Meeting report: pharmaceuticals in water-an interdisciplinary approach to a public health challenge.

abstract：BACKGROUND:Widespread residential pesticide use throughout the United States has resulted in ubiquitous, low-level pesticide exposure. The mix of active pesticide ingredients is changing in response to 2000-2001 regulations restricting use of the organophosphorus insecticides chlorpyrifos and diazinon. OBJECTIVES:We a...

journal_title：Environmental health perspectives

authors： Williams MK,Rundle A,Holmes D,Reyes M,Hoepner LA,Barr DB,Camann DE,Perera FP,Whyatt RM

更新日期：2008-12-01 00:00:00

abstract：:This article summarizes the basic facts about the measurement of ionizing radiation, usually referred to as radiation dosimetry. The article defines the common radiation quantities and units; gives typical levels of natural radiation and medical exposures; and describes the most important biological effects of radiati...

journal_title：Environmental health perspectives

authors： Cameron J

更新日期：1991-02-01 00:00:00

abstract：BACKGROUND:Epidemiologic studies of postnatal PCB exposure and behavior have not reported consistent evidence of adverse associations, possibly because of challenges in exposure estimation. We previously developed a pharmacokinetic model to improve estimation of children's PCB exposure. OBJECTIVES:We aimed to assess w...

journal_title：Environmental health perspectives

authors： Verner MA,Hart JE,Sagiv SK,Bellinger DC,Altshul LM,Korrick SA

更新日期：2015-09-01 00:00:00

abstract：:Epidemiologic studies long have played a role in the understanding of the effects of the general environment and various occupational exposures on the occurrence of acute and chronic diseases of the lung. This article is an overview of epidemiologic study designs that have particular relevance to studies of environmen...

journal_title：Environmental health perspectives

authors： Tager IB

更新日期：2000-08-01 00:00:00

abstract：:Numerous publications and reports have expressed health and safety concerns about the production and use of nanoparticles, especially in areas of exposure monitoring, personal use, and environmental fate and transport. We suggest that stable isotopic tracers, which have been used widely in the earth sciences and in me...

journal_title：Environmental health perspectives

authors： Gulson B,Wong H

更新日期：2006-10-01 00:00:00

abstract：:Aluminum lactate [Al(lact)3] (hydrophilic, hydrolytically unstable) and aluminum acetylacetonate [Al(acae)3] (lipophilic, hydrolytically stable) were tested as potential toxicants to rabbits upon IV administration both as aqueous solutions and as liposome suspensions. Both chemicals behaved as cardiotoxic agents when ...

journal_title：Environmental health perspectives

authors： Bombi GG,Corain B,Favarato M,Giordano R,Nicolini M,Perazzolo M,Tapparo A,Zatta P

更新日期：1990-11-01 00:00:00

abstract：:The results of our previous and recent work on cadmium metabolism in relation to age and diet are presented. Experiments were performed on albino rats aged 1-26 weeks. In some experiments rats were given different foods (milk, meat, bread) instead of standard rat diet. Some animals received trisodium calcium salt of d...

journal_title：Environmental health perspectives

authors： Kostial K

更新日期：1984-03-01 00:00:00

abstract：:Parental occupational exposures might affect childhood cancer in the offspring through genetic changes in the ovum or sperm or through transplacental carcinogenesis. The 24 published epidemiologic studies of this association have all used case-control designs, with controls generally selected from birth certificates o...

journal_title：Environmental health perspectives

authors： Savitz DA,Chen JH

更新日期：1990-08-01 00:00:00

abstract：:Examining global effects of toxic metals on gene expression can be useful for elucidating patterns of biological response, discovering underlying mechanisms of toxicity, and identifying candidate metal-specific genetic markers of exposure and response. Using a 1,200 gene nylon array, we examined changes in gene expres...

journal_title：Environmental health perspectives

authors： Andrew AS,Warren AJ,Barchowsky A,Temple KA,Klei L,Soucy NV,O'Hara KA,Hamilton JW

更新日期：2003-05-01 00:00:00

abstract：:Multiple chemical sensitivity (MCS) is a condition in which persons experience negative health effects in multiple organ systems from exposure to low levels of common chemicals. Although symptoms experienced from particular chemicals vary across persons, they are generally stable within persons. The sensitivities ofte...

