Size-fractionated particle number concentrations and daily mortality in a Chinese city.

Abstract:

BACKGROUND:Associations between airborne particles and health outcomes have been documented worldwide; however, there is limited information regarding health effects associated with different particle sizes. OBJECTIVES:We explored the association between size-fractionated particle number concentrations (PNCs) and daily mortality in Shenyang, China. METHODS:We collected daily data on cause-specific mortality and PNCs for particles measuring 0.25-10 μm in diameter between 1 December 2006 and 30 November 2008. We used quasi-Poisson regression generalized additive models to estimate associations between PNCs and mortality, and we used natural spline smoothing functions to adjust for time-varying covariates and long-term and seasonal trends. RESULTS:Mean numbers of daily deaths were 67, 32, and 7 for all natural causes, cardiovascular diseases, and respiratory diseases, respectively. Interquartile range (IQR) increases in PNCs for particles measuring 0.25-0.50 μm were significantly associated with total and cardiovascular mortality, but not respiratory mortality. Effect estimates were larger for PNCs during the warm season than the cool season, and increased with decreasing particle size. IQR increases in PNCs of 0.25-0.28 μm, 0.35-0.40 μm, and 0.45-0.50 μm particles were associated with 2.41% (95% CI: 1.23, 3.58%), 1.31% (95% CI: 0.52, 2.09%), and 0.45% (95% CI: 0.04, 0.87%) higher total mortality, respectively. Associations were generally stable after adjustment for mass concentrations of ambient particles and gaseous pollutants. CONCLUSIONS:Our findings suggest that particles < 0.5 μm in diameter may be most responsible for adverse health effects of particulate air pollution and that adverse health effects may increase with decreasing particle size.

authors

Meng X,Ma Y,Chen R,Zhou Z,Chen B,Kan H

doi

10.1289/ehp.1206398

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

1174-8

issue

10

eissn

0091-6765

issn

1552-9924

journal_volume

121

pub_type

杂志文章
  • Associations between Environmental Quality and Mortality in the Contiguous United States, 2000-2005.

    abstract:BACKGROUND:Assessing cumulative effects of the multiple environmental factors influencing mortality remains a challenging task. OBJECTIVES:This study aimed to examine the associations between cumulative environmental quality and all-cause and leading cause-specific (heart disease, cancer, and stroke) mortality rates. ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP119

    authors: Jian Y,Messer LC,Jagai JS,Rappazzo KM,Gray CL,Grabich SC,Lobdell DT

    更新日期:2017-03-01 00:00:00

  • The role of airway mucus in pulmonary toxicology.

    abstract::Airway mucus is a complex airway secretion whose primary function as part of the mucociliary transport mechanism is to to serve as renewable and transportable barrier against inhaled particulates and toxic agents. The rheologic properties necessary for this function are imparted by glycoproteins, or mucins. Some respi...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.9410289

    authors: Samet JM,Cheng PW

    更新日期:1994-06-01 00:00:00

  • Severity of health effects associated with building-related illness.

    abstract::Building-related illness ranges from mild rhinitis to potentially life-threatening hypersensitivity pneumonitis and legionellosis. Sick-building syndrome, consisting of headache, mucous membrane irritation, and fatigue, may be present in 30% of all office workers. Hypersensitivity pneumonitis, asthma, and legionellosi...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.919567

    authors: Welch LS

    更新日期:1991-11-01 00:00:00

  • Household exposure to paint and petroleum solvents, chromosomal translocations, and the risk of childhood leukemia.

    abstract:BACKGROUND:Few studies have examined the association between home use of solvents and paint and the risk of childhood leukemia. OBJECTIVES:In this case-control study, we examined whether the use of paint and petroleum solvents at home before birth and in early childhood influenced the risk of leukemia in children. ME...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.11927

    authors: Scélo G,Metayer C,Zhang L,Wiemels JL,Aldrich MC,Selvin S,Month S,Smith MT,Buffler PA

    更新日期:2009-01-01 00:00:00

  • Assessment of Short- and Long-Term Mortality Displacement in Heat-Related Deaths in Brisbane, Australia, 1996-2004.

