Some observations on the interaction of zinc, copper, and iron metabolism in lead and cadmium toxicity.

abstract：BACKGROUND:Chronic exposure to well water arsenic (As) remains a major rural health challenge in Bangladesh and some other developing countries. Many mitigation programs have been implemented to reduce As exposure, although evaluation studies for these efforts are rare in the literature. OBJECTIVES:In this study we es...

journal_title：Environmental health perspectives

authors： Khan K,Ahmed E,Factor-Litvak P,Liu X,Siddique AB,Wasserman GA,Slavkovich V,Levy D,Mey JL,van Geen A,Graziano JH

更新日期：2015-12-01 00:00:00

abstract：:Epidemiologic studies report associations between particulate air pollution and cardiopulmonary morbidity and mortality. Although the underlying pathophysiologic mechanisms remain unclear, it has been hypothesized that altered autonomic function and pulmonary/systemic inflammation may play a role. In this study we exp...

journal_title：Environmental health perspectives

authors： Pope CA 3rd,Hansen ML,Long RW,Nielsen KR,Eatough NL,Wilson WE,Eatough DJ

更新日期：2004-03-01 00:00:00

abstract：:Occupational cancer research methods was identified in 1996 as 1 of 21 priority research areas in the National Occupational Research Agenda (NORA). To implement NORA, teams of experts from various sectors were formed and given the charge to further define research needs and develop strategies to enhance or augment res...

journal_title：Environmental health perspectives

authors： Ward EM,Schulte PA,Bayard S,Blair A,Brandt-Rauf P,Butler MA,Dankovic D,Hubbs AF,Jones C,Karstadt M,Kedderis GL,Melnick R,Redlich CA,Rothman N,Savage RE,Sprinker M,Toraason M,Weston A,Olshan AF,Stewart P,Zahm SH,

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Previous studies have examined fine particulate matter (≤ 2.5 μm; PM2.5) and preterm birth, but there is a dearth of longitudinal studies on this topic and a paucity of studies that have investigated specific sources of this exposure. OBJECTIVES:Our aim was to assess whether anthropogenic sources are associ...

journal_title：Environmental health perspectives

authors： Pereira G,Bell ML,Lee HJ,Koutrakis P,Belanger K

更新日期：2014-10-01 00:00:00

abstract：:The role of the physical environment as a determinant of health is a major concern reported by the general public as well as by many policymakers. However, it remains one of the health determinants for which few available measures or indicators are readily available. This lack of data is compounded by the fact that ev...

journal_title：Environmental health perspectives

authors： Elliott SJ,Eyles J,DeLuca P

更新日期：2001-12-01 00:00:00

abstract：:The ability of questionnaires to predict children's exposure to pesticides was examined as part of the Minnesota Children's Pesticide Exposure Study (MNCPES). The MNCPES focused on a probability sample of 102 children between the ages of 3 and 13 years living in either urban (Minneapolis and St. Paul, MN) or nonurban ...

journal_title：Environmental health perspectives

authors： Sexton K,Adgate JL,Eberly LE,Clayton CA,Whitmore RW,Pellizzari ED,Lioy PJ,Quackenboss JJ

更新日期：2003-01-01 00:00:00

abstract：:Lipocortins are structurally related, glucocorticoid-inducible proteins that inhibit phospholipase A2 (PLA2), thereby reducing the liberation of arachidonic acid from phospholipids and so limiting the synthesis of eicosanoid inflammatory mediators. This study is the first demonstration of one lipocortin, lipocortin 1 ...

journal_title：Environmental health perspectives

authors： Smith SF,Tetley TD,Guz A,Flower RJ

更新日期：1990-04-01 00:00:00

abstract：:This paper summarizes the clinical phenomenology of multiple chemical sensitivity (MCS), outlines the concepts and evidence for the olfactory-limbic, neural sensitization model for MCS, and discusses experimental design implications of the model for exposure-related research. Neural sensitization is the progressive am...

journal_title：Environmental health perspectives

authors： Bell IR,Schwartz GE,Baldwin CM,Hardin EE,Klimas NG,Kline JP,Patarca R,Song ZY

更新日期：1997-03-01 00:00:00

abstract：:Because of their history of widespread use in the United States and unknown long-term health effects, organophosphate pesticides (OPs) are being considered as a chemical class of interest in planning for the National Children's Study, a longitudinal study of children's environmental health. The availability and approp...

journal_title：Environmental health perspectives

authors： Wessels D,Barr DB,Mendola P

更新日期：2003-12-01 00:00:00

abstract：:Lead encephalopathy was induced in developing Long-Evans rats by adding lead carbonate (4% w/w) to the diet of nursing mother immediately after delivery. The morphological and biochemical features of cerebral ontogenesis were studied in 30-day-old rats. By the 30th postnatal day, the overall effect of lead intoxicatio...

