A framework for assessing risks to children from exposure to environmental agents.

abstract：:The study reported here presents the results of an investigation of a marsh-cove ecosystem heavily contaminated by cadmium. The most contaminated aquatic sediments were dredged in 1972-73, but the resuspension of the sediments and recycle of water from the dredge spoil resulted in reestablishment of a large contaminat...

journal_title：Environmental health perspectives

authors： Kneip TJ,Hazen RE

更新日期：1979-02-01 00:00:00

abstract：:The Clean Air Act requires that sensitive subgroups of exposed populations be protected from adverse health effects of air pollution exposure. Hence, data suggesting the existence of sensitive subgroups can have an important impact on regulatory decisions. Some investigators have interpreted differences among individu...

journal_title：Environmental health perspectives

authors： Brunekreef B,Kinney PL,Ware JH,Dockery D,Speizer FE,Spengler JD,Ferris BG Jr

更新日期：1991-01-01 00:00:00

abstract：:A meeting on Marine Biomedical Research, sponsored by the National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health and the Smithsonian Institution Museum of Natural History, was attended by approximately 125 scientists, directors and representatives from many of the country's marine b...

journal_title：Environmental health perspectives

authors： Bessey O

更新日期：1976-02-01 00:00:00

abstract：:According to current data, the capacity to cause nonprogrammed or unscheduled cell proliferation in target tissues, a common characteristic of chemical carcinogens, may play a more important role in the development of tumors than does genotoxicity. This paper provides strong support for the validity of this conclusion...

journal_title：Environmental health perspectives

authors： Yoshikawa K

更新日期：1996-01-01 00:00:00

abstract：:Considerable attention has been given to the relationship between levels of fine particulate matter (particulate matter < or = 2.5 microm in aerodynamic diameter; PM(2.5) in the atmosphere and health effects in human populations. Since the U.S. Environmental Protection Agency began widespread monitoring of PM(2.5) lev...

journal_title：Environmental health perspectives

authors： Holloman CH,Bortnick SM,Morara M,Strauss WJ,Calder CA

更新日期：2004-09-01 00:00:00

abstract：:In most neurotoxicological studies morphological assessment focuses on pathological effects, like degenerative changes in neuronal perikarya, axonopathy, demyelination, and glial and endothelial cell reactions. Similarly, the assessment of physiological and behavioral effects center on evident neurological symptoms, l...

journal_title：Environmental health perspectives

authors： Altman J

更新日期：1987-10-01 00:00:00

abstract：:Asthma is the most common chronic illness of childhood and its prevalence is increasing, causing much concern for identification of risk factors such as air pollution. We previously conducted a study showing a relationship between asthma visits in all persons < 65 years of age to emergency departments (EDs) and air po...

journal_title：Environmental health perspectives

authors： Norris G,YoungPong SN,Koenig JQ,Larson TV,Sheppard L,Stout JW

更新日期：1999-06-01 00:00:00

abstract：OBJECTIVES:The U.S. Environmental Protection Agency is working toward gaining a better understanding of the human health impacts of exposure to complex air pollutant mixtures and the key features that drive the toxicity of these mixtures, which can then be used for future scientific and risk assessments. DATA SOURCES:...

journal_title：Environmental health perspectives

authors： Johns DO,Stanek LW,Walker K,Benromdhane S,Hubbell B,Ross M,Devlin RB,Costa DL,Greenbaum DS

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Associations between airborne particles and health outcomes have been documented worldwide; however, there is limited information regarding health effects associated with different particle sizes. OBJECTIVES:We explored the association between size-fractionated particle number concentrations (PNCs) and dail...

journal_title：Environmental health perspectives

authors： Meng X,Ma Y,Chen R,Zhou Z,Chen B,Kan H

更新日期：2013-10-01 00:00:00

abstract：:Carcinogenic nickel compounds are usually found to be weak mutagens; therefore these compounds may not exert their carcinogenic activity through conventional genotoxic mechanisms. On the other hand, the activities of many nickel compounds have not been adequately investigated. We evaluated the genotoxic activities of ...

journal_title：Environmental health perspectives

authors： Au WW,Heo MY,Chiewchanwit T

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:Enteric illness arising from contaminated water and food is a major health concern worldwide, and tracking the incidences and severity of outbreaks is still a challenging task. Most developed and developing countries have administrative databases for medical visits and services maintained by the government a...

