Prenatal polybrominated diphenyl ether exposures and neurodevelopment in U.S. children through 5 years of age: the HOME study.

abstract：BACKGROUND:Organophosphates elicit developmental neurotoxicity through multiple mechanisms other than their shared property as cholinesterase inhibitors. Accordingly, these agents may differ in their effects on specific brain circuits. OBJECTIVES:We gave parathion to neonatal rats [postnatal days (PNDs) 1-4], at daily...

journal_title：Environmental health perspectives

authors： Slotkin TA,Bodwell BE,Ryde IT,Levin ED,Seidler FJ

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Prostaglandins (PGs) play key roles in development and maintenance of homeostasis of the adult body. Despite these important roles, it remains unclear whether the PG pathway is a target for endocrine disruption. However, several known endocrine-disrupting compounds (EDCs) share a high degree of structural si...

journal_title：Environmental health perspectives

authors： Kristensen DM,Skalkam ML,Audouze K,Lesné L,Desdoits-Lethimonier C,Frederiksen H,Brunak S,Skakkebæk NE,Jégou B,Hansen JB,Junker S,Leffers H

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Childhood lead exposure has been associated with growth delay. However, the association between blood lead levels (BLLs) and insulin-like growth factor 1 (IGF-1) has not been characterized in a large cohort with low-level lead exposure. METHODS:We recruited 394 boys 8-9 years of age from an industrial Russi...

journal_title：Environmental health perspectives

authors： Fleisch AF,Burns JS,Williams PL,Lee MM,Sergeyev O,Korrick SA,Hauser R

更新日期：2013-07-01 00:00:00

abstract：:A comparative analysis was performed of the phenotype and function of peripheral blood leukocytes of two age-matched cohorts of industrial workers in chemical plants, one of which was exposed occupationally to high concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Median actual TCDD burdens were 116 ng/kg ...

journal_title：Environmental health perspectives

authors： Ernst M,Flesch-Janys D,Morgenstern I,Manz A

更新日期：1998-04-01 00:00:00

abstract：:Much public health research has been directed to studies of cancer risks due to chemical agents. Recently, increasing attention has been given to adverse reproductive outcomes as another, shorter-term biologic indicator of public health impact. Further, several low-level ubiquitous physical agents have been implicated...

journal_title：Environmental health perspectives

authors： Meyer RE,Aldrich TE,Easterly CE

更新日期：1989-05-01 00:00:00

abstract：:The effect of sodium selenite administered intragastrically in repeated doses to rats receiving ethylmercuric chloride po in various repeated doses (0.25 or 2.5 mg Hg/kg) on the excretion, whole-body retention, and organ distribution of mercury was studied. Selenium was found to affect the distribution of ethylmercury...

journal_title：Environmental health perspectives

authors： Brzeźnicka EA,Chmielnicka J

更新日期：1981-06-01 00:00:00

abstract：BACKGROUND:Humans living near industrial point emissions can experience high levels of exposures to air pollutants. Map Ta Phut Industrial Estate in Thailand is the location of the largest steel, oil refinery, and petrochemical factory complexes in Southeast Asia. Air pollution is an important source of oxidative stres...

journal_title：Environmental health perspectives

authors： Peluso M,Srivatanakul P,Munnia A,Jedpiyawongse A,Ceppi M,Sangrajrang S,Piro S,Boffetta P

更新日期：2010-01-01 00:00:00

abstract：:Environmental estrogens are of particular concern when exposure occurs during embryonic development. Although there are good models to study estrogenic activity of chemicals in adult animals, developmental exposure is much more difficult to test. The weak estrogenic activity of the environmental estrogen bisphenol A (...

journal_title：Environmental health perspectives

authors： Lemmen JG,Arends RJ,van der Saag PT,van der Burg B

更新日期：2004-11-01 00:00:00

abstract：:Many epidemiologic reports associate ambient levels of particulate matter (PM) with human mortality and morbidity, particularly in people with preexisting cardiopulmonary disease (e.g., chronic obstructive pulmonary disease, infection, asthma). Because much ambient PM is derived from combustion sources, we tested the ...

journal_title：Environmental health perspectives

authors： Costa DL,Dreher KL

更新日期：1997-09-01 00:00:00

abstract：:A previously healthy woman developed hypersensitivity pneumonitis of such severity that she required chronic systemic corticosteroid therapy for symptom control. Detailed investigation of her workplace and home environments revealed fungi in her typical suburban home, to which she had specific serum precipitating anti...

