Effects of endocrine disruptors on dehydroepiandrosterone sulfotransferase and enzymes involved in PAPS synthesis: genomic and nongenomic pathways.

abstract：:The Clean Air Act requires that sensitive subgroups of exposed populations be protected from adverse health effects of air pollution exposure. Hence, data suggesting the existence of sensitive subgroups can have an important impact on regulatory decisions. Some investigators have interpreted differences among individu...

journal_title：Environmental health perspectives

authors： Brunekreef B,Kinney PL,Ware JH,Dockery D,Speizer FE,Spengler JD,Ferris BG Jr

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Cumulative lead exposure is associated with a widened pulse pressure (PP; the -difference between systolic and diastolic blood pressure), a marker of arterial stiffness and a predictor of cardiovascular disease. Polymorphisms in the hemochromatosis gene (HFE) have been shown to modify the impact of cumulativ...

journal_title：Environmental health perspectives

authors： Zhang A,Park SK,Wright RO,Weisskopf MG,Mukherjee B,Nie H,Sparrow D,Hu H

更新日期：2010-09-01 00:00:00

abstract：:Green turtle fibropapillomatosis (GTFP) is a growing threat to the survival of green turtle (Chelonia mydas) populations worldwide. Recent transmission studies point to an infectious etiology. Several field studies suggest that high GTFP prevalence is associated with marine habitats that have been impacted by agricult...

journal_title：Environmental health perspectives

authors： Herbst LH,Klein PA

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:The 1974 Safe Drinking Water Act (SDWA) regulates >170,000 public water systems to protect health, but not >13 million private wells. State and local government requirements for private well water testing are rare and inconsistent; the responsibility to ensure water safety remains with individual households....

journal_title：Environmental health perspectives

authors： Zheng Y,Flanagan SV

更新日期：2017-08-03 00:00:00

abstract：:The nasal cavity is susceptible to chemically induced injury as a result of exposure to inhaled irritants. Some responses of the nasal mucosa to inhaled toxicants are species specific. These species-related differences in response may be due to variations in structural, physiologic, and biochemical factors, such as gr...

journal_title：Environmental health perspectives

authors： Harkema JR

更新日期：1990-04-01 00:00:00

abstract：:Asbestos and other mineral fibers are carcinogenic to humans and animals but differ from many carcinogens in that they do not induce gene mutations. An understanding of these interesting human carcinogens, therefore, is an important problem in cancer research. Asbestos and other fibers induce predominantly two types o...

journal_title：Environmental health perspectives

authors： Barrett JC,Lamb PW,Wiseman RW

更新日期：1989-05-01 00:00:00

abstract：:To evaluate the effectiveness of mass screening for uterine cancer in Japan, we compared the changes in the age-adjusted rates of potential years of life lost (PYLL) due to uterine cancer between 1969 and 1972 to 1973 through 1977 between the high coverage-rate (intensively screened) areas and the comparable control a...

journal_title：Environmental health perspectives

authors： Kuroishi T,Hirose K,Tominaga S

更新日期：1990-07-01 00:00:00

abstract：:The mutagenic activities of several phthalate esters have been evaluated in an 8-azaguanine resistance assay in Salmonella typhimurium. Three phthalate esters were found to be mutagenic: dimethyl phthalate, diethyl phthalate and di-n-butyl phthalate. A number of other phthalate esters were not found to be mutagenic, i...

journal_title：Environmental health perspectives

authors： Seed JL

更新日期：1982-11-01 00:00:00

abstract：:Children may be more susceptible to exposures to environmental toxins than adults and may be more vulnerable to their effects. Because of this, the health care community and those responsible for children need to be alert to possible environmental factors in identifying and responding to the health problems of childre...

journal_title：Environmental health perspectives

authors： Goldman LR

更新日期：1995-09-01 00:00:00

abstract：:The lungs may be exposed to potentially toxic metabolites that are either formed in situ or which are present in the circulation. Therefore, pulmonary injury may be a prominent effect of certain classes of chemicals that undergo bioactivation in the body. The specific types of lung cells damaged may depend upon factor...

journal_title：Environmental health perspectives

authors： Boyd MR

更新日期：1984-04-01 00:00:00

abstract：:Participants at the Napa Conference on Genetic and Molecular Ecotoxicology assessed the status of this field in light of heightened concerns about the genetic effects of exposure to hazardous substances and recent advancements in our capabilities to measure those effects. We present here a synthesis of the ideas discu...

