Genetic predispositions and childhood cancer.


:This article provides an overview of the problem of genetic susceptibility to childhood cancer with a particular emphasis on problems with ascertaining inherited cancer risk and the role of tumor-suppressor gene mutations in cancer predispositions. The association between neurofibromatosis type 1 and childhood leukemia is used to illustrate some of the issues faced by molecular biologists and genetic epidemiologists in identifying and analyzing at-risk individuals. The problem of incomplete penetrance in cancer susceptibility is presented and potential models are discussed. The article concludes with a number of tentative conclusions from existing data and speculations for future studies.


Shannon K




Has Abstract


1998-06-01 00:00:00








106 Suppl 3


  • Mechanisms Underlying Latent Disease Risk Associated with Early-Life Arsenic Exposure: Current Research Trends and Scientific Gaps.

    abstract:BACKGROUND:Millions of individuals worldwide, particularly those living in rural and developing areas, are exposed to harmful levels of inorganic arsenic (iAs) in their drinking water. Inorganic As exposure during key developmental periods is associated with a variety of adverse health effects, including those that are...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Bailey KA,Smith AH,Tokar EJ,Graziano JH,Kim KW,Navasumrit P,Ruchirawat M,Thiantanawat A,Suk WA,Fry RC

    更新日期:2016-02-01 00:00:00

  • Dietary intake and arsenic methylation in a U.S. population.

    abstract::Millions of people worldwide are exposed to arsenic-contaminated drinking water, and ingestion of inorganic arsenic (InAs) has been associated with increased risks of cancer. The primary metabolic pathway of ingested InAs is methylation to monomethyl arsenic (MMA) and dimethyl arsenic (DMA). However, people vary great...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Steinmaus C,Carrigan K,Kalman D,Atallah R,Yuan Y,Smith AH

    更新日期:2005-09-01 00:00:00

  • New microscope gives scientists the inside scoop on living cells.

    abstract::Scientists at Pacific Northwest National Laboratory in Richland, Washington, have developed a unique imaging system capable of focusing on a single living cell within an organism. This new technology will be used in what the multidisciplinary team has termed a "cellular observatory" to study the effect of environmenta...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Medlin J

    更新日期:1999-11-01 00:00:00

  • Aryl hydrocarbon receptor-mediated activity of particulate organic matter from the Paso del Norte airshed along the U.S.-Mexico border.

    abstract::In this study, we determined the biologic activity of dichloromethane-extracted particulate matter < 10 micro m in aerodynamic diameter (PM10) obtained from filters at three sites in the Paso del Norte airshed, which includes El Paso, Texas, USA; Juarez, Chihuahua, Mexico, and Sunland Park, New Mexico, USA. The extrac...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Arrieta DE,Ontiveros CC,Li WW,Garcia JH,Denison MS,McDonald JD,Burchiel SW,Washburn BS

    更新日期:2003-08-01 00:00:00

  • Role of protein kinase C in regulation of gene expression and relevance to tumor promotion.

    abstract::The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) has highly pleiotropic effects on cells in culture and on tissues in vivo, including effects on protein kinase C (PKC) activation and gene expression. In order to determine the mechanism of activation of gene transcription by TPA, DNA sequences whose transc...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Johnson MD,Housey GM,O'Brian CA,Kirschmeier PT,Weinstein IB

    更新日期:1987-12-01 00:00:00

  • Blood pressure in relation to concentrations of PCB congeners and chlorinated pesticides.

    abstract:BACKGROUND:Residents of Anniston, Alabama, live near a Monsanto plant that manufactured polychlorinated biphenyls (PCBs) from 1929 to 1971 and are relatively heavily exposed. OBJECTIVES:The goal of this study was to determine the relationship, if any, between blood pressure and levels of total serum PCBs, several PCB ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Goncharov A,Pavuk M,Foushee HR,Carpenter DO,Anniston Environmental Health Reseach Consortium.

