Abstract:
:A few animal studies on the possible carcinogenic effect of magnetic fields have been published. They have been designed to reveal a possible tumor promotion obtained by applying continuous or pulsed alternating fields at flux densities varying between 0.5 microT and 30 mT on mice or rats initiated with different initiators. One study with 2 mT applied on DMBA-initiated mice may suggest a copromotive effect together with the promoter TPA. Another study on rats suggests an inhibitory effect by a magnetic field on rat liver foci formation, induced with DENA. Cell studies show that magnetic fields at some frequencies, amplitudes, and wave forms interact with biological systems. Thus effects have been seen, e.g., on enzymes related to growth regulation, on calcium balance in the cell, on gene expression, and on pineal metabolism and its excretion of the oncostatic melatonin. Cellular and physiologic studies thus suggest effects that may be related to cell multiplication and tumor promotion.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Holmberg Bdoi
10.1289/ehp.95103s263subject
Has Abstractpub_date
1995-03-01 00:00:00pages
63-7eissn
0091-6765issn
1552-9924journal_volume
103 Suppl 2pub_type
杂志文章,评审abstract::The available data on binary interactions are yet to be considered within the context of mixture risk assessment because of our inability to predict the effect of a third or a fourth chemical in the mixture on the interacting binary pairs. Physiologically based pharmacokinetic (PBPK) models represent a potentially use...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.02110s6989
更新日期:2002-12-01 00:00:00
abstract::Carcinogenic nickel compounds are usually found to be weak mutagens; therefore these compounds may not exert their carcinogenic activity through conventional genotoxic mechanisms. On the other hand, the activities of many nickel compounds have not been adequately investigated. We evaluated the genotoxic activities of ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102s973
更新日期:1994-11-01 00:00:00
abstract::Recent studies have linked air pollution to tens of thousands of premature cardiovascular deaths per year. The mechanisms of such associations remain unclear. In this study we examine the association between blood markers of cardiovascular risk and air pollution in a national sample of the U.S. population. Air polluti...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.01109s3405
更新日期:2001-06-01 00:00:00
abstract:BACKGROUND:Drinking water contamination related to the use of aqueous film-forming foam (AFFF) has been documented at hundreds of military bases, airports, and firefighter training facilities. AFFF has historically contained high levels of long-chain per- and polyfluoroalkyl substances (PFAS), which pose serious health...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP6470
更新日期:2020-09-01 00:00:00
abstract::The association of malignant mesothelioma (MM) and nonoccupational asbestos exposure is currently debated. Our study investigates environmental and domestic asbestos exposure in the city where the largest Italian asbestos cement (AC) factory was located. This population-based case-control study included pleural MM (hi...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.01109915
更新日期:2001-09-01 00:00:00
abstract::A microscopic, ultrastructural, and morphometric study was made of the gills of tench (Tinca tinca, L.) subjected to acute experimental lead nitrate poisoning. Twenty-one adult tench were subjected to poisoning and a further 22 were used as controls. Lesions were characterized by the appearance of edema and epithelial...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9089137
更新日期:1990-11-01 00:00:00
abstract::A review of the literature is provided for the topic of health-related research and power frequency electromagnetic fields. Minimal evidence for concern is present on the basis of animal and plant research. General observation would accord with the implication that there is no single and manifest health effect as the ...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.8775159
更新日期:1987-11-01 00:00:00
abstract::The industrial accident that occurred in the town of Seveso, Italy, in 1976 exposed a large population to substantial amounts of relatively pure 2,3,7,8-tetrachlorodibenzo-p-dioxin. Extensive monitoring of soil levels and measurements of a limited number of human blood samples allowed classification of the exposed pop...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.98106625
更新日期:1998-04-01 00:00:00
abstract::A subset of workers was followed after exposure to polychlorinated biphenyls (PCBs), dioxins, and furans in an occupational medicine clinic setting. Patterns of PCBs found in adipose tissue resembled the pattern seen when soot from the incident or Aroclor 1254 was examined by GC-MS. Adipose tissue also revealed levels...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8560241
更新日期:1985-05-01 00:00:00
abstract::Studies were performed to investigate the effects of FireMaster FF-1, a chemical fire retardant consisting of a mixture of polybrominated biphenyls (PBB), on immune functions in mice and rats. Animals received 22 daily treatments of 0.03, 0.3, 3.0, or 30 mg PBB/kg body weight in a period covering 30 days. PBB exposure...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7823227
更新日期:1978-04-01 00:00:00
abstract::The additives and contaminants which occur in textile fibers vary widely, depending on the type of fiber and the pretreatment which it has received. Synthetic fibers such as nylon and polyester contain trace amounts of contaminants such as catalysts and catalyst deactivators which remain after the synthesis of the bas...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.751141
更新日期:1975-06-01 00:00:00
abstract::Millions of people worldwide are living in areas where ozone (O3) concentrations exceed health standards (an hourly average of 235 micrograms/m3/0.12 ppm, not to be exceeded more than once per year). Ozone induces acute nasal inflammatory responses and significant epithelial lesions in experimental animals and humans....