    abstract:BACKGROUND:Mortality displacement (or "harvesting") has been identified as a key issue in the assessment of the temperature-mortality relationship. However, only a few studies have addressed the "harvesting" issue and findings have not been consistent. OBJECTIVES:We examined the potential impact of both short- and lon...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1307606

    authors: Qiao Z,Guo Y,Yu W,Tong S

    更新日期:2015-08-01 00:00:00

  • Plasma microRNA expression and micronuclei frequency in workers exposed to polycyclic aromatic hydrocarbons.

    abstract:BACKGROUND:Ubiquitous polycyclic aromatic hydrocarbons (PAHs) have been shown to alter gene expression patterns and elevate micronuclei (MN) frequency, but the underlying mechanisms are largely unknown. MicroRNAs (miRNAs) are key gene regulators that may be influenced by PAH exposures and mediate their effects on MN fr...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1307080

    authors: Deng Q,Huang S,Zhang X,Zhang W,Feng J,Wang T,Hu D,Guan L,Li J,Dai X,Deng H,Zhang X,Wu T

    更新日期:2014-07-01 00:00:00

  • Environmental noise pollution in the United States: developing an effective public health response.

    abstract:BACKGROUND:Tens of millions of Americans suffer from a range of adverse health outcomes due to noise exposure, including heart disease and hearing loss. Reducing environmental noise pollution is achievable and consistent with national prevention goals, yet there is no national plan to reduce environmental noise polluti...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1307272

    authors: Hammer MS,Swinburn TK,Neitzel RL

    更新日期:2014-02-01 00:00:00

  • Consequences of the AF-2 incident in Japan.

    abstract::The discovery of the potent mutagenicity of AF-2, which was once used in Japan as a food preservative, has exerted a great influence not only on screening procedures for carcinogenic compounds but also on legislative approaches to mutagenic substances. It promoted the synthesis of exceedingly sensitive and reliable te...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.7929183

    authors: Tazima Y

    更新日期:1979-04-01 00:00:00

  • Health effects of electric and magnetic fields: overview of research recommendations.

    abstract::We developed a series of articles concerning epidemiologic research on potential health effects of electric and magnetic fields. Our goal was to identify methodological issues that have arisen through past studies of cancer, reproduction, and neurobehavioral outcomes in order to suggest strategies to extend knowledge....

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.93101s471

    authors: Savitz DA

    更新日期:1993-12-01 00:00:00

  • Research needs for the risk assessment of health and environmental effects of endocrine disruptors: a report of the U.S. EPA-sponsored workshop.

    abstract::The hypothesis has been put forward that humans and wildlife species adverse suffered adverse health effects after exposure to endocrine-disrupting chemicals. Reported adverse effects include declines in populations, increases in cancers, and reduced reproductive function. The U.S. Environmental Protection Agency spon...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.96104s4715

    authors: Kavlock RJ,Daston GP,DeRosa C,Fenner-Crisp P,Gray LE,Kaattari S,Lucier G,Luster M,Mac MJ,Maczka C,Miller R,Moore J,Rolland R,Scott G,Sheehan DM,Sinks T,Tilson HA

    更新日期:1996-08-01 00:00:00

  • Trends in health in the United States.

    abstract::The National Center for Health Statistics (NCHS) conducts a variety of surveys designed to provide cross-sectional estimates of the prevalence of various factors measuring the health of Americans. When these cross-sectional estimates are put together and plotted over time, they provide a picture of the trends in the h...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8562267

    authors: Feinleib M,Wilson RW

    更新日期:1985-10-01 00:00:00

  • The privileged access model of 1,3-butadiene disposition.

    abstract::In previous attempts to model disposition of 1,3-butadiene in mice and rats, parameter values for 1,2-epoxybut-3-ene metabolism were optimized to reproduce elimination of this gas from closed chambers. However, each of these models predicted much higher concentrations of circulating epoxybutene than were subsequently ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.00108s5911

    authors: Kohn MC,Melnick RL

    更新日期:2000-10-01 00:00:00

  • Rethinking Environmental Protection: Meeting the Challenges of a Changing World.

    abstract:SUMMARY:From climate change to hydraulic fracturing, and from drinking water safety to wildfires, environmental challenges are changing. The United States has made substantial environmental protection progress based on media-specific and single pollutant risk-based frameworks. However, today’s environmental problems ar...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/EHP1465

    authors: Burke TA,Cascio WE,Costa DL,Deener K,Fontaine TD,Fulk FA,Jackson LE,Munns WR,Orme-Zavaleta J,Slimak MW,Zartarian VG

