Abstract:
BACKGROUND:Epidemiologic and experimental studies have reported a variety of health effects in response to ozone (O3) exposure, and some have indicated that certain populations may be at increased or decreased risk of O3-related health effects. OBJECTIVES:We sought to identify potential response-modifying factors to determine whether specific groups of the population or life stages are at increased or decreased risk of O3-related health effects using a weight-of-evidence approach. METHODS:Epidemiologic, experimental, and exposure science studies of potential factors that may modify the relationship between O3 and health effects were identified in U.S. Environmental Protection Agency's 2013 Integrated Science Assessment for Ozone and Related Photochemical Oxidants. Scientific evidence from studies that examined factors that may influence risk were integrated across disciplines to evaluate consistency, coherence, and biological plausibility of effects. The factors identified were then classified using a weight-of-evidence approach to conclude whether a specific factor modified the response of a population or life stage, resulting in an increased or decreased risk of O3-related health effects. DISCUSSION:We found "adequate" evidence that populations with certain genotypes, preexisting asthma, or reduced intake of certain nutrients, as well as different life stages or outdoor workers, are at increased risk of O3-related health effects. In addition, we identified other factors (i.e., sex, socioeconomic status, and obesity) for which there was "suggestive" evidence that they may increase the risk of O3-related health effects. CONCLUSIONS:Using a weight-of-evidence approach, we identified a diverse group of factors that should be considered when characterizing the overall risk of health effects associated with exposures to ambient O3.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Vinikoor-Imler LC,Owens EO,Nichols JL,Ross M,Brown JS,Sacks JDdoi
10.1289/ehp.1307541subject
Has Abstractpub_date
2014-11-01 00:00:00pages
1166-76issue
11eissn
0091-6765issn
1552-9924journal_volume
122pub_type
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更新日期:2020-04-01 00:00:00
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更新日期:1982-11-01 00:00:00
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更新日期:2002-03-01 00:00:00
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journal_title:Environmental health perspectives
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更新日期:1999-08-01 00:00:00
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更新日期:2009-09-01 00:00:00
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更新日期:1985-12-01 00:00:00