Associations between extreme precipitation and gastrointestinal-related hospital admissions in Chennai, India.

Abstract:

BACKGROUND:Understanding the potential links between extreme weather events and human health in India is important in the context of vulnerability and adaptation to climate change. Research exploring such linkages in India is sparse. OBJECTIVES:We evaluated the association between extreme precipitation and gastrointestinal (GI) illness-related hospital admissions in Chennai, India, from 2004 to 2007. METHODS:Daily hospital admissions were extracted from two government hospitals in Chennai, India, and meteorological data were retrieved from the Chennai International Airport. We evaluated the association between extreme precipitation (≥ 90th percentile) and hospital admissions using generalized additive models. Both single-day and distributed lag models were explored over a 15-day period, controlling for apparent temperature, day of week, and long-term time trends. We used a stratified analysis to explore the association across age and season. RESULTS:Extreme precipitation was consistently associated with GI-related hospital admissions. The cumulative summary of risk ratios estimated for a 15-day period corresponding to an extreme event (relative to no precipitation) was 1.60 (95% CI: 1.29, 1.98) among all ages, 2.72 (95% CI: 1.25, 5.92) among the young (≤ 5 years of age), and 1.62 (95% CI: 0.97, 2.70) among the old (≥ 65 years of age). The association was stronger during the pre-monsoon season (March-May), with a cumulative risk ratio of 6.50 (95% CI: 2.22, 19.04) for all ages combined compared with other seasons. CONCLUSIONS:Hospital admissions related to GI illness were positively associated with extreme precipitation in Chennai, India, with positive cumulative risk ratios for a 15-day period following an extreme event in all age groups. Projected changes in precipitation and extreme weather events suggest that climate change will have important implications for human health in India, where health disparities already exist. CITATION:Bush KF, O'Neill MS, Li S, Mukherjee B, Hu H, Ghosh S, Balakrishnan K. 2014. Associations between extreme precipitation and gastrointestinal-related hospital admissions in Chennai, India. Environ Health Perspect 122:249-254; http://dx.doi.org/10.1289/ehp.1306807.

authors

Bush KF,O'Neill MS,Li S,Mukherjee B,Hu H,Ghosh S,Balakrishnan K

doi

10.1289/ehp.1306807

subject

Has Abstract

pub_date

2014-03-01 00:00:00

pages

249-54

issue

3

eissn

0091-6765

issn

1552-9924

journal_volume

122

pub_type

杂志文章
  • Effects of long-term nitrogen dioxide exposure on rat lung: morphological observations.

    abstract::Rats continuously exposed to NO2 at 0.04, 0.4, and 4.0 ppm for as long as 27 months were submitted to morphological observation and electronmicroscopic morphometry of the lung. At 4 ppm exposure for 9 months, bronchial epithelium showed typical proliferation, which progressed further at 18 months. At this stage, proli...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8773157

    authors: Kubota K,Murakami M,Takenaka S,Kawai K,Kyono H

    更新日期:1987-08-01 00:00:00

  • Hemopoietic stem cells: stochastic differentiation and humoral control of proliferation.

    abstract::The central feature of hemopoiesis is life-long, stable cell renewal. This process is supported by hemopoietic stem cells which, in the steady state, appear to be dormant in cell cycling. The entry into cell cycle of the dormant stem cells may be promoted by such factors as interleukin-1, interleukin-6 (IL-6), and gra...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.8980199

    authors: Ogawa M

    更新日期:1989-03-01 00:00:00

  • Alpha-1 antitrypsin deficiency is not a rare disease but a disease that is rarely diagnosed.

    abstract::Articles in the literature on alpha-1 antitrypsin (AAT) deficiency have been interpreted as indicating that AAT deficiency is a rare disease that affects mainly Caucasians (whites) from northern Europe. In a recent publication on the worldwide racial and ethnic distribution of AAT deficiency, new data were presented d...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.6511

    authors: de Serres FJ

    更新日期:2003-12-01 00:00:00

  • Green turtle fibropapillomatosis: challenges to assessing the role of environmental cofactors.

    abstract::Green turtle fibropapillomatosis (GTFP) is a growing threat to the survival of green turtle (Chelonia mydas) populations worldwide. Recent transmission studies point to an infectious etiology. Several field studies suggest that high GTFP prevalence is associated with marine habitats that have been impacted by agricult...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.95103s427

    authors: Herbst LH,Klein PA

    更新日期:1995-05-01 00:00:00

  • Follow-up study of adolescents exposed to di(2-ethylhexyl) phthalate (DEHP) as neonates on extracorporeal membrane oxygenation (ECMO) support.

