Chemistry, biological activity, and uses of formamidine pesticides.

abstract：:There is concern about the human health effects of inhalation of acid compounds found in urban air pollution. It was the purpose of this study to investigate three of these acid compounds, sulfur dioxide (SO2), sulfuric acid (H2SO4), and nitric acid (HNO3) in a group of allergic adolescent subjects. Subjects were expo...

journal_title：Environmental health perspectives

authors： Koenig JQ,Covert DS,Pierson WE

更新日期：1989-02-01 00:00:00

abstract：:We report the results of a coordinated mitigation effort aimed at reducing arsenic (As) exposure in three counties of Guizhou province, China. Mitigation occurred in 2005 and encompassed 21 villages with 47,000 inhabitants, who were exposed to high levels of As in their diet through consumption of As-contaminated chil...

journal_title：Environmental health perspectives

authors： An D,Li D,Liang Y,Jing Z

更新日期：2007-04-01 00:00:00

abstract：:Virginia Bioinformatics Institute, in conjunction with National Institutes of Environmental Health Sciences, hosted a conference, "Toxicogenomics through the Eyes of Informatics," in Bethesda, Maryland, USA, on 12-13 May 2003. Researchers around the world met to discuss how the application of bioinformatics tools, met...

journal_title：Environmental health perspectives

authors： Olden K,Call N,Sobral B,Oakes R

更新日期：2004-05-01 00:00:00

abstract：:Organophosphates in increasing amounts and wider varieties of molecular structure are being used to replace the organochlorine pesticides. It has been assumed that the organophosphates as a class would have a minimal chronic toxicity due to rapid hydrolysis and an unfavorable partitioning as regards to lipids. The phy...

journal_title：Environmental health perspectives

authors： Freed VH,Haque R,Schmedding D,Kohnert R

更新日期：1976-02-01 00:00:00

abstract：:The presence of blue-green algae (BGA) toxins in surface waters used for drinking water sources and recreation is receiving increasing attention around the world as a public health concern. However, potential risks from exposure to these toxins in contaminated health food products that contain BGA have been largely ig...

journal_title：Environmental health perspectives

authors： Gilroy DJ,Kauffman KW,Hall RA,Huang X,Chu FS

更新日期：2000-05-01 00:00:00

abstract：:Methyl parathion (MP), an organophosphate pesticide licensed only for agricultural uses, was sprayed illegally for pest control in Mississippi and Ohio residences. To evaluate the association between MP exposure and neurobehavioral development, we assessed children 6 years or younger at the time of the spraying and lo...

journal_title：Environmental health perspectives

authors： Ruckart PZ,Kakolewski K,Bove FJ,Kaye WE

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Polychlorinated biphenyls (PCBs) in construction materials, such as caulking used around windows and expansion joints, may constitute a source of PCB contamination in the building interiors and in surrounding soil. Several studies of soil contamination have been conducted around buildings where the caulking ...

journal_title：Environmental health perspectives

authors： Herrick RF,Lefkowitz DJ,Weymouth GA

更新日期：2007-02-01 00:00:00

abstract：:A series of experiments is described in which operant methodology is used to study the effects of drugs on "learning." Emphasis is placed on the technique of repeated acquisition as a behavioral baseline for studying this type of transition state. In this technique, each subject is required to learn a new discriminati...

journal_title：Environmental health perspectives

authors： Thompson DM,Moerschbaecher JM

更新日期：1978-10-01 00:00:00

abstract：:Biomedical developments in the 21st century provide an unprecedented opportunity to gain a dynamic systems-level and human-specific understanding of the causes and pathophysiologies of disease. This understanding is a vital need, in view of continuing failures in health research, drug discovery, and clinical translati...

journal_title：Environmental health perspectives

authors： Langley G,Austin CP,Balapure AK,Birnbaum LS,Bucher JR,Fentem J,Fitzpatrick SC,Fowle JR 3rd,Kavlock RJ,Kitano H,Lidbury BA,Muotri AR,Peng SQ,Sakharov D,Seidle T,Trez T,Tonevitsky A,van de Stolpe A,Whelan M,Willett C

更新日期：2015-11-01 00:00:00

abstract：:Flavone and isoflavone phytoestrogens are plant chemicals and are known to be competitive inhibitors of cytochrome P450 aromatase with respect to the androgen substrate. Aromatase is the enzyme that converts androgen to estrogen; therefore, these plant chemicals are thought to be capable of modifying the estrogen leve...

