Suppression of metallothionein-I/II expression and its probable molecular mechanisms.

abstract：:This study investigated the association between biomarkers of fetal exposure to cigarette smoke at the end of pregnancy, cotinine in cord serum and in maternal and newborn urine samples, and quantitative measurement of smoking intake and exposure evaluated by maternal self-reported questionnaire. Study subjects were 4...

journal_title：Environmental health perspectives

authors： Pichini S,Basagaña XB,Pacifici R,Garcia O,Puig C,Vall O,Harris J,Zuccaro P,Segura J,Sunyer J

更新日期：2000-11-01 00:00:00

abstract：:A physiologically based pharmacokinetic model for trichloroethylene (TCE) in rodents and humans was calibrated with published toxicokinetic data sets. A Bayesian statistical framework was used to combine previous information about the model parameters with the data likelihood, to yield posterior parameter distribution...

journal_title：Environmental health perspectives

authors： Bois FY

更新日期：2000-05-01 00:00:00

abstract：:Unlike laboratory animals, people are rarely exposed to a single hazardous chemical. However, most of the information documenting adverse human health effects from environmental and occupational contaminants has come from studies focused on exposure to single chemicals, and there is little information available on how...

journal_title：Environmental health perspectives

authors： Carpenter DO,Arcaro KF,Bush B,Niemi WD,Pang S,Vakharia DD

更新日期：1998-12-01 00:00:00

abstract：:Uranium accumulates in bone, affects bone metabolism in laboratory animals, and when ingested in drinking water increases urinary excretion of calcium and phosphate, important components in the bone structure. However, little is known about bone effects of ingested natural uranium in humans. We studied 146 men and 142...

journal_title：Environmental health perspectives

authors： Kurttio P,Komulainen H,Leino A,Salonen L,Auvinen A,Saha H

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Despite evidence of atrazine toxicity in developing organisms from experimental studies, few studies--and fewer epidemiologic investigations--have examined the potential effects of prenatal exposure. OBJECTIVES:We assessed the association between adverse birth outcomes and urinary biomarkers of prenatal atr...

journal_title：Environmental health perspectives

authors： Chevrier C,Limon G,Monfort C,Rouget F,Garlantézec R,Petit C,Durand G,Cordier S

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Polybrominated diphenyl ethers (PBDEs) have been used as flame retardants and are becoming a ubiquitous environmental contaminant. Adverse effects in the developing brain are of great health concern. OBJECTIVE:We investigated the effect of PBDEs/hydroxylated PBDEs (OH-PBDEs) on thyroid hormone (TH) receptor...

journal_title：Environmental health perspectives

authors： Ibhazehiebo K,Iwasaki T,Kimura-Kuroda J,Miyazaki W,Shimokawa N,Koibuchi N

更新日期：2011-02-01 00:00:00

abstract：:This study assessed whether exposure of male rats to two estrogenic, environmental chemicals, 4-octylphenol (OP) and butyl benzyl phthalate (BBP) during gestation or during the first 21 days of postnatal life, affected testicular size or spermatogenesis in adulthood (90-95 days of age). Chemicals were administered via...

journal_title：Environmental health perspectives

authors： Sharpe RM,Fisher JS,Millar MM,Jobling S,Sumpter JP

更新日期：1995-12-01 00:00:00

abstract：:The Florence Statement on Triclosan and Triclocarban documents a consensus of more than 200 scientists and medical professionals on the hazards of and lack of demonstrated benefit from common uses of triclosan and triclocarban. These chemicals may be used in thousands of personal care and consumer products as well as ...

journal_title：Environmental health perspectives

authors： Halden RU,Lindeman AE,Aiello AE,Andrews D,Arnold WA,Fair P,Fuoco RE,Geer LA,Johnson PI,Lohmann R,McNeill K,Sacks VP,Schettler T,Weber R,Zoeller RT,Blum A

更新日期：2017-06-20 00:00:00

abstract：:The normal mucociliary epithelium of the respiratory tract in chronic cigarette smokers often is replaced focally by a metaplastic squamous epithelium. Because asbestos workers who smoke have a substantially greater risk of bronchogenic carcinoma than nonsmokers, we hypothesized that interaction of asbestos with squam...

journal_title：Environmental health perspectives

authors： Woodworth CD,Mossman BT,Craighead JE

更新日期：1983-09-01 00:00:00

abstract：:The problems of quantitating chrysotile in water by fiber count techniques are reviewed briefly and the use of mass quantitation is suggested as a preferable measure. Chrysotile fiber has been found in almost every sample of natural water examined, but generally transmission electron miscroscopy (TEM) is required beca...

