Abstract:
:In 1998, the Helicobacter pylori [(13)C]urea breath test was offered to all school beginners (birth cohort 1991/1992) in the city of Leipzig and in Leipzig County, Germany, to determine the colonization prevalence and potential transmission pathways of the bacterium. A total of 3,347 school beginners participated in the test, and 2,888 parents completed the detailed, self-administered questionnaire. The H. pylori prevalence was 6.5% [95% confidence interval (CI), 5.3-7.6] in the city and 5.7% (CI, 4.2-7.0) in the county. Using cluster analysis (WARD's method, Euclidean distances), we identified different sets of variables (confirmed by multivariate logistic regression analyses [odds ratios (ORs)] that are signficantly associated with H. pylori positivity. Among city children, the risk is significantly increased with contact to a pet hamster (OR = 2.4; 95% CI, 1.2-4.7; p < 0.015) and travels to Asian countries (OR = 3.7; 95% CI, 1.6-8.7; p < 0.002). Among county children, H. pylori positivity increased significantly with drinking of water from nonmunicipal sources (OR = 16.4; 95% CI, 3.1-88.5; p < 0.001), more than 3 children living in a household (OR = 4.2; 95% CI, 1.2-14.6; p < 0.02), and contact with pet hamsters (OR = 2.4; 95% CI, 1.0-5.7; p < 0.04). These data suggest that, in a general population sample, indirect fecal-oral transmission and living conditions are important risk factors in the spread of H. pylori infection. However, clinical symptoms do not necessarily indicate H. pylori positivity.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Herbarth O,Krumbiegel P,Fritz GJ,Richter M,Schlink U,Müller DM,Richter Tdoi
10.1289/ehp.01109573subject
Has Abstractpub_date
2001-06-01 00:00:00pages
573-7issue
6eissn
0091-6765issn
1552-9924pii
sc271_5_1835journal_volume
109pub_type
杂志文章abstract::The formamidines, a relatively new group of acaricide-insecticides, are novel both in their range of biological activities and in their mode of action, which is presently unknown. This paper is a review of the historical development, properties, structures, uses, and chemistry of this group of pesticides, with particu...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.761457
更新日期:1976-04-01 00:00:00
abstract::The association of blood lead (B-Pb) concentration to blood pressure was investigated in men aged 55 to 75 years living in the Rome area, who had no history of exposure to lead in the workplace and who participated between 1989 and 1990 in an epidemiologic survey for coronary heart disease (New Risk Factor Project). O...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102s9107
更新日期:1994-11-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1206010
更新日期:2013-09-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.8561329
更新日期:1985-09-01 00:00:00
abstract::We analyzed data from 798 lead workers to determine whether polymorphisms in the genes encoding delta-aminolevulinic acid dehydratase (ALAD), endothelial nitric oxide synthase (eNOS), and the vitamin D receptor (VDR) were associated with or modified relations of lead exposure and dose measures with renal outcomes. Lea...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.6116
更新日期:2003-10-01 00:00:00
abstract::We used an improved method for trapping carbon-centered radicals (.R) from the gas-phase to compare radical suites trapped from various tobacco smoke and model smoke systems. Using a nitroxide trap, 3-amino-2,2,5,5-tetramethyl-1-pyrrolidinyloxy (3AP), on solid support, we trapped radicals directly from the gas phase, ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.01109765
更新日期:2001-08-01 00:00:00
abstract::The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) has highly pleiotropic effects on cells in culture and on tissues in vivo, including effects on protein kinase C (PKC) activation and gene expression. In order to determine the mechanism of activation of gene transcription by TPA, DNA sequences whose transc...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.877689
更新日期:1987-12-01 00:00:00
abstract::The National Cancer Institute (NCI) and the National Toxicology Program (NTP) have carried out a number of laboratory animal carcinogenicity studies and presented the results of these experiments in a series of Technical Reports. This paper tabulates the results of the 327 NCI/NTP studies carried out to date on 308 di...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8774229
更新日期:1987-10-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.99107917
更新日期:1999-11-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.749183
更新日期:1974-12-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1206211
更新日期:2013-10-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9000
更新日期:2006-10-01 00:00:00
abstract::In an attempt to elucidate the relationship between DNA adduct formation and tumorigenesis, DNA adducts were measured in the livers and bladders of mice during chronic exposure to several different doses of 2-acetylaminofluorene (2-AAF) and 4-aminobiphenyl (4-ABP). Continuous oral administration of these compounds for...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.94102s6161
更新日期:1994-10-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8221
更新日期:2006-02-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,meta分析,评审
doi:10.1289/ehp/1408092
更新日期:2014-09-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7827103
更新日期:1978-12-01 00:00:00
abstract::Millions of people worldwide are exposed to arsenic-contaminated drinking water, and ingestion of inorganic arsenic (InAs) has been associated with increased risks of cancer. The primary metabolic pathway of ingested InAs is methylation to monomethyl arsenic (MMA) and dimethyl arsenic (DMA). However, people vary great...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7907
更新日期:2005-09-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1307309
更新日期:2014-05-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.0211095
更新日期:2002-01-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8979115
更新日期:1989-02-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.97105s61603
更新日期:1997-12-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
abstract::To examine the effects of dibutyl phthalate (DBP) on gonadal sex differentiation, genetically male tadpoles of Rana rugosa were exposed to dilute solutions of DBP at concentrations of 0.1, 1, or 10 microM during days 19-23 after fertilization, which is the critical period of gonadal sex differentiation in R. rugosa. T...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.001081189
更新日期:2000-12-01 00:00:00
abstract::To evaluate the effectiveness of mass screening for uterine cancer in Japan, we compared the changes in the age-adjusted rates of potential years of life lost (PYLL) due to uterine cancer between 1969 and 1972 to 1973 through 1977 between the high coverage-rate (intensively screened) areas and the comparable control a...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.908751
更新日期:1990-07-01 00:00:00
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journal_title:Environmental health perspectives
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doi:10.1289/ehp.0800149
更新日期:2009-08-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.02110s5773
更新日期:2002-10-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.6933
更新日期:2005-03-01 00:00:00
abstract::Granular activated carbon (GAC), in the presence of dilute aqueous hypochlorite solutions typical of those used in water treatment, was converted to a reagent capable of carrying out free-radical coupling reactions and other oxidations of dilute aqueous solutions of phenols. The products included biphenyls with chlori...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.866997
更新日期:1986-11-01 00:00:00
abstract::The epidemiological data linking air pollution and lung cancer are derived from statistical associations concerning rates of cancer among urban and rural residents, migrant studies and studies of occupational groups exposed to effluents from fossil fuel combinations. Few, if any of these studies, are adequately adjust...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.834733
更新日期:1983-01-01 00:00:00
abstract::A biodosimetric approach to determine alpha-particle dose to the respiratory tract epithelium from known exposures to radon has been developed in the rat. Cytotoxicity assays have been used to obtain dose-conversion factors for cumulative exposures typical of those encountered by underground uranium miners. However, t...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.97105s4913
更新日期:1997-06-01 00:00:00