    更新日期:2017-03-01 00:00:00

  • Cardiovascular and systemic responses to inhaled pollutants in rodents: effects of ozone and particulate matter.

    abstract::Striking similarities have been observed in a number of extrapulmonary responses of rodents to seemingly disparate ambient pollutants. These responses are often characterized by primary decreases in important indices of cardiac and thermoregulatory function, along with secondary decreases in associated parameters. For...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.01109s4539

    authors: Watkinson WP,Campen MJ,Nolan JP,Costa DL

    更新日期:2001-08-01 00:00:00

  • Pesticide-induced immunotoxicity: are Great Lakes residents at risk?

    abstract::Several organophosphate and organochlorine compounds, including pesticides commonly found in the Great Lakes basin, have the potential to induce immunotoxicity. Because of biomagnification and accumulation in the food chain, Great Lakes residents may inadvertently be exposed to these compounds and thus face increased ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.95103s955

    authors: Thomas PT

    更新日期:1995-12-01 00:00:00

  • Residential exposure to traffic-related air pollution and survival after heart failure.

    abstract:BACKGROUND:Although patients with heart failure (HF) have been identified as particularly susceptible to the acute effects of air pollution, the effects of long-term exposure to air pollution on patients with this increasingly prevalent disease are largely unknown. OBJECTIVE:This study was designed to examine the mort...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.10918

    authors: Medina-Ramón M,Goldberg R,Melly S,Mittleman MA,Schwartz J

    更新日期:2008-04-01 00:00:00

  • Workgroup report: Biomonitoring study design, interpretation, and communication--lessons learned and path forward.

    abstract::Human biomonitoring investigations have provided data on a wide array of chemicals in blood and urine and in other tissues and fluids such as hair and human milk. These data have prompted questions such as a) What is the relationship between levels of environmental chemicals in humans and external exposures? b) What i...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8197

    authors: Bates MN,Hamilton JW,LaKind JS,Langenberg P,O'Malley M,Snodgrass W

    更新日期:2005-11-01 00:00:00

  • Does an association between pesticide use and subsequent declines in catch of Atlantic salmon (Salmo salar) represent a case of endocrine disruption?

    abstract::Historical aerial applications of the insecticide Matacil 1.8D provide an opportunity to look for potential effects of the endocrine disrupting compound 4-nonylphenol (4-NP) on Atlantic salmon (Salmo salar) populations. Matacil 1.8D contained the carbamate insecticide aminocarb, with 4-NP as primary solvent. Between 1...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.99107349

    authors: Fairchild WL,Swansburg EO,Arsenault JT,Brown SB

    更新日期:1999-05-01 00:00:00

  • Tracking patterns of enteric illnesses in populations and communities.

    abstract:BACKGROUND:Enteric illness arising from contaminated water and food is a major health concern worldwide, and tracking the incidences and severity of outbreaks is still a challenging task. Most developed and developing countries have administrative databases for medical visits and services maintained by the government a...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.9199

    authors: Peace T,Mazumder A

    更新日期:2007-01-01 00:00:00

  • Exocrine pancreatic pathology in female Harlan Sprague-Dawley rats after chronic treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin and dioxin-like compounds.

    abstract::We evaluated the effect of chronic exposure to dioxin and dioxin-like compounds on the pancreas in female Harlan Sprague-Dawley rats. This investigation represents part of an ongoing National Toxicology Program initiative to determine the relative potency of chronic toxicity and carcinogenicity of polychlorinated diox...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.6869

    authors: Nyska A,Jokinen MP,Brix AE,Sells DM,Wyde ME,Orzech D,Haseman JK,Flake G,Walker NJ

    更新日期:2004-06-01 00:00:00

  • Metabolic activation of toxins: tissue-specific expression and metabolism in target organs.

    abstract::Cytochrome P450 (CYP) enzymes catalyze the generation of reactive species capable of binding with cellular macromolecules, leading to acute and delayed toxicity. Since individual CYP forms differ markedly in their substrate preferences and regulation, the expression profiles of CYP in various cell types are important ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.97105s4767

    authors: Pelkonen O,Raunio H

    更新日期:1997-06-01 00:00:00

  • New tricks for an old assay.

    abstract::For decades, a number of guinea pig tests have been used to identify human contact allergens in workplace and consumer products, but these tests have limitations. In addition to using large numbers of test animals, they also provide only subjective measurements, because the allergic activity is measured by watching th...

