Levels of methyleugenol in a subset of adults in the general U.S. population as determined by high resolution mass spectrometry.

Abstract:

:We developed a sensitive and accurate analytical method for quantifying methyleugenol (ME) in human serum. Our method uses a simple solid-phase extraction followed by a highly specific analysis using isotope dilution gas chromatography-high resolution mass spectrometry. Our method is very accurate; its limit of detection is 3.1 pg/g and its average coefficient of variation is 14% over a 200-pg/g range. We applied this method to measure serum ME concentrations in adults in the general U.S. population. ME was detected in 98% of our samples, with a mean ME concentration of 24 pg/g (range < 3.1-390 pg/g). Lipid adjustment of the data did not alter the distribution. Bivariate and multivariate analyses using selected demographic variables showed only marginal relationships between race/ethnicity and sex/fasting status with serum ME concentrations. Although no demographic variable was a good predictor of ME exposure or dose, our data indicate prevalent exposure of U.S. adults to ME. Detailed pharmacokinetic studies are required to determine the relationship between ME intake and human serum ME concentrations.

authors

Barr DB,Barr JR,Bailey SL,Lapeza CR Jr,Beeson MD,Caudill SP,Maggio VL,Schecter A,Masten SA,Lucier GW,Needham LL,Sampson EJ

doi

10.1289/ehp.00108323

subject

Has Abstract

pub_date

2000-04-01 00:00:00

pages

323-8

issue

4

eissn

0091-6765

issn

1552-9924

pii

sc271_5_1835

journal_volume

108

pub_type

杂志文章
  • Plasma microRNA expression and micronuclei frequency in workers exposed to polycyclic aromatic hydrocarbons.

    abstract:BACKGROUND:Ubiquitous polycyclic aromatic hydrocarbons (PAHs) have been shown to alter gene expression patterns and elevate micronuclei (MN) frequency, but the underlying mechanisms are largely unknown. MicroRNAs (miRNAs) are key gene regulators that may be influenced by PAH exposures and mediate their effects on MN fr...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1307080

    authors: Deng Q,Huang S,Zhang X,Zhang W,Feng J,Wang T,Hu D,Guan L,Li J,Dai X,Deng H,Zhang X,Wu T

    更新日期:2014-07-01 00:00:00

  • Chrysotile biopersistence in the lungs of persons in the general population and exposed workers.

    abstract::Lung burden analysis was performed on 126 autopsy cases of persons who died in New York City from 1966 through 1968. Of the 126 cases, 107 were probably non-occupationally exposed, judging by occupational history and asbestos body content of lung. Fifty-three of the 107 cases contained short chrysotile fibers/fibrils,...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.94102s5235

    authors: Langer AM,Nolan RP

    更新日期:1994-10-01 00:00:00

  • Epidemiological and experimental studies on the effects of methyl isocyanate on the course of pregnancy.

    abstract::Although press reports indicate that the leakage of methyl isocyanate (MIC) on December 3, 1984, in Bhopal has led to an increase in spontaneous abortions, stillbirths, infant mortality, and fetal abnormalities, no clinical or experimental studies on the reproductive toxicity of MIC were reported in scientific journal...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8772153

    authors: Varma DR

    更新日期:1987-06-01 00:00:00

  • Exposure to heterocyclic amines.

    abstract::Many mutagenic heterocyclic amines (HAs) have been isolated from cooked foods and pyrolysates of amino acids and proteins, and the carcinogenicity of 10 of these HAs in rodents and of 1 in monkeys has been reported. Quantification of these carcinogenic HAs in various kinds of cooked foods indicated that the level of 2...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.9399129

    authors: Wakabayashi K,Ushiyama H,Takahashi M,Nukaya H,Kim SB,Hirose M,Ochiai M,Sugimura T,Nagao M

    更新日期:1993-03-01 00:00:00

  • Children--unique and vulnerable. Environmental risks facing children and recommendations for response.

    abstract::Children may be more susceptible to exposures to environmental toxins than adults and may be more vulnerable to their effects. Because of this, the health care community and those responsible for children need to be alert to possible environmental factors in identifying and responding to the health problems of childre...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.95103s613

    authors: Goldman LR

    更新日期:1995-09-01 00:00:00

  • Three decades of silicosis: disease trends at autopsy in South African gold miners.

