Diseases associated with immunosuppression.

abstract：BACKGROUND:Miners inhaling respirable coal dust (CD) frequently develop coal workers' pneumoconiosis, a dust-associated pneumoconiosis characterized by lung inflammation and variable fibrosis. Many coal miners are also exposed to polycyclic aromatic hydrocarbon (PAH) components of diesel engine exhaust and cigarette sm...

journal_title：Environmental health perspectives

authors： Ghanem MM,Battelli LA,Mercer RR,Scabilloni JF,Kashon ML,Ma JY,Nath J,Hubbs AF

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Few human studies have examined bisphenol A (BPA) exposure in relation to semen quality and reproductive hormones in men, and results are divergent. OBJECTIVES:We examined associations between urinary BPA concentration and reproductive hormones, as well as semen quality, in young men from the general popula...

journal_title：Environmental health perspectives

authors： Lassen TH,Frederiksen H,Jensen TK,Petersen JH,Joensen UN,Main KM,Skakkebaek NE,Juul A,Jørgensen N,Andersson AM

更新日期：2014-05-01 00:00:00

abstract：:Metals continually rank at the top of the U.S. Environmental Protection Agency's annual list of agents that pose the greatest hazard to the people of the United States. Metals aren't going away, either. They do not biodegrade, and they often concentrate in human and animal cells and tissue. Many metals are known human...

journal_title：Environmental health perspectives

authors： Fisher BE

更新日期：1999-05-01 00:00:00

abstract：:The Environmental Public Health Tracking Network (EPHTN) proposes to link environmental hazards and exposures to health outcomes. Statistical methods used in case-control and cohort studies to link health outcomes to individual exposure estimates are well developed. However, reliable exposure estimates for many contam...

journal_title：Environmental health perspectives

authors： Mather FJ,White LE,Langlois EC,Shorter CF,Swalm CM,Shaffer JG,Hartley WR

更新日期：2004-10-01 00:00:00

abstract：:Di(2-ethylhexyl) phthalate (DEHP) is used to make polyvinyl chloride (PVC) plastic tubing soft and flexible. Animal data show that adverse effects of DEHP exposure may include reduced fertility, reduced sperm production in males, and ovarian dysfunction in females. Known treatments that involve high DEHP exposures are...

journal_title：Environmental health perspectives

authors： Rais-Bahrami K,Nunez S,Revenis ME,Luban NL,Short BL

更新日期：2004-09-01 00:00:00

abstract：:Some have hypothesized that community water containing sodium silicofluoride and hydrofluosilicic acid may increase blood lead (PbB) concentrations in children by leaching of lead from water conduits and by increasing absorption of lead from water. Our analysis aimed to evaluate the relation between water fluoridation...

journal_title：Environmental health perspectives

authors： Macek MD,Matte TD,Sinks T,Malvitz DM

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:The presence of pharmaceuticals in aquatic environments and in drinking water has prompted significant public interest regarding potential adverse ecological effects and risks to human health. OBJECTIVES:The Environmental Health Summit held in North Carolina, 10-11 November 2008, explored the issues associa...

journal_title：Environmental health perspectives

authors： Rodriguez-Mozaz S,Weinberg HS

更新日期：2010-07-01 00:00:00

abstract：:A meeting on Marine Biomedical Research, sponsored by the National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health and the Smithsonian Institution Museum of Natural History, was attended by approximately 125 scientists, directors and representatives from many of the country's marine b...

journal_title：Environmental health perspectives

authors： Bessey O

更新日期：1976-02-01 00:00:00

abstract：:This paper summarizes two roundtable discussions held at the conclusion of the International Conference on Biopersistence of Respirable Synthetic Fibres and Minerals. The first round table addressed the role of biopersistence in the pathogenicity of fiber-induced disease. The panel included T. W. Hesterberg (Chairman)...

journal_title：Environmental health perspectives

authors： McClellan RO,Hesterberg TW

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:The World Health Organization (WHO) released the fourth edition of Guidelines for Drinking-Water Quality in July 2011. In this edition, the 400-µg/L drinking-water guideline for manganese (Mn) was discontinued with the assertion that because "this health-based value is well above concentrations of manganese ...

