Workshop on perinatal exposure to dioxin-like compounds. V. Immunologic effects.


:The immune system comprises a highly integrated network of multiple tissues and cell types with complicated interactions and effects. It is modulated by the endocrine and nervous systems and there is growing realization of its multifunctionality. The session focusing on immunologic effects of dioxin and related compounds following prenatal exposure involved a review of the immunotoxic effects that have been reported for polyhalogenated aromatic hydrocarbons (PHAHs), a discussion of species differences in responses, and development of the immune system, and data from two ongoing epidemiological studies comparing the immune status of children exposed to higher-than-average concentrations of PHAHs both prenatally and lactationally.


Birnbaum LS




Has Abstract


1995-03-01 00:00:00








103 Suppl 2


  • Low-Dose Bisphenol A in a Rat Model of Endometrial Cancer: A CLARITY-BPA Study.

    abstract:BACKGROUND:Bisphenol A (BPA) is known to be biologically active in experimental models even at low levels of exposure. However, its impact on endometrial cancer remains unclear. OBJECTIVES:This study aimed to investigate whether lifelong exposure to different doses of BPA induced uterine abnormalities and molecular ch...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Leung YK,Biesiada J,Govindarajah V,Ying J,Kendler A,Medvedovic M,Ho SM

    更新日期:2020-12-01 00:00:00

  • Variability over 1 week in the urinary concentrations of metabolites of diethyl phthalate and di(2-ethylhexyl) phthalate among eight adults: an observational study.

    abstract:BACKGROUND:Phthalates are metabolized and eliminated in urine within hours after exposure. Several reports suggest that concentrations of phthalate metabolites in a spot urine sample can provide a reliable estimation of exposure to phthalates for up to several months. OBJECTIVES:We examined inter- and intraperson and ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Preau JL Jr,Wong LY,Silva MJ,Needham LL,Calafat AM

    更新日期:2010-12-01 00:00:00

  • Neurochemistry and toxicology: overview.

    abstract::We have witnessed a tremendous increase in our knowledge of the molecular and biochemical mechanisms which underly the activities of the nervous system. Such knowledge is essential in order to determine the basic mechanisms involved in neurotoxic events. An overview of how neurotoxins could conceivably interfere with ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Damstra T

    更新日期:1978-10-01 00:00:00

  • Application of HPLC to the isolation of molecular targets in dosimetry studies.

    abstract::High-performance liquid chromatography (HPLC) methods are described which permit the rapid isolation of multiple target macromolecules from the tissues of animals exposed to chemical mutagens. DNA and selected chromosomal proteins are isolated in a simple two step separation scheme. Isolated nuclei are dissolved in 3 ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Balhorn R,Mazrimas JA,Corzett M

    更新日期:1985-10-01 00:00:00

  • Tobacco smoke exposure and altered nasal responses to live attenuated influenza virus.

    abstract:BACKGROUND:Epidemiologic evidence links tobacco smoke and increased risk for influenza in humans, but the specific host defense pathways involved are unclear. OBJECTIVE:We developed a model to examine influenza-induced innate immune responses in humans and test the hypothesis that exposure to cigarette smoke alters na...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Noah TL,Zhou H,Monaco J,Horvath K,Herbst M,Jaspers I

    更新日期:2011-01-01 00:00:00

  • Developmental toxicity of ethylene glycol monopropyl ether acetate (EGPEA) in the rat.

    abstract::Pregnant rats were exposed by inhalation to vapor concentrations of 100, 200, 400 or 800 ppm of ethylene glycol monopropyl ether acetate on days 6 through 15 of gestation. Concentrations of 400 and 800 ppm reduced the feed intake, mean body weight and red blood cell counts. Mean corpuscular volume and mean corpuscular...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Krasavage WJ,Katz GV

    更新日期:1984-08-01 00:00:00

  • A Combined Morphometric and Statistical Approach to Assess Nonmonotonicity in the Developing Mammary Gland of Rats in the CLARITY-BPA Study.

    abstract:BACKGROUND:The Consortium Linking Academic and Regulatory Insights on Bisphenol-A (CLARITY-BPA) is a rare collaboration of guideline-compliant (core) studies and academic hypothesis-based studies to assess the effects of bisphenol A (BPA). OBJECTIVES:We aimed to a) determine whether BPA showed effects on the developin...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Montévil M,Acevedo N,Schaeberle CM,Bharadwaj M,Fenton SE,Soto AM

