Mechanisms underlying Children's susceptibility to environmental toxicants.

abstract：OBJECTIVE:This study was designed to determine whether prenatal mercury exposure, including potential releases from the World Trade Center (WTC) disaster, adversely affects fetal growth and child development. METHODS:We determined maternal and umbilical cord blood total mercury of nonsmoking women who delivered at ter...

journal_title：Environmental health perspectives

authors： Lederman SA,Jones RL,Caldwell KL,Rauh V,Sheets SE,Tang D,Viswanathan S,Becker M,Stein JL,Wang RY,Perera FP

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Traffic noise affects a large number of people, particularly in urbanized areas. Noise causes stress and annoyance, but less is known about the relationship between noise and depression. OBJECTIVE:We investigated the association of residential road traffic noise with depressive symptoms using 5-year follow-...

journal_title：Environmental health perspectives

authors： Orban E,McDonald K,Sutcliffe R,Hoffmann B,Fuks KB,Dragano N,Viehmann A,Erbel R,Jöckel KH,Pundt N,Moebus S

更新日期：2016-05-01 00:00:00

abstract：:Striking similarities have been observed in a number of extrapulmonary responses of rodents to seemingly disparate ambient pollutants. These responses are often characterized by primary decreases in important indices of cardiac and thermoregulatory function, along with secondary decreases in associated parameters. For...

journal_title：Environmental health perspectives

authors： Watkinson WP,Campen MJ,Nolan JP,Costa DL

更新日期：2001-08-01 00:00:00

abstract：:Asthma is the most common chronic illness of childhood and its prevalence is increasing, causing much concern for identification of risk factors such as air pollution. We previously conducted a study showing a relationship between asthma visits in all persons < 65 years of age to emergency departments (EDs) and air po...

journal_title：Environmental health perspectives

authors： Norris G,YoungPong SN,Koenig JQ,Larson TV,Sheppard L,Stout JW

更新日期：1999-06-01 00:00:00

abstract：:Mineral fibers and particulates represent one of the best documented, economically important, and ubiquitously occurring categories of human carcinogens. Yet, while a wealth of information exists concerning the mechanism of action of physical, chemical, and viral carcinogens, virtually nothing is known relative to the...

journal_title：Environmental health perspectives

authors： Hart RW,Daniel FB,Kindig OR,Beach CA,Joseph LB,Wells RC

更新日期：1980-02-01 00:00:00

abstract：:In recent years, exposure of man to increasing amounts of metals has occurred rather generally from industrial contamination and variably from intake of dietary mineral supplements. Adverse effects of individual metals can be markedly altered by dietary levels of other essential and nonessential inorganic elements, es...

journal_title：Environmental health perspectives

authors： Fox MR

更新日期：1978-08-01 00:00:00

abstract：:In this paper we give some examples of using databases of genotoxicity and carcinogenicity for quantitative and qualitative correlation studies between short-term tests and carcinogenicity. The quality of the databases is obviously important, but one of the major deficiencies of present databases is that they are too ...

journal_title：Environmental health perspectives

authors： Parodi S,Malacarne D,Taningher M

更新日期：1991-12-01 00:00:00

abstract：BACKGROUND:Benchmark dose (BMD) modeling is an important step in human health risk assessment and is used as the default approach to identify the point of departure for risk assessment. A probabilistic framework for dose-response assessment has been proposed and advocated by various institutions and organizations; ther...

journal_title：Environmental health perspectives

authors： Shao K,Shapiro AJ

更新日期：2018-01-11 00:00:00

abstract：:Antisera elicited in rabbits were used in radioimmunoassay (RIA) and enzyme-linked immunosorbent assay (ELISA) to determine femtomole quantities of deoxyguanosin-(8-yl)-acetylaminofluorene (dg-8-AAF) and deoxyguanosin-(8-yl)-aminofluorene (dg-8-AF). These adducts have been monitored in liver and kidney DNA of male Wis...

journal_title：Environmental health perspectives

authors： Poirier MC,True B,Laishes BA

更新日期：1983-03-01 00:00:00

abstract：:This article reviews the epidemiologic studies of the association of ischemic heart disease risk and environmental tobacco smoke (ETS) exposure from a spouse who smokes. Seventeen studies (nine cohort, eight case-control) comprising more than 485,000 lifelong nonsmokers and 7,345 coronary heart disease (CHD) events we...