journal_title：Environmental health perspectives

authors： Krigman MR,Hogan EL

更新日期：1974-05-01 00:00:00

abstract：:We developed a sensitive and accurate analytical method for quantifying methyleugenol (ME) in human serum. Our method uses a simple solid-phase extraction followed by a highly specific analysis using isotope dilution gas chromatography-high resolution mass spectrometry. Our method is very accurate; its limit of detect...

journal_title：Environmental health perspectives

authors： Barr DB,Barr JR,Bailey SL,Lapeza CR Jr,Beeson MD,Caudill SP,Maggio VL,Schecter A,Masten SA,Lucier GW,Needham LL,Sampson EJ

更新日期：2000-04-01 00:00:00

abstract：:In this article we report a simple and efficient method for detecting nonsteroidal estrogens in a biologic sample. This method uses polyclonal antibodies to estradiol (E2) to immunoprecipitate these major biologically active steroidal estrogens, leaving behind the nonsteroidal estrogens, which are then detected in a c...

journal_title：Environmental health perspectives

authors： Natarajan K,Overstreet JW,Rogers JM,Denison MS,Chen J,Lohstroh PN,McConnell DS,Lasley BL

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:Exposure to organophosphate (OP) pesticides is an occupational hazard for farmworkers and affects their children through the take-home pathway. OBJECTIVES:We examined the effectiveness of a randomized community intervention to reduce pesticide exposure among farmworkers and their children. METHODS:We condu...

journal_title：Environmental health perspectives

authors： Thompson B,Coronado GD,Vigoren EM,Griffith WC,Fenske RA,Kissel JC,Shirai JH,Faustman EM

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Exposures to high-dose ionizing radiation and high-dose rate ionizing radiation are established risk factors for childhood acute leukemia (AL). The risk of AL following exposure to lower doses due to natural background radiation (NBR) has yet to be conclusively determined. METHODS:AL cases diagnosed over 19...

journal_title：Environmental health perspectives

authors： Demoury C,Marquant F,Ielsch G,Goujon S,Debayle C,Faure L,Coste A,Laurent O,Guillevic J,Laurier D,Hémon D,Clavel J

更新日期：2017-04-01 00:00:00

abstract：:Groups of female SENCAR or BALB/c mice were initiated once intraperitoneally with 300 micrograms/mouse of 7,12-dimethylbenz(a)anthracene (DMBA) or 20 mg/mouse of urethane at 7 weeks of age. Beginning one week later, mice received topically applied acetone or 12-O-tetradecanoylphorbol-13-acetate (TPA), once weekly, at ...

journal_title：Environmental health perspectives

authors： Ward JM,Rehm S,Devor D,Hennings H,Wenk ML

更新日期：1986-09-01 00:00:00

abstract：BACKGROUND:In an effort to decrease the rates of smoking conventional tobacco cigarettes, electronic cigarettes (e-cigarettes) have been proposed as an effective smoking cessation tool. However, little is known about their toxicological impacts. This is concerning given that e-cigarette use is perceived as less harmful...

journal_title：Environmental health perspectives

authors： Church JS,Chace-Donahue F,Blum JL,Ratner JR,Zelikoff JT,Schwartzer JJ

更新日期：2020-04-01 00:00:00

abstract：:Haloalkane toxicity originates from attack on biological targets by reactive intermediates derived from haloalkane metabolism by a hemoprotein, cytochrome P-450. Carbon-centered radicals and their peroxyl derivatives are most likely involved. The reactions of iron porphyrin--a model for cytochrome P-450--with various ...

journal_title：Environmental health perspectives

authors： Brault D

更新日期：1985-12-01 00:00:00

abstract：:Consideration of needs for public health interventions and new research requires comparative assessments of the health benefits that are likely to result from alternative uses of limited regulatory and technical resources. This paper briefly examines regulatory and research priorities in the light of recent informatio...

journal_title：Environmental health perspectives

authors： Hattis D

更新日期：1981-10-01 00:00:00

abstract：BACKGROUND:Understanding the potential links between extreme weather events and human health in India is important in the context of vulnerability and adaptation to climate change. Research exploring such linkages in India is sparse. OBJECTIVES:We evaluated the association between extreme precipitation and gastrointes...

journal_title：Environmental health perspectives

authors： Bush KF,O'Neill MS,Li S,Mukherjee B,Hu H,Ghosh S,Balakrishnan K

更新日期：2014-03-01 00:00:00

abstract：:Previous investigations suggest that dietary sources of polycyclic aromatic hydrocarbons (PAHs) contribute to the PAH-DNA adduct load in peripheral white blood cells (WBCs). In the current study, we measured PAH-DNA adducts by enzyme-linked immunosorbent assay in WBCs obtained from 47 California wildland (forest) fire...