journal_title：Environmental health perspectives

authors： Peace T,Mazumder A

更新日期：2007-01-01 00:00:00

abstract：:Inorganic particulate matter in foods and drugs is discussed from the standpoint of determination by optical microscopy, source, and regulatory significance. Some particulate matter may be generated as extraneous material and traced to specific operational practices during processing and production with excessive leve...

journal_title：Environmental health perspectives

authors： Eisenberg WV

更新日期：1974-12-01 00:00:00

abstract：:To study the effect of processing on polybrominated biphenyl (PBB) levels, milk from four dairy herds containing less than 0.3 ppm (fat basis) of physiologically incorporated PBBs was presented individually into cream, skim milk, butter, and stirred curd cheese. Pasteurized and freeze-dried whole milk, skim milk, and ...

journal_title：Environmental health perspectives

authors： Zabik ME,Johnson TM,Smith S

更新日期：1978-04-01 00:00:00

abstract：:In 1998, the Helicobacter pylori [(13)C]urea breath test was offered to all school beginners (birth cohort 1991/1992) in the city of Leipzig and in Leipzig County, Germany, to determine the colonization prevalence and potential transmission pathways of the bacterium. A total of 3,347 school beginners participated in t...

journal_title：Environmental health perspectives

authors： Herbarth O,Krumbiegel P,Fritz GJ,Richter M,Schlink U,Müller DM,Richter T

更新日期：2001-06-01 00:00:00

abstract：:Widespread and persistent organochlorine (OC) contaminants, such as polychlorinated biphenyls (PCBs) and pesticides, are known to have broad-ranging toxicities in wildlife. In this study we investigated, for the first time, their possible health effects on loggerhead sea turtles (Caretta caretta). Nonlethal fat biopsi...

journal_title：Environmental health perspectives

authors： Keller JM,Kucklick JR,Stamper MA,Harms CA,McClellan-Green PD

更新日期：2004-07-01 00:00:00

abstract：:A previously healthy woman developed hypersensitivity pneumonitis of such severity that she required chronic systemic corticosteroid therapy for symptom control. Detailed investigation of her workplace and home environments revealed fungi in her typical suburban home, to which she had specific serum precipitating anti...

journal_title：Environmental health perspectives

authors： Apostolakos MJ,Rossmoore H,Beckett WS

更新日期：2001-09-01 00:00:00

abstract：:Cap43 is a protein whose RNA is induced under conditions of severe hypoxia or prolonged elevations of intracellular calcium. Additionally, Ni and Co also induce Cap43 because they produce a state of hypoxia in cells. Cap43 protein is expressed at low levels in normal tissues; however, in a variety of cancers, includin...

journal_title：Environmental health perspectives

authors： Cangul H,Salnikow K,Yee H,Zagzag D,Commes T,Costa M

更新日期：2002-10-01 00:00:00

abstract：:The effects of chrysotile on DNA synthesis in the gastrointestinal tract of the rat were studied by measuring the uptake of tritium-labeled thymidine; whole stomach, small intestine, colon liver were removed, cleaned, and homogenized and the DNA was isolated and assayed for tritium label.A dose-response study indicate...

journal_title：Environmental health perspectives

authors： Amacher DE,Alarif A,Epstein SS

更新日期：1974-12-01 00:00:00

abstract：BACKGROUND:Although animal experiments have shown that cadmium exposure results in severe dental caries, limited epidemiologic data are available on this issue. OBJECTIVES:We aimed to examine the relationship between environmental cadmium exposure and dental caries in children 6-12 years of age. METHODS:We analyzed c...

journal_title：Environmental health perspectives

authors： Arora M,Weuve J,Schwartz J,Wright RO

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Findings from national surveys suggest that everyone in the United States is exposed to perchlorate. At high doses, perchlorate, thiocyanate, and nitrate inhibit iodide uptake into the thyroid and decrease thyroid hormone production. Small changes in thyroid hormones during pregnancy, including changes withi...

journal_title：Environmental health perspectives

authors： Steinmaus C,Pearl M,Kharrazi M,Blount BC,Miller MD,Pearce EN,Valentin-Blasini L,DeLorenze G,Hoofnagle AN,Liaw J

