Metabolism of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) in isolated liver cells from guinea pig, hamster, mouse, and rat.

abstract：:Mineral fibers and particulates represent one of the best documented, economically important, and ubiquitously occurring categories of human carcinogens. Yet, while a wealth of information exists concerning the mechanism of action of physical, chemical, and viral carcinogens, virtually nothing is known relative to the...

journal_title：Environmental health perspectives

authors： Hart RW,Daniel FB,Kindig OR,Beach CA,Joseph LB,Wells RC

更新日期：1980-02-01 00:00:00

abstract：:Heightened concern over endocrine-disrupting chemicals is driven by the hypothesis that they could reduce reproductive success and affect wildlife populations, but there is little evidence for this expectation. The pharmaceutical ethynylestradiol (EE2) is a potent endocrine modulator and is present in the aquatic envi...

journal_title：Environmental health perspectives

authors： Nash JP,Kime DE,Van der Ven LT,Wester PW,Brion F,Maack G,Stahlschmidt-Allner P,Tyler CR

更新日期：2004-12-01 00:00:00

abstract：:A major concern of the chlorination of aquatic humic materials is the ubiquitous production of trihalomethanes. A large number of other chlorinated organic compounds, however, have been shown to be formed by chlorine's reaction with humic substances. In this study, humic material was concentrated from a coastal North ...

journal_title：Environmental health perspectives

authors： Johnson JD,Christman RF,Norwood DL,Millington DS

更新日期：1982-12-01 00:00:00

abstract：:We have developed and applied a new measurement methodology to investigate dermal absorption of chloroform while bathing. Ten subjects bathed in chlorinated water while breathing pure air through a face mask. Their exhaled breath was delivered to a glow discharge source/ion trap mass spectrometer for continuous real-t...

journal_title：Environmental health perspectives

authors： Gordon SM,Wallace LA,Callahan PJ,Kenny DV,Brinkman MC

更新日期：1998-06-01 00:00:00

abstract：:The populations of the developed nations of the world exhibit an increase in blood pressure with age, while in primitive societies blood pressure remains relatively constant throughout adult life. Hypertension may be a complex of diseases all having the same clinical manifestations but not being caused necessarily by ...

journal_title：Environmental health perspectives

authors： Tuthill RW,Calabrese EJ

更新日期：1979-04-01 00:00:00

abstract：:Southwest metropolitan Mexico City (SWMMC) inhabitants have been exposed several hours per day for the last 6 years to photochemical smog, ozone being the most important oxidant pollutant. Subjects exposed to the SWMMC atmosphere develop several histopathological changes in their nasal mucosa: dysplasia is the most si...

journal_title：Environmental health perspectives

authors： Calderon-Garcidueñas L,Roy-Ocotla G

更新日期：1993-06-01 00:00:00

abstract：:The occurrence of high cadmium levels in the digestive gland (hepatopancreas) of the crab Cancer pagurus is reviewed and its possible significance to human health is discussed. Previous attempts to isolate this cadmium in its native form are briefly reviewed and the present method used in this laboratory to isolate cr...

journal_title：Environmental health perspectives

authors： Overnell J

更新日期：1986-03-01 00:00:00

abstract：:The mammalian respiratory tract is densely innervated by autonomic and sensory nerves around airways and blood vessels. Subsets of these nerves contain a number of putative neurotransmitter peptides, such as substance P and calcitonin gene-related peptide (CGRP) in sensory nerves and vasoactive intestinal polypeptide ...

journal_title：Environmental health perspectives

authors： Springall DR,Edginton JA,Price PN,Swanston DW,Noel C,Bloom SR,Polak JM

更新日期：1990-04-01 00:00:00

abstract：:Many mammals methylate trivalent inorganic arsenic in liver to species that are released into the bloodstream and excreted in urine and feces. This study addresses how methylated arsenicals pass through cell membranes. We have previously shown that aquaglyceroporin channels, including Escherichia coli GlpF, Saccharomy...

journal_title：Environmental health perspectives

authors： Liu Z,Styblo M,Rosen BP

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:The relationship of fine particulate matter < 2.5 microm in diameter (PM(2.5)) air pollution with mortality and cardiovascular disease is well established, with more recent long-term studies reporting larger effect sizes than earlier long-term studies. Some studies have suggested the coarse fraction, particl...

journal_title：Environmental health perspectives

authors： Puett RC,Hart JE,Yanosky JD,Paciorek C,Schwartz J,Suh H,Speizer FE,Laden F

