Drinking water contaminants, gene polymorphisms, and fetal growth.

abstract：BACKGROUND:Previous literature suggests an association between organochlorines and behavioral measures in childhood, including inattention. OBJECTIVE:This study was designed to assess whether prenatal organochlorine exposure is associated with measures of attention in early infancy. METHODS:We investigated an associa...

journal_title：Environmental health perspectives

authors： Sagiv SK,Nugent JK,Brazelton TB,Choi AL,Tolbert PE,Altshul LM,Korrick SA

更新日期：2008-05-01 00:00:00

abstract：:Uranium accumulates in bone, affects bone metabolism in laboratory animals, and when ingested in drinking water increases urinary excretion of calcium and phosphate, important components in the bone structure. However, little is known about bone effects of ingested natural uranium in humans. We studied 146 men and 142...

journal_title：Environmental health perspectives

authors： Kurttio P,Komulainen H,Leino A,Salonen L,Auvinen A,Saha H

更新日期：2005-01-01 00:00:00

abstract：:The rapid development of the chemical industry, combustion of fossil fuels, and smoking of tobacco have resulted in contact of the general population with benzo(a)pyrene and other carcinogenic aromatic hydrocarbons. Persons especially at risk occupationally are those engaged in thermal processing of oil shale, coal, a...

journal_title：Environmental health perspectives

authors： Pashin YV,Bakhitova LM

更新日期：1979-06-01 00:00:00

abstract：:Chronic exposure to oxidants is associated with an increased incidence of malignancy; however, the mechanism(s) by which oxidants contribute to carcinogenesis is unknown. Since oncogene activation plays an important role in carcinogenesis, we hypothesized that hydroxyl radical-induced DNA damage might contribute to ca...

journal_title：Environmental health perspectives

authors： Jackson JH

更新日期：1994-12-01 00:00:00

abstract：:The past and current EPA research and regulatory programs as they relate to non-regulated emissions from light-duty motor vehicles are reviewed. Provisions of Sections 202(a) and 211 of the 1970 Clean Air Act Amendments are discussed and their relationships to the nonregulated emissions issue detailed. The EPA positio...

journal_title：Environmental health perspectives

authors： Moran JB

更新日期：1975-04-01 00:00:00

abstract：BACKGROUND:Polybrominated diphenyl ethers (PBDEs), commonly used in building materials, electronics, plastics, polyurethane foams, and textiles, are health hazards found in the environment. OBJECTIVE:In this study we investigated the effects of PBDE-209, a deca-PBDE, on the regulation of growth and apoptosis of breast...

journal_title：Environmental health perspectives

authors： Li ZH,Liu XY,Wang N,Chen JS,Chen YH,Huang JT,Su CH,Xie F,Yu B,Chen DJ

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Mortality displacement (or "harvesting") has been identified as a key issue in the assessment of the temperature-mortality relationship. However, only a few studies have addressed the "harvesting" issue and findings have not been consistent. OBJECTIVES:We examined the potential impact of both short- and lon...

journal_title：Environmental health perspectives

authors： Qiao Z,Guo Y,Yu W,Tong S

更新日期：2015-08-01 00:00:00

abstract：:Multiple chemical sensitivity (MCS) is a condition in which persons experience negative health effects in multiple organ systems from exposure to low levels of common chemicals. Although symptoms experienced from particular chemicals vary across persons, they are generally stable within persons. The sensitivities ofte...

journal_title：Environmental health perspectives

authors： Gibson PR,Elms AN,Ruding LA

更新日期：2003-09-01 00:00:00

abstract：:A cohort of 12,110 male workers employed 1 or more years in eight styrene-butadiene polymer (SBR) manufacturing plants in the United States and Canada has been followed for mortality over a 40-year period, 1943 to 1982. The all-cause mortality of these workers was low [standardized mortality ratio (SMR) = 0.81] compar...

journal_title：Environmental health perspectives

authors： Matanoski GM,Santos-Burgoa C,Schwartz L

更新日期：1990-06-01 00:00:00

abstract：:One of the most serious consequences of cancer therapy is the development of a second cancer, especially leukemia. Several distinct subsets of therapy-related leukemia can now be distinguished. Classic therapy-related myeloid leukemia typically occurs 5 to 7 years after exposure to alkylating agents and/or irradiation...

journal_title：Environmental health perspectives

authors： Larson RA,LeBeau MM,Vardiman JW,Rowley JD

更新日期：1996-12-01 00:00:00

abstract：:Pregnant rats were exposed by inhalation to vapor concentrations of 100, 200, 400 or 800 ppm of ethylene glycol monopropyl ether acetate on days 6 through 15 of gestation. Concentrations of 400 and 800 ppm reduced the feed intake, mean body weight and red blood cell counts. Mean corpuscular volume and mean corpuscular...

