Abstract：
:The industrial accident that occurred in the town of Seveso, Italy, in 1976 exposed a large population to substantial amounts of relatively pure 2,3,7,8-tetrachlorodibenzo-p-dioxin. Extensive monitoring of soil levels and measurements of a limited number of human blood samples allowed classification of the exposed population into three categories, A (highest exposure), B (median exposure), and R (lowest exposure). Early health investigations including liver function, immune function, neurologic impairment, and reproductive effects yielded inconclusive results. Chloracne (nearly 200 cases with a definite exposure dependence) was the only effect established with certainty. Long-term studies were conducted using the large population living in the surrounding noncontaminated territory as reference. An excess mortality from cardiovascular and respiratory diseases was uncovered, possibly related to the psychosocial consequences of the accident in addition to the chemical contamination. An excess of diabetes cases was also found. Results of cancer incidence and mortality follow-up showed an increased occurrence of cancer of the gastrointestinal sites and of the lymphatic and hematopoietic tissue. Experimental and epidemiologic data as well as mechanistic knowledge support the hypothesis that the observed cancer excesses are associated with dioxin exposure. Results cannot be viewed as conclusive. The study is continuing in an attempt to overcome the existing limitations (few individual exposure data, short latency period, and small population size for certain cancer types) and to explore new research paths (e.g., differences in individual susceptibility).
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Bertazzi PA,Bernucci I,Brambilla G,Consonni D,Pesatori ACdoi
10.1289/ehp.98106625subject
Has Abstractpub_date
1998-04-01 00:00:00pages
625-33eissn
0091-6765issn
1552-9924journal_volume
106 Suppl 2pub_type
杂志文章,评审abstract：BACKGROUND:The relationship of fine particulate matter < 2.5 microm in diameter (PM(2.5)) air pollution with mortality and cardiovascular disease is well established, with more recent long-term studies reporting larger effect sizes than earlier long-term studies. Some studies have suggested the coarse fraction, particl...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.0900572
更新日期：2009-11-01 00:00:00
abstract：:As a consequence of contamination by effluents from local electronics manufacturing facilities, the New Bedford Harbor and estuary in southeastern Massachusetts is among the sites in the United States that are considered the most highly contaminated by polychlorinated biphenyls (PCBs). Since 1993, measures of intraute...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.98106513
更新日期：1998-08-01 00:00:00
abstract：BACKGROUND:C60 fullerenes and single-walled carbon nanotubes (SWCNT) are projected to be used in medicine and consumer products with potential human exposure. The hazardous effects of these particles are expected to involve oxidative stress with generation of oxidatively damaged DNA that might be the initiating event i...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.11922
更新日期：2009-05-01 00:00:00
abstract：:High-dose boric acid (BA) exposure produces testicular lesions in adult rats characterized by inhibited spermiation (IS) that may progress to atrophy. In vivo and in vitro studies addressed possible mechanisms. In vivo, boron tissue disposition was examined, since no detailed data existed, and relevant boron concentra...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.94102s799
更新日期：1994-11-01 00:00:00
abstract：BACKGROUND:Findings from national surveys suggest that everyone in the United States is exposed to perchlorate. At high doses, perchlorate, thiocyanate, and nitrate inhibit iodide uptake into the thyroid and decrease thyroid hormone production. Small changes in thyroid hormones during pregnancy, including changes withi...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.1409614
更新日期：2016-06-01 00:00:00
abstract：:Short articles on the following topics: *NIEHS Strategic Plan: New Frontiers in Environmental Sciences and Human Health; Beyond the Bench: Environmental Health Nursing: Putting Knowledge into Practice; Headliners: Inhibition of RLIP76 Causes Complete Regression of Melanoma in Mice. ...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：
更新日期：2006-05-01 00:00:00
abstract：:Ingestion is an important exposure route for polycyclic aromatic hydrocarbons (PAHs) to enter the human body. Although the formation of hazardous PAH metabolites by human biotransformation enzymes is well documented, nothing is known about the PAH transformation potency of human intestinal microbiota. Using a gastroin...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.7259
更新日期：2005-01-01 00:00:00
abstract：:Potential public health effects associated with exposure to metal emissions from hazardous waste incinerators through noninhalation pathways were evaluated. Instead of relying on modeling the movement of toxicants through various environmental media, an approach based on estimating changes from baseline levels of expo...
journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.94102105
更新日期：1994-06-01 00:00:00
abstract：:Exposure of rats to quartz (or various other particles) can lead to the development of lung tumors. At the moment, the mechanisms involved in particle-induced tumor formation are not clarified. However, it is suggested that inflammation, in conjunction with the production of reactive oxygen species (ROS) and an enhanc...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.97105s51291
更新日期：1997-09-01 00:00:00
abstract：:For decades, a number of guinea pig tests have been used to identify human contact allergens in workplace and consumer products, but these tests have limitations. In addition to using large numbers of test animals, they also provide only subjective measurements, because the allergic activity is measured by watching th...
journal_title：Environmental health perspectives
pub_type： 新闻
doi：10.1289/ehp.98106a488
更新日期：1998-10-01 00:00:00
abstract：BACKGROUND:Phthalates comprise a large class of chemicals used in a variety of consumer products. Several have anti-androgenic properties, and in rodents prenatal exposure has been associated with reduced anogenital distance (AGD)-the distance from the anus to the genitals in male offspring. Few human studies have been...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.1509870
更新日期：2016-07-01 00:00:00
abstract：:A brief description of chromosome aberrations and sister chromatid exchange (SCE) as cytogenetic endpoints for evaluation of DNA damaging agents is presented. Problems associated with the use of cytogenetic assays as population monitors of radiation and chemical exposures are discussed. Adequate cell sample size requi...
journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.8142107
更新日期：1981-12-01 00:00:00
abstract：BACKGROUND:Traffic noise has been associated with cardiovascular and metabolic disorders. Potential modes of action are through stress and sleep disturbance, which may lead to endocrine dysregulation and overweight. OBJECTIVES:We aimed to investigate the relationship between residential traffic and railway noise and a...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.1409052
更新日期：2016-03-01 00:00:00
abstract：:We analyzed data from 798 lead workers to determine whether polymorphisms in the genes encoding delta-aminolevulinic acid dehydratase (ALAD), endothelial nitric oxide synthase (eNOS), and the vitamin D receptor (VDR) were associated with or modified relations of lead exposure and dose measures with renal outcomes. Lea...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.6116
更新日期：2003-10-01 00:00:00
abstract：:The rapid development of the chemical industry, combustion of fossil fuels, and smoking of tobacco have resulted in contact of the general population with benzo(a)pyrene and other carcinogenic aromatic hydrocarbons. Persons especially at risk occupationally are those engaged in thermal processing of oil shale, coal, a...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.7930185
更新日期：1979-06-01 00:00:00
abstract：BACKGROUND:The National Institutes of Health's Environmental influences on Child Health Outcomes (ECHO) initiative aims to understand the impact of environmental factors on childhood disease. Over 40,000 chemicals are approved for commercial use. The challenge is to prioritize chemicals for biomonitoring that may prese...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/EHP5133
更新日期：2019-12-01 00:00:00
abstract：BACKGROUND:Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental pollutants, known human lung carcinogens, and potent mammary carcinogens in laboratory animals. However, the association between PAHs and breast cancer in women is unclear. Vehicular traffic is a major ambient source of PAH exposure. OBJEC...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.1307736
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Methylmercury (MeHg) exposure has been linked to an increased risk of coronary heart disease (CHD). Paraoxonase 1 (PON1), an enzyme located in the high-density-lipoprotein (HDL) fraction of blood lipids, may protect against CHD by metabolizing toxic oxidized lipids associated with low-density liproprotein an...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.1003296
更新日期：2011-08-01 00:00:00
abstract：:Concentrations of polychlorinated biphenyls (PCBs), hydroxylated metabolites of PCBs (HO-PCBs) and octachlorostyrene (4-HO-HpCS), and pentachlorophenol (PCP) were determined in umbilical cord plasma samples from three different regions of Québec. The regions studied included two coastal areas where exposure to PCBs is...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.02110411
更新日期：2002-04-01 00:00:00
abstract：:The hypothesis has been put forward that humans and wildlife species adverse suffered adverse health effects after exposure to endocrine-disrupting chemicals. Reported adverse effects include declines in populations, increases in cancers, and reduced reproductive function. The U.S. Environmental Protection Agency spon...
journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.96104s4715
更新日期：1996-08-01 00:00:00
abstract：:Carbon monoxide is widely distributed in the environment, and acute or chronic toxic effects may be of considerable public health significance. A review of the basis for current ambient standards is given. Mortality and morbidity studies have been negative or equivocal in relating carbon monoxide levels to health effe...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.8352131
更新日期：1983-10-01 00:00:00
abstract：:The epidemiological data linking air pollution and lung cancer are derived from statistical associations concerning rates of cancer among urban and rural residents, migrant studies and studies of occupational groups exposed to effluents from fossil fuel combinations. Few, if any of these studies, are adequately adjust...
journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.834733
更新日期：1983-01-01 00:00:00
abstract：:A review and summary is given of analytical, biochemical, and immunological studies made following an immunodiagnostic investigation which revealed significant decreases in the numbers, and changes in the functional integrity, of both T-and B-lymphocytes in a group of Michigan dairy farmers exposed to polybrominated b...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.8560107
更新日期：1985-05-01 00:00:00
abstract：:Metallothioneins (MTs) are encoded by a multigene family in man. We have isolated those genes and analyzed the structure of some of them. The MT-II variant is encoded by a single functional gene: MT-IIA. The MT-IIB gene is a processed pseudogene derived from a reverse transcript of MT-II mRNA. On the other hand, the M...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.8454111
更新日期：1984-03-01 00:00:00
abstract：:Comments on "Determination of bisphenol A and related aromatic compounds released from Bis-GMA-based composites and sealants by high performance liquid chromatography." by ulgar R, Olea-Serrano MF, Novillo-Fertrell A, Rivas A, Pazos P, Pedraza V, Navajas J-M, Olea N. Environ Health Perspect 108:21-27 (2000). ...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.108-a546a
更新日期：2000-12-01 00:00:00
abstract：BACKGROUND:Globally, 2.8 billion people rely on household solid fuels. Reducing the resulting adverse health, environmental, and development consequences will involve transitioning through a mix of clean fuels and improved solid fuel stoves (IS) of demonstrable effectiveness. To date, achieving uptake of IS has present...
journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.1306639
更新日期：2014-02-01 00:00:00
abstract：BACKGROUND:In a 1994 Ninth Circuit decision on the remand of Daubert v. Merrell Dow Pharmaceuticals, Inc., Judge Alex Kosinski wrote that science done for the purpose of litigation should be subject to more stringent standards of admissibility than other science. OBJECTIVES:We analyze this proposition by considering l...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.9987
更新日期：2008-01-01 00:00:00
abstract：:The pneumoconioses are associated with chronic inflammatory processes during which increased amounts of reactive oxygen species are formed in the lower respiratory tract. To characterize the effect(s) of these processes on the defense system against free radicals, we studied 91 individuals with long-term occupational ...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.9084165
更新日期：1990-03-01 00:00:00
abstract：BACKGROUND:Biomass smoke is an important source of particulate matter (PM), and much remains to be discovered with respect to the human health effects associated with this specific PM source. Exposure to biomass smoke can occur in one of two main categories: short-term exposures consist of periodic, seasonal exposures ...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.11378
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Methylmercury (MeHg) exhibits neurotoxicity through accumulation in the brain. The transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) plays an important role in reducing the cellular accumulation of MeHg. OBJECTIVES:We investigated the protective effect of isothiocyanates, which are kno...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.1003123
更新日期：2011-08-01 00:00:00