journal_title：Environmental health perspectives

authors： Gibson PR,Elms AN,Ruding LA

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:The Consortium Linking Academic and Regulatory Insights on Bisphenol-A (CLARITY-BPA) is a rare collaboration of guideline-compliant (core) studies and academic hypothesis-based studies to assess the effects of bisphenol A (BPA). OBJECTIVES:We aimed to a) determine whether BPA showed effects on the developin...

journal_title：Environmental health perspectives

authors： Montévil M,Acevedo N,Schaeberle CM,Bharadwaj M,Fenton SE,Soto AM

更新日期：2020-05-01 00:00:00

abstract：:This study assessed whether exposure of male rats to two estrogenic, environmental chemicals, 4-octylphenol (OP) and butyl benzyl phthalate (BBP) during gestation or during the first 21 days of postnatal life, affected testicular size or spermatogenesis in adulthood (90-95 days of age). Chemicals were administered via...

journal_title：Environmental health perspectives

authors： Sharpe RM,Fisher JS,Millar MM,Jobling S,Sumpter JP

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND:Previous studies have examined fine particulate matter (≤ 2.5 μm; PM2.5) and preterm birth, but there is a dearth of longitudinal studies on this topic and a paucity of studies that have investigated specific sources of this exposure. OBJECTIVES:Our aim was to assess whether anthropogenic sources are associ...

journal_title：Environmental health perspectives

authors： Pereira G,Bell ML,Lee HJ,Koutrakis P,Belanger K

更新日期：2014-10-01 00:00:00

abstract：:Lead-induced nephropathy produces both tubular and interstitial manifestations of cell injury, but the pathophysiology of these lesions is not completely understood. Delineation of the molecular factors underlying renal handling of lead is one of central importance in understanding the mechanisms of renal cell injury ...

journal_title：Environmental health perspectives

authors： Fowler BA,DuVal G

更新日期：1991-02-01 00:00:00

abstract：:We conducted a case-control study to determine the contribution of lead to blood from consumption of calcium supplements approximating the recommended daily intakes over a 6-month period. Subjects were males and females ages 21 to 47 years (geometric mean 32 years) with a geometric mean blood lead concentration of 2.5...

journal_title：Environmental health perspectives

authors： Gulson BL,Mizon KJ,Palmer JM,Korsch MJ,Taylor AJ

更新日期：2001-03-01 00:00:00

abstract：:The past and current EPA research and regulatory programs as they relate to non-regulated emissions from light-duty motor vehicles are reviewed. Provisions of Sections 202(a) and 211 of the 1970 Clean Air Act Amendments are discussed and their relationships to the nonregulated emissions issue detailed. The EPA positio...

journal_title：Environmental health perspectives

authors： Moran JB

更新日期：1975-04-01 00:00:00

abstract：:The effects of inhaled zinc oxide/hexachloroethane smoke (11,580 mg x min/m3) and intratracheally instilled zinc chloride (2.5 mg/kg body weight) have been studied in rat lung. The effects of subsequent treatment with 70% oxygen have been studied after both procedures. Both the inhalation of the smoke and instillation...

journal_title：Environmental health perspectives

authors： Brown RF,Marrs TC,Rice P,Masek LC

更新日期：1990-04-01 00:00:00

abstract：:Previously we have demonstrated that several xenobiotics can induce multidrug (mdr) gene expression in cultures of primary isolated hepatocytes. One of the best of these xenobiotic inducers in rat hepatocytes is 2-acetylaminofluorene (2-AAF), which induces mdr expression by an enhancement of mdr gene transcription. In...

journal_title：Environmental health perspectives

authors： Gant TW,Schrenk D,Silverman JA,Thorgeirsson SS

更新日期：1994-10-01 00:00:00

abstract：:Because of rampant concern that estrogenic chemicals in the environment may be adversely affecting the health of humans and wildlife, reliable methods for detecting and characterizing estrogenic chemicals are needed. It is important that general agreement be reached on which tests to use and that these tests then be a...

journal_title：Environmental health perspectives

authors： Shelby MD,Newbold RR,Tully DB,Chae K,Davis VL

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND:The nontherapeutic use of antibiotics in swine feed can select for antibiotic resistance in swine enteric bacteria. Leaking swine waste storage pits and the land-application of swine manure can result in the dispersion of resistant bacteria to water sources. However, there are few data comparing levels of re...