    journal_title:Environmental health perspectives

    pub_type: 新闻

    doi:10.1289/ehp.98106a488

    authors: Clay R

    更新日期:1998-10-01 00:00:00

  • Thyroid-hormone-disrupting chemicals: evidence for dose-dependent additivity or synergism.

    abstract::Endocrine disruption from environmental contaminants has been linked to a broad spectrum of adverse outcomes. One concern about endocrine-disrupting xenobiotics is the potential for additive or synergistic (i.e., greater-than-additive) effects of mixtures. A short-term dosing model to examine the effects of environmen...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8195

    authors: Crofton KM,Craft ES,Hedge JM,Gennings C,Simmons JE,Carchman RA,Carter WH Jr,DeVito MJ

    更新日期:2005-11-01 00:00:00

  • Local variations in CO and particulate air pollution and adverse birth outcomes in Los Angeles County, California, USA.

    abstract::We extended our previous analyses of term low birth weight (LBW) and preterm birth to 1994-2000, a period of declining air pollution levels in the South Coast Air Basin. We speculated that the effects we observed previously for carbon monoxide, particulate matter < 10 microm in aerodynamic diameter (PM10), and traffic...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.7751

    authors: Wilhelm M,Ritz B

    更新日期:2005-09-01 00:00:00

  • Predicting health effects of exposures to compounds with estrogenic activity: methodological issues.

    abstract::Many substances are active in in vitro tests for estrogenic activity, but data from multigenerational and other toxicity studies are not available for many of those substances. Controversy has arisen, therefore, concerning the likelihood of adverse health effects. Based on a toxic equivalence factor risk assessment ap...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.97105s3655

    authors: Rudel R

    更新日期:1997-04-01 00:00:00

  • Risks and benefits of green spaces for children: a cross-sectional study of associations with sedentary behavior, obesity, asthma, and allergy.

    abstract:BACKGROUND:Green spaces have been associated with both health benefits and risks in children; however, available evidence simultaneously investigating these conflicting influences, especially in association with different types of greenness, is scarce. OBJECTIVES:We aimed to simultaneously evaluate health benefits and...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1308038

    authors: Dadvand P,Villanueva CM,Font-Ribera L,Martinez D,Basagaña X,Belmonte J,Vrijheid M,Gražulevičienė R,Kogevinas M,Nieuwenhuijsen MJ

    更新日期:2014-12-01 00:00:00

  • Determination of sulfur trioxide in engine exhaust.

    abstract::Sulfur trioxide in the exhaust gas of an internal combustion engine is removed and concentrated by absorption in a solution of 80% isopropyl alcohol, which quantitatively absorbs it and inhibits the oxidation of any sulfur dioxide which may be absorbed. The absorbed sulfur trioxide (sulfuric acid) is determined by an ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.7510117

    authors: Arnold DR

    更新日期:1975-04-01 00:00:00

  • Impact of benzene metabolites on differentiation of bone marrow progenitor cells.

    abstract::Interleukin-3 (IL-3) and granulocyte/macrophage-colony-stimulating factor (GM-CSF) are responsible for maintaining survival and stimulating growth of early dormant hematopoietic progenitor cells (HPC). These cytokines exhibit extensive overlap, with GM-CSF supporting growth and differentiation of myeloid HPC. A charac...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.961041247

    authors: Irons RD,Stillman WS

    更新日期:1996-12-01 00:00:00

  • A time-series analysis of air pollution and preterm birth in Pennsylvania, 1997-2001.

    abstract::Preterm delivery can lead to serious infant health outcomes, including death and lifelong disability. Small increases in preterm delivery risk in relation to spatial gradients of air pollution have been reported, but previous studies may have controlled inadequately for individual factors. Using a time-series analysis...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.7646

    authors: Sagiv SK,Mendola P,Loomis D,Herring AH,Neas LM,Savitz DA,Poole C

    更新日期:2005-05-01 00:00:00

  • Carcinogenicity of airborne combustion products observed in subcutaneous tissue and lungs of laboratory rodents.

    abstract::Most air pollution in West Germany is caused by combustion products. Particulate organic matter released by incomplete combustion is suspected to contribute to the "urban factor" of lung cancer frequency in urban-industrial centers. The carcinogenic potential of single components, groups of compounds and total source ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8347293

    authors: Pott F,Stöber W

    更新日期:1983-01-01 00:00:00