Abstract:
:The purpose of the study was to determine whether the risk of childhood acute lymphoblastic leukemia (ALL) associated with drinking water disinfection by-products was modified in the presence of variants in genes involved in the metabolism of trihalomethanes (THMs). We included a subset of cases from a population-based case-control study in a case-only study to estimate the interaction odds ratios (IORs) between prenatal and postnatal exposure to THMs and polymorphisms in the GSTT1 and CYP2E1 genes. We compared cases with and without a given variant regarding their exposure to THMs using unconditional logistic regression. The IOR for a postnatal average of total THM above the 95th percentile with GSTT1 null genotype was 9.1 [95% confidence interval (95% CI), 1.4-57.8]. With CYP2E1 (variant G-1259C, known as the allele CYP2E1*5), the effect of exposure during pregnancy for an average exposure to total THM at or above the 75th percentile was 9.7 (95% CI, 1.1-86.0). These results contrast strongly with those from our case-control analysis, in which we considered the exposure to THMs only in relation with ALL, and observed no increase in risk or very moderate ones. The present preliminary study shows suggestive but imprecise results. We found no similar results in the literature, underscoring the need for other studies as well as the potential usefulness of combining exposure and relevant genetic information in such studies.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Infante-Rivard C,Amre D,Sinnett Ddoi
10.1289/ehp.02110591subject
Has Abstractpub_date
2002-06-01 00:00:00pages
591-3issue
6eissn
0091-6765issn
1552-9924pii
sc271_5_1835journal_volume
110pub_type
杂志文章abstract::A review of the literature is provided for the topic of health-related research and power frequency electromagnetic fields. Minimal evidence for concern is present on the basis of animal and plant research. General observation would accord with the implication that there is no single and manifest health effect as the ...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.8775159
更新日期:1987-11-01 00:00:00
abstract:OBJECTIVE:We reviewed the scientific background for the current health-based World Health Organization (WHO) guideline value for manganese in drinking water. DATA SOURCES AND EXTRACTION:The initial starting point was the background document for the development of the WHO's guideline value for manganese in drinking wat...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.10316
更新日期:2007-11-01 00:00:00
abstract::In rats, a single administration of acrylonitrile (vinyl cyanide) produces a rapidly occurring bilateral adrenal apoplexy. Structure-activity studies have shown that a close derivative, propionitrile (ethyl cyanide), causes duodenal ulcer without markedly affecting the adrenal glands. Prolonging the two-carbon chain o...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7511135
更新日期:1975-06-01 00:00:00
abstract:BACKGROUND:Although a long latency period of toxicity after exposure to methylmercury (MeHg) is known to exist in humans, few animal studies have addressed this issue. Substantiation of delayed MeHg toxicity in animals would affect the risk evaluation of MeHg. OBJECTIVES:Our goal in this study was to demonstrate the e...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.10906
更新日期:2008-06-01 00:00:00
abstract::Direct studies of the function of a given cell type often require that the cell type be obtained in pure culture. A number of different specific metabolic activities have been attributed to pulmonary endothelial cells, yet with few exceptions the conclusions were based on indirect evidence. Thus, to improve our abilit...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8035171
更新日期:1980-04-01 00:00:00
abstract::We review pharmacokinetic and pharmacodynamic factors that should be considered in the design and interpretation of developmental neurotoxicity studies. Toxicologic effects on the developing nervous system depend on the delivered dose, exposure duration, and developmental stage at which exposure occurred. Several phar...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.01109s1101
更新日期:2001-03-01 00:00:00
abstract::The central feature of hemopoiesis is life-long, stable cell renewal. This process is supported by hemopoietic stem cells which, in the steady state, appear to be dormant in cell cycling. The entry into cell cycle of the dormant stem cells may be promoted by such factors as interleukin-1, interleukin-6 (IL-6), and gra...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.8980199
更新日期:1989-03-01 00:00:00
abstract:BACKGROUND:Organophosphate developmental neurotoxicity involves multiple mechanisms converging on neural cell replication and differentiation. OBJECTIVES:We evaluated mechanisms contributing to the adverse effects of chlorpyrifos (CPF) on DNA synthesis, cell number and size, and cell signaling mediated by adenylyl cyc...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.10194
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:Exceptional aging, defined as reaching age 85 years, shows geographic inequalities that may depend on local environmental conditions. Links between particulate pollution-a well-recognized environmental risk factor-and exceptional aging have not been investigated. OBJECTIVES:We conducted a nationwide analysi...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP197
更新日期:2016-11-01 00:00:00
abstract::Fanconi anemia (FA) is an autosomal recessive disorder characterized by diverse developmental abnormalities, progressive bone marrow failure, and a markedly increased incidence of malignancy. FA cells are hypersensitive to DNA cross-linking agents, suggesting a general defect in the repair of DNA cross-links. Some for...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.02110s5773
更新日期:2002-10-01 00:00:00
abstract::The Tradescantia genetic system developed by the late Dr. Arnold H. Sparrow for the study of effects of ionizing radiation is applicable to chemical mutagen detection. Early radiobiological data demonstrated that the stamen hairs were sensitive to as little as 0.25 rad of x-rays and that the number of cells showing a ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.782751
更新日期:1978-12-01 00:00:00
abstract::A brief description of chromosome aberrations and sister chromatid exchange (SCE) as cytogenetic endpoints for evaluation of DNA damaging agents is presented. Problems associated with the use of cytogenetic assays as population monitors of radiation and chemical exposures are discussed. Adequate cell sample size requi...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.8142107
更新日期:1981-12-01 00:00:00
abstract::Fish and other seafood may contain organic mercury but also beneficial nutrients such as n-3 polyunsaturated fatty acids. We endeavored to study whether maternal fish consumption during pregnancy harms or benefits fetal brain development. We examined associations of maternal fish intake during pregnancy and maternal h...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8041
