Genetic predispositions and childhood cancer.

Abstract:

:This article provides an overview of the problem of genetic susceptibility to childhood cancer with a particular emphasis on problems with ascertaining inherited cancer risk and the role of tumor-suppressor gene mutations in cancer predispositions. The association between neurofibromatosis type 1 and childhood leukemia is used to illustrate some of the issues faced by molecular biologists and genetic epidemiologists in identifying and analyzing at-risk individuals. The problem of incomplete penetrance in cancer susceptibility is presented and potential models are discussed. The article concludes with a number of tentative conclusions from existing data and speculations for future studies.

authors

Shannon K

doi

10.1289/ehp.98106801

subject

Has Abstract

pub_date

1998-06-01 00:00:00

pages

801-6

eissn

0091-6765

issn

1552-9924

journal_volume

106 Suppl 3

pub_type

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