    abstract::Di(2-ethylhexyl) phthalate (DEHP) is used to make polyvinyl chloride (PVC) plastic tubing soft and flexible. Animal data show that adverse effects of DEHP exposure may include reduced fertility, reduced sperm production in males, and ovarian dysfunction in females. Known treatments that involve high DEHP exposures are...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.6901

    authors: Rais-Bahrami K,Nunez S,Revenis ME,Luban NL,Short BL

    更新日期:2004-09-01 00:00:00

  • Chronic cadmium exposure in vitro causes acquisition of multiple tumor cell characteristics in human pancreatic epithelial cells.

    abstract:BACKGROUND:Cancer may be a stem cell (SC)-based disease involving formation of cancer SCs (CSCs) potentially arising from transformation of normal SCs. Cadmium has been linked to human pancreatic cancer. OBJECTIVE:We studied cadmium exposure of human pancreatic ductal epithelial (HPDE) cells and whether SCs may be tar...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1205082

    authors: Qu W,Tokar EJ,Kim AJ,Bell MW,Waalkes MP

    更新日期:2012-09-01 00:00:00

  • Exposure to regular gasoline and ethanol oxyfuel during refueling in Alaska.

    abstract::Although most people are thought to receive their highest acute exposures to gasoline while refueling, relatively little is actually known about personal, nonoccupational exposures to gasoline during refueling activities. This study was designed to measure exposures associated with the use of an oxygenated fuel under ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.97105850

    authors: Backer LC,Egeland GM,Ashley DL,Lawryk NJ,Weisel CP,White MC,Bundy T,Shortt E,Middaugh JP

    更新日期:1997-08-01 00:00:00

  • Road Traffic Noise Exposure and Filled Prescriptions for Antihypertensive Medication: A Danish Cohort Study.

    abstract:BACKGROUND:Epidemiological research on effects of transportation noise on incident hypertension is inconsistent. OBJECTIVES:We aimed to investigate whether residential road traffic noise increases the risk for hypertension. METHODS:In a population-based cohort of 57,053 individuals 50-64 years of age at enrollment, w...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP6273

    authors: Thacher JD,Poulsen AH,Roswall N,Hvidtfeldt U,Raaschou-Nielsen O,Jensen SS,Ketzel M,Brandt J,Overvad K,Tjønneland A,Münzel T,Sørensen M

    更新日期:2020-05-01 00:00:00

  • Selective retention of hydroxylated PCB metabolites in blood.

    abstract::Polychlorinated biphenyls (PCBs) are important environmental contaminants, and their toxicity to wildlife and humans are of major concern. PCBs form persistent and abundant metabolites, PCB methyl sulfones, that accumulate in biota. We now report that certain hydroxylated PCB metabolites show a strong and selective ac...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.94102464

    authors: Bergman A,Klasson-Wehler E,Kuroki H

    更新日期:1994-05-01 00:00:00

  • Anogenital distance and penile length in infants with hypospadias or cryptorchidism: comparison with normative data.

    abstract:BACKGROUND:Anogenital distance (AGD) in animals is a sensitive biomarker of fetal endocrine disruption and the associated testicular dysgenesis syndrome (TDS). However, AGD in human infants with cryptorchidism and hypospadias, which are potential manifestations of TDS during childhood, is not clearly described. OBJECT...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1307178

    authors: Thankamony A,Lek N,Carroll D,Williams M,Dunger DB,Acerini CL,Ong KK,Hughes IA

    更新日期:2014-02-01 00:00:00

  • The role of the Thomsen-Friedenreich antigen as a tumor-associated molecule.

    abstract::The Thomsen-Friedenreich antigen (Gal-GalNAc) represents a tumor-associated molecule, which is assumed to be one of the few chemically well-defined antigens with a proven association with malignancy. In order to analyze the role of the carbohydrate structure Gal-GalNAc for gastrointestinal tumors, we immunized Balb/c ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.9088255

    authors: Dippold W,Steinborn A,Meyer zum Büschenfelde KH

    更新日期:1990-08-01 00:00:00

  • Concepts, labeling procedures, and design of cell proliferation studies relating to carcinogenesis.

    abstract::Chemicals may induce cell proliferation directly as mitogens or indirectly via cell death with subsequent proliferation to replace lost cells. Chemically induced proliferation has been demonstrated to play a role in the carcinogenic process. A wide range of procedures and techniques are currently being used to define ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.93101s559

    authors: Goldsworthy TL,Butterworth BE,Maronpot RR

    更新日期:1993-12-01 00:00:00

  • Prenatal Exposure to Glycol Ethers and Neurocognitive Abilities in 6-Year-Old Children: The PELAGIE Cohort Study.