    更新日期:2020-05-01 00:00:00

  • Mechanisms underlying Children's susceptibility to environmental toxicants.

    abstract::An important public health challenge has been the need to protect children's health. To accomplish this goal, the scientific community needs scientifically based child-specific risk assessment methods. Critical to their development is the need to understand mechanisms underlying children's sensitivity to environmental...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审


    authors: Faustman EM,Silbernagel SM,Fenske RA,Burbacher TM,Ponce RA

    更新日期:2000-03-01 00:00:00

  • Coupling between annual and ENSO timescales in the malaria-climate association in Colombia.

    abstract::We present evidence that the El Niño phenomenon intensifies the annual cycle of malaria cases for Plasmodium vivax and Plasmodium falciparum in endemic areas of Colombia as a consequence of concomitant anomalies in the normal annual cycle of temperature and precipitation. We used simultaneous analyses of both variable...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Poveda G,Rojas W,Quiñones ML,Vélez ID,Mantilla RI,Ruiz D,Zuluaga JS,Rua GL

    更新日期:2001-05-01 00:00:00

  • U.S. cancer mortality 1950-1978: a strategy for analyzing spatial and temporal patterns.

    abstract::There are a number of technical and statistical problems in monitoring the temporal and spatial variation of local area death rates in the United States for evidence of systematically elevated risks. An analytic strategy is proposed to reduce one of the major statistical concerns, i.e., that of identifying areas with ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Manton KG,Stallard E,Creason JP,Riggan WB

    更新日期:1985-05-01 00:00:00

  • Effects of decabrominated diphenyl ether (PBDE-209) in regulation of growth and apoptosis of breast, ovarian, and cervical cancer cells.

    abstract:BACKGROUND:Polybrominated diphenyl ethers (PBDEs), commonly used in building materials, electronics, plastics, polyurethane foams, and textiles, are health hazards found in the environment. OBJECTIVE:In this study we investigated the effects of PBDE-209, a deca-PBDE, on the regulation of growth and apoptosis of breast...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Li ZH,Liu XY,Wang N,Chen JS,Chen YH,Huang JT,Su CH,Xie F,Yu B,Chen DJ

    更新日期:2012-04-01 00:00:00

  • Cancer mortality in U.S. counties with plastics and related industries.

    abstract::Counties in the United States have been identified with chemical establishments whose primary manufacturing processes use vinyl chloride. Site-specific cancer mortality comparisons have revealed an excess of multiple myeloma in males associated with two of the manufacturing categories, synthetic rubber and synthetic f...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Mason TJ

    更新日期:1975-06-01 00:00:00

  • Cell-specific activation and detoxification of benzene metabolites in mouse and human bone marrow: identification of target cells and a potential role for modulation of apoptosis in benzene toxicity.

    abstract::The role of cell-specific metabolism in benzene toxicity was examined in both murine and human bone marrow. Hemopoietic progenitor cells and stromal cells are important control points for regulation of hemopoiesis. We show that the selective toxicity of hydroquinone at the level of the macrophage in murine bone marrow...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Ross D,Siegel D,Schattenberg DG,Sun XM,Moran JL

    更新日期:1996-12-01 00:00:00

  • Associations of toenail arsenic, cadmium, mercury, manganese, and lead with blood pressure in the normative aging study.

    abstract:BACKGROUND:Arsenic, cadmium, mercury, and lead are associated with cardiovascular disease in epidemiologic research. These associations may be mediated by direct effects of the metals on blood pressure (BP) elevation. Manganese is associated with cardiovascular dysfunction and hypotension in occupational cohorts. OBJE...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Mordukhovich I,Wright RO,Hu H,Amarasiriwardena C,Baccarelli A,Litonjua A,Sparrow D,Vokonas P,Schwartz J

    更新日期:2012-01-01 00:00:00

  • Evaluation of the effectiveness of mass screening for uterine cancer in Japan: the potential years of life lost.

