Abstract:
:The pneumoconioses are associated with chronic inflammatory processes during which increased amounts of reactive oxygen species are formed in the lower respiratory tract. To characterize the effect(s) of these processes on the defense system against free radicals, we studied 91 individuals with long-term occupational exposure to coal mine dust. Thirty-one subjects were classified with radiological evidence to be pneumoconiotics, while 58 control miners had no pulmonary disorders. We measured antioxidant parameters in red blood cells, considering the latter to reflect the oxidative stress in the lung. Glutathione levels were significantly decreased (p = 0.04) in red blood cells of miners with coal workers' pneumoconiosis with radiograph classification 0/1 to 2/1, while in miners with classification 3/2 to 3/3, the plasma iron concentrations were significantly decreased (p = 0.04). Moreover, some factors of the anti-oxidant system (superoxide dismutase, catalase, glutathione peroxidase) were correlated in the diseased but not in the control miners. Taken together, all data support the role of the erythrocyte as a circulating anti-oxidant carrier and also that changes in red blood cell anti-oxidant factors reflect the oxidative stress imposed by the pneumoconiotic (inflammatory) processes in the lung.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Engelen JJ,Borm PJ,van Sprundel M,Leenaerts Ldoi
10.1289/ehp.9084165subject
Has Abstractpub_date
1990-03-01 00:00:00pages
165-72eissn
0091-6765issn
1552-9924journal_volume
84pub_type
杂志文章abstract:BACKGROUND:Although numerous epidemiologic studies now use models of intraurban exposure, there has been little systematic evaluation of the performance of different models. OBJECTIVES:In this present article we proposed a modeling framework for assessing exposure model performance and the role of spatial autocorrelat...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9849
更新日期:2007-08-01 00:00:00
abstract:BACKGROUND:Previous studies indicate that the design of streets and sidewalks can influence physical activity among residents. Park features also influence park use and park-based physical activity. Although individuals can walk on streets and sidewalks, walking loops in parks offer a setting to walk in nature and to a...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP293
更新日期:2017-02-01 00:00:00
abstract::The presence of blue-green algae (BGA) toxins in surface waters used for drinking water sources and recreation is receiving increasing attention around the world as a public health concern. However, potential risks from exposure to these toxins in contaminated health food products that contain BGA have been largely ig...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.00108435
更新日期:2000-05-01 00:00:00
abstract::Many thousand organic compounds are in common use and new ones introduced daily. With many of these materials, little is known about their toxic hazard. For years scientists have been investigating the relation of structure and properties to biological activity. Among the factors relating to toxicity are bioaccumulati...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.793075
更新日期:1979-06-01 00:00:00
abstract:BACKGROUND:Epidemiologic studies of postnatal PCB exposure and behavior have not reported consistent evidence of adverse associations, possibly because of challenges in exposure estimation. We previously developed a pharmacokinetic model to improve estimation of children's PCB exposure. OBJECTIVES:We aimed to assess w...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1408084
更新日期:2015-09-01 00:00:00
abstract::The occurrence of high cadmium levels in the digestive gland (hepatopancreas) of the crab Cancer pagurus is reviewed and its possible significance to human health is discussed. Previous attempts to isolate this cadmium in its native form are briefly reviewed and the present method used in this laboratory to isolate cr...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8665101
更新日期:1986-03-01 00:00:00
abstract::Hamsters were exposed to an aerosol of fused aluminosilicate particles (FAP) labeled with 57Co. Three groups of animals were given bronchopulmonary lavage, beginning at either 1 week, 1 month, or 6 months after exposure. Each treated group was lavaged eight times over a period of 25 days. Each lavage involved 10 salin...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9297209
更新日期:1992-07-01 00:00:00
abstract::The hypothesis has been put forward that humans and wildlife species adverse suffered adverse health effects after exposure to endocrine-disrupting chemicals. Reported adverse effects include declines in populations, increases in cancers, and reduced reproductive function. The U.S. Environmental Protection Agency spon...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.96104s4715
更新日期:1996-08-01 00:00:00
abstract::In this paper we report DNA binding of butadiene monoepoxide, a first metabolite of 1,3-butadiene catalyzed by monooxygenases. We prepared alkylated purines as marker compounds for 32-P-postlabeling and electrochemical analysis and developed methods to measure the corresponding products. The traditional postlabeling a...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.96104s3655
更新日期:1996-05-01 00:00:00
abstract:BACKGROUND:Ambient levels of pesticides ("pesticide drift") are detectable at residences near agricultural field sites. OBJECTIVE:Our goal was to evaluate the hypothesis that maternal residence near agricultural pesticide applications during key periods of gestation could be associated with the development of autism s...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.10168
更新日期:2007-10-01 00:00:00
abstract::A potential connection exists between exposure to organochlorine chemicals and the increasing prevalence of endometriosis. Evidence shows that dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin) can increase the incidence and severity of the disease in monkeys and can promote the growth or survival of endometrial tissue impl...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.0211015
更新日期:2002-01-01 00:00:00
abstract::Food allergy affects between 5% and 7.5% of children and between 1% and 2% of adults. The greater prevalence of food allergy in children reflects both the increased predisposition of children to develop food allergies and the development of immunologic tolerance to certain foods over time. Immunoglobulin (Ig) E-mediat...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.5702
更新日期:2003-02-01 00:00:00
abstract:BACKGROUND:Human epidemiological and animal studies suggest that developmental exposure to contaminants that activate the aryl hydrocarbon receptor (AHR) lead to suppression of immune system function throughout life. The persistence of immune deficiency throughout life suggests that the cellular target of AHR activatio...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1509820