journal_title：Environmental health perspectives

authors： Thun M,Henley J,Apicella L

更新日期：1999-12-01 00:00:00

abstract：:Biomarkers are desirable for quantitating human exposure to environmental tobacco smoke (ETS) and for predicting potential health risks for exposed individuals. A number of biomarkers of ETS have been proposed. At present cotinine, measured in blood, saliva, or urine, appears to be the most specific and the most sensi...

journal_title：Environmental health perspectives

authors： Benowitz NL

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Studies on the health effects of polychlorinated biphenyls (PCBs) call for an understanding of past and present human exposure. Time-resolved mechanistic models may supplement information on concentrations in individuals obtained from measurements and/or statistical approaches if they can be shown to reprodu...

journal_title：Environmental health perspectives

authors： Nøst TH,Breivik K,Wania F,Rylander C,Odland JØ,Sandanger TM

更新日期：2016-03-01 00:00:00

abstract：:The timing of some key embryological events is given for man, rat, chick, and certain other animals. Such times, however, are approximations, and variations occur among members of the same strain and even among members of the same litter. Some differences in developmental patterns are indicated. ...

journal_title：Environmental health perspectives

authors： Monie IW

更新日期：1976-12-01 00:00:00

abstract：:Effects of respirable aerosols of sulfuric acid, ammonium sulfate, sodium sulfite, and ammonium persulfate on lungs of rats are reviewed. The literature regarding interactions between ozone or nitrogen dioxide and acidic aerosols (ammonium sulfate, sulfuric acid) is discussed. An unexpected interaction between nitroge...

journal_title：Environmental health perspectives

authors： Last JA

更新日期：1989-02-01 00:00:00

abstract：:Residents living in communities near Superfund sites have expressed concern that releases from these facilities affect their health, including adverse effects on their immune systems. We used data from six cross-sectional studies to evaluate whether people who live near several Superfund sites are more likely to have ...

journal_title：Environmental health perspectives

authors： Williamson DM,White MC,Poole C,Kleinbaum D,Vogt R,North K

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Animal studies suggest that early-life lead exposure influences gene expression and production of proteins associated with Alzheimer's disease (AD). OBJECTIVES:We attempted to assess the relationship between early-life lead exposure and potential biomarkers for AD among young men and women. We also attempte...

journal_title：Environmental health perspectives

authors： Mazumdar M,Xia W,Hofmann O,Gregas M,Ho Sui S,Hide W,Yang T,Needleman HL,Bellinger DC

更新日期：2012-05-01 00:00:00

abstract：:We measured volatile organic compound (VOC) exposures in multiple locations for a diverse population of children who attended two inner-city schools in Minneapolis, Minnesota. Fifteen common VOCs were measured at four locations: outdoors (O), indoors at school (S), indoors at home (H), and in personal samples (P). Con...

journal_title：Environmental health perspectives

authors： Adgate JL,Church TR,Ryan AD,Ramachandran G,Fredrickson AL,Stock TH,Morandi MT,Sexton K

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Exposure to metals has been implicated in the pathogenesis of Parkinson disease (PD). OBJECTIVES:We sought to examine in a large prospective study of female nurses whether exposure to airborne metals was associated with risk of PD. METHODS:We linked the U.S. Environmental Protection Agency (EPA)'s Air Toxi...

journal_title：Environmental health perspectives

authors： Palacios N,Fitzgerald K,Roberts AL,Hart JE,Weisskopf MG,Schwarzschild MA,Ascherio A,Laden F

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Globally, 2.8 billion people rely on household solid fuels. Reducing the resulting adverse health, environmental, and development consequences will involve transitioning through a mix of clean fuels and improved solid fuel stoves (IS) of demonstrable effectiveness. To date, achieving uptake of IS has present...

journal_title：Environmental health perspectives

authors： Rehfuess EA,Puzzolo E,Stanistreet D,Pope D,Bruce NG

更新日期：2014-02-01 00:00:00

abstract：:We have witnessed a tremendous increase in our knowledge of the molecular and biochemical mechanisms which underly the activities of the nervous system. Such knowledge is essential in order to determine the basic mechanisms involved in neurotoxic events. An overview of how neurotoxins could conceivably interfere with ...

journal_title：Environmental health perspectives

authors： Damstra T

更新日期：1978-10-01 00:00:00

abstract：BACKGROUND:Thyroid hormones are important regulators of brain development. During critical periods of development, even transient disorders in thyroid hormone availability may lead to profound neurologic impairment. Animal experiments have shown that certain environmental pollutants, including heavy metals and organoch...