    abstract:BACKGROUND:Eliminating silicosis is a priority of the International Labour Organization and the World Health Organization. Prevalence is particularly high in developing countries. OBJECTIVES:We describe trends in silicosis among South African gold miners who had had an autopsy between 1975 and 2007 and quantify the co...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.0900918

    authors: Nelson G,Girdler-Brown B,Ndlovu N,Murray J

    更新日期:2010-03-01 00:00:00

  • Clues from wildlife to create an assay for thyroid system disruption.

    abstract::In 1996 the U.S. Congress charged the U.S. Environmental Protection Agency to develop a screening program to test chemicals for their possible estrogenic and other endocrine effects. Shortly thereafter, the Chemical Guidelines Program of the Organisation for Economic Co-operation and Development's (OECD) Environmental...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.02110s3363

    authors: Colborn T

    更新日期:2002-06-01 00:00:00

  • Prenatal Exposure to DDT and Pyrethroids for Malaria Control and Child Neurodevelopment: The VHEMBE Cohort, South Africa.

    abstract:BACKGROUND:Although indoor residual spraying (IRS) with dichlorodiphenyltrichloroethane (DDT) and pyrethroids effectively controls malaria, it potentially increases human exposure to these insecticides. Previous studies suggest that prenatal exposure to these insecticides may impact human neurodevelopment. OBJECTIVES:...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP2129

    authors: Eskenazi B,An S,Rauch SA,Coker ES,Maphula A,Obida M,Crause M,Kogut KR,Bornman R,Chevrier J

    更新日期:2018-04-06 00:00:00

  • Respiratory symptoms and annoyance in the vicinity of coal-fired plants.

    abstract::This study constitutes one part of a program for assessing the impact of coal-fired power plants on the surrounding communities. A questionnaire was mailed to a total of 12,000 subjects living in six areas with coal-fired plants and in matched reference areas. The participation rate was 77.3%. In one coal-fired plant/...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8670239

    authors: Pershagen G,Hammar N,Vartiainen E

    更新日期:1986-12-01 00:00:00

  • Indications of repair of radon-induced chromosome damage in human lymphocytes: an adaptive response induced by low doses of X-rays.

    abstract::Naturally occurring radon is a relatively ubiquitous environmental carcinogen to which large numbers of people can be exposed over their lifetimes. The accumulation of radon in homes, therefore, has led to a large program to determine the effects of the densely ionizing alpha particles that are produced when radon dec...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.93101s373

    authors: Wolff S,Afzal V,Jostes RF,Wiencke JK

    更新日期:1993-10-01 00:00:00

  • Chemical plants remain vulnerable to terrorists: a call to action.

    abstract::U.S. chemical plants currently have potentially catastrophic vulnerabilities as terrorist targets. The possible consequences of these vulnerabilities echo from the tragedies of the Bhopal incident in 1984 to the terrorist attacks on 11 September 2001 and, most recently, Hurricanes Katrina and Rita. Findings from a 200...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8762

    authors: Lippin TM,McQuiston TH,Bradley-Bull K,Burns-Johnson T,Cook L,Gill ML,Howard D,Seymour TA,Stephens D,Williams BK

    更新日期:2006-09-01 00:00:00

  • Long isoforms of NRF1 contribute to arsenic-induced antioxidant response in human keratinocytes.

    abstract:BACKGROUND:Human exposure to inorganic arsenic (iAs), a potent oxidative stressor, causes various dermal disorders, including hyperkeratosis and skin cancer. Nuclear factor-erythroid 2-related factor 1 (NRF1, also called NFE2L1) plays a critical role in regulating the expression of many antioxidant response element (AR...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1002304

    authors: Zhao R,Hou Y,Xue P,Woods CG,Fu J,Feng B,Guan D,Sun G,Chan JY,Waalkes MP,Andersen ME,Pi J

    更新日期:2011-01-01 00:00:00

  • Evaluation of serum immunoglobulins among individuals living near six Superfund sites.

    abstract::Residents living in communities near Superfund sites have expressed concern that releases from these facilities affect their health, including adverse effects on their immune systems. We used data from six cross-sectional studies to evaluate whether people who live near several Superfund sites are more likely to have ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8946

    authors: Williamson DM,White MC,Poole C,Kleinbaum D,Vogt R,North K

    更新日期:2006-07-01 00:00:00

  • Air pollution exposure and markers of placental growth and function: the generation R study.

    abstract:BACKGROUND:Air pollution exposure during pregnancy might affect placental growth and function, perhaps leading to pregnancy complications. OBJECTIVE:We prospectively evaluated the associations of maternal air pollution exposure with markers of placental growth and function among 7,801 pregnant women in the Netherlands...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1204918

    authors: van den Hooven EH,Pierik FH,de Kluizenaar Y,Hofman A,van Ratingen SW,Zandveld PY,Russcher H,Lindemans J,Miedema HM,Steegers EA,Jaddoe VW