更新日期：2009-11-01 00:00:00

abstract：:We include in this review an assessment of the formation, environmental fate, and mammalian and ecotoxicity of CW agent degradation products relevant to environmental and occupational health. These parent CW agents include several vesicants: sulfur mustards [undistilled sulfur mustard (H), sulfur mustard (HD), and an ...

journal_title：Environmental health perspectives

authors： Munro NB,Talmage SS,Griffin GD,Waters LC,Watson AP,King JF,Hauschild V

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND:National disparities in asbestos use will likely lead to an unequal burden of asbestos diseases. OBJECTIVES:As economic status may be linked to asbestos use, we assessed, globally, the relationship between indicators of national economic development and asbestos use. METHODS:For the 135 countries that have...

journal_title：Environmental health perspectives

authors： Le GV,Takahashi K,Karjalainen A,Delgermaa V,Hoshuyama T,Miyamura Y,Furuya S,Higashi T,Pan G,Wagner G

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Urbanization has been correlated with hypertension (HTN) in developing countries undergoing rapid economic and environmental transitions. OBJECTIVES:We examined the relationships among living environment (urban, suburban, and rural), day/night land surface temperatures (LST), and blood pressure in selected ...

journal_title：Environmental health perspectives

authors： Estes MG Jr,Al-Hamdan MZ,Crosson W,Estes SM,Quattrochi D,Kent S,McClure LA

更新日期：2009-12-01 00:00:00

abstract：:Examining global effects of toxic metals on gene expression can be useful for elucidating patterns of biological response, discovering underlying mechanisms of toxicity, and identifying candidate metal-specific genetic markers of exposure and response. Using a 1,200 gene nylon array, we examined changes in gene expres...

journal_title：Environmental health perspectives

authors： Andrew AS,Warren AJ,Barchowsky A,Temple KA,Klei L,Soucy NV,O'Hara KA,Hamilton JW

更新日期：2003-05-01 00:00:00

abstract：:The many anatomical, physiological, and biochemical differences among various mammalian species make it difficult to extrapolate carcinogenic potency data from animals to humans. The process is further complicated by the multistep origin of most malignant tumors in animals and humans due to the interaction of target c...

journal_title：Environmental health perspectives

authors： Slaga TJ

更新日期：1988-04-01 00:00:00

abstract：BACKGROUND:Whether there is a causal relation between long-term exposure to traffic and asthma development is so far not clear. This may be explained by inaccurate exposure assessment. OBJECTIVE:We investigated the associations of long-term traffic-related exposures with asthma onset assessed retrospectively and respi...

journal_title：Environmental health perspectives

authors： Oftedal B,Nystad W,Brunekreef B,Nafstad P

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC), or liver cancer, is the third leading cause of cancer deaths worldwide, with prevalence 16-32 times higher in developing countries than in developed countries. Aflatoxin, a contaminant produced by the fungi Aspergillus flavus and Aspergillus parasiticus in maize and nuts, is a...

journal_title：Environmental health perspectives

authors： Liu Y,Wu F

更新日期：2010-06-01 00:00:00

abstract：:The ability of a series of haloalkanes, haloethanols and haloacetaldehydes to induce mutations in Salmonella typhrimurium and preferentially to inhibit the growth of DNA polymerase-deficient E. coli (pol A(+)/pol A(-)) was investigated. For the haloalkanes investigated, the order of reactivities towards the E. coli po...

journal_title：Environmental health perspectives

authors： Rosenkranz HS

更新日期：1977-12-01 00:00:00

abstract：:The chlorinated hydrocarbons chloroform (CHCl3), 1,1-dichlorethane (1,1-DCE) and 1,2-dichloroethane (1,2-DCE) have been detected in finished drinking water. When administered to B6C3F1 mice by gavage in corn oil, these compounds have been shown to induce hepatic tumors. The present study examines the effect on liver t...

journal_title：Environmental health perspectives

authors： Klaunig JE,Ruch RJ,Pereira MA

更新日期：1986-11-01 00:00:00

abstract：BACKGROUND:The impact of prenatal lead exposure on neurodevelopment remains unclear in terms of consistency, the trimester of greatest vulnerability, and the best method for estimating fetal lead exposure. OBJECTIVE:We studied prenatal lead exposure's impact on neurodevelopment using repeated measures of fetal dose as...

journal_title：Environmental health perspectives

authors： Hu H,Téllez-Rojo MM,Bellinger D,Smith D,Ettinger AS,Lamadrid-Figueroa H,Schwartz J,Schnaas L,Mercado-García A,Hernández-Avila M