journal_title：Environmental health perspectives

authors： Krasavage WJ,Katz GV

更新日期：1984-08-01 00:00:00

abstract：BACKGROUND:Thyroid hormones are important regulators of brain development. During critical periods of development, even transient disorders in thyroid hormone availability may lead to profound neurologic impairment. Animal experiments have shown that certain environmental pollutants, including heavy metals and organoch...

journal_title：Environmental health perspectives

authors： Maervoet J,Vermeir G,Covaci A,Van Larebeke N,Koppen G,Schoeters G,Nelen V,Baeyens W,Schepens P,Viaene MK

更新日期：2007-12-01 00:00:00

abstract：:The integrated exposure uptake biokinetic model for lead in children was developed to provide plausible blood lead distributions corresponding to particular combinations of multimedia lead exposure. The model is based on a set of equations that convert lead exposure (expressed as micrograms per day) to blood lead conc...

journal_title：Environmental health perspectives

authors： White PD,Van Leeuwen P,Davis BD,Maddaloni M,Hogan KA,Marcus AH,Elias RW

更新日期：1998-12-01 00:00:00

abstract：:The assessment of mixture effects of estrogenic agents is regarded as an issue of high priority by many governmental agencies and expert decision-making bodies all over the world. However, the few mixture studies published so far have suffered from conceptual and experimental problems and are considered to be inconclu...

journal_title：Environmental health perspectives

authors： Payne J,Rajapakse N,Wilkins M,Kortenkamp A

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:Increasing evidence suggests a proatherogenic role for lipoprotein-associated phospholipase A₂ (Lp-PLA2). A meta-analysis of published cohorts has shown that Lp-PLA2 is an independent predictor of coronary heart disease events and stroke. OBJECTIVE:In this study, we investigated whether the association betw...

journal_title：Environmental health perspectives

authors： Brüske I,Hampel R,Baumgärtner Z,Rückerl R,Greven S,Koenig W,Peters A,Schneider A

更新日期：2011-07-01 00:00:00

abstract：:We conducted a study on building-related respiratory disease and associated social impact in an office building with water incursions in the northeastern United States. An initial questionnaire had 67% participation (888/1,327). Compared with the U.S. adult population, prevalence ratios were 2.2-2.5 for wheezing, life...

journal_title：Environmental health perspectives

authors： Cox-Ganser JM,White SK,Jones R,Hilsbos K,Storey E,Enright PL,Rao CY,Kreiss K

更新日期：2005-04-01 00:00:00

abstract：:Heat is the primary weather-related cause of death in the United States. Increasing heat and humidity, at least partially related to anthropogenic climate change, suggest that a long-term increase in heat-related mortality could occur. We calculated the annual excess mortality on days when apparent temperatures--an in...

journal_title：Environmental health perspectives

authors： Davis RE,Knappenberger PC,Michaels PJ,Novicoff WM

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:The rapidly increasing dissemination of carbapenem-resistant Enterobacteriaceae (CRE) in both humans and animals poses a global threat to public health. However, the transmission of CRE between humans and animals has not yet been well studied. OBJECTIVES:We investigated the prevalence, risk factors, and dri...

journal_title：Environmental health perspectives

authors： Li J,Bi Z,Ma S,Chen B,Cai C,He J,Schwarz S,Sun C,Zhou Y,Yin J,Hulth A,Wang Y,Shen Z,Wang S,Wu C,Nilsson LE,Walsh TR,Börjesson S,Shen J,Sun Q,Wang Y

更新日期：2019-10-01 00:00:00

abstract：:Calcium has been implicated as a regulatory factor in many physiological and pathophysiological processes in the renal cell. Under physiological conditions, the cytosolic free calcium concentration is maintained at approximately 100 nM. Most of the releasable cell Ca2+ resides in the nonmitochondrial compartments. In ...

journal_title：Environmental health perspectives

authors： Bonventre JV

更新日期：1990-03-01 00:00:00

abstract：:The association of malignant mesothelioma (MM) and nonoccupational asbestos exposure is currently debated. Our study investigates environmental and domestic asbestos exposure in the city where the largest Italian asbestos cement (AC) factory was located. This population-based case-control study included pleural MM (hi...

journal_title：Environmental health perspectives

authors： Magnani C,Dalmasso P,Biggeri A,Ivaldi C,Mirabelli D,Terracini B

更新日期：2001-09-01 00:00:00

abstract：:A literature review of experimental and human exposure studies of skin permeation and cutaneous hypersensitivity reactions evoked by chromium was carried out to provide a basis for making a risk assessment of chromium as a soil contaminant. In vitro and in vivo studies demonstrated that 1 to 4% of the applied dose of ...

