Abstract:
:Previous investigations suggest that dietary sources of polycyclic aromatic hydrocarbons (PAHs) contribute to the PAH-DNA adduct load in peripheral white blood cells (WBCs). In the current study, we measured PAH-DNA adducts by enzyme-linked immunosorbent assay in WBCs obtained from 47 California wildland (forest) firefighters at two time points (early and late) during an active forest fire season. PAH-DNA adduct levels were not associated with recent firefighting activity, but were positively associated with frequency of charbroiled food consumption in the previous 2 weeks. In addition, adduct levels declined with time since last ingestion of charbroiled food. These studies indicate that recent consumption of charbroiled food contributes to the PAH-DNA adduct load in peripheral WBCs.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Rothman N,Poirier MC,Haas RA,Correa-Villasenor A,Ford P,Hansen JA,O'Toole T,Strickland PTdoi
10.1289/ehp.9399265subject
Has Abstractpub_date
1993-03-01 00:00:00pages
265-7eissn
0091-6765issn
1552-9924journal_volume
99pub_type
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更新日期:2003-05-01 00:00:00
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更新日期:2002-06-01 00:00:00