    更新日期:2012-12-01 00:00:00

  • Impatiens pollen germination and tube growth as a bioassay for toxic substances.

    abstract::Pollen of Impatiens sultanii Hook F. germinates and forms tubes rapidly at 25 degrees C in a simple medium containing 111.0 ppm CaCl2, 13.6 ppm KH2PO4, and 1000 ppm boric acid. Calcium, potassium, and boron are essential for germination and tube growth, but sucrose is not required. Pollen tubes grow with equal rapidit...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.813795

    authors: Bilderback DE

    更新日期:1981-01-01 00:00:00

  • Early-life exposure to outdoor air pollution and respiratory health, ear infections, and eczema in infants from the INMA study.

    abstract:BACKGROUND:Prenatal and early-life periods may be critical windows for harmful effects of air pollution on infant health. OBJECTIVES:We studied the association of air pollution exposure during pregnancy and the first year of life with respiratory illnesses, ear infections, and eczema during the first 12-18 months of a...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1205281

    authors: Aguilera I,Pedersen M,Garcia-Esteban R,Ballester F,Basterrechea M,Esplugues A,Fernández-Somoano A,Lertxundi A,Tardón A,Sunyer J

    更新日期:2013-03-01 00:00:00

  • Hearing loss in workers exposed to toluene and noise.

    abstract::In this study we investigated the risk of hearing loss among workers exposed to both toluene and noise. We recruited 58 workers at an adhesive materials manufacturing plant who were exposured to both toluene and noise [78.6-87.1 A-weighted decibels; dB(A)], 58 workers exposed to noise only [83.5-90.1 dB(A)], and 58 ad...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8959

    authors: Chang SJ,Chen CJ,Lien CH,Sung FC

    更新日期:2006-08-01 00:00:00

  • Effect of methylene chloride inhalation on replicative DNA synthesis in the lungs of female B6C3F1 mice.

    abstract::In the National Toxicology Program 2-year inhalation study of dichloromethane (DCM), there was a significant increase in pulmonary neoplasms in female B6C3F1 mice exposed to 2000 ppm (overall rates of 30/48 versus 5/50 in control). Replicative DNA synthesis was examined to evaluate the potential role of treatment-indu...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.93101s5271

    authors: Kanno J,Foley JF,Kari F,Anderson MW,Maronpot RR

    更新日期:1993-12-01 00:00:00

  • Reaction products of chlorine dioxide.

    abstract::Inspection of the available literature reveals that a detailed investigation of the aqueous organic chemistry of chlorine dioxide and systematic identification of products formed during water disinfection has not been considered. This must be done before an informed assessment can be made of the relative safety of usi...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8246101

    authors: Stevens AA

    更新日期:1982-12-01 00:00:00

  • Effects of perinatal exposure to PCBs and dioxins on play behavior in Dutch children at school age.

    abstract::Polychlorinated biphenyls (PCBs) and dioxins are known as neurotoxic compounds that may modulate sex steroid hormones. Steroid hormones play a mediating role in brain development and may influence behaviors that show sex differences, such as childhood play behavior. In this study we evaluated the effects of perinatal ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.021100593

    authors: Vreugdenhil HJ,Slijper FM,Mulder PG,Weisglas-Kuperus N

    更新日期:2002-10-01 00:00:00

  • Prenatal Exposure to Glycol Ethers and Neurocognitive Abilities in 6-Year-Old Children: The PELAGIE Cohort Study.

    abstract:BACKGROUND:Glycol ethers (GE) are widely used organic solvents. Despite the potential neurotoxicity of several families of organic solvents, little is known about the impact of GE on the neurodevelopment of infants and children. OBJECTIVES:We investigated the relation between urinary concentrations of GE metabolites i...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP39

    authors: Béranger R,Garlantézec R,Le Maner-Idrissi G,Lacroix A,Rouget F,Trowbridge J,Warembourg C,Monfort C,Le Gléau F,Jourdin M,Multigner L,Cordier S,Chevrier C

    更新日期:2017-04-01 00:00:00

  • Differential Activation of a Mouse Estrogen Receptor β Isoform (mERβ2) with Endocrine-Disrupting Chemicals (EDCs).