journal_title：Environmental health perspectives

authors： Rothman N,Poirier MC,Haas RA,Correa-Villasenor A,Ford P,Hansen JA,O'Toole T,Strickland PT

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:Lead (Pb) exposure has been associated with a host of pathological conditions in humans. In rodents Pb exposure has been shown to alter the hypothalamic-pituitary-adrenal (HPA) axis function. OBJECTIVE:We investigated the effects of lead on responses of the HPA axis to a psychosocial laboratory stressor adm...

journal_title：Environmental health perspectives

authors： Fortin MC,Cory-Slechta DA,Ohman-Strickland P,Nwankwo C,Yanger TS,Todd AC,Moynihan J,Walton J,Brooks A,Fiedler N

更新日期：2012-02-01 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) are persistent pollutants that are ubiquitous in the food chain, and detectable amounts are in the blood of almost every person in most populations that have been examined. Extensive evidence from animal studies shows that PCBs are neurotoxins, even at low doses. Interpretation of huma...

journal_title：Environmental health perspectives

authors： Longnecker MP,Wolff MS,Gladen BC,Brock JW,Grandjean P,Jacobson JL,Korrick SA,Rogan WJ,Weisglas-Kuperus N,Hertz-Picciotto I,Ayotte P,Stewart P,Winneke G,Charles MJ,Jacobson SW,Dewailly E,Boersma ER,Altshul LM,Heinzow B

更新日期：2003-01-01 00:00:00

abstract：:Human exposure to carcinogenic Cr(VI) compounds is found among workers in a large number of professional groups, and it can also occur through environmental pollution. A significant number of toxic waste sites contain Cr as a major contaminant. In this paper we summarize our efforts to apply measurements of DNA-protei...

journal_title：Environmental health perspectives

authors： Zhitkovich A,Voitkun V,Kluz T,Costa M

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:Because of complex interactions of climate variables at the levels of the pathogen, vector, and host, the potential influence of climate change on vector-borne and zoonotic diseases (VBZDs) is poorly understood and difficult to predict. Climate effects on the nonvector-borne zoonotic diseases are especially ...

journal_title：Environmental health perspectives

authors： Mills JN,Gage KL,Khan AS

更新日期：2010-11-01 00:00:00

abstract：:Congress has demonstrated interest in toxic compensation legislation, but not enough agreement to make significant progress. Advocates of reform claim that the legal system is heavily weighed against victims who seek compensation through the courts. Proposed reforms include a compensation fund and a cause of action in...

journal_title：Environmental health perspectives

authors： Anderson RC

更新日期：1985-10-01 00:00:00

abstract：BACKGROUND:The impact of prenatal lead exposure on neurodevelopment remains unclear in terms of consistency, the trimester of greatest vulnerability, and the best method for estimating fetal lead exposure. OBJECTIVE:We studied prenatal lead exposure's impact on neurodevelopment using repeated measures of fetal dose as...

journal_title：Environmental health perspectives

authors： Hu H,Téllez-Rojo MM,Bellinger D,Smith D,Ettinger AS,Lamadrid-Figueroa H,Schwartz J,Schnaas L,Mercado-García A,Hernández-Avila M

更新日期：2006-11-01 00:00:00

abstract：:Techniques are available to minimize the concentration of asbestos fibers in drinking water. Filtration research conducted at locations on Lake Superior and in the Cascade Mountains in Washington has shown that amphibole and chrysotile fibers can be removed by granular media filtration. Removal percentages can exceed ...

journal_title：Environmental health perspectives

authors： Logsdon GS

更新日期：1983-11-01 00:00:00

abstract：:In vitro liver preparations are increasingly used for the study of hepatotoxicity of chemicals. In recent years their actual advantages and limitations have been better defined. The cell models, slices, and mainly primary hepatocyte cultures, appear to be the most powerful in vitro systems, as liver-specific functions...

journal_title：Environmental health perspectives

authors： Guillouzo A

更新日期：1998-04-01 00:00:00

abstract：:To set occupational exposure limits (OELs) for aerosol particles, dusts, or chemicals, one has to evaluate whether mechanistic considerations permit identification of a no observed effect level (NOEL). In the case of carcinogenic effects, this can be assumed if no genotoxicity is involved, and exposure is considered s...

journal_title：Environmental health perspectives

authors： Greim HA,Ziegler-Skylakakis K

更新日期：1997-09-01 00:00:00

abstract：:Metals have been mined and used since ancient times. The industrial era has seen a sharp increase in both the amounts and variety of metals that find applications in industry. The inadvertent release of metals, such as from fossil fuel consumption, also adds to the global burden. A number of catastrophic outbreaks hav...

journal_title：Environmental health perspectives

authors： Clarkson T

更新日期：1995-02-01 00:00:00