    更新日期:2011-03-01 00:00:00

  • Morphological and behavioral markers of environmentally induced retardation of brain development: an animal model.

    abstract::In most neurotoxicological studies morphological assessment focuses on pathological effects, like degenerative changes in neuronal perikarya, axonopathy, demyelination, and glial and endothelial cell reactions. Similarly, the assessment of physiological and behavioral effects center on evident neurological symptoms, l...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审


    authors: Altman J

    更新日期:1987-10-01 00:00:00

  • Colorectal Cancer and Long-Term Exposure to Trihalomethanes in Drinking Water: A Multicenter Case-Control Study in Spain and Italy.

    abstract:BACKGROUND:Evidence on the association between colorectal cancer and exposure to disinfection by-products in drinking water is inconsistent. OBJECTIVES:We assessed long-term exposure to trihalomethanes (THMs), the most prevalent group of chlorination by-products, to evaluate the association with colorectal cancer. ME...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,多中心研究


    authors: Villanueva CM,Gracia-Lavedan E,Bosetti C,Righi E,Molina AJ,Martín V,Boldo E,Aragonés N,Perez-Gomez B,Pollan M,Acebo IG,Altzibar JM,Zabala AJ,Ardanaz E,Peiró R,Tardón A,Chirlaque MD,Tavani A,Polesel J,Serraino D,Pi

    更新日期:2017-01-01 00:00:00

  • Children--unique and vulnerable. Environmental risks facing children and recommendations for response.

    abstract::Children may be more susceptible to exposures to environmental toxins than adults and may be more vulnerable to their effects. Because of this, the health care community and those responsible for children need to be alert to possible environmental factors in identifying and responding to the health problems of childre...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Goldman LR

    更新日期:1995-09-01 00:00:00

  • Let the "A" in WASH Stand for Air: Integrating Research and Interventions to Improve Household Air Pollution (HAP) and Water, Sanitation and Hygiene (WaSH) in Low-Income Settings.

    abstract:BACKGROUND:Research often suffers from overspecialization, a practice nurtured in academia and reinforced by funders. Indeed, investigators in household air pollution (HAP) and water, sanitation and hygiene (WaSH), working in poor parts of the world, rarely interact despite having similar training and using similar met...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Clasen T,Smith KR

    更新日期:2019-02-01 00:00:00

  • Perchloroethylene-contaminated drinking water and the risk of breast cancer: additional results from Cape Cod, Massachusetts, USA.

    abstract::In 1998 we published the results of a study suggesting an association between breast cancer and perchloroethylene (PCE; also called tetrachloroethylene) exposure from public drinking water. The present case-control study was undertaken to evaluate this association further. The cases were composed of female residents o...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Aschengrau A,Rogers S,Ozonoff D

    更新日期:2003-02-01 00:00:00

  • Environmental xenobiotics may disrupt normal endocrine function by interfering with the binding of physiological ligands to steroid receptors and binding proteins.

    abstract::The disruption of the reproductive system of male and female animals in the wild has been attributed to environmental chemicals (xenobiotics). The effects seen mirror alterations one might anticipate if the steroid hormone-dependent processes that regulate these systems were impaired. To determine whether xenobiotics ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Danzo BJ

    更新日期:1997-03-01 00:00:00

  • The risk of childhood cancer from intrauterine and preconceptional exposure to ionizing radiation.

    abstract::The findings of studies investigating whether exposures to ionizing radiation before birth, either pre- or post-conception, increase the risk of childhood cancer have provoked much scientific controversy. An epidemiological association between the abdominal exposure of pregnant women to diagnostic X-rays and childhood...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审


    authors: Wakeford R

    更新日期:1995-11-01 00:00:00

  • Heat-related mortality and adaptation to heat in the United States.

    abstract:BACKGROUND:In a changing climate, increasing temperatures are anticipated to have profound health impacts. These impacts could be mitigated if individuals and communities adapt to changing exposures; however, little is known about the extent to which the population may be adapting. OBJECTIVE:We investigated the hypoth...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Bobb JF,Peng RD,Bell ML,Dominici F