更新日期：2006-11-01 00:00:00

abstract：:Asthma is the most common chronic illness of childhood and its prevalence is increasing, causing much concern for identification of risk factors such as air pollution. We previously conducted a study showing a relationship between asthma visits in all persons < 65 years of age to emergency departments (EDs) and air po...

journal_title：Environmental health perspectives

authors： Norris G,YoungPong SN,Koenig JQ,Larson TV,Sheppard L,Stout JW

更新日期：1999-06-01 00:00:00

abstract：:It was considered that the fall in lung function seen after exposure to cotton dust may be attributable in part to the activity of arachidonic acid metabolites, such as leucotrienes as well as to the more established release of histamine by cotton dust. However, we found that cotton and barley dusts elicited poor rele...

journal_title：Environmental health perspectives

authors： Thomson TA,Edwards JH,Al-Zubaidy TS,Brown RC,Poole A,Nicholls PJ

更新日期：1986-04-01 00:00:00

abstract：:We assessed exposure to dioxin-like compounds using chemical and bioassay analysis in different matrices in a female population. A total of 106 serum and 9 follicular fluid samples were collected from infertile women attending Centers for Reproductive Medicine in Belgium from 1996 to 1998. Major polychlorinated biphen...

journal_title：Environmental health perspectives

authors： Pauwels A,Cenijn PH,Schepens PJ,Brouwer A

更新日期：2000-06-01 00:00:00

abstract：:Concern about apparent increases in the prevalence of hypospadias--a congenital male reproductive-tract abnormality--in the 1960s to 1980s and the possible connection to increasing exposures to endocrine-disrupting chemicals have underlined the importance of effective surveillance of hypospadias prevalence in the popu...

journal_title：Environmental health perspectives

authors： Dolk H,Vrijheid M,Scott JE,Addor MC,Botting B,de Vigan C,de Walle H,Garne E,Loane M,Pierini A,Garcia-Minaur S,Physick N,Tenconi R,Wiesel A,Calzolari E,Stone D

更新日期：2004-03-01 00:00:00

abstract：:The natural occurrence of palladium (Pd) is rare. It is obtained as a by-product during the extraction of platinum and, until the present time, its uses were small in number--principally in the manufacture of jewelry, dental alloys, chemical catalysts, and electrical contacts. Interest in Pd toxicology has been limite...

journal_title：Environmental health perspectives

authors： Wiester MJ

更新日期：1975-12-01 00:00:00

abstract：:Methyl parathion (MP), an organophosphate pesticide licensed only for agricultural uses, was sprayed illegally for pest control in Mississippi and Ohio residences. To evaluate the association between MP exposure and neurobehavioral development, we assessed children 6 years or younger at the time of the spraying and lo...

journal_title：Environmental health perspectives

authors： Ruckart PZ,Kakolewski K,Bove FJ,Kaye WE

更新日期：2004-01-01 00:00:00

abstract：:We tested the hypothesis that exposure of healthy volunteers to concentrated ambient air particles (CAPS) between 0.1 and 2.5 microm in diameter is associated with modulation of human alveolar macrophage (AM) function, cytokine production, and immune phenotype in both blood and lung. Thirty-eight volunteers were expos...

journal_title：Environmental health perspectives

authors： Harder SD,Soukup JM,Ghio AJ,Devlin RB,Becker S

更新日期：2001-08-01 00:00:00

abstract：:Comamonas testosteroni YZW-D was isolated from Passaic River sediment for its ability to degrade isophthalate and terephthalate. Degradation of the two isomeric compounds proceeds via separately inducible catabolic pathways that converge at protocatechuate. Analysis of the catabolic pathways by which these two isomers...

journal_title：Environmental health perspectives

authors： Wang YZ,Zhou Y,Zylstra GJ

更新日期：1995-06-01 00:00:00

abstract：:The importance of urban dust as a source of lead for young children is still disputed. Although blood-lead data from various population surveys usually show a peak concentration in early childhood, there is evidence that such a peak is small or absent altogether in children without much access to the general environme...

journal_title：Environmental health perspectives

authors： Duggan MJ

更新日期：1983-04-01 00:00:00

abstract：:This working paper summarizes the known ultrastructural and biochemical effects of lead, mercury, cadmium, and arsenic on subcellular organelle systems following in vivo administration. Documented metal-induced alterations in nuclear, mitochondrial, microsomal, and lysosomal functions are discussed in relation to thei...

journal_title：Environmental health perspectives

authors： Fowler BA

更新日期：1978-02-01 00:00:00