Examples of uses of databases for quantitative and qualitative correlation studies between genotoxicity and carcinogenicity.

abstract：:Determination of polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) in fly ash and cinders collected from nine municipal incinerators in Japan was made. The concentrations of PCDDs and PCDFs in this study were generally in the same range as those in Europe and North America. However, t...

journal_title：Environmental health perspectives

authors： Wakimoto T,Tatsukawa R

更新日期：1985-02-01 00:00:00

abstract：:Although press reports indicate that the leakage of methyl isocyanate (MIC) on December 3, 1984, in Bhopal has led to an increase in spontaneous abortions, stillbirths, infant mortality, and fetal abnormalities, no clinical or experimental studies on the reproductive toxicity of MIC were reported in scientific journal...

journal_title：Environmental health perspectives

authors： Varma DR

更新日期：1987-06-01 00:00:00

abstract：:Some have hypothesized that community water containing sodium silicofluoride and hydrofluosilicic acid may increase blood lead (PbB) concentrations in children by leaching of lead from water conduits and by increasing absorption of lead from water. Our analysis aimed to evaluate the relation between water fluoridation...

journal_title：Environmental health perspectives

authors： Macek MD,Matte TD,Sinks T,Malvitz DM

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:The upward trend in industrial nations in the incidence of male genitourinary (GU) conditions may be attributed to increased exposure to endocrine disruptors. Polybrominated biphenyl (PBB), a brominated flame retardant, is one such suspected endocrine disruptor. OBJECTIVE:We investigated the relationship be...

journal_title：Environmental health perspectives

authors： Small CM,DeCaro JJ,Terrell ML,Dominguez C,Cameron LL,Wirth J,Marcus M

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:In the developing brain, serotonin (5HT) systems are among the most sensitive to disruption by organophosphates. OBJECTIVES:We exposed neonatal rats to daily doses of diazinon or parathion on postnatal days (PND)1-4 and evaluated 5HT receptors and the 5HT transporter in brainstem and forebrain on PND5, focu...

journal_title：Environmental health perspectives

authors： Slotkin TA,Tate CA,Ryde IT,Levin ED,Seidler FJ

更新日期：2006-10-01 00:00:00

abstract：:We previously reported that cell cultures of human proximal tubule (HPT) cells respond to ionic cadmium in a manner consistent with well-defined Cd(2+)-elicited responses reported for in vivo systems. However, one unique finding was that the transepithelial electrical resistance and tight junction sealing strands were...

journal_title：Environmental health perspectives

authors： Hazen-Martin DJ,Todd JH,Sens MA,Khan W,Bylander JE,Smyth BJ,Sens DA

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:Industrial air pollution is a public health hazard. Previous evidence documented increased respiratory symptoms and hospitalizations in children who live near the factories in the largest chipboard manufacturing district in Italy (Viadana). OBJECTIVES:We evaluated the association of outdoor exposure to form...

journal_title：Environmental health perspectives

authors： Marcon A,Fracasso ME,Marchetti P,Doria D,Girardi P,Guarda L,Pesce G,Pironi V,Ricci P,de Marco R

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Psychological sequelae are among the most pronounced effects in populations following exposure to oil spills. Women in particular represent a vulnerable yet influential population but have remained relatively understudied with respect to the Deepwater Horizon oil spill (DHOS). OBJECTIVE:To describe the rela...

journal_title：Environmental health perspectives

authors： Rung AL,Gaston S,Oral E,Robinson WT,Fontham E,Harrington DJ,Trapido E,Peters ES

更新日期：2016-09-01 00:00:00

abstract：:As a result of the Leadership Conference on Biomedical Research and the Environment, the Facilities Committee focused its work on the development of best environmental practices at biomedical research facilities at the university and independent research facility level as well as consideration of potential involvement...

journal_title：Environmental health perspectives

authors： Medlin EL,Grupenhoff JT

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:Experimental tools for studying the complex steroidogenic interactions that occur between placenta and fetus during human pregnancy are extremely limited. OBJECTIVES:We aimed to develop a co-culture model to study steroidogenesis by the human fetoplacental unit and its disruption by exposure to environmenta...

journal_title：Environmental health perspectives

authors： Hudon Thibeault AA,Deroy K,Vaillancourt C,Sanderson JT

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Arsenicals (roxarsone and nitarsone) used in poultry production likely increase inorganic arsenic (iAs), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), and roxarsone or nitarsone concentrations in poultry meat. However, the association between poultry intake and exposure to these arsenic species, ...