    更新日期:2014-08-01 00:00:00

  • Estimated reduction in cancer risk due to PAH exposures if source control measures during the 2008 Beijing Olympics were sustained.

    abstract:BACKGROUND:The 2008 Beijing Olympic Games provided a unique case study to investigate the effect of source control measures on the reduction in air pollution, and associated inhalation cancer risk, in a Chinese megacity. OBJECTIVES:We measured 17 carcinogenic polycyclic aromatic hydrocarbons (PAHs) and estimated the l...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Jia Y,Stone D,Wang W,Schrlau J,Tao S,Simonich SL

    更新日期:2011-06-01 00:00:00

  • Implications of aquatic animal health for human health.

    abstract::Human health and aquatic animal health are organically related at three distinct interfaces. Aquatic animals serve as important contributors to the nutritional protein, lipid, and vitamin requirements of humans; as carriers and transmitters of many infectious and parasitic diseases to which humans are susceptible; and...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审


    authors: Dawe CJ

    更新日期:1990-06-01 00:00:00

  • Bioaerosol lung damage in a worker with repeated exposure to fungi in a water-damaged building.

    abstract::There has been increased concern over health effects related to potential exposure of building occupants to bioaerosols. We report the case of a worker with a respiratory illness related to bioaerosol exposure in a water-damaged building with extensive fungal contamination. We performed environmental tests to evaluate...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Trout D,Bernstein J,Martinez K,Biagini R,Wallingford K

    更新日期:2001-06-01 00:00:00

  • Arsenic exposure and cognitive performance in Mexican schoolchildren.

    abstract:BACKGROUND:Previous studies have suggested an effect of high arsenic concentration on cognitive and neurobehavioral function in humans. OBJECTIVE:Our goal was to identify demographic and nutritional factors that are associated with As exposure and the influence of this exposure on cognitive function in school-age chil...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Rosado JL,Ronquillo D,Kordas K,Rojas O,Alatorre J,Lopez P,Garcia-Vargas G,Del Carmen Caamaño M,Cebrián ME,Stoltzfus RJ

    更新日期:2007-09-01 00:00:00

  • Computer-assisted studies of molecular structure and genotoxic activity by pattern recognition techniques.

    abstract::Often a compound's biological activity is determined by complex relationships between its structural components. Such a relationship often can only be adequately described and exploited by multivariate structure-activity relationship (SAR) studies that can deal with many variables simultaneously. Pattern recognition (...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审


    authors: Stouch TR,Jurs PC

    更新日期:1985-09-01 00:00:00

  • Selective retention of hydroxylated PCB metabolites in blood.

    abstract::Polychlorinated biphenyls (PCBs) are important environmental contaminants, and their toxicity to wildlife and humans are of major concern. PCBs form persistent and abundant metabolites, PCB methyl sulfones, that accumulate in biota. We now report that certain hydroxylated PCB metabolites show a strong and selective ac...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Bergman A,Klasson-Wehler E,Kuroki H

    更新日期:1994-05-01 00:00:00

  • May 2006 NEIHS News.

    abstract::Short articles on the following topics: *NIEHS Strategic Plan: New Frontiers in Environmental Sciences and Human Health; Beyond the Bench: Environmental Health Nursing: Putting Knowledge into Practice; Headliners: Inhibition of RLIP76 Causes Complete Regression of Melanoma in Mice. ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Hood E,Tillett T,Phelps J

    更新日期:2006-05-01 00:00:00

  • Mutagenic and carcinogenic properties of polycyclic aromatic hydrocarbons.

    abstract::The rapid development of the chemical industry, combustion of fossil fuels, and smoking of tobacco have resulted in contact of the general population with benzo(a)pyrene and other carcinogenic aromatic hydrocarbons. Persons especially at risk occupationally are those engaged in thermal processing of oil shale, coal, a...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Pashin YV,Bakhitova LM

    更新日期:1979-06-01 00:00:00

  • A Web-Based System for Bayesian Benchmark Dose Estimation.