    abstract:BACKGROUND:Glycol ethers (GE) are widely used organic solvents. Despite the potential neurotoxicity of several families of organic solvents, little is known about the impact of GE on the neurodevelopment of infants and children. OBJECTIVES:We investigated the relation between urinary concentrations of GE metabolites i...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP39

    authors: Béranger R,Garlantézec R,Le Maner-Idrissi G,Lacroix A,Rouget F,Trowbridge J,Warembourg C,Monfort C,Le Gléau F,Jourdin M,Multigner L,Cordier S,Chevrier C

    更新日期:2017-04-01 00:00:00

  • p53 Plays an important role in cell fate determination after exposure to microcystin-LR.

    abstract:BACKGROUND:Microcystin-LR, a cyclic heptapeptide, possesses the ability to inhibit the serine/threonine protein phosphatases PP1 and PP2A and, consequently, exhibits acute hepatocytotoxicity. Moreover, microcystin-LR induces cellular proliferation, resulting in tumor-promoting activity in hepatocytes. However, mechanis...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1001899

    authors: Takumi S,Komatsu M,Furukawa T,Ikeda R,Sumizawa T,Akenaga H,Maeda Y,Aoyama K,Arizono K,Ando S,Takeuchi T

    更新日期:2010-09-01 00:00:00

  • Isothiocyanates reduce mercury accumulation via an Nrf2-dependent mechanism during exposure of mice to methylmercury.

    abstract:BACKGROUND:Methylmercury (MeHg) exhibits neurotoxicity through accumulation in the brain. The transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) plays an important role in reducing the cellular accumulation of MeHg. OBJECTIVES:We investigated the protective effect of isothiocyanates, which are kno...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1003123

    authors: Toyama T,Shinkai Y,Yasutake A,Uchida K,Yamamoto M,Kumagai Y

    更新日期:2011-08-01 00:00:00

  • Prediction and assessment of the effects of mixtures of four xenoestrogens.

    abstract::The assessment of mixture effects of estrogenic agents is regarded as an issue of high priority by many governmental agencies and expert decision-making bodies all over the world. However, the few mixture studies published so far have suffered from conceptual and experimental problems and are considered to be inconclu...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.00108983

    authors: Payne J,Rajapakse N,Wilkins M,Kortenkamp A

    更新日期:2000-10-01 00:00:00

  • Sequence specificity of mutagenesis in the cI gene of bacteriophage lambda.

    abstract::Studies of DNA base sequence alterations have shown that for every agent the mutagenic process is specific with respect to the types of base changes induced and the location of the changes in the DNA. Analysis of the types of mutations produced by mutagenic agents can provide insight into the mechanism of mutation and...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8562157

    authors: Skopek TR,Wood RD,Hutchinson F

    更新日期:1985-10-01 00:00:00

  • Clues from wildlife to create an assay for thyroid system disruption.

    abstract::In 1996 the U.S. Congress charged the U.S. Environmental Protection Agency to develop a screening program to test chemicals for their possible estrogenic and other endocrine effects. Shortly thereafter, the Chemical Guidelines Program of the Organisation for Economic Co-operation and Development's (OECD) Environmental...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.02110s3363

    authors: Colborn T

    更新日期:2002-06-01 00:00:00

  • Association between Early Life Exposure to Air Pollution and Working Memory and Attention.

    abstract:BACKGROUND:Although previous studies have reported negative associations between exposure to air pollution and cognition, studies of the effects of prenatal and postnatal exposures in early childhood have been limited. OBJECTIVES:We sought to assess the role exposure to fine particulate matter ([Formula: see text]) du...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP3169

    authors: Rivas I,Basagaña X,Cirach M,López-Vicente M,Suades-González E,Garcia-Esteban R,Álvarez-Pedrerol M,Dadvand P,Sunyer J

    更新日期:2019-05-01 00:00:00

  • Workshop to identify critical windows of exposure for children's health: reproductive health in children and adolescents work group summary.

    abstract::This work group report addresses the central question: What are the critical windows during development (preconception through puberty) when exposure to xenobiotics may have the greatest adverse impact on subsequent reproductive health? The reproductive system develops in stages, with sex-specific organogenesis occurr...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.00108s3505

    authors: Lemasters GK,Perreault SD,Hales BF,Hatch M,Hirshfield AN,Hughes CL,Kimmel GL,Lamb JC,Pryor JL,Rubin C,Seed JG

    更新日期:2000-06-01 00:00:00

  • Occurrence of cadmium in crabs (Cancer pagurus) and the isolation and properties of cadmium metallothionein.