    abstract::To evaluate the effectiveness of mass screening for uterine cancer in Japan, we compared the changes in the age-adjusted rates of potential years of life lost (PYLL) due to uterine cancer between 1969 and 1972 to 1973 through 1977 between the high coverage-rate (intensively screened) areas and the comparable control a...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Kuroishi T,Hirose K,Tominaga S

    更新日期:1990-07-01 00:00:00

  • Identifying populations potentially exposed to agricultural pesticides using remote sensing and a Geographic Information System.

    abstract::Pesticides used in agriculture may cause adverse health effects among the population living near agricultural areas. However, identifying the populations most likely to be exposed is difficult. We conducted a feasibility study to determine whether satellite imagery could be used to reconstruct historical crop patterns...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Ward MH,Nuckols JR,Weigel SJ,Maxwell SK,Cantor KP,Miller RS

    更新日期:2000-01-01 00:00:00

  • Hormesis as a biological hypothesis.

    abstract::A comprehensive effort was undertaken to identify articles demonstrating chemical hormesis. Nearly 4000 potentially relevant articles were retrieved from preliminary computer database searches by using various key word descriptors and extensive cross-referencing. A priori evaluation criteria were established including...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审


    authors: Calabrese EJ,Baldwin LA

    更新日期:1998-02-01 00:00:00

  • Testing their metal.

    abstract::Metals continually rank at the top of the U.S. Environmental Protection Agency's annual list of agents that pose the greatest hazard to the people of the United States. Metals aren't going away, either. They do not biodegrade, and they often concentrate in human and animal cells and tissue. Many metals are known human...

    journal_title:Environmental health perspectives

    pub_type: 新闻


    authors: Fisher BE

    更新日期:1999-05-01 00:00:00

  • Urinary bisphenol A levels in young men: association with reproductive hormones and semen quality.

    abstract:BACKGROUND:Few human studies have examined bisphenol A (BPA) exposure in relation to semen quality and reproductive hormones in men, and results are divergent. OBJECTIVES:We examined associations between urinary BPA concentration and reproductive hormones, as well as semen quality, in young men from the general popula...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Lassen TH,Frederiksen H,Jensen TK,Petersen JH,Joensen UN,Main KM,Skakkebaek NE,Juul A,Jørgensen N,Andersson AM

    更新日期:2014-05-01 00:00:00

  • Colorectal Cancer and Long-Term Exposure to Trihalomethanes in Drinking Water: A Multicenter Case-Control Study in Spain and Italy.

    abstract:BACKGROUND:Evidence on the association between colorectal cancer and exposure to disinfection by-products in drinking water is inconsistent. OBJECTIVES:We assessed long-term exposure to trihalomethanes (THMs), the most prevalent group of chlorination by-products, to evaluate the association with colorectal cancer. ME...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,多中心研究


    authors: Villanueva CM,Gracia-Lavedan E,Bosetti C,Righi E,Molina AJ,Martín V,Boldo E,Aragonés N,Perez-Gomez B,Pollan M,Acebo IG,Altzibar JM,Zabala AJ,Ardanaz E,Peiró R,Tardón A,Chirlaque MD,Tavani A,Polesel J,Serraino D,Pi

    更新日期:2017-01-01 00:00:00

  • Exposure of Adult Female Mice to Low Doses of di(2-ethylhexyl) Phthalate Alone or in an Environmental Phthalate Mixture: Evaluation of Reproductive Behavior and Underlying Neural Mechanisms.

    abstract:BACKGROUND:We have previously shown that adult male mice exposure to low doses of an ubiquitous endocrine disruptor, di(2-ethylhexyl) phthalate (DEHP), alters courtship behavior. OBJECTIVE:The effects of adult exposure to low doses of DEHP alone or in an environmental phthalate mixture on estrous cyclicity, reproducti...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Adam N,Brusamonti L,Mhaouty-Kodja S

    更新日期:2021-01-01 00:00:00

  • Prenatal Exposure to DDT and Pyrethroids for Malaria Control and Child Neurodevelopment: The VHEMBE Cohort, South Africa.

    abstract:BACKGROUND:Although indoor residual spraying (IRS) with dichlorodiphenyltrichloroethane (DDT) and pyrethroids effectively controls malaria, it potentially increases human exposure to these insecticides. Previous studies suggest that prenatal exposure to these insecticides may impact human neurodevelopment. OBJECTIVES:...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Eskenazi B,An S,Rauch SA,Coker ES,Maphula A,Obida M,Crause M,Kogut KR,Bornman R,Chevrier J

