Abstract:
:Aluminum lactate [Al(lact)3] (hydrophilic, hydrolytically unstable) and aluminum acetylacetonate [Al(acae)3] (lipophilic, hydrolytically stable) were tested as potential toxicants to rabbits upon IV administration both as aqueous solutions and as liposome suspensions. Both chemicals behaved as cardiotoxic agents when administered as aqueous solutions, but Al(acae)3 was at least two orders of magnitude more active than Al(lact)3. Al(acae)3, but not Al(lact)3, caused myocardial infarcts resembling those in humans (with contraction bands) at doses as low as 0.24 mg/kg body weight, as well as a prominent acanthocytosis. Al(lact)3, when administered as a liposome suspension, was about 300 times more toxic than in aqueous solution, although cardiac damage was not infarctual in character. Both chemical and physical speciation of aluminum(III) thus play an essential role in determining the toxicity of the metal.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Bombi GG,Corain B,Favarato M,Giordano R,Nicolini M,Perazzolo M,Tapparo A,Zatta Pdoi
10.1289/ehp.9089217subject
Has Abstractpub_date
1990-11-01 00:00:00pages
217-23eissn
0091-6765issn
1552-9924journal_volume
89pub_type
杂志文章abstract::The ability of a series of haloalkanes, haloethanols and haloacetaldehydes to induce mutations in Salmonella typhrimurium and preferentially to inhibit the growth of DNA polymerase-deficient E. coli (pol A(+)/pol A(-)) was investigated. For the haloalkanes investigated, the order of reactivities towards the E. coli po...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.772179
更新日期:1977-12-01 00:00:00
abstract::Two remote maritime populations were evaluated for their biological exposure to organochlorines in 1989-1990. Because of their high intake of seafood, these two populations have high biological levels. One hundred nine breast milk samples from Inuit women from Arctic Québec were analyzed to determine levels of polychl...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102s1205
更新日期:1994-01-01 00:00:00
abstract::Exposure to low levels of chemicals indoors is often to a mixture of volatile organic compounds (VOCs). It is of interest to determine if the symptomatic and sensory responses can be attributed to a single chemical or to a mixture of chemicals. To determine if sensory or symptomatic responses differ with exposure to s...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.98106739
更新日期:1998-11-01 00:00:00
abstract:BACKGROUND:"Airwave" is the new communication system currently being rolled out across the United Kingdom for the police and emergency services, based on the Terrestrial Trunked Radio Telecommunications System (TETRA). Some police officers have complained about skin rashes, nausea, headaches, and depression as a conseq...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.0901416
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Anogenital distance (AGD) in animals is a sensitive biomarker of fetal endocrine disruption and the associated testicular dysgenesis syndrome (TDS). However, AGD in human infants with cryptorchidism and hypospadias, which are potential manifestations of TDS during childhood, is not clearly described. OBJECT...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1307178
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Cadmium (Cd) is a ubiquitous environmental toxicant that can accumulate in the placenta during pregnancy, where it may impair placental function and affect fetal development. OBJECTIVES:We aimed to investigate Cd-associated variations in placental DNA methylation (DNAM) and associations with gene expression...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP2192
更新日期:2018-01-22 00:00:00
abstract::The formamidines, a relatively new group of acaricide-insecticides, are novel both in their range of biological activities and in their mode of action, which is presently unknown. This paper is a review of the historical development, properties, structures, uses, and chemistry of this group of pesticides, with particu...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.761457
更新日期:1976-04-01 00:00:00
abstract::This paper examines behavioral changes in natural populations of wildlife associated with pollution. Although some changes such as lack of nest attentiveness and decreased nest defense have been noted, the results have not been consistent and have been difficult to relate to specific pollutants. Experimental studies i...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.96104s2331
更新日期:1996-04-01 00:00:00
abstract:OBJECTIVE:The World Health Organization is the agency responsible for reporting the Millennium Development Goal (MDG) indicator "percentage of population using solid fuels." In this article, we present the results of a comprehensive assessment of solid fuel use, conducted in 2005, and discuss the implications of our fi...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8603
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND:Cirrhosis of the liver is thought to be a major cause of morbidity and mortality in sub-Saharan Africa, but few controlled studies on the etiology of cirrhosis have been conducted in this region. OBJECTIVES:We aimed to elucidate the association between environmental and infectious exposures and cirrhosis in...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.11661
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND:In a 1994 Ninth Circuit decision on the remand of Daubert v. Merrell Dow Pharmaceuticals, Inc., Judge Alex Kosinski wrote that science done for the purpose of litigation should be subject to more stringent standards of admissibility than other science. OBJECTIVES:We analyze this proposition by considering l...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9987
更新日期:2008-01-01 00:00:00
abstract::Nitrate contamination of drinking water implies a genotoxic risk to man due to the endogenous formation of carcinogenic N-nitroso compounds from nitrate-derived nitrite. Thus far, epidemiological studies have presented conflicting results on the relation of drinking water nitrate levels with gastric cancer incidence. ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94-1567968
更新日期:1991-08-01 00:00:00
abstract::The N-oxidation of carcinogenic arylamines to form N-hydroxy arylamines has long been regarded as a necessary metabolic step for conversion to proximate carcinogenic derivatives. In contrast, arylamine ring-oxidation has been generally considered to be an important detoxification mechanism. Both enzymatic reactions ar...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9087233
更新日期:1990-07-01 00:00:00
abstract::A comprehensive effort was undertaken to identify articles demonstrating chemical hormesis. Nearly 4000 potentially relevant articles were retrieved from preliminary computer database searches by using various key word descriptors and extensive cross-referencing. A priori evaluation criteria were established including...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.98106s1357
