Abstract:
:In August 1997 we performed a follow-up survey of 146 lead-poisoned children from a community near a previously active auto battery recycling smelter in Haina near Santo Domingo, Dominican Republic. Our follow-up survey confirmed a severe incidence of elevated blood lead (BPb) and erythrocyte protoporphyrin/zinc protoporphyrin (EP-ZnPP) levels. The mean BPb level was 32 micrograms/dL and the mean EP-ZnPP level was 128 micrograms/dL. The frequency distribution of BPb showed that only 9% of the children had BPb levels below the currently acceptable 10 micrograms/dL threshold level, 23% had between 10 and 19 micrograms/dL, 40% had between 20 and 39 micrograms/dL, 27% had between 40 and 99 micrograms/dL, and the remainder had > 100 micrograms/dL. These findings are significantly greater than the mean BPb and EP-ZnPP levels of 14 and 35 micrograms/dL, respectively, in a comparison group of 63 children in Barsequillo, 4 miles away. BPb frequency distributions for these groups were < 10 micrograms/dL (42%), 10-19 micrograms/dL (32%), and 20-39 micrograms/dL (16%); in the remaining 10%, BPb levels were between 40 and 99 micrograms/dL. Similarly, the corresponding frequency distribution of EP-ZnPP levels in Haina children were proportional to the severity of lead poisoning and significantly higher than those of the Barsequillo comparison group. This study reveals that at least 28% of Haina children require immediate treatment; of these, 5% with lead levels > 70 micrograms/dL are also at risk for severe neurologic sequelae, and urgent action is imperative.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Kaul B,Sandhu RS,Depratt C,Reyes Fdoi
10.1289/ehp.99107917subject
Has Abstractpub_date
1999-11-01 00:00:00pages
917-20issue
11eissn
0091-6765issn
1552-9924pii
sc271_5_1835journal_volume
107pub_type
杂志文章abstract:BACKGROUND:Cadmium exposure may increase the risk of cardiovascular disease. The only published longitudinal study on cadmium and incident cardiovascular disease was performed in American Indians with relatively high cadmium exposure. OBJECTIVES:Our aim was to examine the association between blood cadmium at baseline ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1509735
更新日期:2016-05-01 00:00:00
abstract::Groundwater contamination is a serious problem that is growing in the United States, but its true extent is not known and it is difficult to determine because of the complexities of contaminants, their transformation, and fate in groundwater systems. It is also difficult to predict their movement in groundwater. Since...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9086239
更新日期:1990-06-01 00:00:00
abstract:BACKGROUND:Epidemiologic evidence links tobacco smoke and increased risk for influenza in humans, but the specific host defense pathways involved are unclear. OBJECTIVE:We developed a model to examine influenza-induced innate immune responses in humans and test the hypothesis that exposure to cigarette smoke alters na...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1002258
更新日期:2011-01-01 00:00:00
abstract::Fish and shellfish caught in polluted waters contain potentially dangerous amounts of toxic and carcinogenic chemicals. Public concern was heightened when a large percentage of winter flounder taken from Boston Harbor was found to have visible cancer of the liver; winter flounder outside the estuary area had no liver ...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.90-1519487
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Although indoor residual spraying (IRS) with dichlorodiphenyltrichloroethane (DDT) and pyrethroids effectively controls malaria, it potentially increases human exposure to these insecticides. Previous studies suggest that prenatal exposure to these insecticides may impact human neurodevelopment. OBJECTIVES:...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP2129
更新日期:2018-04-06 00:00:00
abstract::Toxicity testing in AS52 cells (24-hr exposures) gave LC50 values of 2 to 130 micrograms Ni/ml for particulate nickel compounds and 45 to 60 micrograms Ni/ml for water-soluble salts (NiCl2, NiSO4, Ni(CH3COO)2). The Ni(OH)2, NiCO3, and sulfides (Ni3S2, Ni7S6, "amorphous NiS") exhibited similar toxicities (LC50's of 2 t...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102s369
更新日期:1994-09-01 00:00:00
abstract:BACKGROUND:Perfluoroalkyl acids are persistent compounds used in various industrial -applications. Of these compounds, perfluorooctanoate (PFOA) is currently detected in humans worldwide. A recent study on low-dose developmental exposure to PFOA in mice reported increased weight and elevated biomarkers of adiposity in ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1104034
更新日期:2012-05-01 00:00:00
abstract::Groundwater pollution has become a worrisome phenomenon, mainly for aquifers underlying industrialized areas. In order to evaluate the risk of pollution, a model of the aquifer is needed. Herewith, we describe a quasi-tridimensional model, which we applied to a multilayered aquifer where a phreatic aquifer was coupled...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.898377
更新日期:1989-11-01 00:00:00