journal_title：Environmental health perspectives

authors： Anderson S,Sadinski W,Shugart L,Brussard P,Depledge M,Ford T,Hose J,Stegeman J,Suk W,Wirgin I

更新日期：1994-12-01 00:00:00

abstract：:We assessed the reproducibility of X-ray fluorescence-based lead measurements from multiple measurements made on a low-concentration plaster of paris phantom and in five subjects measured five times on two occasions. Over a 6-month period, 220 measurements of the same phantom were obtained and showed a standard deviat...

journal_title：Environmental health perspectives

authors： Gordon CL,Webber CE,Chettle DR

更新日期：1994-08-01 00:00:00

abstract：:Airway mucus is a complex airway secretion whose primary function as part of the mucociliary transport mechanism is to to serve as renewable and transportable barrier against inhaled particulates and toxic agents. The rheologic properties necessary for this function are imparted by glycoproteins, or mucins. Some respi...

journal_title：Environmental health perspectives

authors： Samet JM,Cheng PW

更新日期：1994-06-01 00:00:00

abstract：:Acute exposures to isobutane, propane, F-12, and F-11 in concentrations of 250, 500, or 1000 ppm for periods of 1 min to 8 hr did not produce any untoward physiological effects as determined by the methods employed which included serial EKG's and continuous monitoring of modified V5 by telemetry during exposure. Repet...

journal_title：Environmental health perspectives

authors： Stewart RD,Newton PE,Baretta ED,Herrmann AA,Forster HV,Soto RJ

更新日期：1978-10-01 00:00:00

abstract：:Scientists at Pacific Northwest National Laboratory in Richland, Washington, have developed a unique imaging system capable of focusing on a single living cell within an organism. This new technology will be used in what the multidisciplinary team has termed a "cellular observatory" to study the effect of environmenta...

journal_title：Environmental health perspectives

authors： Medlin J

更新日期：1999-11-01 00:00:00

abstract：:Humans are exposed to a large number of environmental chemicals: Some of these may be toxic, and many others have unknown or poorly characterized health effects. There is intense interest in determining the impact of exposure to environmental chemical mixtures on human health. As the study of mixtures continues to evo...

journal_title：Environmental health perspectives

authors： Braun JM,Gennings C,Hauser R,Webster TF

更新日期：2016-01-01 00:00:00

abstract：:Many assays for oncogenic transformation have been developed ranging from those in established rodent cell lines where morphological alteration is scored, to those in human cells growing in nude mice where tumor invasiveness is scored. In general, systems that are most quantitative are also the least relevant in terms...

journal_title：Environmental health perspectives

authors： Hall EJ,Hei TK

更新日期：1990-08-01 00:00:00

abstract：:Polycyclic aromatic hydrocarbons (PAHs) are toxic pollutants released by the World Trade Center (WTC) fires and various urban combustion sources. Benzo[a]pyrene (BaP) is a representative member of the class of PAHs. PAH-DNA adducts, or BaP-DNA adducts as their proxy, provide a measure of chemical-specific genetic dama...

journal_title：Environmental health perspectives

authors： Perera FP,Tang D,Rauh V,Lester K,Tsai WY,Tu YH,Weiss L,Hoepner L,King J,Del Priore G,Lederman SA

更新日期：2005-08-01 00:00:00

abstract：:In August 1997 we performed a follow-up survey of 146 lead-poisoned children from a community near a previously active auto battery recycling smelter in Haina near Santo Domingo, Dominican Republic. Our follow-up survey confirmed a severe incidence of elevated blood lead (BPb) and erythrocyte protoporphyrin/zinc proto...

journal_title：Environmental health perspectives

authors： Kaul B,Sandhu RS,Depratt C,Reyes F

更新日期：1999-11-01 00:00:00

abstract：:Pyrethroids are important insecticides used in agriculture, forestry, horticulture, and in the home. In humans, they are rapidly metabolized and renally eliminated. In numerous studies, pyrethroid metabolites have been detected in urine after occupational exposure to insecticides. In this study, we used a new, reliabl...