    abstract::The occurrence of high cadmium levels in the digestive gland (hepatopancreas) of the crab Cancer pagurus is reviewed and its possible significance to human health is discussed. Previous attempts to isolate this cadmium in its native form are briefly reviewed and the present method used in this laboratory to isolate cr...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8665101

    authors: Overnell J

    更新日期:1986-03-01 00:00:00

  • Long-term exposure to environmental concentrations of the pharmaceutical ethynylestradiol causes reproductive failure in fish.

    abstract::Heightened concern over endocrine-disrupting chemicals is driven by the hypothesis that they could reduce reproductive success and affect wildlife populations, but there is little evidence for this expectation. The pharmaceutical ethynylestradiol (EE2) is a potent endocrine modulator and is present in the aquatic envi...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.7209

    authors: Nash JP,Kime DE,Van der Ven LT,Wester PW,Brion F,Maack G,Stahlschmidt-Allner P,Tyler CR

    更新日期:2004-12-01 00:00:00

  • DNA adducts in peripheral blood lymphocytes from aluminum production plant workers determined by 32P-postlabeling and enzyme-linked immunosorbent assay.

    abstract::32P-Postlabeling analysis and enzyme-linked immunosorbent assay (ELISA) have been used to detect DNA adducts in peripheral blood lymphocytes from primary aluminum production plant workers who were exposed occupationally to a mixture of polycyclic aromatic hydrocarbons (PAHs). Preliminary results reported here are from...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.9399307

    authors: Schoket B,Phillips DH,Poirier MC,Vincze I

    更新日期:1993-03-01 00:00:00

  • Comparison of gas-phase free-radical populations in tobacco smoke and model systems by HPLC.

    abstract::We used an improved method for trapping carbon-centered radicals (.R) from the gas-phase to compare radical suites trapped from various tobacco smoke and model smoke systems. Using a nitroxide trap, 3-amino-2,2,5,5-tetramethyl-1-pyrrolidinyloxy (3AP), on solid support, we trapped radicals directly from the gas phase, ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.01109765

    authors: Flicker TM,Green SA

    更新日期:2001-08-01 00:00:00

  • The intersection of risk assessment and neurobehavioral toxicity.

    abstract::Neurobehavioral toxicology is now established as a core discipline of the environmental health sciences. Despite its recognized scientific prowess, stemming from its deep roots in psychology and neuroscience and its acknowledged successes, it faces additional demands and challenges. The latter, in fact, are a product ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.96104s2173

    authors: Weiss B,Elsner J

    更新日期:1996-04-01 00:00:00

  • The role of airway mucus in pulmonary toxicology.

    abstract::Airway mucus is a complex airway secretion whose primary function as part of the mucociliary transport mechanism is to to serve as renewable and transportable barrier against inhaled particulates and toxic agents. The rheologic properties necessary for this function are imparted by glycoproteins, or mucins. Some respi...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.9410289

    authors: Samet JM,Cheng PW

    更新日期:1994-06-01 00:00:00

  • Interaction of asbestos with metaplastic squamous epithelium developing in organ cultures of hamster trachea.

    abstract::The normal mucociliary epithelium of the respiratory tract in chronic cigarette smokers often is replaced focally by a metaplastic squamous epithelium. Because asbestos workers who smoke have a substantially greater risk of bronchogenic carcinoma than nonsmokers, we hypothesized that interaction of asbestos with squam...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.835127

    authors: Woodworth CD,Mossman BT,Craighead JE

    更新日期:1983-09-01 00:00:00

  • Mutagenicity of halogenated alkanes and their derivatives.

    abstract::The ability of a series of haloalkanes, haloethanols and haloacetaldehydes to induce mutations in Salmonella typhrimurium and preferentially to inhibit the growth of DNA polymerase-deficient E. coli (pol A(+)/pol A(-)) was investigated. For the haloalkanes investigated, the order of reactivities towards the E. coli po...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.772179

    authors: Rosenkranz HS

    更新日期:1977-12-01 00:00:00

  • Effects of lead on the kidney: roles of high-affinity lead-binding proteins.

    abstract::Lead-induced nephropathy produces both tubular and interstitial manifestations of cell injury, but the pathophysiology of these lesions is not completely understood. Delineation of the molecular factors underlying renal handling of lead is one of central importance in understanding the mechanisms of renal cell injury ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.919177

    authors: Fowler BA,DuVal G

    更新日期:1991-02-01 00:00:00

  • Role of ozone and granular activated carbon in the removal of mutagenic compounds.

    abstract::The identification of certain organic compounds in drinking water has led water treatment specialists to be increasingly concerned about the eventual risks of such pollutants to the health of consumers. Our experiments focused on the role of ozone and granular activated carbon in removing mutagenic compounds and precu...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8669159

    authors: Bourbigot MM,Hascoet MC,Levi Y,Erb F,Pommery N

    更新日期:1986-11-01 00:00:00