journal_title：Environmental health perspectives

authors： Frisbie SH,Mitchell EJ,Dustin H,Maynard DM,Sarkar B

更新日期：2012-06-01 00:00:00

abstract：:We present a model to plan a rational strategy for cancer prevention that has two main functions--assessment and intervention. The assessment function includes three main components: to identify populations at high cancer risk, which may be due to their ethnic group, occupational and environmental exposures, family hi...

journal_title：Environmental health perspectives

authors： Anton-Culver H

更新日期：1995-11-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to assess whether the joint effects of three androgen receptor antagonists (vinclozolin, flutamide, procymidone) on male sexual differentiation after in utero and postnatal exposures can be predicted based on dose-response data of the individual chemicals. METHODS:Test chemicals and...

journal_title：Environmental health perspectives

authors： Hass U,Scholze M,Christiansen S,Dalgaard M,Vinggaard AM,Axelstad M,Metzdorff SB,Kortenkamp A

更新日期：2007-12-01 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) are a family of persistent organic contaminants suspected to cause adverse effects in wildlife and humans. In rodents, PCBs bind to the aryl hydrocarbon (AhR) and pregnane X receptors (PXR) inducing the expression of catabolic cytochrome p450 enzymes of the CYP1A and 3A families. We fo...

journal_title：Environmental health perspectives

authors： Tabb MM,Kholodovych V,Grün F,Zhou C,Welsh WJ,Blumberg B

更新日期：2004-02-01 00:00:00

abstract：:Differential CYP1A1 inducibility, reflecting variations in aromatic hydrocarbon receptor (AHR) affinity among inbred mouse strains, is an important determinant of environmental toxicity. We took advantage of the Ahr polymorphism in C57BL/6 and DBA/2 mice to develop an oligonucleotide-hybridization screening approach f...

journal_title：Environmental health perspectives

authors： Maier A,Micka J,Miller K,Denko T,Chang CY,Nebert DW,Alvaro Puga

更新日期：1998-07-01 00:00:00

abstract：:We studied peripheral lymphocyte HPRT variant frequency and endogenous nitrosation in human populations exposed to various nitrate levels in their drinking water. Four test populations of women volunteers were compared. Low and medium tap water nitrate exposure groups (14 and 21 subjects) were using public water suppl...

journal_title：Environmental health perspectives

authors： van Maanen JM,Welle IJ,Hageman G,Dallinga JW,Mertens PL,Kleinjans JC

更新日期：1996-05-01 00:00:00

abstract：:Implications of the multistage theory of carcinogenesis for evaluating the effect of exposure to carcinogens in the workplace are described. This theory predicts different patterns of excess risk related to duration of exposure, age at initial exposure, and follow-up time since exposure stopped, depending upon which s...

journal_title：Environmental health perspectives

authors： Brown CC,Chu KC

更新日期：1983-04-01 00:00:00

abstract：:Previously we have demonstrated that several xenobiotics can induce multidrug (mdr) gene expression in cultures of primary isolated hepatocytes. One of the best of these xenobiotic inducers in rat hepatocytes is 2-acetylaminofluorene (2-AAF), which induces mdr expression by an enhancement of mdr gene transcription. In...

journal_title：Environmental health perspectives

authors： Gant TW,Schrenk D,Silverman JA,Thorgeirsson SS

更新日期：1994-10-01 00:00:00

abstract：:N-Substituted aromatic compounds can be metabolized in most species to N-acetylated derivatives that are themselves subject to further enzymatic transformations, including hydrolysis and N,O-acyltransfer. These proceses can either potentiate or ameliorate the biological responses to these N-substituted derivatives. De...

journal_title：Environmental health perspectives

authors： King CM,Glowinski IB

更新日期：1983-03-01 00:00:00

abstract：BACKGROUND:Human exposure to inorganic arsenic (iAs), a potent oxidative stressor, causes various dermal disorders, including hyperkeratosis and skin cancer. Nuclear factor-erythroid 2-related factor 1 (NRF1, also called NFE2L1) plays a critical role in regulating the expression of many antioxidant response element (AR...

journal_title：Environmental health perspectives

authors： Zhao R,Hou Y,Xue P,Woods CG,Fu J,Feng B,Guan D,Sun G,Chan JY,Waalkes MP,Andersen ME,Pi J

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:The mortality impacts of hot and cold temperatures have been thoroughly documented, with most locations reporting a U-shaped relationship with a minimum mortality temperature (MMT) at which mortality is lowest. How MMT may have evolved over previous decades as the global mean surface temperature has increase...