journal_title：Environmental health perspectives

authors： Bagdon RE,Hazen RE

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND:Many pesticides in current use have recently been revealed as in vitro androgen receptor (AR) antagonists, but information about their combined effects is lacking. OBJECTIVE:We investigated the combined effects and the competitive AR antagonism of pesticide mixtures. METHODS:We used the MDA-kb2 assay to te...

journal_title：Environmental health perspectives

authors： Orton F,Rosivatz E,Scholze M,Kortenkamp A

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:The toxicity of many xenobiotic compounds is believed to involve oxidative injury to cells. Direct assessment of mechanistic events involved in xenobiotic-induced oxidative stress is not easily achievable. Development of genetically encoded probes designed for monitoring intracellular redox changes represent...

journal_title：Environmental health perspectives

authors： Gibbs-Flournoy EA,Simmons SO,Bromberg PA,Dick TP,Samet JM

更新日期：2013-03-01 00:00:00

abstract：:Polybrominated biphenyls (PBBs) cause a mixed-type (phenobarbital- plus 3-methylcholanthrene-like) induction of liver microsomal drug metabolizing enzymes in rats. However, 2,2',4,4',5,5'-hexabromobiphenyl and 2,2',3,4,4',5,5'-heptabromobiphenyl, which together comprise less than 80% of PBBs (FireMaster), were shown t...

journal_title：Environmental health perspectives

authors： Moore RW,Dannan GA,Aust SD

更新日期：1978-04-01 00:00:00

abstract：:We have demonstrated that the pyrolysis products of amino acids and proteins in model systems are mutagenic. The mutagenic principles in the pyrolyzates of amino acids have been isolated and identified by Sugimura et al. We have isolated and identified amino-alpha-carbolines from pyrolyzed soybean globulin as mutagens...

journal_title：Environmental health perspectives

authors： Yoshida D,Matsumoto T,Okamoto H,Mizusaki S,Kushi A,Fukuhara Y

更新日期：1986-08-01 00:00:00

abstract：BACKGROUND:Although public concern has focused on the environmental impact of the Deepwater Horizon oil spill, the public health impact on a broad range of coastal communities is minimally known. OBJECTIVE:We sought to determine the acute level of distress (depression, anxiety), mechanisms of adjustment (coping, resil...

journal_title：Environmental health perspectives

authors： Grattan LM,Roberts S,Mahan WT Jr,McLaughlin PK,Otwell WS,Morris JG Jr

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Organophosphate developmental neurotoxicity involves multiple mechanisms converging on neural cell replication and differentiation. OBJECTIVES:We evaluated mechanisms contributing to the adverse effects of chlorpyrifos (CPF) on DNA synthesis, cell number and size, and cell signaling mediated by adenylyl cyc...

journal_title：Environmental health perspectives

authors： Slotkin TA,MacKillop EA,Ryde IT,Seidler FJ

更新日期：2007-09-01 00:00:00

abstract：:Alveolar macrophages were treated with carbon blacks and adsorbates in order to evaluate the biologic effect of adsorbate, adsorbent and adsorbate-adsorbent complexes. Their capacity to phagocytize a subsequent challenge via the Fc-membrane receptor was quantified. Phagocytosis was suppressed in a dose-related manner ...

journal_title：Environmental health perspectives

authors： Jakab GJ,Risby TH,Sehnert SS,Hmieleski RR,Farrington JE

更新日期：1990-06-01 00:00:00

abstract：:We present evidence that the El Niño phenomenon intensifies the annual cycle of malaria cases for Plasmodium vivax and Plasmodium falciparum in endemic areas of Colombia as a consequence of concomitant anomalies in the normal annual cycle of temperature and precipitation. We used simultaneous analyses of both variable...

journal_title：Environmental health perspectives

authors： Poveda G,Rojas W,Quiñones ML,Vélez ID,Mantilla RI,Ruiz D,Zuluaga JS,Rua GL

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Environmental heat exposure is a public health concern. The impacts of environmental heat on mortality and morbidity at the population scale are well documented, but little is known about specific exposures that individuals experience. OBJECTIVES:The first objective of this work was to catalyze discussion o...

journal_title：Environmental health perspectives

authors： Kuras ER,Richardson MB,Calkins MM,Ebi KL,Hess JJ,Kintziger KW,Jagger MA,Middel A,Scott AA,Spector JT,Uejio CK,Vanos JK,Zaitchik BF,Gohlke JM,Hondula DM

更新日期：2017-08-01 00:00:00