journal_title：Environmental health perspectives

authors： Nigra AE,Nachman KE,Love DC,Grau-Perez M,Navas-Acien A

更新日期：2017-03-01 00:00:00

abstract：:In this paper we report DNA binding of butadiene monoepoxide, a first metabolite of 1,3-butadiene catalyzed by monooxygenases. We prepared alkylated purines as marker compounds for 32-P-postlabeling and electrochemical analysis and developed methods to measure the corresponding products. The traditional postlabeling a...

journal_title：Environmental health perspectives

authors： Koivisto P,Adler ID,Sorsa M,Peltonen K

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND:The pesticide atrazine does not bind to or activate the classical estrogen receptor (ER), but it up-regulates the aromatase activity in estrogen-sensitive tumor cells. The G protein estrogen receptor (GPR30/GPER) has been reported to be involved in certain biological responses to endogenous estrogens and env...

journal_title：Environmental health perspectives

authors： Albanito L,Lappano R,Madeo A,Chimento A,Prossnitz ER,Cappello AR,Dolce V,Abonante S,Pezzi V,Maggiolini M

更新日期：2015-05-01 00:00:00

abstract：:Until recently, mutagenicity testing was done on preselected compounds in a manner in which the testing laboratories knew the identity of the substances under test and the "expected" results, i.e., positive for compounds selected because of their carcinogenicity and negative for food additives. There is no completed s...

journal_title：Environmental health perspectives

authors： Valcovic LR

更新日期：1977-10-01 00:00:00

abstract：BACKGROUND:THE APHENA (AIR POLLUTION AND HEALTH: A Combined European and North American Approach) study is a collaborative analysis of multicity time-series data on the effect of air pollution on population health, bringing together data from the European APHEA (Air Pollution and Health: A European Approach) and U.S. N...

journal_title：Environmental health perspectives

authors： Samoli E,Peng R,Ramsay T,Pipikou M,Touloumi G,Dominici F,Burnett R,Cohen A,Krewski D,Samet J,Katsouyanni K

更新日期：2008-11-01 00:00:00

abstract：:The effects of DEHP on sperm morphology and on peripheral blood micronuclei were studied for 12 weeks following five subacute IP injections of DEHP at 1/6, 1/12, and 1/60 of the LD50 per day. Sperm morphology was examined in both adult mice and rats, while peripheral blood micronuclei were scored in mice up to 4 weeks...

journal_title：Environmental health perspectives

authors： Douglas GR,Hugenholtz AP,Blakey DH

更新日期：1986-03-01 00:00:00

abstract：BACKGROUND:The effect of indoor nitrogen dioxide concentrations on asthma morbidity among inner-city preschool children is uncertain. OBJECTIVES:Our goal was to estimate the effect of indoor NO2 concentrations on asthma morbidity in an inner-city population while adjusting for other indoor pollutants. METHODS:We recr...

journal_title：Environmental health perspectives

authors： Hansel NN,Breysse PN,McCormack MC,Matsui EC,Curtin-Brosnan J,Williams DL,Moore JL,Cuhran JL,Diette GB

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Humans living near industrial point emissions can experience high levels of exposures to air pollutants. Map Ta Phut Industrial Estate in Thailand is the location of the largest steel, oil refinery, and petrochemical factory complexes in Southeast Asia. Air pollution is an important source of oxidative stres...

journal_title：Environmental health perspectives

authors： Peluso M,Srivatanakul P,Munnia A,Jedpiyawongse A,Ceppi M,Sangrajrang S,Piro S,Boffetta P

更新日期：2010-01-01 00:00:00

abstract：:Historical aerial applications of the insecticide Matacil 1.8D provide an opportunity to look for potential effects of the endocrine disrupting compound 4-nonylphenol (4-NP) on Atlantic salmon (Salmo salar) populations. Matacil 1.8D contained the carbamate insecticide aminocarb, with 4-NP as primary solvent. Between 1...

journal_title：Environmental health perspectives

authors： Fairchild WL,Swansburg EO,Arsenault JT,Brown SB

更新日期：1999-05-01 00:00:00

abstract：:The neurochemical basis of memory has been approached experimentally in four different ways: the bioassay; the interventive approach; the interventive-correlative approach; and the correlative approach. These approaches are fundamentally similar to those used for the study of the chemistry of any behavior. Each of the...

