Abstract：
:Along the Texas-Mexico border, the prevalence of neural tube defects (NTDs) among Mexican-American women doubled during 1990-1991. The human outbreak began during the same crop year as epizootics attributed to exposure to fumonisin, a mycotoxin that often contaminates corn. Because Mexican Americans in Texas consume large quantities of corn, primarily in the form of tortillas, they may be exposed to high levels of fumonisins. We examined whether or not maternal exposure to fumonisins increases the risk of NTDs in offspring using a population-based case-control study. We estimated fumonisin exposure from a postpartum sphinganine:sphingosine (sa:so) ratio, a biomarker for fumonisin exposure measured in maternal serum, and from maternal recall of periconceptional corn tortilla intake. After adjusting for confounders, moderate (301-400) compared with low (< or = 100) consumption of tortillas during the first trimester was associated with increased odds ratios (ORs) of having an NTD-affected pregnancy (OR = 2.4; 95% confidence interval, 1.1-5.3). No increased risks were observed at intakes higher than 400 tortillas (OR = 0.8 for 401-800, OR = 1.0 for > 800). Based on the postpartum sa:so ratio, increasing levels of fumonisin exposure were associated with increasing ORs for NTD occurrences, except for the highest exposure category (sa:so > 0.35). Our findings suggest that fumonisin exposure increases the risk of NTD, proportionate to dose, up to a threshold level, at which point fetal death may be more likely to occur. These results also call for population studies that can more directly measure individual fumonisin intakes and assess effects on the developing embryo.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Missmer SA,Suarez L,Felkner M,Wang E,Merrill AH Jr,Rothman KJ,Hendricks KAdoi
10.1289/ehp.8221subject
Has Abstractpub_date
2006-02-01 00:00:00pages
237-41issue
2eissn
0091-6765issn
1552-9924journal_volume
114pub_type
杂志文章abstract：:The timing of some key embryological events is given for man, rat, chick, and certain other animals. Such times, however, are approximations, and variations occur among members of the same strain and even among members of the same litter. Some differences in developmental patterns are indicated. ...
journal_title：Environmental health perspectives
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doi：10.1289/ehp.761855
更新日期：1976-12-01 00:00:00
abstract：BACKGROUND:Previous studies have suggested an effect of high arsenic concentration on cognitive and neurobehavioral function in humans. OBJECTIVE:Our goal was to identify demographic and nutritional factors that are associated with As exposure and the influence of this exposure on cognitive function in school-age chil...
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journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
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更新日期：1978-04-01 00:00:00
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更新日期：2018-09-01 00:00:00
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journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
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更新日期：1997-09-01 00:00:00
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更新日期：2000-04-01 00:00:00
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更新日期：2015-09-01 00:00:00
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更新日期：1994-03-01 00:00:00
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更新日期：1993-12-01 00:00:00
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更新日期：1991-05-01 00:00:00
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更新日期：2006-07-01 00:00:00
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