journal_title：Environmental health perspectives

authors： Apostolakos MJ,Rossmoore H,Beckett WS

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:Pesticides have been associated with Parkinson's disease (PD), but there are few data on important exposure characteristics such as dose-effect relations. It is unknown whether associations depend on clinical PD subtypes. OBJECTIVES:We examined quantitative aspects of occupational pesticide exposure associa...

journal_title：Environmental health perspectives

authors： Moisan F,Spinosi J,Delabre L,Gourlet V,Mazurie JL,Bénatru I,Goldberg M,Weisskopf MG,Imbernon E,Tzourio C,Elbaz A

更新日期：2015-11-01 00:00:00

abstract：:One of the most serious consequences of cancer therapy is the development of a second cancer, especially leukemia. Several distinct subsets of therapy-related leukemia can now be distinguished. Classic therapy-related myeloid leukemia typically occurs 5 to 7 years after exposure to alkylating agents and/or irradiation...

journal_title：Environmental health perspectives

authors： Larson RA,LeBeau MM,Vardiman JW,Rowley JD

更新日期：1996-12-01 00:00:00

abstract：:Isolated rat and human hepatocytes in primary culture were shown to metabolize AAF to reactive intermediates which damaged hepatocyte DNA. A significant increase in unscheduled DNA synthesis was detectable by autoradiography in rat and human hepatocytes exposed to concentrations of AAF as low as 1 microM. When rat hep...

journal_title：Environmental health perspectives

authors： Strom SC,Jirtle RL,Michalopoulos G

更新日期：1983-03-01 00:00:00

abstract：BACKGROUND:Animal and epidemiologic studies suggest that exposure to light at night (LAN) may disrupt circadian patterns and decrease nocturnal secretion of melatonin, which may disturb estrogen regulation, leading to increased breast cancer risk. OBJECTIVES:We examined the association between residential outdoor LAN ...

journal_title：Environmental health perspectives

authors： James P,Bertrand KA,Hart JE,Schernhammer ES,Tamimi RM,Laden F

更新日期：2017-08-17 00:00:00

abstract：BACKGROUND:Extreme heat events (EHEs) are increasing in frequency in large U.S. cities and are responsible for a greater annual number of climate-related fatalities, on average, than any other form of extreme weather. In addition, low-density, sprawling patterns of urban development have been associated with enhanced s...

journal_title：Environmental health perspectives

authors： Stone B,Hess JJ,Frumkin H

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:THE APHENA (AIR POLLUTION AND HEALTH: A Combined European and North American Approach) study is a collaborative analysis of multicity time-series data on the effect of air pollution on population health, bringing together data from the European APHEA (Air Pollution and Health: A European Approach) and U.S. N...

journal_title：Environmental health perspectives

authors： Samoli E,Peng R,Ramsay T,Pipikou M,Touloumi G,Dominici F,Burnett R,Cohen A,Krewski D,Samet J,Katsouyanni K

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Fine particulate matter (FPM) in ambient air causes premature mortality due to cardiac disease in susceptible populations. OBJECTIVE:Our objective in this study was to determine the most influential FPM components. METHODS:A mouse model of atherosclerosis (ApoE-/-) was exposed to either filtered air or con...

journal_title：Environmental health perspectives

authors： Lippmann M,Ito K,Hwang JS,Maciejczyk P,Chen LC

更新日期：2006-11-01 00:00:00

abstract：:As a result of the Leadership Conference on Biomedical Research and the Environment, the Facilities Committee focused its work on the development of best environmental practices at biomedical research facilities at the university and independent research facility level as well as consideration of potential involvement...

journal_title：Environmental health perspectives

authors： Medlin EL,Grupenhoff JT

更新日期：2000-12-01 00:00:00

abstract：:Alveolar macrophages were treated with carbon blacks and adsorbates in order to evaluate the biologic effect of adsorbate, adsorbent and adsorbate-adsorbent complexes. Their capacity to phagocytize a subsequent challenge via the Fc-membrane receptor was quantified. Phagocytosis was suppressed in a dose-related manner ...

journal_title：Environmental health perspectives

authors： Jakab GJ,Risby TH,Sehnert SS,Hmieleski RR,Farrington JE

更新日期：1990-06-01 00:00:00

abstract：:Lipocortins are structurally related, glucocorticoid-inducible proteins that inhibit phospholipase A2 (PLA2), thereby reducing the liberation of arachidonic acid from phospholipids and so limiting the synthesis of eicosanoid inflammatory mediators. This study is the first demonstration of one lipocortin, lipocortin 1 ...