更新日期:1998-02-01 00:00:00
abstract::Idiopathic Parkinson's disease (IPD) represents a common neurodegenerative disorder. An estimated 2% of the U.S. population, age 65 and older, develops IPD. The number of IPD patients will certainly increase over the next several decades as the baby-boomers gradually step into this high-risk age group, concomitant wit...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.00108s3429
更新日期:2000-06-01 00:00:00
abstract:BACKGROUND:Epidemiological research on effects of transportation noise on incident hypertension is inconsistent. OBJECTIVES:We aimed to investigate whether residential road traffic noise increases the risk for hypertension. METHODS:In a population-based cohort of 57,053 individuals 50-64 years of age at enrollment, w...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP6273
更新日期:2020-05-01 00:00:00
abstract::In recent years, it has become apparent that minerals can trigger alterations in gene expression by initiating signaling events upstream of gene transactivation. These cascades may be initiated at the cell surface after interaction of minerals with the plasma membrane either through receptorlike mechanisms or integrin...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.97105s51121
更新日期:1997-09-01 00:00:00
abstract::Parental occupational exposures might affect childhood cancer in the offspring through genetic changes in the ovum or sperm or through transplacental carcinogenesis. The 24 published epidemiologic studies of this association have all used case-control designs, with controls generally selected from birth certificates o...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.9088325
更新日期:1990-08-01 00:00:00
abstract:BACKGROUND:Few studies have examined the relationship between long-term exposure to ambient fine particulate matter (PM2.5) and nonaccidental mortality in rural populations. OBJECTIVE:We examined the relationship between PM2.5 and nonaccidental and cardiovascular mortality in the U.S. Agricultural Health Study cohort....
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1307277
更新日期:2014-06-01 00:00:00
abstract::Children are uniquely vulnerable to toxic chemicals in the environment. Among the environmental toxicants to which children are at risk of exposure are endocrine disruptors (EDs)--chemicals that have the capacity to interfere with hormonal signaling systems. EDs may alter feedback loops in the brain, pituitary, gonads...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.5799
更新日期:2003-10-01 00:00:00
abstract::Differential CYP1A1 inducibility, reflecting variations in aromatic hydrocarbon receptor (AHR) affinity among inbred mouse strains, is an important determinant of environmental toxicity. We took advantage of the Ahr polymorphism in C57BL/6 and DBA/2 mice to develop an oligonucleotide-hybridization screening approach f...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.106-1533118
更新日期:1998-07-01 00:00:00
abstract::Implications of the multistage theory of carcinogenesis for evaluating the effect of exposure to carcinogens in the workplace are described. This theory predicts different patterns of excess risk related to duration of exposure, age at initial exposure, and follow-up time since exposure stopped, depending upon which s...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8350293
更新日期:1983-04-01 00:00:00
abstract:BACKGROUND:Associations between airborne particles and health outcomes have been documented worldwide; however, there is limited information regarding health effects associated with different particle sizes. OBJECTIVES:We explored the association between size-fractionated particle number concentrations (PNCs) and dail...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1206398
更新日期:2013-10-01 00:00:00
abstract::Syrian hamster embryo cells were treated with galactose oxidase, followed by reduction with tritiated sodium borohydride at pH 7.4. The labeling patterns of galactosyl and N-acetyl galactosaminyl residues on the cell surface were altered in comparing scraped vs. unscraped and buffer vs. media-soaked cells treated with...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8034103
更新日期:1980-02-01 00:00:00
abstract::Clinical and experimental studies on respiratory involvement and alterations in immune status were carried out. Respiratory distress occurring in these patients has improved gradually for 14 years but still remains. Copious expectoration at an early stage of the disease may be related to the fact that a number of disc...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.59-1568074
更新日期:1985-02-01 00:00:00
abstract::Differences in genetic susceptibility to hazardous chemicals affect individuals of both human and nonhuman populations. In both cases, differences in response to chemicals or general ill health result as a function of these differences in genetic susceptibility. However, ecological systems are a compilation of hundred...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.97105s4843
更新日期:1997-06-01 00:00:00
abstract:BACKGROUND:A critical question regarding the association between short-term exposure to ozone and mortality is the extent to which this relationship is confounded by ambient exposure to particles. OBJECTIVES:We investigated whether particulate matter < 10 and < 2.5 microm in aerodynamic diameter (PM(10) and PM(2.5)) i...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.10108
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVES:The National Environmental Policy Act and related state laws require many public agencies to analyze and disclose potentially significant environmental effects of agency actions, including effects on human health. In this paper we review the purpose and procedures of environmental impact assessment (EIA), ex...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.11132
更新日期:2008-08-01 00:00:00
abstract::mental retardation: timing and thresholds; (italic)b(/italic)) endocrine dysfunction and developmental disabilities: dose and target implications; (italic)c(/italic)) attention-deficit disorder-ADHD and learning disabilities; and (italic)d(/italic)) new horizons: extending the boundaries. Support for the Rochester con...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.00108s3373
更新日期:2000-06-01 00:00:00
abstract::The articles in this monograph focus on the mechanisms whereby ambient particulate matter (PM) and co-pollutants deposited in the respiratory tract cause cardiovascular and systemic effects, especially in persons with preexisting conditions such as allergic hyperresponsiveness and pulmonary, cardiac, and vascular dise...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.01109s4479
更新日期:2001-08-01 00:00:00