS exposure was negatively associated with all measures of HRV. During exposure periods, we observed an average decrement of approximately 12% in the standard deviation of all normal-to-normal heart beat intervals (an estimate of overall HRV). ETS exposures were not associated with mean heart rate or blood oxygen saturation. Altered cardiac autonomic function, assessed by decrements in HRV, is associated with acute exposure to ETS and may be part of the pathophysiologic mechanisms linking ETS exposure and increased cardiac vulnerability.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Pope CA 3rd,Eatough DJ,Gold DR,Pang Y,Nielsen KR,Nath P,Verrier RL,Kanner REdoi
10.1289/ehp.01109711subject
Has Abstractpub_date
2001-07-01 00:00:00pages
711-6issue
7eissn
0091-6765issn
1552-9924pii
sc271_5_1835journal_volume
109pub_type
杂志文章abstract::Aluminum lactate [Al(lact)3] (hydrophilic, hydrolytically unstable) and aluminum acetylacetonate [Al(acae)3] (lipophilic, hydrolytically stable) were tested as potential toxicants to rabbits upon IV administration both as aqueous solutions and as liposome suspensions. Both chemicals behaved as cardiotoxic agents when ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9089217
更新日期:1990-11-01 00:00:00
abstract::As a consequence of contamination by effluents from local electronics manufacturing facilities, the New Bedford Harbor and estuary in southeastern Massachusetts is among the sites in the United States that are considered the most highly contaminated by polychlorinated biphenyls (PCBs). Since 1993, measures of intraute...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.98106513
更新日期:1998-08-01 00:00:00
abstract::Environmental pollution with the nephrotoxic metal cadmium is considered a potential health risk for the general population. In 1976 it was reported that the cadmium concentration in human kidney cortex in Sweden had increased in parallel with increasing levels in soil and grain during the twentieth century. Since the...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.98106175
更新日期:1998-04-01 00:00:00
abstract::Chronic exposure of rodents to high dose levels of drugs, food additives and environmental chemicals frequently results in liver enlargement. Several of these compounds have been found to enhance the incidence of liver tumors in animals briefly exposed previously to hepatocarcinogens. Accordingly, it has been advanced...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8350113
更新日期:1983-04-01 00:00:00
abstract:BACKGROUND:Genetics may partially explain observed heterogeneity in associations between traffic-related air pollution and incident asthma. OBJECTIVE:Our aim was to investigate the impact of gene variants associated with oxidative stress and inflammation on associations between air pollution and incident childhood ast...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1307459
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:Health risks differ by fine particle (aerodynamic diameter ≤ 2.5 μm) component, although with substantial variability. Traditional methods to assess component-specific risks are limited, suggesting the need for alternative methods. OBJECTIVES:We examined whether the odds of daily hospital admissions differ ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1002646
更新日期:2011-10-01 00:00:00
abstract::Lipocortins are structurally related, glucocorticoid-inducible proteins that inhibit phospholipase A2 (PLA2), thereby reducing the liberation of arachidonic acid from phospholipids and so limiting the synthesis of eicosanoid inflammatory mediators. This study is the first demonstration of one lipocortin, lipocortin 1 ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.85-1568329
更新日期:1990-04-01 00:00:00
abstract::Although acute adverse effects on asthma have been frequently found for the U.S. Environmental Protection Agency's principal criteria air pollutants, there is little epidemiologic information on specific hydrocarbons from toxic emission sources. We conducted a panel study of 22 Hispanic children with asthma who were 1...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.5992
更新日期:2003-04-01 00:00:00
abstract::Human milk is a repository for certain classes of long-lived, fat-soluble environmental contaminant chemicals. Some members of this class, such as the chlorinated pesticides and the chlorinated biphenyls, can be expected to be present at chemical waste disposal sites. Analysis of samples of breast milk obtained from w...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.834887
更新日期:1983-02-01 00:00:00
abstract:BACKGROUND:Although from a societal point of view a modal shift from car to bicycle may have beneficial health effects due to decreased air pollution emissions, decreased greenhouse gas emissions, and increased levels of physical activity, shifts in individual adverse health effects such as higher exposure to air pollu...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.0901747
更新日期:2010-08-01 00:00:00
abstract::Southwest metropolitan Mexico City (SWMMC) inhabitants have been exposed several hours per day for the last 6 years to photochemical smog, ozone being the most important oxidant pollutant. Subjects exposed to the SWMMC atmosphere develop several histopathological changes in their nasal mucosa: dysplasia is the most si...