journal_title：Environmental health perspectives

authors： Smith SF,Tetley TD,Guz A,Flower RJ

更新日期：1990-04-01 00:00:00

abstract：:The steroids trenbolone acetate (TbA) and melengestrol acetate (MGA) are licensed as growth promoters for farm animals in several meat-exporting countries. Although many studies have explored their safety for both animals and consumers, little is known about their fate after excretion by the animal. Our study aimed to...

journal_title：Environmental health perspectives

authors： Schiffer B,Daxenberger A,Meyer K,Meyer HH

更新日期：2001-11-01 00:00:00

abstract：:This study was undertaken to explore the effects of chronic low-level cadmium ingestion in Dahl hypertension-resistant (R) and hypertension-sensitive (S) lines of rats. Groups of weanling female R and S rats were given 0 or 1 mg cadmium/1. in drinking water and fed either a low salt (0.4% NaCl) or a high salt (4% NaCl...

journal_title：Environmental health perspectives

authors： Ohanian EV,Iwai J

更新日期：1979-02-01 00:00:00

abstract：:The possible risk for human health arising from consumption of lead-polluted shellfish was suggested by experiments on the bioavailability for mice of a "biologically detoxified" form of the metal. In this work, young mice were fed with a mixed diet including mussels collected in a Pb-polluted area. Metal concentratio...

journal_title：Environmental health perspectives

authors： Regoli F,Orlando E

更新日期：1994-09-01 00:00:00

abstract：:Methyl parathion (MP), an organophosphate pesticide licensed only for agricultural uses, was sprayed illegally for pest control in Mississippi and Ohio residences. To evaluate the association between MP exposure and neurobehavioral development, we assessed children 6 years or younger at the time of the spraying and lo...

journal_title：Environmental health perspectives

authors： Ruckart PZ,Kakolewski K,Bove FJ,Kaye WE

更新日期：2004-01-01 00:00:00

abstract：:Syrian hamster embryo cells were treated with galactose oxidase, followed by reduction with tritiated sodium borohydride at pH 7.4. The labeling patterns of galactosyl and N-acetyl galactosaminyl residues on the cell surface were altered in comparing scraped vs. unscraped and buffer vs. media-soaked cells treated with...

journal_title：Environmental health perspectives

authors： Newman HA,Saat YA,Hart RW

更新日期：1980-02-01 00:00:00

abstract：:Fluorescence in situ hybridization with chromosome-specific composite DNA probes (chromosome painting) is a reliable and efficient method for detecting structural chromosome aberrations. Painting is now being used to quantify chromosome damage in many human populations. In one such study we evaluated 91 unexposed peop...

journal_title：Environmental health perspectives

authors： Tucker JD,Moore DH 2nd

更新日期：1996-05-01 00:00:00

abstract：:Children and their parents in residences are often protected by insecticides from nuisance and disease-bearing mosquitoes. The annual worldwide consumption of the four major types of residential insecticide products--aerosols, mosquito coils, liquid vaporizers, and vaporizing mats--is in the billions of units. Mosquit...

journal_title：Environmental health perspectives

authors： Krieger RI,Dinoff TM,Zhang X

更新日期：2003-09-01 00:00:00

abstract：:In an attempt to elucidate the relationship between DNA adduct formation and tumorigenesis, DNA adducts were measured in the livers and bladders of mice during chronic exposure to several different doses of 2-acetylaminofluorene (2-AAF) and 4-aminobiphenyl (4-ABP). Continuous oral administration of these compounds for...

journal_title：Environmental health perspectives

authors： Poirier MC,Beland FA

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:Hexavalent chromium [Cr(VI)] is recognized as a human carcinogen via inhalation. However, the molecular mechanisms by which Cr(VI) causes cancers are not well understood. OBJECTIVES:We evaluated cyclooxygenase-2 (COX-2) expression and the signaling pathway leading to this induction due to Cr(VI) exposure in...

journal_title：Environmental health perspectives

authors： Zuo Z,Cai T,Li J,Zhang D,Yu Y,Huang C

更新日期：2012-04-01 00:00:00

abstract：:We have previously reported that rats are resilient to the hepatotoxic and lethal combination of chlordecone (CD) and carbon tetrachloride (CCl4) during early postnatal development. The overall findings pointed to stimulated cell division and tissue repair mechanisms as the underlying cause of resistance. The objectiv...

journal_title：Environmental health perspectives

authors： Dalu A,Rao PS,Mehendale HM

更新日期：1998-09-01 00:00:00