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.102-1567497
更新日期:1994-12-01 00:00:00
abstract::1,3-Butadiene is a major monomer in the rubber and plastics industry and is one of the highest-production industrial chemicals in the United States. Although not highly acutely toxic to rodents, inhalation of concentrations as low as 6.25 ppm causes tumors in mice. Butadiene is oncogenic in rats, but much higher expos...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.93101s6161
更新日期:1993-12-01 00:00:00
abstract::A major concern of the chlorination of aquatic humic materials is the ubiquitous production of trihalomethanes. A large number of other chlorinated organic compounds, however, have been shown to be formed by chlorine's reaction with humic substances. In this study, humic material was concentrated from a coastal North ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.824663
更新日期:1982-12-01 00:00:00
abstract::An important public health challenge has been the need to protect children's health. To accomplish this goal, the scientific community needs scientifically based child-specific risk assessment methods. Critical to their development is the need to understand mechanisms underlying children's sensitivity to environmental...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.00108s113
更新日期:2000-03-01 00:00:00
abstract::Short articles on the following topics: *NIEHS Strategic Plan: New Frontiers in Environmental Sciences and Human Health; Beyond the Bench: Environmental Health Nursing: Putting Knowledge into Practice; Headliners: Inhibition of RLIP76 Causes Complete Regression of Melanoma in Mice. ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:Exposure to arsenic via drinking water is a global environmental health problem. In utero exposure to arsenic via drinking water increases the risk of lower respiratory tract infections during infancy and mortality from bronchiectasis in early adulthood. OBJECTIVES:We aimed to investigate how arsenic exposu...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1205590
更新日期:2013-02-01 00:00:00
abstract::We have witnessed a tremendous increase in our knowledge of the molecular and biochemical mechanisms which underly the activities of the nervous system. Such knowledge is essential in order to determine the basic mechanisms involved in neurotoxic events. An overview of how neurotoxins could conceivably interfere with ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7826121
更新日期:1978-10-01 00:00:00
abstract::Environmental tobacco smoke (ETS) has been associated with cardiovascular mortality. Pathophysiologic pathways leading from ETS exposure to cardiopulmonary disease are still being explored. Reduced cardiac autonomic function, as measured by heart rate variability (HRV), has been associated with cardiac vulnerability a...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.01109711
更新日期:2001-07-01 00:00:00
abstract::In April 2004, one of the largest aflatoxicosis outbreaks occurred in rural Kenya, resulting in 317 cases and 125 deaths. Aflatoxin-contaminated homegrown maize was the source of the outbreak, but the extent of regional contamination and status of maize in commercial markets (market maize) were unknown. We conducted a...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7998
更新日期:2005-12-01 00:00:00
abstract::In recent years there has been an increasing focus in environmental risk assessment on children as a potentially susceptible population. There also has been growing recognition of the need for a systematic approach for organizing, evaluating, and incorporating the available data on children's susceptibilities in risk ...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.6182
更新日期:2004-02-01 00:00:00
abstract::The potential impact of an agent altering male reproductive function is greater for humans than for animals. Consequently, it is essential that sensitive criteria be used to look for effects on a multiplicity of target sites when an agent is evaluated using an animal model. No animal model has reproductive characteris...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8670149
更新日期:1986-12-01 00:00:00
abstract::The main source of cadmium in the diet is cereal or meat, especially in liver and kidney. Since the cadmium in both liver and kidney is bound to metallothionein, a heat-stable protein, the gastrointestinal absorption and metabolism of cadmium metallothionein (CdMt) was studied in detail. The selective renal cadmium de...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7928127
更新日期:1979-02-01 00:00:00
abstract::Among the issues dealing with identifying potential adverse immunologic effects (i.e., suppression, hypersensitivity, or autoimmunity) associated with xenobiotic exposure, general agreement exists among the regulatory and pharmaceutical communities that predictive tests for autoimmunity are in most need of development...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.99107s5679
更新日期:1999-10-01 00:00:00
abstract::A brief history of the development of the field of aquatic toxicology is provided. In order to provide a perspective on the state-of-the-art in aquatic toxicology relative to classical toxicology, the two fields are compared from the standpoint of the type of scientist practicing each field, the respective objectives ...
journal_title:Environmental health perspectives
pub_type: 历史文章,杂志文章
doi:10.1289/ehp.8034159
更新日期:1980-02-01 00:00:00
abstract::Two remote maritime populations were evaluated for their biological exposure to organochlorines in 1989-1990. Because of their high intake of seafood, these two populations have high biological levels. One hundred nine breast milk samples from Inuit women from Arctic Québec were analyzed to determine levels of polychl...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102s1205
更新日期:1994-01-01 00:00:00
abstract::The 26th annual conference of the International Society for Environmental Epidemiology was held 24-28 August 2014 in Seattle, Washington. The conference theme was "From Local to Global: Advancing Science for Policy in Environmental Health." Sessions highlighted results assessing the burden of diseases from environment...
journal_title:Environmental health perspectives
pub_type:
doi:10.1289/ehp.isee2014
更新日期:2014-10-30 00:00:00
abstract::Free-radical metabolites can be generated metabolically by a one-electron reductase-catalyzed reaction or a "peroxidase" catalyzed oxidation or by photoactivation of a wide variety of aromatic xenobiotics. Radicals may also be generated during lipid peroxidation. Some radicals can react with DNA or bind covalently or ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8564219
更新日期:1985-12-01 00:00:00
abstract:BACKGROUND:Particulate matter (PM) in outdoor air pollution was recently designated a Group I carcinogen by the International Agency for Research on Cancer (IARC). This determination was based on the evidence regarding the relationship of PM2.5 and PM10 to lung cancer risk; however, the IARC evaluation did not include ...
journal_title:Environmental health perspectives
pub_type: 杂志文章,meta分析,评审
doi:10.1289/ehp/1408092
更新日期:2014-09-01 00:00:00
abstract::Outdoor ambient air pollutant exposures in communities are relevant to the acute exacerbation and possibly the onset of asthma. However, the complexity of pollutant mixtures and etiologic heterogeneity of asthma has made it difficult to identify causal components in those mixtures. Occupational exposures associated wi...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.02110s4573
更新日期:2002-08-01 00:00:00