journal_title：Environmental health perspectives

authors： Maervoet J,Vermeir G,Covaci A,Van Larebeke N,Koppen G,Schoeters G,Nelen V,Baeyens W,Schepens P,Viaene MK

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Ambient levels of pesticides ("pesticide drift") are detectable at residences near agricultural field sites. OBJECTIVE:Our goal was to evaluate the hypothesis that maternal residence near agricultural pesticide applications during key periods of gestation could be associated with the development of autism s...

journal_title：Environmental health perspectives

authors： Roberts EM,English PB,Grether JK,Windham GC,Somberg L,Wolff C

更新日期：2007-10-01 00:00:00

abstract：:It is generally agreed that estrogens, and possibly androgens, are important in the etiology of breast cancer, but no consensus exists as to the precise estrogenic or androgenic environment that characterizes risk, or the exogenous factors that influence the hormonal milieu. Nearly all the epidemiological studies cond...

journal_title：Environmental health perspectives

authors： Toniolo PG

更新日期：1997-04-01 00:00:00

abstract：:The phenylphosphonothioate insecticides EPN and leptophos, and several analogs, were evaluated with respect to their delayed neurotoxic effects in hens and their environmental behavior in a terrestrial-aquatic model ecosystem. Acute toxicity to insects was highly correlated with sigma sigma of the substituted phenyl g...

journal_title：Environmental health perspectives

authors： Francis BM,Hansen LG,Fukuto TR,Lu PY,Metcalf RL

更新日期：1980-06-01 00:00:00

abstract：:Fluorescence in situ hybridization with chromosome-specific composite DNA probes (chromosome painting) is a reliable and efficient method for detecting structural chromosome aberrations. Painting is now being used to quantify chromosome damage in many human populations. In one such study we evaluated 91 unexposed peop...

journal_title：Environmental health perspectives

authors： Tucker JD,Moore DH 2nd

更新日期：1996-05-01 00:00:00

abstract：:Methyl parathion (MP), an organophosphate pesticide licensed only for agricultural uses, was sprayed illegally for pest control in Mississippi and Ohio residences. To evaluate the association between MP exposure and neurobehavioral development, we assessed children 6 years or younger at the time of the spraying and lo...

journal_title：Environmental health perspectives

authors： Ruckart PZ,Kakolewski K,Bove FJ,Kaye WE

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Exposure to air pollution has been associated with higher C-reactive protein (CRP) levels, suggesting an inflammatory response. Not much is known about this association in pregnancy. OBJECTIVES:We investigated the associations of air pollution exposure during pregnancy with maternal and fetal CRP levels in ...

journal_title：Environmental health perspectives

authors： van den Hooven EH,de Kluizenaar Y,Pierik FH,Hofman A,van Ratingen SW,Zandveld PY,Lindemans J,Russcher H,Steegers EA,Miedema HM,Jaddoe VW

更新日期：2012-05-01 00:00:00

abstract：:Techniques are available to minimize the concentration of asbestos fibers in drinking water. Filtration research conducted at locations on Lake Superior and in the Cascade Mountains in Washington has shown that amphibole and chrysotile fibers can be removed by granular media filtration. Removal percentages can exceed ...

journal_title：Environmental health perspectives

authors： Logsdon GS

更新日期：1983-11-01 00:00:00

abstract：:Under a mandate from the U.S. Congress, the National Toxicology Program (NTP) of the U.S. Department of Health and Human Services conducts animal bioassays for carcinogenicity of potentially toxic chemicals to which the U.S. population might be exposed. Methyleugenol, a natural as well as synthesized substance, was no...

journal_title：Environmental health perspectives

authors： Schecter A,Lucier GW,Cunningham ML,Abdo KM,Blumenthal G,Silver AG,Melnick R,Portier C,Barr DB,Barr JR,Stanfill SB,Patterson DG Jr,Needham LL,Stopford W,Masten S,Mignogna J,Tung KC

更新日期：2004-05-01 00:00:00

abstract：:The review of over 800 references on aluminum (Al) published since the mid-fifties covers the occurrence of Al in soil, air, water, plants and food products, as well as air and water pollution problems. In addition, the existing quality criteria, the biology and toxicology of Al, and the therapeutic and medical uses a...

journal_title：Environmental health perspectives

authors： Sorenson JR,Campbell IR,Tepper LB,Lingg RD

更新日期：1974-08-01 00:00:00