journal_title：Environmental health perspectives

authors： Kao YC,Zhou C,Sherman M,Laughton CA,Chen S

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:The 1974 Safe Drinking Water Act (SDWA) regulates >170,000 public water systems to protect health, but not >13 million private wells. State and local government requirements for private well water testing are rare and inconsistent; the responsibility to ensure water safety remains with individual households....

journal_title：Environmental health perspectives

authors： Zheng Y,Flanagan SV

更新日期：2017-08-03 00:00:00

abstract：:Traditional models of toxicity have relied on dissecting chemical action into pharmacokinetic and pharmacodynamic processes. However, the integration of genomic information with toxicology will enhance our basic understanding of these processes and significantly change the way we apply toxicological information to ris...

journal_title：Environmental health perspectives

authors： Thomas RS,Rank DR,Penn SG,Zastrow GM,Hayes KR,Hu T,Pande K,Lewis M,Jovanovich SB,Bradfield CA

更新日期：2002-12-01 00:00:00

abstract：:Most published environmental remediation interventions have been directed at single allergens and have employed demanding strategies; few have been performed in the homes of inner-city children disproportionately burdened by asthma. Our objective was a) to describe the allergen sensitivities, environmental tobacco smo...

journal_title：Environmental health perspectives

authors： Crain EF,Walter M,O'Connor GT,Mitchell H,Gruchalla RS,Kattan M,Malindzak GS,Enright P,Evans R 3rd,Morgan W,Stout JW

更新日期：2002-09-01 00:00:00

abstract：:The combined effects of carbon monoxide and low temperature on daily variation in hospital admissions for congestive heart failure (CHF) were examined for a 4-year period in Chicago, Illinois. Medicare hospital admissions for CHF were analyzed as a function of the maximum hourly temperature, maximum hourly levels of c...

journal_title：Environmental health perspectives

authors： Morris RD,Naumova EN

更新日期：1998-10-01 00:00:00

abstract：:Exposure of rats to quartz (or various other particles) can lead to the development of lung tumors. At the moment, the mechanisms involved in particle-induced tumor formation are not clarified. However, it is suggested that inflammation, in conjunction with the production of reactive oxygen species (ROS) and an enhanc...

journal_title：Environmental health perspectives

authors： Nehls P,Seiler F,Rehn B,Greferath R,Bruch J

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND:Few studies have examined the association between home use of solvents and paint and the risk of childhood leukemia. OBJECTIVES:In this case-control study, we examined whether the use of paint and petroleum solvents at home before birth and in early childhood influenced the risk of leukemia in children. ME...

journal_title：Environmental health perspectives

authors： Scélo G,Metayer C,Zhang L,Wiemels JL,Aldrich MC,Selvin S,Month S,Smith MT,Buffler PA

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Animal studies suggest that early-life lead exposure influences gene expression and production of proteins associated with Alzheimer's disease (AD). OBJECTIVES:We attempted to assess the relationship between early-life lead exposure and potential biomarkers for AD among young men and women. We also attempte...

journal_title：Environmental health perspectives

authors： Mazumdar M,Xia W,Hofmann O,Gregas M,Ho Sui S,Hide W,Yang T,Needleman HL,Bellinger DC

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:The impact of prenatal lead exposure on neurodevelopment remains unclear in terms of consistency, the trimester of greatest vulnerability, and the best method for estimating fetal lead exposure. OBJECTIVE:We studied prenatal lead exposure's impact on neurodevelopment using repeated measures of fetal dose as...

journal_title：Environmental health perspectives

authors： Hu H,Téllez-Rojo MM,Bellinger D,Smith D,Ettinger AS,Lamadrid-Figueroa H,Schwartz J,Schnaas L,Mercado-García A,Hernández-Avila M

更新日期：2006-11-01 00:00:00

abstract：:The neurochemical basis of memory has been approached experimentally in four different ways: the bioassay; the interventive approach; the interventive-correlative approach; and the correlative approach. These approaches are fundamentally similar to those used for the study of the chemistry of any behavior. Each of the...

journal_title：Environmental health perspectives

authors： Dunn AJ

更新日期：1978-10-01 00:00:00

abstract：:The normal mucociliary epithelium of the respiratory tract in chronic cigarette smokers often is replaced focally by a metaplastic squamous epithelium. Because asbestos workers who smoke have a substantially greater risk of bronchogenic carcinoma than nonsmokers, we hypothesized that interaction of asbestos with squam...

journal_title：Environmental health perspectives

authors： Woodworth CD,Mossman BT,Craighead JE

更新日期：1983-09-01 00:00:00

abstract：:We present a case of a diamond polisher who developed occupational asthma as a result of prolonged exposure to various potent and well-recognized asthma-inducing agents, including cobalt dust. Although the patient was seen by various medical professionals during the initial course of his illness and given an early dia...