journal_title：Environmental health perspectives

authors： Speil S

更新日期：1974-12-01 00:00:00

abstract：:The unique nonrespiratory functions of the lungs have become more apparent in recent years. The isolated perfused lung model offers many advantages over other methods for the study of pulmonary metabolism, xenobiotic disposition and the influence of interactions among agents of different physical forms. Detailed descr...

journal_title：Environmental health perspectives

authors： Niemeier RW

更新日期：1984-06-01 00:00:00

abstract：:The X-ray crystallographic structural determinations of synthetic estrogens and antiestrogens provide reliable information on the global minimum energy conformation of these molecules or a local minimum energy conformation that is within 1 or 2 kcal/mole of the global minimum. In favorable cases, state-of-the-art mole...

journal_title：Environmental health perspectives

authors： Duax WL,Griffin JF,Weeks CM,Korach KS

更新日期：1985-09-01 00:00:00

abstract：:There are still many uncertainties regarding the risk of adverse pregnancy outcomes associated with exposure to drinking water disinfection by-products. In Montréal, Québec, Canada, we carried out a hospital-based case-control study including 493 cases of intrauterine growth restriction defined as birth weight below t...

journal_title：Environmental health perspectives

authors： Infante-Rivard C

更新日期：2004-08-01 00:00:00

abstract：:We evaluated predictors of plasma concentrations of dichlorodiphenyldichloroethylene (DDE), a metabolite of dichlorodiphenyltrichloroethane (DDT), and polychlorinated biphenyls (PCBs) in a group of 240 women, controls from a breast cancer case-control study nested in the Nurses' Health Study. We considered personal at...

journal_title：Environmental health perspectives

authors： Laden F,Neas LM,Spiegelman D,Hankinson SE,Willett WC,Ireland K,Wolff MS,Hunter DJ

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Humans have been exposed to fine and ultrafine particles throughout their history. Since the Industrial Revolution, sources, doses, and types of nanoparticles have changed dramatically. In the last decade, the rapidly developing field of nanotechnology has led to an increase of engineered nanoparticles with ...

journal_title：Environmental health perspectives

authors： Wick P,Malek A,Manser P,Meili D,Maeder-Althaus X,Diener L,Diener PA,Zisch A,Krug HF,von Mandach U

更新日期：2010-03-01 00:00:00

abstract：:The use of physiologically based pharmacokinetic (PBPK) models has been proposed as a means of estimating the dose of the reactive metabolites of carcinogenic xenobiotics reaching target tissues, thereby affording an opportunity to base estimates of potential cancer risk on tissue dose rather than external levels of e...

journal_title：Environmental health perspectives

authors： Krewski D,Withey JR,Ku LF,Andersen ME

更新日期：1994-12-01 00:00:00

abstract：:The cytotoxic action of a series of mineral dusts has been studied using Chinese hamster V79-4 cells obtained from three separate laboratories in the UK. The dusts which have been studied include samples of asbestos from the Union Internationale Contre le Cancer reference series and an internationally available sample...

journal_title：Environmental health perspectives

authors： Lock SO,Chamberlain M

更新日期：1983-09-01 00:00:00

abstract：:The assessment of mixture effects of estrogenic agents is regarded as an issue of high priority by many governmental agencies and expert decision-making bodies all over the world. However, the few mixture studies published so far have suffered from conceptual and experimental problems and are considered to be inconclu...

journal_title：Environmental health perspectives

authors： Payne J,Rajapakse N,Wilkins M,Kortenkamp A

更新日期：2000-10-01 00:00:00

abstract：:The physiological function of copper(I)-metallothionein is not well understood. The respiratory function of hemocyanin, a copper(I)-containing respiratory protein found in the hemolymph of many invertebrates, has been known a long time. However, the mechanism by which Cu(I) is inserted into the oxygen-binding site of ...

journal_title：Environmental health perspectives

authors： Brouwer M,Whaling P,Engel DW

更新日期：1986-03-01 00:00:00

abstract：:Short-term increases in ambient air pollution have been associated with an increased incidence of acute cardiac events. We assessed the effect of inhalation exposure to concentrated ambient particles (CAPs) on myocardial ischemia in a canine model of coronary artery occlusion. Six mongrel dogs underwent thoracotomy fo...