abstract::Groups of female SENCAR or BALB/c mice were initiated once intraperitoneally with 300 micrograms/mouse of 7,12-dimethylbenz(a)anthracene (DMBA) or 20 mg/mouse of urethane at 7 weeks of age. Beginning one week later, mice received topically applied acetone or 12-O-tetradecanoylphorbol-13-acetate (TPA), once weekly, at ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.866861
更新日期:1986-09-01 00:00:00
abstract::Mass poisonings, called yusho and yu-cheng, occurred in western Japan in 1968 and central Taiwan in 1979, respectively. These occurrences were separately caused by ingestion of rice oils contaminated with polychlorinated biphenyls (PCBs), polychlorinated dibenzofurans (PCDFs) and polychlorinated quaterphenyls. The tot...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8560321
更新日期:1985-05-01 00:00:00
abstract::Mineral fibers and particulates represent one of the best documented, economically important, and ubiquitously occurring categories of human carcinogens. Yet, while a wealth of information exists concerning the mechanism of action of physical, chemical, and viral carcinogens, virtually nothing is known relative to the...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.803459
更新日期:1980-02-01 00:00:00
abstract::Soil samples were collected from 28 fields which had received manure from Michigan's most highly contaminated dairy herds. The number of fields in each concentration range of PBB in soil were: 2, not detectable; 15, 0.0 to 8.0 ppb; 6, 14-102 ppb, and 5, 153 to 371 ppb. Plant tissue sampled from the 10 most highly cont...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.78231
更新日期:1978-04-01 00:00:00
abstract::We found an epidemic of juvenile hypothyroidism among a population of self-defined "downwinders" living near the Hanford nuclear facility located in southeast Washington State. The episode followed massive releases of 131I. Self-reported data on 60 cases of juvenile hypothyroidism (<20 years of age) among a group of 8...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.99107303
更新日期:1999-04-01 00:00:00
abstract::Man-made endocrine-disrupting chemicals (EDCs) present a threat to biodiversity, even in remote areas. To date, numerous wildlife species have been affected by EDCs in the environment, but it is likely that many more species are suffering effects that have not yet been reported. Impaired reproduction, damaged brain fu...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.8070
更新日期:2006-04-01 00:00:00
abstract::Monoterpenes are found in the essential oils of many plants including fruits, vegetables, and herbs. They prevent the carcinogenesis process at both the initiation and promotion/progression stages. In addition, monoterpenes are effective in treating early and advanced cancers. Monoterpenes such as limonene and perilly...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.97105s4977
更新日期:1997-06-01 00:00:00
abstract:BACKGROUND:Warm sea surface temperatures (SSTs) are positively related to incidence of ciguatera fish poisoning (CFP). Increased severe storm frequency may create more habitat for ciguatoxic organisms. Although climate change could expand the endemic range of CFP, the relationship between CFP incidence and specific env...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1307196
更新日期:2014-06-01 00:00:00
abstract::Chronic exposure of rodents to high dose levels of drugs, food additives and environmental chemicals frequently results in liver enlargement. Several of these compounds have been found to enhance the incidence of liver tumors in animals briefly exposed previously to hepatocarcinogens. Accordingly, it has been advanced...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8350113
更新日期:1983-04-01 00:00:00
abstract::Techniques are available to minimize the concentration of asbestos fibers in drinking water. Filtration research conducted at locations on Lake Superior and in the Cascade Mountains in Washington has shown that amphibole and chrysotile fibers can be removed by granular media filtration. Removal percentages can exceed ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8353169
更新日期:1983-11-01 00:00:00
abstract:BACKGROUND:The etiologies of the male urogenital anomalies hypospadias and cryptorchidism remain unclear. It has been suggested that maternal diet and environmental contaminants may affect the risk of these anomalies via placental or hormonal disturbances. OBJECTIVES:We examined associations between organic food consu...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1409518
更新日期:2016-03-01 00:00:00
abstract::The formamidines, a relatively new group of acaricide-insecticides, are novel both in their range of biological activities and in their mode of action, which is presently unknown. This paper is a review of the historical development, properties, structures, uses, and chemistry of this group of pesticides, with particu...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.761457
更新日期:1976-04-01 00:00:00
abstract::On 15-16 September 1997, the U.S. Environmental Protection Agency sponsored the Conference on Preventable Causes of Cancer in Children. The conference was convened to examine rising trends in reported incidence of childhood cancer and the association of these trends with environmental exposures. This paper summarizes ...