journal_title：Environmental health perspectives

authors： Wilk-Rivard E,Szeinuk J

更新日期：2001-12-01 00:00:00

abstract：:Human fibroblasts (HFW) were 10-fold more susceptible than Chinese hamster ovary (CHO-K1) cells to sodium arsenite. Comparison of cellular antioxidant enzyme activities showed that CHO-K1 cells contained 3- and 8-fold more glutathione-peroxidase and catalase activities, respectively, than HFW cells. Since vitamin E, m...

journal_title：Environmental health perspectives

authors： Lee TC,Ho IC

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:Bisphenol A (BPA) is widely used in the manufacture of polycarbonate plastic bottles, food and beverage can linings, thermal receipts, and dental sealants. Animal and human studies suggest that BPA may disrupt thyroid function. Although thyroid hormones play a determinant role in human growth and brain devel...

journal_title：Environmental health perspectives

authors： Chevrier J,Gunier RB,Bradman A,Holland NT,Calafat AM,Eskenazi B,Harley KG

更新日期：2013-01-01 00:00:00

abstract：:Although exposure to many industrially important monomers is controlled by law, few of these reactive chemicals have been determined in human tissues. Analogy with other fat-soluble organic substances strongly implies that these monomers may be retained in tissue, subject to the usual physiological constraints of meta...

journal_title：Environmental health perspectives

authors： Wolff MS

更新日期：1976-10-01 00:00:00

abstract：:Although allergic diseases such as asthma and hay fever are a major cause of morbidity in industrialized countries, most studies have focused on patterns of prevalence among children and adolescents, with relatively few studies on variations in prevalence by race/ethnicity and socioeconomic position among adults. Our ...

journal_title：Environmental health perspectives

authors： Chen JT,Krieger N,Van Den Eeden SK,Quesenberry CP

更新日期：2002-04-01 00:00:00

abstract：:This study assessed whether exposure of male rats to two estrogenic, environmental chemicals, 4-octylphenol (OP) and butyl benzyl phthalate (BBP) during gestation or during the first 21 days of postnatal life, affected testicular size or spermatogenesis in adulthood (90-95 days of age). Chemicals were administered via...

journal_title：Environmental health perspectives

authors： Sharpe RM,Fisher JS,Millar MM,Jobling S,Sumpter JP

更新日期：1995-12-01 00:00:00

abstract：:Studies of structure-activity relationships and molecular mechanisms of action are fundamental to our understanding of the harmful effects of chemicals on the environment and their more direct effects on human health. It is important to identify factors that determine toxicological effects of foreign chemicals in biol...

journal_title：Environmental health perspectives

authors： McKinney JD

更新日期：1985-09-01 00:00:00

abstract：:Groups of female SENCAR or BALB/c mice were initiated once intraperitoneally with 300 micrograms/mouse of 7,12-dimethylbenz(a)anthracene (DMBA) or 20 mg/mouse of urethane at 7 weeks of age. Beginning one week later, mice received topically applied acetone or 12-O-tetradecanoylphorbol-13-acetate (TPA), once weekly, at ...

journal_title：Environmental health perspectives

authors： Ward JM,Rehm S,Devor D,Hennings H,Wenk ML

更新日期：1986-09-01 00:00:00

abstract：BACKGROUND:Evidence suggests that cardiovascular effects of air pollution are mediated by inflammation and that air pollution can induce genetic expression of the interleukin-6 gene (IL6). OBJECTIVES:We investigated whether IL6 and fibrinogen gene variants can affect plasma IL-6 responses to air pollution in patients ...

journal_title：Environmental health perspectives

authors： Ljungman P,Bellander T,Schneider A,Breitner S,Forastiere F,Hampel R,Illig T,Jacquemin B,Katsouyanni K,von Klot S,Koenig W,Lanki T,Nyberg F,Pekkanen J,Pistelli R,Pitsavos C,Rosenqvist M,Sunyer J,Peters A

更新日期：2009-09-01 00:00:00

abstract：:Uranium accumulates in bone, affects bone metabolism in laboratory animals, and when ingested in drinking water increases urinary excretion of calcium and phosphate, important components in the bone structure. However, little is known about bone effects of ingested natural uranium in humans. We studied 146 men and 142...

journal_title：Environmental health perspectives

authors： Kurttio P,Komulainen H,Leino A,Salonen L,Auvinen A,Saha H

更新日期：2005-01-01 00:00:00