更新日期:2016-07-01 00:00:00
abstract::Exposure to ultrafine particles (UFPs) from vehicle exhaust has been related to risk of cardiovascular and pulmonary disease and cancer, even though exposure assessment is difficult. We studied personal exposure in terms of number concentrations of UFPs in the breathing zone, using portable instruments in six 18-hr pe...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7562
更新日期:2005-11-01 00:00:00
abstract::It has been estimated that 4 of 1,000 live births and 35% of spontaneous abortions are aneuploid and that an important proportion of embryo and newborn aneuploidy is of paternal origin. Exposure to organophosphorous pesticides (OP) has been associated with sperm hyperploidy/polyploidy. Therefore, we aimed to assess th...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.011091237
更新日期:2001-12-01 00:00:00
abstract::Prostaglandin-H synthase is unique among enzymes of the plant and animal kingdom in its ability to biosynthesize and metabolize hydroperoxides. Its cyclooxygenase activity oxygenates polyunsaturated fatty acids to hydroperoxy endoperoxides, and its peroxidase activity reduces the hydroperoxy group to hydroxy groups. H...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.90885
更新日期:1990-08-01 00:00:00
abstract::Polychlorinated biphenyls (PCBs) are persistent pollutants that are ubiquitous in the food chain, and detectable amounts are in the blood of almost every person in most populations that have been examined. Extensive evidence from animal studies shows that PCBs are neurotoxins, even at low doses. Interpretation of huma...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.5463
更新日期:2003-01-01 00:00:00
abstract::Environmental estrogens are of particular concern when exposure occurs during embryonic development. Although there are good models to study estrogenic activity of chemicals in adult animals, developmental exposure is much more difficult to test. The weak estrogenic activity of the environmental estrogen bisphenol A (...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7155
更新日期:2004-11-01 00:00:00
abstract::Trichloroethylene is an organic chemical that has been used in dry cleaning, for metal degreasing, and as a solvent for oils and resins. It has been shown to cause liver and kidney cancer in experimental animals. This article reviews over 80 published papers and letters on the cancer epidemiology of people exposed to ...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.00108s2161
更新日期:2000-05-01 00:00:00
abstract::The phthalate acid esters (PAEs), and, in particular, di(2-ethylhexyl) phthalate (DEHP) and its monoester, monoethylhexyl phthalate (MEHP), can adversely affect rodent testes but only at high doses. Rat gonadal zinc levels can be decreased by the injection of DEHP, but not MEHP. The rat prostate gland seems to be part...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.824585
更新日期:1982-11-01 00:00:00
abstract:BACKGROUND:Persistent organic pollutants (POPs) are developmental toxicants, but the impact of both maternal and paternal exposures on offspring birth size is largely unexplored. OBJECTIVE:We examined associations between maternal and paternal serum concentrations of 63 POPs, comprising five major classes of pollutant...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1308016
更新日期:2015-01-01 00:00:00
abstract::[35S]t-Butylbicyclophosphorothionate or [35S]TBPS is an improved radioligand for the picrotoxinin binding site in rat brain synaptic membranes. The toxic isomers of the hexachlorocyclohexanes, polychlorobornanes, and chlorinated cyclodienes displace [35S]TBPS with a stereospecificity and potency generally correlated w...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
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更新日期:1985-09-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9961
更新日期:2007-09-01 00:00:00
abstract::Studies have shown that female mosquitofish living downstream of a paper mill located on the Fenholloway River, Florida, have masculinized secondary sex characteristics, including altered anal fin development and reproductive behavior. Masculinization can be caused by exposure to androgens in the water or from an alte...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.02110s3429
更新日期:2002-06-01 00:00:00
abstract::The ability of a series of haloalkanes, haloethanols and haloacetaldehydes to induce mutations in Salmonella typhrimurium and preferentially to inhibit the growth of DNA polymerase-deficient E. coli (pol A(+)/pol A(-)) was investigated. For the haloalkanes investigated, the order of reactivities towards the E. coli po...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.772179
更新日期:1977-12-01 00:00:00
abstract::Bisphenol A (BPA) is the monomer used to manufacture polycarbonate plastic, the resin lining of cans, and other products, with global capacity in excess of 6.4 billion lb/year. Because the ester bonds in these BPA-based polymers are subject to hydrolysis, leaching of BPA has led to widespread human exposure. A recent ...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.7713
更新日期:2005-08-01 00:00:00
abstract::Children are uniquely vulnerable to toxic chemicals in the environment. Among the environmental toxicants to which children are at risk of exposure are endocrine disruptors (EDs)--chemicals that have the capacity to interfere with hormonal signaling systems. EDs may alter feedback loops in the brain, pituitary, gonads...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.5799
更新日期:2003-10-01 00:00:00
abstract::The central feature of hemopoiesis is life-long, stable cell renewal. This process is supported by hemopoietic stem cells which, in the steady state, appear to be dormant in cell cycling. The entry into cell cycle of the dormant stem cells may be promoted by such factors as interleukin-1, interleukin-6 (IL-6), and gra...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.8980199
更新日期:1989-03-01 00:00:00
abstract::Previously we have demonstrated that several xenobiotics can induce multidrug (mdr) gene expression in cultures of primary isolated hepatocytes. One of the best of these xenobiotic inducers in rat hepatocytes is 2-acetylaminofluorene (2-AAF), which induces mdr expression by an enhancement of mdr gene transcription. In...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102s6209
更新日期:1994-10-01 00:00:00
abstract::To assess levels of chlorinated contaminants in breast milk, we measured organochlorine pesticides, polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins (PCDDs), and polychlorinated dibenzofurans (PCDFs) in breast milk samples collected in 1994 according to the World Health Organization protocol from 92 donors...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.98106797
更新日期:1998-12-01 00:00:00