更新日期：2016-06-01 00:00:00

abstract：:Chlordane is a polychlorinated hydrocarbon that causes liver enlargement and induces mixed-function oxidases similar to those induced by phenobarbitone in the mouse. We have assessed the hepatocarcinogenicity (after 2 years) and the time course (over 6 months) of liver and thyroid cell proliferation in C57Bl/10J mice ...

journal_title：Environmental health perspectives

authors： Barrass N,Stewart M,Warburton S,Aitchison J,Jackson D,Wadsworth P,Marsden A,Orton T

更新日期：1993-12-01 00:00:00

abstract：:Along the Texas-Mexico border, the prevalence of neural tube defects (NTDs) among Mexican-American women doubled during 1990-1991. The human outbreak began during the same crop year as epizootics attributed to exposure to fumonisin, a mycotoxin that often contaminates corn. Because Mexican Americans in Texas consume l...

journal_title：Environmental health perspectives

authors： Missmer SA,Suarez L,Felkner M,Wang E,Merrill AH Jr,Rothman KJ,Hendricks KA

更新日期：2006-02-01 00:00:00

abstract：:In recent years there have been a significant number of publications on the benefits and challenges of community-based participatory research (CBPR). In this introduction we give an overview of three projects presented in this mini-monograph and highlight their commonalities and differences in developing community-uni...

journal_title：Environmental health perspectives

authors： Srinivasan S,Collman GW

更新日期：2005-12-01 00:00:00

abstract：:The Tradescantia genetic system developed by the late Dr. Arnold H. Sparrow for the study of effects of ionizing radiation is applicable to chemical mutagen detection. Early radiobiological data demonstrated that the stamen hairs were sensitive to as little as 0.25 rad of x-rays and that the number of cells showing a ...

journal_title：Environmental health perspectives

authors： Schairer LA,Van't Hof J,Hayes CG,Burton RM,de Serres FJ

更新日期：1978-12-01 00:00:00

abstract：:This paper concerns the testing for Hardy-Weinberg equilibrium and the estimation of gene frequency in the human leukocyte antigens (HLA) system. An extensive simulation study for both testing and estimation is given for investigating the performance of the projection method by Eguchi and Matsuura, which has a closed ...

journal_title：Environmental health perspectives

authors： Matsuura M,Eguchi S

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND:Agricultural work and occupational pesticide use have been associated with increased risk of renal cell carcinoma (RCC), the most common form of kidney cancer. However, few prospective studies have investigated links to specific pesticides. OBJECTIVE:We evaluated the lifetime use of individual pesticides an...

journal_title：Environmental health perspectives

authors： Andreotti G,Beane Freeman LE,Shearer JJ,Lerro CC,Koutros S,Parks CG,Blair A,Lynch CF,Lubin JH,Sandler DP,Hofmann JN

更新日期：2020-06-01 00:00:00

abstract：:The heterocyclic aromatic amine 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) was evaluated for carcinogenic effects in macaques, primarily cynomolgus monkeys. IQ was administered by gavage five times a week at doses of 10 or 20 mg/kg. IQ induced hepatocellular carcinoma in 55% of the animals at the low dose and in 95%...

journal_title：Environmental health perspectives

authors： Adamson RH,Takayama S,Sugimura T,Thorgeirsson UP

更新日期：1994-02-01 00:00:00

abstract：:Many substances are active in in vitro tests for estrogenic activity, but data from multigenerational and other toxicity studies are not available for many of those substances. Controversy has arisen, therefore, concerning the likelihood of adverse health effects. Based on a toxic equivalence factor risk assessment ap...

journal_title：Environmental health perspectives

authors： Rudel R

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:Ambient levels of pesticides ("pesticide drift") are detectable at residences near agricultural field sites. OBJECTIVE:Our goal was to evaluate the hypothesis that maternal residence near agricultural pesticide applications during key periods of gestation could be associated with the development of autism s...

journal_title：Environmental health perspectives

authors： Roberts EM,English PB,Grether JK,Windham GC,Somberg L,Wolff C

更新日期：2007-10-01 00:00:00

abstract：:This paper examines recent risk assessments for benzene and observes a number of inconsistencies within the study and consistencies between studies that should effect the quantitative determination of the risk from benzene exposure. Comparisons across studies show that only acute myeloid leukemia (AML) is found to be ...

journal_title：Environmental health perspectives

authors： Lamm SH,Walters AS,Wilson R,Byrd DM,Grunwald H

更新日期：1989-07-01 00:00:00