journal_title：Environmental health perspectives

authors： Wellenius GA,Coull BA,Godleski JJ,Koutrakis P,Okabe K,Savage ST,Lawrence JE,Murthy GG,Verrier RL

更新日期：2003-04-01 00:00:00

abstract：:Residents living in communities near Superfund sites have expressed concern that releases from these facilities affect their health, including adverse effects on their immune systems. We used data from six cross-sectional studies to evaluate whether people who live near several Superfund sites are more likely to have ...

journal_title：Environmental health perspectives

authors： Williamson DM,White MC,Poole C,Kleinbaum D,Vogt R,North K

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Drinking water in multiple water districts in the Mid-Ohio Valley has been contaminated with perfluorooctanoic acid (PFOA), which was released by a nearby DuPont chemical plant. Two highly contaminated water districts began granular activated carbon filtration in 2007. OBJECTIVES:To determine the rate of de...

journal_title：Environmental health perspectives

authors： Bartell SM,Calafat AM,Lyu C,Kato K,Ryan PB,Steenland K

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Understanding the potential links between extreme weather events and human health in India is important in the context of vulnerability and adaptation to climate change. Research exploring such linkages in India is sparse. OBJECTIVES:We evaluated the association between extreme precipitation and gastrointes...

journal_title：Environmental health perspectives

authors： Bush KF,O'Neill MS,Li S,Mukherjee B,Hu H,Ghosh S,Balakrishnan K

更新日期：2014-03-01 00:00:00

abstract：:Biological monitoring of exposure to chemicals in the workplace is an important component of exposure assessment and prevention of adverse health effects. It should be employed in conjunction with ambient air monitoring to provide information on the absorbed dose of a chemical agent and the effect of all routes of exp...

journal_title：Environmental health perspectives

authors： Morgan MS

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND:Due to the large number of chemicals not yet tested for carcinogenicity but to which people are exposed, the limited number of human and animal cancer studies conducted each year, and the frequent need for a timely response, mechanistic data are playing an increasingly important role in carcinogen hazard ide...

journal_title：Environmental health perspectives

authors： Atwood ST,Lunn RM,Garner SC,Jahnke GD

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Phthalates may pose a risk for perinatal developmental effects. An important question relates to the choice of suitable biological matrices for assessing exposure during this period. OBJECTIVES:This study was designed to measure the concentrations of phthalate diesters or their metabolites in breast milk, b...

journal_title：Environmental health perspectives

authors： Högberg J,Hanberg A,Berglund M,Skerfving S,Remberger M,Calafat AM,Filipsson AF,Jansson B,Johansson N,Appelgren M,Håkansson H

更新日期：2008-03-01 00:00:00

abstract：:Most of the general population is exposed to carbaryl and other contemporary-use insecticides at low levels. Studies of laboratory animals, in addition to limited human data, show an association between carbaryl exposure and decreased semen quality. In the present study we explored whether environmental exposures to 1...

journal_title：Environmental health perspectives

authors： Meeker JD,Ryan L,Barr DB,Herrick RF,Bennett DH,Bravo R,Hauser R

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVE:We reviewed the scientific background for the current health-based World Health Organization (WHO) guideline value for manganese in drinking water. DATA SOURCES AND EXTRACTION:The initial starting point was the background document for the development of the WHO's guideline value for manganese in drinking wat...

journal_title：Environmental health perspectives

authors： Ljung K,Vahter M

更新日期：2007-11-01 00:00:00

abstract：:Worldwide climate change and loss of biodiversity are issues of global scope and importance that have recently become subjects of considerable public concern. Unlike classical public health issues and many environmental issues, their perceived threat lies in their potential to disrupt ecological functioning and stabil...

journal_title：Environmental health perspectives

authors： Jutro PR

更新日期：1991-12-01 00:00:00

abstract：:Metabolic enzymes involved in benzene activation or detoxification, including NAD(P)H, quinone oxidoreductase 1 (NQO1), cytochrome P450 2E1 (CYP2E1), myeloperoxidase (MPO), glutathione-S-transferase mu-1 (GSTM1), and glutathione-S-transferase theta-1 (GSTT1), were studied for their roles in human susceptibility to ben...

journal_title：Environmental health perspectives

authors： Wan J,Shi J,Hui L,Wu D,Jin X,Zhao N,Huang W,Xia Z,Hu G

更新日期：2002-12-01 00:00:00