journal_title：Environmental health perspectives

authors： Heudorf U,Angerer J

更新日期：2001-03-01 00:00:00

abstract：:Several examples of categorized data from epidemiological studies are analyzed to illustrate that more informative analysis than tests of independence can be performed by fitting models. All of the analyses fit into a unified conceptual framework that can be performed by weighted least squares. The methods presented s...

journal_title：Environmental health perspectives

authors： Grizzle JE,Koch GG

更新日期：1979-10-01 00:00:00

abstract：:It is necessary but not sufficient to develop laboratory animal models in sensory behavioral toxicology for screening toxic substances and for the analysis of sensory impairment at threshold levels of stimulation. It is important to develop more thorough and quantitative tests of impairment which in their greater comp...

journal_title：Environmental health perspectives

authors： Stebbins WC

更新日期：1982-04-01 00:00:00

abstract：:Aluminum lactate [Al(lact)3] (hydrophilic, hydrolytically unstable) and aluminum acetylacetonate [Al(acae)3] (lipophilic, hydrolytically stable) were tested as potential toxicants to rabbits upon IV administration both as aqueous solutions and as liposome suspensions. Both chemicals behaved as cardiotoxic agents when ...

journal_title：Environmental health perspectives

authors： Bombi GG,Corain B,Favarato M,Giordano R,Nicolini M,Perazzolo M,Tapparo A,Zatta P

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:The National Institutes of Health's Environmental influences on Child Health Outcomes (ECHO) initiative aims to understand the impact of environmental factors on childhood disease. Over 40,000 chemicals are approved for commercial use. The challenge is to prioritize chemicals for biomonitoring that may prese...

journal_title：Environmental health perspectives

authors： Pellizzari ED,Woodruff TJ,Boyles RR,Kannan K,Beamer PI,Buckley JP,Wang A,Zhu Y,Bennett DH,(Environmental influences on Child Health Outcomes).

更新日期：2019-12-01 00:00:00

abstract：:The natural occurrence of palladium (Pd) is rare. It is obtained as a by-product during the extraction of platinum and, until the present time, its uses were small in number--principally in the manufacture of jewelry, dental alloys, chemical catalysts, and electrical contacts. Interest in Pd toxicology has been limite...

journal_title：Environmental health perspectives

authors： Wiester MJ

更新日期：1975-12-01 00:00:00

abstract：:This article provides an overview of the problem of genetic susceptibility to childhood cancer with a particular emphasis on problems with ascertaining inherited cancer risk and the role of tumor-suppressor gene mutations in cancer predispositions. The association between neurofibromatosis type 1 and childhood leukemi...

journal_title：Environmental health perspectives

authors： Shannon K

更新日期：1998-06-01 00:00:00

abstract：:The populations of the developed nations of the world exhibit an increase in blood pressure with age, while in primitive societies blood pressure remains relatively constant throughout adult life. Hypertension may be a complex of diseases all having the same clinical manifestations but not being caused necessarily by ...

journal_title：Environmental health perspectives

authors： Tuthill RW,Calabrese EJ

更新日期：1979-04-01 00:00:00

abstract：BACKGROUND:Although it is well established that air pollutants can exacerbate asthma, the link with new asthma onset in children is less clear. OBJECTIVE:We assessed the association between the onset of childhood asthma with both time of birth and time-varying exposures to outdoor air pollutants. METHOD:An open cohor...

journal_title：Environmental health perspectives

authors： Tétreault LF,Doucet M,Gamache P,Fournier M,Brand A,Kosatsky T,Smargiassi A

更新日期：2016-08-01 00:00:00

abstract：:There are a number of technical and statistical problems in monitoring the temporal and spatial variation of local area death rates in the United States for evidence of systematically elevated risks. An analytic strategy is proposed to reduce one of the major statistical concerns, i.e., that of identifying areas with ...

journal_title：Environmental health perspectives

authors： Manton KG,Stallard E,Creason JP,Riggan WB

更新日期：1985-05-01 00:00:00

abstract：BACKGROUND:Previous studies indicate that the design of streets and sidewalks can influence physical activity among residents. Park features also influence park use and park-based physical activity. Although individuals can walk on streets and sidewalks, walking loops in parks offer a setting to walk in nature and to a...

journal_title：Environmental health perspectives

authors： Cohen DA,Han B,Evenson KR,Nagel C,McKenzie TL,Marsh T,Williamson S,Harnik P

更新日期：2017-02-01 00:00:00