Genetic predispositions and childhood cancer.

abstract：BACKGROUND:Although animal experiments have shown that cadmium exposure results in severe dental caries, limited epidemiologic data are available on this issue. OBJECTIVES:We aimed to examine the relationship between environmental cadmium exposure and dental caries in children 6-12 years of age. METHODS:We analyzed c...

journal_title：Environmental health perspectives

authors： Arora M,Weuve J,Schwartz J,Wright RO

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Dozens of studies link acute exposure to particulate matter (PM) air pollution with premature mortality and morbidity, but questions remain about which species and sources in the vast PM mixture are responsible for the observed health effects. Although a few studies exist on the effects of species and source...

journal_title：Environmental health perspectives

authors： Ostro B,Tobias A,Querol X,Alastuey A,Amato F,Pey J,Pérez N,Sunyer J

更新日期：2011-12-01 00:00:00

abstract：:Human biomonitoring investigations have provided data on a wide array of chemicals in blood and urine and in other tissues and fluids such as hair and human milk. These data have prompted questions such as a) What is the relationship between levels of environmental chemicals in humans and external exposures? b) What i...

journal_title：Environmental health perspectives

authors： Bates MN,Hamilton JW,LaKind JS,Langenberg P,O'Malley M,Snodgrass W

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Benchmark dose (BMD) modeling is an important step in human health risk assessment and is used as the default approach to identify the point of departure for risk assessment. A probabilistic framework for dose-response assessment has been proposed and advocated by various institutions and organizations; ther...

journal_title：Environmental health perspectives

authors： Shao K,Shapiro AJ

更新日期：2018-01-11 00:00:00

abstract：:In August 1997 we performed a follow-up survey of 146 lead-poisoned children from a community near a previously active auto battery recycling smelter in Haina near Santo Domingo, Dominican Republic. Our follow-up survey confirmed a severe incidence of elevated blood lead (BPb) and erythrocyte protoporphyrin/zinc proto...

journal_title：Environmental health perspectives

authors： Kaul B,Sandhu RS,Depratt C,Reyes F

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVE:We previously demonstrated that among 54 infants in neonatal intensive care units, exposure to polyvinyl chloride plastic medical devices containing the plasticizer di(2-ethylhexyl) phthalate (DEHP) is associated with urinary concentrations of mono(2-ethylhexyl) phthalate (MEHP) , a DEHP metabolite. In this f...

journal_title：Environmental health perspectives

authors： Weuve J,Sánchez BN,Calafat AM,Schettler T,Green RA,Hu H,Hauser R

更新日期：2006-09-01 00:00:00

abstract：:Parental occupational exposures might affect childhood cancer in the offspring through genetic changes in the ovum or sperm or through transplacental carcinogenesis. The 24 published epidemiologic studies of this association have all used case-control designs, with controls generally selected from birth certificates o...

journal_title：Environmental health perspectives

authors： Savitz DA,Chen JH

更新日期：1990-08-01 00:00:00

abstract：:The available data on the influence of selenium on the toxicity of methylmercury and of methylmercury on selenium as a nutrient and toxic agent are reviewed. Selenium as selenite has a relative protective effect on acute and subacute toxicity of methylmercury in the rat and the quail. The protective mechanism is far f...

journal_title：Environmental health perspectives

authors： Skerfving S

更新日期：1978-08-01 00:00:00

abstract：:As a consequence of contamination by effluents from local electronics manufacturing facilities, the New Bedford Harbor and estuary in southeastern Massachusetts is among the sites in the United States that are considered the most highly contaminated by polychlorinated biphenyls (PCBs). Since 1993, measures of intraute...

journal_title：Environmental health perspectives

authors： Korrick SA,Altshul L

更新日期：1998-08-01 00:00:00

abstract：:Exposure to aflatoxin B1 (AFB1), an important cofactor in the etiology of hepatocellular carcinoma in Taiwan, is influenced by dietary and other factors. The present study examined the intraindividual variability in AFB1-albumin adducts, the most reliable long-term biomarker of AFB1 exposure, and whether the baseline ...

journal_title：Environmental health perspectives

authors： Ahsan H,Wang LY,Chen CJ,Tsai WY,Santella RM

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:Endocrine disrupting chemicals (EDCs) are xenobiotics that mimic the interaction of natural hormones and alter synthesis, transport, or metabolic pathways. The prospect of EDCs causing adverse health effects in humans and wildlife has led to the development of scientific and regulatory approaches for evaluat...