    更新日期:2018-04-06 00:00:00

  • Persistent pesticides in human breast milk and cryptorchidism.

    abstract:INTRODUCTION:Prenatal exposure to some pesticides can adversely affect male reproductive health in animals. We investigated a possible human association between maternal exposure to 27 organochlorine compounds used as pesticides and cryptorchidism among male children. DESIGN:Within a prospective birth cohort, we perfo...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Damgaard IN,Skakkebaek NE,Toppari J,Virtanen HE,Shen H,Schramm KW,Petersen JH,Jensen TK,Main KM,Nordic Cryptorchidism Study Group.

    更新日期:2006-07-01 00:00:00

  • A role for associated transition metals in the immunotoxicity of inhaled ambient particulate matter.

    abstract::Epidemiologic studies demonstrate that infection, specifically pneumonia, contributes substantially to the increased morbidity and mortality among elderly individuals following exposure to ambient particulate matter (PM). This laboratory has previously demonstrated that a single inhalation exposure of Streptococcus pn...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Zelikoff JT,Schermerhorn KR,Fang K,Cohen MD,Schlesinger RB

    更新日期:2002-10-01 00:00:00

  • A Bayesian hierarchical approach for relating PM(2.5) exposure to cardiovascular mortality in North Carolina.

    abstract::Considerable attention has been given to the relationship between levels of fine particulate matter (particulate matter < or = 2.5 microm in aerodynamic diameter; PM(2.5) in the atmosphere and health effects in human populations. Since the U.S. Environmental Protection Agency began widespread monitoring of PM(2.5) lev...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Holloman CH,Bortnick SM,Morara M,Strauss WJ,Calder CA

    更新日期:2004-09-01 00:00:00

  • Neurogenic inflammation and sensitivity to environmental chemicals.

    abstract::Neurogenic inflammation as a pathway distinct from antigen-driven, immune-mediated inflammation may play a pivotal role in understanding a broad class of environmental health problems resulting from chemical exposures. Recent progress in understanding the mediators, triggers, and regulation of neurogenic inflammation ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审


    authors: Meggs WJ

    更新日期:1993-08-01 00:00:00

  • Transfer and Metabolism of the Xenoestrogen Zearalenone in Human Perfused Placenta.

    abstract:BACKGROUND:Pregnancy is a sensitive condition during which adverse environmental exposures should be monitored thoroughly and minimized whenever possible. In particular, the hormone balance during gestation is delicate, and disturbance may cause acute or chronic long-term health effects. A potential endocrine disruptio...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Warth B,Preindl K,Manser P,Wick P,Marko D,Buerki-Thurnherr T

    更新日期:2019-10-01 00:00:00

  • Xenobiotics and cell Death/Injury in neurodegenerative diseases

    abstract::With the "graying of America," the prevalence of neurodegenerative diseases such as Alzheimer disease (AD) and Parkinson disease (PD) will make increasingly greater demands on Medicare/Medicaid resources, which will greatly strain the national economy. It is imperative that prevention and intervention strategies for t...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章



    更新日期:1999-07-01 00:00:00

  • Aromatase activity in the ovary and brain of the eastern mosquitofish (Gambusia holbrooki) exposed to paper mill effluent.

    abstract::Studies have shown that female mosquitofish living downstream of a paper mill located on the Fenholloway River, Florida, have masculinized secondary sex characteristics, including altered anal fin development and reproductive behavior. Masculinization can be caused by exposure to androgens in the water or from an alte...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Orlando EF,Davis WP,Guillette LJ Jr

    更新日期:2002-06-01 00:00:00

  • Evolution of Minimum Mortality Temperature in Stockholm, Sweden, 1901-2009.

    abstract:BACKGROUND:The mortality impacts of hot and cold temperatures have been thoroughly documented, with most locations reporting a U-shaped relationship with a minimum mortality temperature (MMT) at which mortality is lowest. How MMT may have evolved over previous decades as the global mean surface temperature has increase...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Åström DO,Tornevi A,Ebi KL,Rocklöv J,Forsberg B

    更新日期:2016-06-01 00:00:00