journal_title：Environmental health perspectives

authors： Dunn AJ

更新日期：1978-10-01 00:00:00

abstract：:We review pharmacokinetic and pharmacodynamic factors that should be considered in the design and interpretation of developmental neurotoxicity studies. Toxicologic effects on the developing nervous system depend on the delivered dose, exposure duration, and developmental stage at which exposure occurred. Several phar...

journal_title：Environmental health perspectives

authors： Dorman DC,Allen SL,Byczkowski JZ,Claudio L,Fisher JE Jr,Fisher JW,Harry GJ,Li AA,Makris SL,Padilla S,Sultatos LG,Mileson BE

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:A critical question regarding the association between short-term exposure to ozone and mortality is the extent to which this relationship is confounded by ambient exposure to particles. OBJECTIVES:We investigated whether particulate matter < 10 and < 2.5 microm in aerodynamic diameter (PM(10) and PM(2.5)) i...

journal_title：Environmental health perspectives

authors： Bell ML,Kim JY,Dominici F

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Cohort studies in North America and western Europe have reported increased risk of mortality associated with long-term exposure to fine particles (PM2.5), but to date, no such studies have been reported in China, where higher levels of exposure are experienced. OBJECTIVES:We estimated the association betwee...

journal_title：Environmental health perspectives

authors： Yin P,Brauer M,Cohen A,Burnett RT,Liu J,Liu Y,Liang R,Wang W,Qi J,Wang L,Zhou M

更新日期：2017-11-07 00:00:00

abstract：:Ingestion is an important exposure route for polycyclic aromatic hydrocarbons (PAHs) to enter the human body. Although the formation of hazardous PAH metabolites by human biotransformation enzymes is well documented, nothing is known about the PAH transformation potency of human intestinal microbiota. Using a gastroin...

journal_title：Environmental health perspectives

authors： Van de Wiele T,Vanhaecke L,Boeckaert C,Peru K,Headley J,Verstraete W,Siciliano S

更新日期：2005-01-01 00:00:00

abstract：:Organophosphates in increasing amounts and wider varieties of molecular structure are being used to replace the organochlorine pesticides. It has been assumed that the organophosphates as a class would have a minimal chronic toxicity due to rapid hydrolysis and an unfavorable partitioning as regards to lipids. The phy...

journal_title：Environmental health perspectives

authors： Freed VH,Haque R,Schmedding D,Kohnert R

更新日期：1976-02-01 00:00:00

abstract：:A few animal studies on the possible carcinogenic effect of magnetic fields have been published. They have been designed to reveal a possible tumor promotion obtained by applying continuous or pulsed alternating fields at flux densities varying between 0.5 microT and 30 mT on mice or rats initiated with different init...

journal_title：Environmental health perspectives

authors： Holmberg B

更新日期：1995-03-01 00:00:00

abstract：:Acetylcholinesterase (AChE) is the enzyme that hydrolyzes the neurotransmitter acetylcholine at cholinergic synapses and neuromuscular junctions. However, results from our laboratory and others indicate that AChE has an extrasynaptic, noncholinergic role during neural development. This article is a review of our findi...

journal_title：Environmental health perspectives

authors： Bigbee JW,Sharma KV,Gupta JJ,Dupree JL

更新日期：1999-02-01 00:00:00

abstract：:Sulfur trioxide in the exhaust gas of an internal combustion engine is removed and concentrated by absorption in a solution of 80% isopropyl alcohol, which quantitatively absorbs it and inhibits the oxidation of any sulfur dioxide which may be absorbed. The absorbed sulfur trioxide (sulfuric acid) is determined by an ...

journal_title：Environmental health perspectives

authors： Arnold DR

更新日期：1975-04-01 00:00:00

abstract：:Implementation of the Toxic Substances Control Act of 1977 creates the need to reliably establish testing priorities because laboratory resources are limited and the number of industrial chemicals requiring evaluation is overwhelming. The use of quantitative structure activity relationship (QSAR) models as rapid and p...

journal_title：Environmental health perspectives

authors： McKim JM,Bradbury SP,Niemi GJ

更新日期：1987-04-01 00:00:00

abstract：:We conducted a case-control study to determine the contribution of lead to blood from consumption of calcium supplements approximating the recommended daily intakes over a 6-month period. Subjects were males and females ages 21 to 47 years (geometric mean 32 years) with a geometric mean blood lead concentration of 2.5...

journal_title：Environmental health perspectives

authors： Gulson BL,Mizon KJ,Palmer JM,Korsch MJ,Taylor AJ

更新日期：2001-03-01 00:00:00