    abstract:BACKGROUND:Endocrine-disrupting chemicals (EDCs) are suspected of altering estrogenic signaling through estrogen receptor (ER) α or β (mERβ1 in mice). Several EDC effects have been reported in animal studies and extrapolated to human studies. Unlike humans, rodents express a novel isoform of ERβ (mERβ2) with a modified...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP396

    authors: Donoghue LJ,Neufeld TI,Li Y,Arao Y,Coons LA,Korach KS

    更新日期:2017-04-01 00:00:00

  • Computer-assisted studies of molecular structure and genotoxic activity by pattern recognition techniques.

    abstract::Often a compound's biological activity is determined by complex relationships between its structural components. Such a relationship often can only be adequately described and exploited by multivariate structure-activity relationship (SAR) studies that can deal with many variables simultaneously. Pattern recognition (...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.8561329

    authors: Stouch TR,Jurs PC

    更新日期:1985-09-01 00:00:00

  • Maternal residence near agricultural pesticide applications and autism spectrum disorders among children in the California Central Valley.

    abstract:BACKGROUND:Ambient levels of pesticides ("pesticide drift") are detectable at residences near agricultural field sites. OBJECTIVE:Our goal was to evaluate the hypothesis that maternal residence near agricultural pesticide applications during key periods of gestation could be associated with the development of autism s...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.10168

    authors: Roberts EM,English PB,Grether JK,Windham GC,Somberg L,Wolff C

    更新日期:2007-10-01 00:00:00

  • Abstracts of the 26th Annual Conference of the International Society for Environmental Epidemiology (ISEE), 24-28 August 2014, Seattle, Washington.

    abstract::The 26th annual conference of the International Society for Environmental Epidemiology was held 24-28 August 2014 in Seattle, Washington. The conference theme was "From Local to Global: Advancing Science for Policy in Environmental Health." Sessions highlighted results assessing the burden of diseases from environment...

    journal_title:Environmental health perspectives

    pub_type:

    doi:10.1289/ehp.isee2014

    authors:

    更新日期:2014-10-30 00:00:00

  • Blood lead and blood pressure: some implications for the situation in The Netherlands.

    abstract::Studies performed earlier have shown a positive relation between blood lead (a parameter for lead body burden) and blood pressure, whereas such a relation between urine cadmium (a parameter for cadmium body burden) and blood pressure could not be shown. Median (i.e., 50th percentile, P50) blood levels in the general p...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.887867

    authors: de Kort WL,Zwennis WC

    更新日期:1988-06-01 00:00:00

  • Environmental fate and aquatic toxicology studies on phthalate esters.

    abstract::A comprehensive environmental fate and effects testing program, sponsored by the Chemical Manufacturers Association (CMA) Phthalate Esters Program Panel, has been completed. Based on the results, a preliminary safety assessment has shown that all of the 14 commercially important phthalates tested have sufficiently hig...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8665337

    authors: Group EF Jr

    更新日期:1986-03-01 00:00:00

  • GSTT1 and CYP2E1 polymorphisms and trihalomethanes in drinking water: effect on childhood leukemia.

    abstract::The purpose of the study was to determine whether the risk of childhood acute lymphoblastic leukemia (ALL) associated with drinking water disinfection by-products was modified in the presence of variants in genes involved in the metabolism of trihalomethanes (THMs). We included a subset of cases from a population-base...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.02110591

    authors: Infante-Rivard C,Amre D,Sinnett D

    更新日期:2002-06-01 00:00:00

  • Epidemiologic studies of environmental agents and systemic autoimmune diseases.

    abstract::Systemic lupus erythematosus and systemic scleroderma are autoimmune diseases thought to have an exogenous trigger. This review summarizes relevant case-control and cohort studies that investigated exogenous sex hormones, silica, silicone, solvents, pesticides, mercuric chloride, and hair dyes as putative risk factors...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.99107s5743

    authors: Mayes MD

    更新日期:1999-10-01 00:00:00

  • Aflatoxin exposure and viral hepatitis in the etiology of liver cirrhosis in the Gambia, West Africa.

    abstract:BACKGROUND:Cirrhosis of the liver is thought to be a major cause of morbidity and mortality in sub-Saharan Africa, but few controlled studies on the etiology of cirrhosis have been conducted in this region. OBJECTIVES:We aimed to elucidate the association between environmental and infectious exposures and cirrhosis in...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.11661

    authors: Kuniholm MH,Lesi OA,Mendy M,Akano AO,Sam O,Hall AJ,Whittle H,Bah E,Goedert JJ,Hainaut P,Kirk GD

    更新日期:2008-11-01 00:00:00