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:Studies on the health effects of polychlorinated biphenyls (PCBs) call for an understanding of past and present human exposure. Time-resolved mechanistic models may supplement information on concentrations in individuals obtained from measurements and/or statistical approaches if they can be shown to reprodu...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1409191
更新日期:2016-03-01 00:00:00
abstract::In this study, we determined the biologic activity of dichloromethane-extracted particulate matter < 10 micro m in aerodynamic diameter (PM10) obtained from filters at three sites in the Paso del Norte airshed, which includes El Paso, Texas, USA; Juarez, Chihuahua, Mexico, and Sunland Park, New Mexico, USA. The extrac...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.6058
更新日期:2003-08-01 00:00:00
abstract::During the last three decades, the use of modern organic synthetic pesticides has increased about 40-fold. Total U.S. production, for domestic and expert use, in 1976 was about 1.4 million pounds. Crops receiving the most intensive application of various pesticides were cotton for insecticides, corn for herbicides, an...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7827103
更新日期:1978-12-01 00:00:00
abstract:BACKGROUND:Green spaces have been associated with both health benefits and risks in children; however, available evidence simultaneously investigating these conflicting influences, especially in association with different types of greenness, is scarce. OBJECTIVES:We aimed to simultaneously evaluate health benefits and...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1308038
更新日期:2014-12-01 00:00:00
abstract::The Florence Statement on Triclosan and Triclocarban documents a consensus of more than 200 scientists and medical professionals on the hazards of and lack of demonstrated benefit from common uses of triclosan and triclocarban. These chemicals may be used in thousands of personal care and consumer products as well as ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP1788
更新日期:2017-06-20 00:00:00
abstract::Differential CYP1A1 inducibility, reflecting variations in aromatic hydrocarbon receptor (AHR) affinity among inbred mouse strains, is an important determinant of environmental toxicity. We took advantage of the Ahr polymorphism in C57BL/6 and DBA/2 mice to develop an oligonucleotide-hybridization screening approach f...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.106-1533118
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND:Polybrominated diphenyl ethers (PBDEs) are persistent chemicals that have been widely used as flame retardants in furniture, carpet padding, car seats, and other consumer products during the past three decades. OBJECTIVE:We examined whether in utero exposure to PBDEs is associated with child cognitive funct...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1307562
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Cohort studies in North America and western Europe have reported increased risk of mortality associated with long-term exposure to fine particles (PM2.5), but to date, no such studies have been reported in China, where higher levels of exposure are experienced. OBJECTIVES:We estimated the association betwee...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP1673
更新日期:2017-11-07 00:00:00
abstract:BACKGROUND:Inorganic arsenic (iAs) causes cancer and possibly other adverse health outcomes. Arsenic-based drugs are permitted in poultry production; however, the contribution of chicken consumption to iAs intake is unknown. OBJECTIVES:We sought to characterize the arsenic species profile in chicken meat and estimate ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1206245
更新日期:2013-07-01 00:00:00
abstract::Fumonisin B1(FB1) is a fungal metabolite of Fusarium verticillioides (= F. moniliforme), a fungus that grows on many crops worldwide. Previous studies demonstrated that male BD IX rats consuming diets containing 50 ppm fumonisin B1 developed hepatocellular carcinomas. In our recent studies, diets containing FB1 at 50 ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.01109s2309
更新日期:2001-05-01 00:00:00
abstract::With this research I tested the hypothesis that individual preferences for specific ecosystem components and restorative environments are significantly associated with quality of life (QOL). A total of 379 human subjects responded to a structured 18-item questionnaire on topophilia and to the 26-item World Health Orga...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7467
更新日期:2005-02-01 00:00:00
abstract::Over the past decade much information has been published on the analysis of organics extracted from treated water. Certain of these organics have been shown to be by-products of the chlorination disinfection process and to possess harmful effects at high concentrations. This has resulted in increased interest in alter...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.824687
更新日期:1982-12-01 00:00:00
abstract:BACKGROUND:Cumulative lead exposure is associated with a widened pulse pressure (PP; the -difference between systolic and diastolic blood pressure), a marker of arterial stiffness and a predictor of cardiovascular disease. Polymorphisms in the hemochromatosis gene (HFE) have been shown to modify the impact of cumulativ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1002251
更新日期:2010-09-01 00:00:00
abstract::In this paper we report yields, identities, and mutagenicities of products from heating a polycyclic aromatic hydrocarbon (PAH)-contaminated, Superfund-related synthetic soil matrix without exogenous oxygen. We heated batch samples of soil pretreated with 5.08 wt% (by weight) pyrene in a tubular furnace under a consta...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.00108709
更新日期:2000-08-01 00:00:00
abstract::Isoflavonoids and related compounds such as coumestrol have classically been categorized as phytoestrogens because these environmentally derived substances bind to the estrogen receptor (ER) and increase uterine wet weight in immature rats and mice. Assessment of the binding affinities of isoflavonoids for ER and subs...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.95103574
更新日期:1995-06-01 00:00:00
abstract::A set of 53 individuals from a population highly exposed to airborne hexachlorobenzene (HCB) were selected to study the elimination kinetics of this chemical in humans. The volunteers provided blood, 24-hr urine, and feces samples for analysis of HCB and metabolites. The serum HCB concentrations ranged from 2.4 to 1,4...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.00108595
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:Lead (Pb) exposure has been associated with a host of pathological conditions in humans. In rodents Pb exposure has been shown to alter the hypothalamic-pituitary-adrenal (HPA) axis function. OBJECTIVE:We investigated the effects of lead on responses of the HPA axis to a psychosocial laboratory stressor adm...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1103873
更新日期:2012-02-01 00:00:00