journal_title:Environmental health perspectives
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1289/ehp.101-1519752
更新日期:1993-06-01 00:00:00
abstract::The past and current EPA research and regulatory programs as they relate to non-regulated emissions from light-duty motor vehicles are reviewed. Provisions of Sections 202(a) and 211 of the 1970 Clean Air Act Amendments are discussed and their relationships to the nonregulated emissions issue detailed. The EPA positio...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.75105
更新日期:1975-04-01 00:00:00
abstract:BACKGROUND:The damaging effects of exposure to environmental toxicants differentially affect genetically distinct individuals, but the mechanisms contributing to these differences are poorly understood. Genetic variation affects the establishment of the gene regulatory landscape and thus gene expression, and we hypothe...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP1937
更新日期:2017-10-16 00:00:00
abstract:BACKGROUND:Humans have been exposed to fine and ultrafine particles throughout their history. Since the Industrial Revolution, sources, doses, and types of nanoparticles have changed dramatically. In the last decade, the rapidly developing field of nanotechnology has led to an increase of engineered nanoparticles with ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.0901200
更新日期:2010-03-01 00:00:00
abstract::The immune system comprises a highly integrated network of multiple tissues and cell types with complicated interactions and effects. It is modulated by the endocrine and nervous systems and there is growing realization of its multifunctionality. The session focusing on immunologic effects of dioxin and related compou...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.95103s2157
更新日期:1995-03-01 00:00:00
abstract::A subset of workers was followed after exposure to polychlorinated biphenyls (PCBs), dioxins, and furans in an occupational medicine clinic setting. Patterns of PCBs found in adipose tissue resembled the pattern seen when soot from the incident or Aroclor 1254 was examined by GC-MS. Adipose tissue also revealed levels...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8560241
更新日期:1985-05-01 00:00:00
abstract:BACKGROUND:Phthalates are metabolized and eliminated in urine within hours after exposure. Several reports suggest that concentrations of phthalate metabolites in a spot urine sample can provide a reliable estimation of exposure to phthalates for up to several months. OBJECTIVES:We examined inter- and intraperson and ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1002231
更新日期:2010-12-01 00:00:00
abstract::Historical aerial applications of the insecticide Matacil 1.8D provide an opportunity to look for potential effects of the endocrine disrupting compound 4-nonylphenol (4-NP) on Atlantic salmon (Salmo salar) populations. Matacil 1.8D contained the carbamate insecticide aminocarb, with 4-NP as primary solvent. Between 1...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.99107349
更新日期:1999-05-01 00:00:00
abstract::Children may be more susceptible to exposures to environmental toxins than adults and may be more vulnerable to their effects. Because of this, the health care community and those responsible for children need to be alert to possible environmental factors in identifying and responding to the health problems of childre...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.95103s613
更新日期:1995-09-01 00:00:00
abstract:BACKGROUND:Previous studies have suggested an effect of high arsenic concentration on cognitive and neurobehavioral function in humans. OBJECTIVE:Our goal was to identify demographic and nutritional factors that are associated with As exposure and the influence of this exposure on cognitive function in school-age chil...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9961
更新日期:2007-09-01 00:00:00
abstract::There is growing public pressure to minimize the use of vertebrates in ecotoxicity testing; therefore, effective alternatives to toxicity tests causing suffering are being sought. This report discusses alternatives and differs in some respects from the reports of the other three groups because the primary concern is w...
journal_title:Environmental health perspectives
pub_type:
doi:10.1289/ehp.98106441
更新日期:1998-04-01 00:00:00
abstract::We examined the estrogenicity of binary mixtures of the hydroxylated polychlorinated biphenyls (OHPCBs) 2,4,6-trichloro-4'-biphenylol (2,4,6-TCB-4'-OH) and 2,3,4,5-tetrachloro-4'-biphenylol and the pesticides endosulfan and dieldrin. The OHPCBs and pesticides were tested in both the MCF-7 focus assay and a competitive...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.98106s41041
更新日期:1998-08-01 00:00:00
abstract:BACKGROUND:Rodent models for urban air pollution show consistent induction of inflammatory responses in major brain regions. However, the initial impact of air pollution particulate material on olfactory gateways has not been reported. OBJECTIVE:We evaluated the olfactory neuroepithelium (OE) and brain regional respon...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP134
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Previous studies have examined fine particulate matter (≤ 2.5 μm; PM2.5) and preterm birth, but there is a dearth of longitudinal studies on this topic and a paucity of studies that have investigated specific sources of this exposure. OBJECTIVES:Our aim was to assess whether anthropogenic sources are associ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1307741
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Use of pyrethroid insecticides has increased dramatically over the past decade; however, data on their potential health effects, particularly on children, are limited. OBJECTIVE:We examined the cross-sectional association between postnatal pyrethroid exposure and parental report of learning disability (LD) ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1308031
更新日期:2014-12-01 00:00:00
abstract::Pollen of Impatiens sultanii Hook F. germinates and forms tubes rapidly at 25 degrees C in a simple medium containing 111.0 ppm CaCl2, 13.6 ppm KH2PO4, and 1000 ppm boric acid. Calcium, potassium, and boron are essential for germination and tube growth, but sucrose is not required. Pollen tubes grow with equal rapidit...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.813795
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:Pregnancy is a sensitive condition during which adverse environmental exposures should be monitored thoroughly and minimized whenever possible. In particular, the hormone balance during gestation is delicate, and disturbance may cause acute or chronic long-term health effects. A potential endocrine disruptio...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP4860
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Most research on walking for transport has focused on the walkability of residential neighborhoods, overlooking the contribution of places of work/study and the ease with which destinations outside the immediate neighborhood can be accessed, referred to as regional accessibility. OBJECTIVES:We aimed to exam...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP3395
更新日期:2019-09-01 00:00:00
abstract::Untreated wastewater from the Mexico City basin has been used for decades to irrigate cropland in the Mezquital Valley, State of Hidalgo, Mexico. Excess irrigation water recharges the near-surface aquifer that is used as a domestic water supply source. We assessed the groundwater quality of three key groundwater sourc...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.99107553
更新日期:1999-07-01 00:00:00
abstract::Africa is quickly becoming a destination for information technology in the form of tons of used computers, fax machines, cell phones, and other electronics. Although many of these machines can be repaired and resold, up to 75% of the electronics shipped to Africa is junk. This equipment, when dumped, may leach lead, m...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.114-a232
更新日期:2006-04-01 00:00:00