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Chemical properties of air pollutants and cause-specific hospital admissions among the elderly in Atlanta, Georgia.

Abstract：

BACKGROUND:Health risks differ by fine particle (aerodynamic diameter ≤ 2.5 μm) component, although with substantial variability. Traditional methods to assess component-specific risks are limited, suggesting the need for alternative methods. OBJECTIVES:We examined whether the odds of daily hospital admissions differ by pollutant chemical properties. METHODS:We categorized pollutants by chemical properties and examined their impacts on the odds of daily hospital admissions among Medicare recipients > 64 years of age in counties in Atlanta, Georgia, for 1998-2006. We analyzed data in two stages. In the first stage we applied a case-crossover analysis to simultaneously estimate effects of 65 pollutants measured in the Aerosol Research and Inhalation Epidemiology Study on cause-specific hospital admissions, controlling for temperature and ozone. In the second stage, we regressed pollutant-specific slopes from the first stage on pollutant properties. We calculated uncertainty estimates using a bootstrap procedure. We repeated the two-stage analyses using coefficients from first-stage models that included single pollutants plus ozone and meteorological variables only. We based our primary analyses on exposures on day of admission. RESULTS:We found that 24-hr transition metals and alkanes were associated with increased odds [0.26%; 95% confidence interval (CI), 0.02-0.48; and 0.37%; 95% CI, 0.04-0.72, respectively] of hospital admissions for cardiovascular disease (CVD). Transition metals were significantly associated with increased hospital admissions for ischemic heart disease, congestive heart failure, and atrial fibrillation. Increased respiratory-related hospital admissions were significantly associated with alkanes. Aromatics and microcrystalline oxides were significantly associated with decreased CVD- and respiratory-related hospital admissions. CONCLUSIONS:The two-stage approach showed transition metals to be consistently associated with increased odds of CVD-related hospital admissions.

journal_name

Environ Health Perspect

journal_title

Environmental health perspectives

authors

Suh HH,Zanobetti A,Schwartz J,Coull BA

doi

10.1289/ehp.1002646

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

1421-8

issue

eissn

0091-6765

issn

1552-9924

journal_volume

119

pub_type

杂志文章

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Chemical properties of air pollutants and cause-specific hospital admissions among the elderly in Atlanta, Georgia.