Abstract:
:Humans are exposed to a large number of environmental genotoxic agents. These can increase the probability that somatic mutation will occur. The use of genotoxicity testing is essential for assessment of potential human toxicity so that hazards can be prevented. Cytogenetic monitoring of human populations exposed to chemicals has proved to be a useful tool for detecting the chemical mutagenic effects. Cytogenetic analysis of human chromosomes in peripheral lymphocytes allows direct detection of mutation in somatic cells. Cytogenetic monitoring of a group of traffic policemen from Cairo, Egypt, was an example of a human population study. The induction of chromosomal damage was studied in a group of 28 traffic policemen with exposure of over 10 years and a control group of 15 policemen trainers. Blood lead level was significantly higher in the traffic policemen (30 +/- 8.7) unit compared to the control group (18.2 +/- 1.2) unit. The percentage of chromosomal aberrations (7.7 +/- 3.1), as well as the mean sister chromatid exchanges (7.5 +/- 3.4), were significantly higher among the traffic policemen than in the control group. The percentage of chromosomal aberrations was 2.8 +/- 2.1 and the mean sister chromatid exchanges was 4.8 +/- 2.9 in the control group. On the other hand, the increase in chromosome damage among the traffic policemen was enhanced further by smoking. Several problems that are found in biomonitoring studies are discussed.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Anwar WAdoi
10.1289/ehp.94102s4131subject
Has Abstractpub_date
1994-10-01 00:00:00pages
131-4eissn
0091-6765issn
1552-9924journal_volume
102 Suppl 4pub_type
杂志文章,评审abstract::This cross-sectional study examined the association between environmental lead measurements surrounding a Los Angeles County battery recycling facility and the blood lead levels of the children living nearby. Environmental lead measurements and blood lead levels of young children living in a community adjacent to a st...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.96104314
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.102-1567497
更新日期:1994-12-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
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更新日期:1993-10-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
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journal_title:Environmental health perspectives
pub_type: 杂志文章
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更新日期:2005-12-01 00:00:00
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journal_title:Environmental health perspectives
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doi:10.1289/EHP6067
更新日期:2020-04-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.97105s51235
更新日期:1997-09-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.856273
更新日期:1985-10-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
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更新日期:1993-04-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.95103s263
更新日期:1995-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-12-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
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更新日期:2007-07-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9089137
更新日期:1990-11-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
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更新日期:2006-04-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.919567
更新日期:1991-11-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.96104522
更新日期:1996-05-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.00108109
更新日期:2000-02-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1307562
更新日期:2014-08-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.97105s1105
更新日期:1997-02-01 00:00:00
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journal_title:Environmental health perspectives
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更新日期:2013-10-01 00:00:00
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journal_title:Environmental health perspectives
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更新日期:1999-08-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP396
更新日期:2017-04-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
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更新日期:2017-04-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
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更新日期:2015-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:1993-03-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP935
更新日期:2017-08-17 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
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更新日期:1996-12-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP5251
更新日期:2019-10-01 00:00:00