    abstract:BACKGROUND:Benchmark dose (BMD) modeling is an important step in human health risk assessment and is used as the default approach to identify the point of departure for risk assessment. A probabilistic framework for dose-response assessment has been proposed and advocated by various institutions and organizations; ther...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Shao K,Shapiro AJ

    更新日期:2018-01-11 00:00:00

  • Airborne particles of the california central valley alter the lungs of healthy adult rats.

    abstract::Epidemiologic studies have shown that airborne particulate matter (PM) with a mass median aerodynamic diameter < 10 microm (PM10) is associated with an increase in respiratory-related disease. However, there is a growing consensus that particles < 2.5 microm (PM2.5), including many in the ultrafine (< 0.1 microm) size...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Smith KR,Kim S,Recendez JJ,Teague SV,Ménache MG,Grubbs DE,Sioutas C,Pinkerton KE

    更新日期:2003-06-01 00:00:00

  • Tobacco smoke exposure and altered nasal responses to live attenuated influenza virus.

    abstract:BACKGROUND:Epidemiologic evidence links tobacco smoke and increased risk for influenza in humans, but the specific host defense pathways involved are unclear. OBJECTIVE:We developed a model to examine influenza-induced innate immune responses in humans and test the hypothesis that exposure to cigarette smoke alters na...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Noah TL,Zhou H,Monaco J,Horvath K,Herbst M,Jaspers I

    更新日期:2011-01-01 00:00:00

  • Health status and PCBs in blood of workers exposed to PCBs and of their children.

    abstract::A follow-up study of capacitor manufacturing workers exposed to polychlorinated biphenyls (PCBs) and their children was conducted since 1973. PCB levels in whole blood of workers as well as in breast milk of the exposed lactating mothers were approximately 10 to 100 times those of nonexposed Japanese. Blood PCB levels...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Hara I

    更新日期:1985-02-01 00:00:00

  • Induction of inflammation in vascular endothelial cells by metal oxide nanoparticles: effect of particle composition.

    abstract:BACKGROUND:The mechanisms governing the correlation between exposure to ultrafine particles and the increased incidence of cardiovascular disease remain unknown. Ultrafine particles appear to cross the pulmonary epithelial barrier into the bloodstream, raising the possibility of direct contact with the vascular endothe...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Gojova A,Guo B,Kota RS,Rutledge JC,Kennedy IM,Barakat AI

    更新日期:2007-03-01 00:00:00

  • Formation and persistence of 8-oxoguanine in rat lung cells as an important determinant for tumor formation following particle exposure.

    abstract::Exposure of rats to quartz (or various other particles) can lead to the development of lung tumors. At the moment, the mechanisms involved in particle-induced tumor formation are not clarified. However, it is suggested that inflammation, in conjunction with the production of reactive oxygen species (ROS) and an enhanc...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Nehls P,Seiler F,Rehn B,Greferath R,Bruch J

    更新日期:1997-09-01 00:00:00

  • Formation of mutagens by heating foods and model systems.

    abstract::We have demonstrated that the pyrolysis products of amino acids and proteins in model systems are mutagenic. The mutagenic principles in the pyrolyzates of amino acids have been isolated and identified by Sugimura et al. We have isolated and identified amino-alpha-carbolines from pyrolyzed soybean globulin as mutagens...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Yoshida D,Matsumoto T,Okamoto H,Mizusaki S,Kushi A,Fukuhara Y

    更新日期:1986-08-01 00:00:00

  • Workshop to identify critical windows of exposure for children's health: reproductive health in children and adolescents work group summary.

    abstract::This work group report addresses the central question: What are the critical windows during development (preconception through puberty) when exposure to xenobiotics may have the greatest adverse impact on subsequent reproductive health? The reproductive system develops in stages, with sex-specific organogenesis occurr...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审


    authors: Lemasters GK,Perreault SD,Hales BF,Hatch M,Hirshfield AN,Hughes CL,Kimmel GL,Lamb JC,Pryor JL,Rubin C,Seed JG

    更新日期:2000-06-01 00:00:00