journal_title：Environmental health perspectives

authors： Sapkota AR,Curriero FC,Gibson KE,Schwab KJ

更新日期：2007-07-01 00:00:00

abstract：:Most contemporary bioinsecticides are derived from scaled-up cultures of Bacillus thuringiensis subspecies israelensis (Bti) and kurstaki (Btk), whose particulate fractions contain mostly B. thuringiensis spores (> 10(12)/L) and proteinaceous aggregates, including crystal-like parasporal inclusion bodies (PIB). Based ...

journal_title：Environmental health perspectives

authors： Tayabali AF,Seligy VL

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:Sulfation plays an important role both in detoxification and in the control of steroid activity. Studies in rodents have shown that the conversion of dehydroepiandrosterone (DHEA) to DHEA-sulfate is involved in learning and the memory process. METHODS:The effects of a range of plasticizers and related compo...

journal_title：Environmental health perspectives

authors： Harris R,Turan N,Kirk C,Ramsden D,Waring R

更新日期：2007-12-01 00:00:00

abstract：:This report reviews the recent literature on the adverse effects of occupational factors on fertility and related reproductive outcomes. Few studies fulfill the criteria of good study design because of small sample size, insensitive measures of effect, selection, recall, and observation bias, weak if any control of co...

journal_title：Environmental health perspectives

authors： Baranski B

更新日期：1993-07-01 00:00:00

abstract：:Metallothionein (MT) promoter was methylated in rat hepatoma and in mouse lymphosarcoma cells by methylation of cytosine within the CpG dinucleotide region. After demethylation of MT-I promoter in mouse lymphosarcoma cells or in the transplanted rat hepatoma with 5-azacytidine, a potent inhibitor of DNA methyltransfer...

journal_title：Environmental health perspectives

authors： Jacob ST,Majumder S,Ghoshal K

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:Cumulative lead exposure is associated with a widened pulse pressure (PP; the -difference between systolic and diastolic blood pressure), a marker of arterial stiffness and a predictor of cardiovascular disease. Polymorphisms in the hemochromatosis gene (HFE) have been shown to modify the impact of cumulativ...

journal_title：Environmental health perspectives

authors： Zhang A,Park SK,Wright RO,Weisskopf MG,Mukherjee B,Nie H,Sparrow D,Hu H

更新日期：2010-09-01 00:00:00

abstract：:The current Good Manufacturing Practice (cGMP) and effluent emission (use and disposal) regulations of the U.S. Food and Drug Administration (FDA) and manufacturing effluent discharge and emission regulations of the U.S. Environmental Protection Agency (U.S. EPA) require contained manufacture, use, and disposal of pha...

journal_title：Environmental health perspectives

authors： Velagaleti R,Burns PK,Gill M,Prothro J

更新日期：2002-03-01 00:00:00

abstract：:In 1976, near Seveso, Italy, an industrial accident caused the release of large quantities of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) into the atmosphere, resulting in the highest levels of the toxicant ever recorded in humans. The contaminated area was divided into three zones (A, B, R) corresponding to decreasing...

journal_title：Environmental health perspectives

authors： Landi MT,Consonni D,Patterson DG Jr,Needham LL,Lucier G,Brambilla P,Cazzaniga MA,Mocarelli P,Pesatori AC,Bertazzi PA,Caporaso NE

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:Diethylstilbestrol (DES) is a synthetic estrogen associated with adverse effects on reproductive organs. DES-induced toxicity of the mouse seminal vesicle (SV) is mediated by estrogen receptor α (ERα), which alters expression of seminal vesicle secretory protein IV (Svs4) and lactoferrin (Ltf) genes. OBJECT...

journal_title：Environmental health perspectives

authors： Li Y,Hamilton KJ,Lai AY,Burns KA,Li L,Wade PA,Korach KS

更新日期：2014-03-01 00:00:00

abstract：:As a consequence of contamination by effluents from local electronics manufacturing facilities, the New Bedford Harbor and estuary in southeastern Massachusetts is among the sites in the United States that are considered the most highly contaminated by polychlorinated biphenyls (PCBs). Since 1993, measures of intraute...

journal_title：Environmental health perspectives

authors： Korrick SA,Altshul L

更新日期：1998-08-01 00:00:00

abstract：:The 11 September 2001 terrorist attack on New York City's World Trade Center (WTC) caused an unprecedented environmental emergency. The collapse of the towers sent a tremendous cloud of crushed building materials and other pollutants into the air of lower Manhattan. In response to the calamity, federal, state, and cit...

journal_title：Environmental health perspectives

authors： Gavett SH

更新日期：2003-06-01 00:00:00