journal_title：Environmental health perspectives

authors： Mansouri K,Kleinstreuer N,Abdelaziz AM,Alberga D,Alves VM,Andersson PL,Andrade CH,Bai F,Balabin I,Ballabio D,Benfenati E,Bhhatarai B,Boyer S,Chen J,Consonni V,Farag S,Fourches D,García-Sosa AT,Gramatica P,Grisoni F

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Agricultural work and occupational pesticide use have been associated with increased risk of renal cell carcinoma (RCC), the most common form of kidney cancer. However, few prospective studies have investigated links to specific pesticides. OBJECTIVE:We evaluated the lifetime use of individual pesticides an...

journal_title：Environmental health perspectives

authors： Andreotti G,Beane Freeman LE,Shearer JJ,Lerro CC,Koutros S,Parks CG,Blair A,Lynch CF,Lubin JH,Sandler DP,Hofmann JN

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Polybrominated diphenyl ethers (PBDEs) are persistent chemicals that have been widely used as flame retardants in furniture, carpet padding, car seats, and other consumer products during the past three decades. OBJECTIVE:We examined whether in utero exposure to PBDEs is associated with child cognitive funct...

journal_title：Environmental health perspectives

authors： Chen A,Yolton K,Rauch SA,Webster GM,Hornung R,Sjödin A,Dietrich KN,Lanphear BP

更新日期：2014-08-01 00:00:00

abstract：:Asthma is the most common chronic illness of childhood and its prevalence is increasing, causing much concern for identification of risk factors such as air pollution. We previously conducted a study showing a relationship between asthma visits in all persons < 65 years of age to emergency departments (EDs) and air po...

journal_title：Environmental health perspectives

authors： Norris G,YoungPong SN,Koenig JQ,Larson TV,Sheppard L,Stout JW

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Previous studies have suggested an effect of high arsenic concentration on cognitive and neurobehavioral function in humans. OBJECTIVE:Our goal was to identify demographic and nutritional factors that are associated with As exposure and the influence of this exposure on cognitive function in school-age chil...

journal_title：Environmental health perspectives

authors： Rosado JL,Ronquillo D,Kordas K,Rojas O,Alatorre J,Lopez P,Garcia-Vargas G,Del Carmen Caamaño M,Cebrián ME,Stoltzfus RJ

更新日期：2007-09-01 00:00:00

abstract：:The activities of plants and plant/microbial associations may offer a viable means of accomplishing the in situ remediation of contaminated soils. Two uses of plants for phytoremediation are reported here. In one set of studies, the ability of plants to foster degradative microorganisms was investigated. Results indic...

journal_title：Environmental health perspectives

authors： Shann JR

更新日期：1995-06-01 00:00:00

abstract：:The use of physiologically based pharmacokinetic (PBPK) models has been proposed as a means of estimating the dose of the reactive metabolites of carcinogenic xenobiotics reaching target tissues, thereby affording an opportunity to base estimates of potential cancer risk on tissue dose rather than external levels of e...

journal_title：Environmental health perspectives

authors： Krewski D,Withey JR,Ku LF,Andersen ME

更新日期：1994-12-01 00:00:00

abstract：:Environmental estrogens are of particular concern when exposure occurs during embryonic development. Although there are good models to study estrogenic activity of chemicals in adult animals, developmental exposure is much more difficult to test. The weak estrogenic activity of the environmental estrogen bisphenol A (...

journal_title：Environmental health perspectives

authors： Lemmen JG,Arends RJ,van der Saag PT,van der Burg B

更新日期：2004-11-01 00:00:00

abstract：:Neurogenic inflammation as a pathway distinct from antigen-driven, immune-mediated inflammation may play a pivotal role in understanding a broad class of environmental health problems resulting from chemical exposures. Recent progress in understanding the mediators, triggers, and regulation of neurogenic inflammation ...

journal_title：Environmental health perspectives

authors： Meggs WJ

更新日期：1993-08-01 00:00:00

abstract：:To assess the possibility that increases in UV-B exposure on the earth's surface could lead to impaired resistance to several infectious diseases, we studied the effect of UV-B exposure on resistance against Trichinella spiralis. Wistar rats, orally infected with T. spiralis larvae, were exposed to suberythemal doses ...

journal_title：Environmental health perspectives

authors： Goettsch W,Garssen J,Deijns A,de Gruijl FR,van Loveren H

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND:The rapidly increasing dissemination of carbapenem-resistant Enterobacteriaceae (CRE) in both humans and animals poses a global threat to public health. However, the transmission of CRE between humans and animals has not yet been well studied. OBJECTIVES:We investigated the prevalence, risk factors, and dri...

