Abstract:
:We found an epidemic of juvenile hypothyroidism among a population of self-defined "downwinders" living near the Hanford nuclear facility located in southeast Washington State. The episode followed massive releases of 131I. Self-reported data on 60 cases of juvenile hypothyroidism (<20 years of age) among a group of 801 Hanford downwinders are presented, as well as data concerning the thyroid status of approximately 160,000 children exposed to radioiodine before 10 years of age as a result of the 26 April 1986 Chernobyl explosion in the former Soviet Union. These children were residents of five regions near Chernobyl. They were examined by standardized screening protocols over a period of 5 years from 1991 to 1996. They are a well-defined group of 10 samples. Fifty-six cases of hypothyroidism were found among boys and 92 among girls. Body burdens of 137Cs have been correlated with hypothyroidism prevalence rates. On the other hand, the group of juvenile (<20 years of age) Hanford downwinders is not a representative sample. Most of the 77 cases of juvenile hypothyroidism in the Hanford group were diagnosed from 1945 to 1970. However, the ratio of reported cases to the county population under 20 years of age is roughly correlated with officially estimated mean levels of cumulative thyroid 131I uptake in these counties, providing evidence that juvenile hypothyroidism was associated with radioiodine exposures. Because even subtle hypothyroidism may be of clinical significance in childhood and can be treated, it may be useful to screen for the condition in populations exposed to radioiodine fallout. Although radiation exposure is associated with hypothyroidism, its excess among fallout-exposed children has not been previously quantified.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Goldsmith JR,Grossman CM,Morton WE,Nussbaum RH,Kordysh EA,Quastel MR,Sobel RB,Nussbaum FDdoi
10.1289/ehp.99107303subject
Has Abstractpub_date
1999-04-01 00:00:00pages
303-8issue
4eissn
0091-6765issn
1552-9924journal_volume
107pub_type
杂志文章abstract:BACKGROUND:Evidence suggests that cardiovascular effects of air pollution are mediated by inflammation and that air pollution can induce genetic expression of the interleukin-6 gene (IL6). OBJECTIVES:We investigated whether IL6 and fibrinogen gene variants can affect plasma IL-6 responses to air pollution in patients ...
journal_title:Environmental health perspectives
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更新日期:2009-09-01 00:00:00
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更新日期:2019-10-01 00:00:00
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更新日期:1996-12-01 00:00:00
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更新日期:2009-01-01 00:00:00
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更新日期:1981-12-01 00:00:00
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更新日期:1993-11-01 00:00:00
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更新日期:2005-10-01 00:00:00
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更新日期:1988-06-01 00:00:00
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更新日期:2010-07-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2011-04-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1205590
更新日期:2013-02-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.7713
更新日期:2005-08-01 00:00:00
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更新日期:2000-06-01 00:00:00
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doi:10.1289/ehp.1409052
更新日期:2016-03-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP6202
更新日期:2020-04-01 00:00:00
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doi:10.1289/ehp.7375
更新日期:2005-04-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2011-02-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1997-02-01 00:00:00
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journal_title:Environmental health perspectives
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更新日期:1998-11-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1994-10-01 00:00:00
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更新日期:2013-09-01 00:00:00
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更新日期:1974-12-01 00:00:00
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更新日期:2000-12-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.99107553
更新日期:1999-07-01 00:00:00
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更新日期:2001-02-01 00:00:00
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更新日期:1986-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-03-01 00:00:00