journal_title:Environmental health perspectives
pub_type:
doi:10.1289/ehp.98106867
更新日期:1998-06-01 00:00:00
abstract:BACKGROUND:Residents of Anniston, Alabama, live near a Monsanto plant that manufactured polychlorinated biphenyls (PCBs) from 1929 to 1971 and are relatively heavily exposed. OBJECTIVES:The goal of this study was to determine the relationship, if any, between blood pressure and levels of total serum PCBs, several PCB ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1002830
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:The goal of this study was to identify mental, behavioral, and cognitive disorders that may be triggered or exacerbated during heat waves, predisposing individuals to heat-related morbidity and mortality. DESIGN:Using health outcome data from Adelaide, South Australia, for 1993-2006, we estimated the effect ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.11339
更新日期:2008-10-01 00:00:00
abstract::Many substances are active in in vitro tests for estrogenic activity, but data from multigenerational and other toxicity studies are not available for many of those substances. Controversy has arisen, therefore, concerning the likelihood of adverse health effects. Based on a toxic equivalence factor risk assessment ap...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.97105s3655
更新日期:1997-04-01 00:00:00
abstract::Dietary vitamin E affects the susceptibility of mice and rats to ozone and nitrogen dioxide, suggesting a free radical mechanism of toxicity. Conventional peroxidation does not completely explain the effects of alterations of lung fatty acid composition on both nitrogen dioxide and ozone toxicity. A new scheme is prop...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7929105
更新日期:1979-04-01 00:00:00
abstract:BACKGROUND:Preterm birth (PTB), a leading cause of infant mortality and morbidity, has a complex etiology with a multitude of interacting causes and risk factors. The role of environmental contaminants, particularly bisphenol A (BPA), is understudied with regard to PTB. OBJECTIVES:In the present study we examined the ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1408126
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Human epidemiological and animal studies suggest that developmental exposure to contaminants that activate the aryl hydrocarbon receptor (AHR) lead to suppression of immune system function throughout life. The persistence of immune deficiency throughout life suggests that the cellular target of AHR activatio...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1509820
更新日期:2016-07-01 00:00:00
abstract::There is accumulating evidence that the multistage carcinogenic process is associated with the progressive acquisition of mutations in cellular proto-oncogenes and in growth-suppressor genes. At the same time, several types of evidence indicate that nongenotoxic agents and epigenetic events also play an important role...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.9193175
更新日期:1991-06-01 00:00:00
abstract::Enhanced transport of trace metal in porous media can occur in the presence of a ligand or "carrier" that has a high affinity for binding the pollutant, is dispersed and mobile in the soil environment, is recalcitrant with respect to microbial degradation, and is acceptable to the public. These aspects of the facilita...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.95103s153
更新日期:1995-02-01 00:00:00
abstract:OBJECTIVE:We synthesized the main findings from an international epidemiologic study on the impact of biopersistent organic pollutants (POPs) on human reproductive function. DATA SOURCES AND EXTRACTION:We used a database with interview and biological data from 2,269 women and their spouses, and 18 published core paper...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.10700
更新日期:2008-03-01 00:00:00