journal_title：Environmental health perspectives

authors： Li J,Bi Z,Ma S,Chen B,Cai C,He J,Schwarz S,Sun C,Zhou Y,Yin J,Hulth A,Wang Y,Shen Z,Wang S,Wu C,Nilsson LE,Walsh TR,Börjesson S,Shen J,Sun Q,Wang Y

更新日期：2019-10-01 00:00:00

abstract：:Locating geographic hot spots of cancer may lead to new causal hypotheses and ultimately to new knowledge of cancer-causing factors. The Cape Cod region of Massachusetts has experienced elevated incidence of breast cancer compared with statewide averages. The origins of the excess remain largely unexplained, even afte...

journal_title：Environmental health perspectives

authors： Paulu C,Aschengrau A,Ozonoff D

更新日期：2002-05-01 00:00:00

abstract：:Exposure to environmental pollutants may contribute to the development of coronary heart disease (CHD). We determined the ZIP codes containing or abutting each of the approximately 900 hazardous waste sites in New York and identified the major contaminants in each. Three categories of ZIP codes were then distinguished...

journal_title：Environmental health perspectives

authors： Sergeev AV,Carpenter DO

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:Methylmercury (MeHg) exposure has been linked to an increased risk of coronary heart disease (CHD). Paraoxonase 1 (PON1), an enzyme located in the high-density-lipoprotein (HDL) fraction of blood lipids, may protect against CHD by metabolizing toxic oxidized lipids associated with low-density liproprotein an...

journal_title：Environmental health perspectives

authors： Ayotte P,Carrier A,Ouellet N,Boiteau V,Abdous B,Sidi EA,Château-Degat ML,Dewailly É

更新日期：2011-08-01 00:00:00

abstract：:Metallothionein from livers of mice was isolated by gel chromatography and isoelectric focusing. One of two forms thus obtained contained 32 percent cysteine. This form, labeled in vitro with 109Cd, was injected intravenously in mice, and the distribution of 109Cd was studied. Animals killed after 4 hrs had over 80 pe...

journal_title：Environmental health perspectives

authors： Nordberg M,Nordberg GF

更新日期：1975-12-01 00:00:00

abstract：:There is widespread concern regarding the safety of silver-mercury amalgam dental restorations, yet little evidence to support their harm or safety. We examined whether mercury dental amalgams are adversely associated with cognitive functioning in a cross-sectional sample of healthy working adults. We studied 550 adul...

journal_title：Environmental health perspectives

authors： Factor-Litvak P,Hasselgren G,Jacobs D,Begg M,Kline J,Geier J,Mervish N,Schoenholtz S,Graziano J

更新日期：2003-05-01 00:00:00

abstract：:Previously, we found that exposure of neonatal rats to chlorpyrifos (CPF) produced brain cell damage and loss, with resultant abnormalities of synaptic development. We used the same biomarkers to examine prenatal CPF treatment so as to define the critical period of vulnerability. One group of pregnant rats received CP...

journal_title：Environmental health perspectives

authors： Qiao D,Seidler FJ,Padilla S,Slotkin TA

更新日期：2002-11-01 00:00:00

abstract：:Epidemiologic studies demonstrate that infection, specifically pneumonia, contributes substantially to the increased morbidity and mortality among elderly individuals following exposure to ambient particulate matter (PM). This laboratory has previously demonstrated that a single inhalation exposure of Streptococcus pn...

journal_title：Environmental health perspectives

authors： Zelikoff JT,Schermerhorn KR,Fang K,Cohen MD,Schlesinger RB

更新日期：2002-10-01 00:00:00

abstract：:Spontaneous fetal death has been observed among various mammalian species after exposure to polychlorinated biphenyls (PCBs). Our exposure-based cohort study assessed the relationship between consumption of PCB-contaminated Lake Ontario sport fish and spontaneous fetal death using 1820 multigravid fertile women from t...

journal_title：Environmental health perspectives

authors： Mendola P,Buck GM,Vena JE,Zielezny M,Sever LE

更新日期：1995-05-01 00:00:00

abstract：:For workers in the nuclear industry, the primary route for the entry of radioactive materials into the body is by inhalation, and the rate of clearance of particles from the pulmonary region of the lung is an important factor in determining radiation dose. It is the function of alveolar macrophages (AM) to maintain th...

journal_title：Environmental health perspectives

authors： Kellington JP,Gibson K,Buckle TM,Talbot RJ,Hornby SB

更新日期：1992-07-01 00:00:00