journal_title：Environmental health perspectives

authors： Åström DO,Tornevi A,Ebi KL,Rocklöv J,Forsberg B

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Global climate change is anticipated to reduce future cereal yields and threaten food security, thus potentially increasing the risk of undernutrition. The causation of undernutrition is complex, and there is a need to develop models that better quantify the potential impacts of climate change on population ...

journal_title：Environmental health perspectives

authors： Lloyd SJ,Kovats RS,Chalabi Z

更新日期：2011-12-01 00:00:00

abstract：:The association between ambient air pollution and adverse health effects, such as emergency room visits, hospitalizations, and mortality from respiratory and cardiovascular diseases, has been studied extensively in many countries, including Canada. Recently, studies conducted in China, the Czech Republic, and the Unit...

journal_title：Environmental health perspectives

authors： Liu S,Krewski D,Shi Y,Chen Y,Burnett RT

更新日期：2003-11-01 00:00:00

abstract：:Idiopathic Parkinson's disease (IPD) represents a common neurodegenerative disorder. An estimated 2% of the U.S. population, age 65 and older, develops IPD. The number of IPD patients will certainly increase over the next several decades as the baby-boomers gradually step into this high-risk age group, concomitant wit...

journal_title：Environmental health perspectives

authors： Aschner M

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:Phthalates may pose a risk for perinatal developmental effects. An important question relates to the choice of suitable biological matrices for assessing exposure during this period. OBJECTIVES:This study was designed to measure the concentrations of phthalate diesters or their metabolites in breast milk, b...

journal_title：Environmental health perspectives

authors： Högberg J,Hanberg A,Berglund M,Skerfving S,Remberger M,Calafat AM,Filipsson AF,Jansson B,Johansson N,Appelgren M,Håkansson H

更新日期：2008-03-01 00:00:00

abstract：:The presence of blue-green algae (BGA) toxins in surface waters used for drinking water sources and recreation is receiving increasing attention around the world as a public health concern. However, potential risks from exposure to these toxins in contaminated health food products that contain BGA have been largely ig...

journal_title：Environmental health perspectives

authors： Gilroy DJ,Kauffman KW,Hall RA,Huang X,Chu FS

更新日期：2000-05-01 00:00:00

abstract：:Scientists at Pacific Northwest National Laboratory in Richland, Washington, have developed a unique imaging system capable of focusing on a single living cell within an organism. This new technology will be used in what the multidisciplinary team has termed a "cellular observatory" to study the effect of environmenta...

journal_title：Environmental health perspectives

authors： Medlin J

更新日期：1999-11-01 00:00:00

abstract：:Although allergic diseases such as asthma and hay fever are a major cause of morbidity in industrialized countries, most studies have focused on patterns of prevalence among children and adolescents, with relatively few studies on variations in prevalence by race/ethnicity and socioeconomic position among adults. Our ...

journal_title：Environmental health perspectives

authors： Chen JT,Krieger N,Van Den Eeden SK,Quesenberry CP

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND:Experimental tools for studying the complex steroidogenic interactions that occur between placenta and fetus during human pregnancy are extremely limited. OBJECTIVES:We aimed to develop a co-culture model to study steroidogenesis by the human fetoplacental unit and its disruption by exposure to environmenta...

journal_title：Environmental health perspectives

authors： Hudon Thibeault AA,Deroy K,Vaillancourt C,Sanderson JT

更新日期：2014-04-01 00:00:00

abstract：:The importance of urban dust as a source of lead for young children is still disputed. Although blood-lead data from various population surveys usually show a peak concentration in early childhood, there is evidence that such a peak is small or absent altogether in children without much access to the general environme...

journal_title：Environmental health perspectives

authors： Duggan MJ

更新日期：1983-04-01 00:00:00

abstract：BACKGROUND:Exposure to arsenic via drinking water is a global environmental health problem. In utero exposure to arsenic via drinking water increases the risk of lower respiratory tract infections during infancy and mortality from bronchiectasis in early adulthood. OBJECTIVES:We aimed to investigate how arsenic exposu...

journal_title：Environmental health perspectives

authors： Ramsey KA,Bosco A,McKenna KL,Carter KW,Elliot JG,Berry LJ,Sly PD,Larcombe AN,Zosky GR

更新日期：2013-02-01 00:00:00